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    QUANTITATIVE MEASUREMENT OF NANO/MICRO PARTICLE ENDOCYTOSIS WITH CELL MASS SPECTROMETRY
    673.
    发明申请
    QUANTITATIVE MEASUREMENT OF NANO/MICRO PARTICLE ENDOCYTOSIS WITH CELL MASS SPECTROMETRY 审中-公开
    纳米/微粒子内毒素与细胞质谱的定量测量

    公开(公告)号：US20110236882A1

    公开(公告)日：2011-09-29

    申请号：US13075160

    申请日：2011-03-29

    Applicant: Huan-Chang LIN ,  Hsin-Hung LIN ,  Cai-Yu KAO ,  Alice L. Yu ,  Wen-Ping PENG ,  Chung-Hsuan Chen

    Inventor： Huan-Chang LIN ,  Hsin-Hung LIN ,  Cai-Yu KAO ,  Alice L. Yu ,  Wen-Ping PENG ,  Chung-Hsuan Chen

    IPC: C12Q1/70 ,  C12Q1/02 ,  C12Q1/68

    CPC classification number: G01N33/5091 ,  G01N33/5008 ,  G01N33/569 ,  G01N33/6848

    Abstract: Methods for detecting the presence of nanoparticles or microparticles by cell mass spectrometry (CMS) are provided. CMS methods are provided for determining the number of nanoparticles or microparticles in each cell. Nanoparticles whose intracellular concentration can be determines by the CMS methods of the invention include polymeric nanoparticles (NPs), liposomes, viral-based NPs, carbon nanotubes, diamond NPs, polymeric micelles, nanocarriers, liposomes, and viral nanoparticles. Determination of the efficiency of drug delivery and intracellular titer of pathogens according to the invention is disclosed. Methods for determining intracellular uptake of virus particles are provided.

    Abstract translation: 提供了通过细胞质谱法（CMS）检测纳米颗粒或微粒的存在的方法。 提供CMS方法用于确定每个细胞中纳米颗粒或微粒的数量。 通过本发明的CMS方法可以确定其细胞内浓度的纳米颗粒包括聚合物纳米颗粒（NP），脂质体，基于病毒的NP，碳纳米管，金刚石NP，聚合胶束，纳米载体，脂质体和病毒纳米颗粒。 公开了根据本发明的药物递送效率和病原体细胞内滴度的测定。 提供了确定病毒颗粒的细胞内吸收的方法。

    ALIGNMENT AND ANTI-DRIFT MECHANISM
    678.
    发明申请
    ALIGNMENT AND ANTI-DRIFT MECHANISM 有权
    对准和防止机制

    公开(公告)号：US20110098926A1

    公开(公告)日：2011-04-28

    申请号：US12604722

    申请日：2009-10-23

    Applicant: Ing-Shouh Hwang ,  En-Te Hwu ,  Hans Ulrich Danzebrink ,  Hartmut Illers

    Inventor： Ing-Shouh Hwang ,  En-Te Hwu ,  Hans Ulrich Danzebrink ,  Hartmut Illers

    IPC: G06G7/78

    CPC classification number: G01Q10/065 ,  G01Q70/04

    Abstract: A system includes a displacement sensor, an actuator connected to the displacement sensor, and a feedback unit. The displacement sensor is configured to measure at least one of a relative position and a relative orientation between the displacement sensor and the target object. The feedback unit receives a signal from the displacement sensor related to the measured relative position or relative orientation and controls the actuator to move the displacement sensor on the basis of variations in the received signal arising due to a change in environmental conditions.

    Abstract translation: 系统包括位移传感器，连接到位移传感器的致动器和反馈单元。 位移传感器构造成测量位移传感器和目标物体之间的相对位置和相对取向中的至少一个。 反馈单元从位移传感器接收与所测量的相对位置或相对取向相关的信号，并且基于由于环境条件的变化而产生的接收信号的变化来控制致动器来移动位移传感器。

    Fabricating Scaffolds and Other Cell-Growth Structures Using Microfluidics to Culture Biological Samples
    679.
    发明申请
    Fabricating Scaffolds and Other Cell-Growth Structures Using Microfluidics to Culture Biological Samples 有权
    使用微流体培养生物样品制备支架和其他细胞生长结构

    公开(公告)号：US20110091972A1

    公开(公告)日：2011-04-21

    申请号：US12582575

    申请日：2009-10-20

    Applicant: Keng-Hui Lin ,  Narayan Mishra ,  Yen-Liang Liu ,  Chen-chie Wang

    Inventor： Keng-Hui Lin ,  Narayan Mishra ,  Yen-Liang Liu ,  Chen-chie Wang

    IPC: C12N5/00 ,  B29C44/36

    CPC classification number: C12N5/0655 ,  B29C44/00 ,  C12M25/14 ,  C12N5/0068 ,  C12N2533/74

    Abstract: Methods and apparatuses for using microfluidics to generate bubbles and using the generated bubbles to construct scaffolds and cell-holding structures for culturing biological samples or analytes. In one implementation, a scaffold for growing cells is provided to include a matrix of interconnected cavities formed from mixing a gas and a liquid containing a cross linkable material to produce a matrix of gas bubbles of substantially the same size and cross linking the cross linkable material to form a structure in which cells are grown. In another implementation, a scaffold apparatus for growing cells includes a ball of a cross linked material forming an exterior shell that encloses to form a hollow interior inside the ball and biological samples embedded in the external shell.

    Abstract translation: 使用微流体产生气泡并使用生成的气泡构建用于培养生物样品或分析物的支架和细胞保持结构的方法和装置。 在一个实施方案中，提供了用于生长细胞的支架，以包括通过混合气体和含有可交联材料的液体形成的互连腔的基质，以产生基本上相同尺寸的气泡基质并交联可交联材料 以形成细胞生长的结构。 在另一实施方案中，用于生长细胞的支架装置包括形成外壳的交联材料球，所述外壳包围以形成球内的中空内部并嵌入外壳中的生物样品。

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