公开(公告)号：US10895560B2

公开(公告)日：2021-01-19

申请号：US16651722

申请日：2018-03-18

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Daqi Gao ,  Zejian Wang ,  Xiaoqin Zhang ,  Jiamin Song

IPC: G01N33/00 ,  G01N1/24 ,  G06N3/08

Abstract: Provided is a sensory quality evaluation method for tobacco and tobacco products using an electronic nose instrument. The electronic nose instrument includes a gas sensor array module, an automatic smoke sampling system, a computer control and data analysis system, and an automatic ignition device. These components are integrated in a test box to make the instrument be structure miniaturization and work automation. The large tobacco data is established, in which the relationship between the responses of gas sensor array and the brand labels and sensory quality index scores by testing a large number of standard cigarette samples. A cascade type of modular neural networks is proposed with revised activation function and new decision-making and quantification rules to simulate the smoking and evaluating process of the professional panel. The electronic nose instrument and method realize on-site detection, discrimination and quality score estimation of a large number of tobacco and tobacco products.

公开(公告)号：US10788450B2

公开(公告)日：2020-09-29

申请号：US15546671

申请日：2016-01-08

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Yitao Long ,  Chan Cao ,  Yongxu Hu

IPC: C12Q1/6869 ,  G01N33/487 ,  G01N27/447

Abstract: A preparation method for an aerolysin nanopore in this disclosure comprises the following steps: (1) pretreatment of an aerolysin; (2) preparation of a lipid bilayer membrane by pulling process; (3) forming of the aerolysin nanopore: the aerolysin nanopore is obtained at a current of 50±5 pA. The aerolysin nanopore prepared in the invention is structurally stable and has a high resolution with the whole internal cavity carried with a positive charge, can be used for detection without modification and is easily operated. Further, the aerolysin nanopore can be applied in DNA sequencing, DNA damage and Micro-RNA detection.

公开(公告)号：US10787651B2

公开(公告)日：2020-09-29

申请号：US16620525

申请日：2018-04-13

Applicant: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. ,  EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Huilei Yu ,  Yan Zhang ,  Jianhe Xu ,  Qian Zhao ,  Jiang Pan ,  Feng Liu ,  Guoqiang Lin

IPC: C12N9/02 ,  C12P17/02 ,  C12P11/00 ,  C12P17/10 ,  C12P17/16 ,  A61K38/00

Abstract: A Bradyrhizobium monooxygenase, a gene for encoding the monooxygenase, a recombinant expression vector comprising the gene and a recombinant transformant, a method of preparing the monooxygenase by the recombinant expression transformant, and a method of preparing an optically pure chiral sulfoxide by the monooxygenase, in particular to a method of preparing prazole drugs by means of catalyzing the asymmetric oxidation of thioether, a prazole precursor. As compared with other methods of preparing an optically pure sulfoxide, the product produced by the monooxygenase of the present invention as a catalyst has high optical purity, avoids the generation of the byproduct sulfone, and has advantages of mild reaction conditions, simple and convenient operations, easy amplification, etc.

公开(公告)号：US10774355B2

公开(公告)日：2020-09-15

申请号：US16310741

申请日：2016-06-16

Applicant: East China University of Science and Technology

Inventor： Fengqing Wang ,  Liqin Xu ,  Yongjun Liu ,  Haohao Liu ,  Liangbin Xiong ,  Dongzhi Wei

IPC: C12P33/00 ,  C12P33/02 ,  C12N9/02 ,  C12R1/325 ,  C12R1/33 ,  C12R1/34 ,  C12R1/32

Abstract: The present invention relates to a genetically-engineered Mycobacterium strain and a use thereof in the preparation of steroidal compounds. The genetically-engineered Mycobacterium strain is a Mycobacteria which lacks of acyl-CoA dehydrogenase genes fadE31, fadE32 and fadE33, wherein acyl-CoA dehydrogenase genes fadE31, fadE32 and fadE33 respectively encode proteins as follows: having amino acid sequences according to SEQ ID NOs 4, 6 and 8; derived by substituting, deleting or inserting one or more amino acids in the amino acid sequence defined by preceding protein and having the same function as that of the preceding protein. The present invention constructs a genetically-engineered Mycobacterium strain and applies it in preparing steroidal compounds, thereby enriching the types of valuable intermediates, improving the production efficiency and product quality of steroid drugs, reducing energy consumption in the steroid drugs production, simplifying production steps, and reducing production costs.

公开(公告)号：US20200248069A1

公开(公告)日：2020-08-06

申请号：US16652208

申请日：2018-09-29

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Linyong Zhu ,  Yi Yang ,  Bingkun Bao ,  Chenxia Zhang ,  Dasheng Zhang ,  Chunyan Bao ,  Qiuning Lin ,  Ningfeng Li ,  Xin Hua ,  Yongliang Zhao ,  Renmei Liu ,  Zhengda Chen ,  Yuying Sun

IPC: C09K11/07 ,  G01N33/68 ,  G01N33/58 ,  C07C255/23 ,  C07D263/54 ,  C07D277/64 ,  C07D233/96 ,  C07D307/68 ,  C07D495/04 ,  C07D333/60 ,  C07D413/06 ,  C07D409/06 ,  C07D417/06 ,  C07D215/38 ,  C07D401/06 ,  C07D495/14

Abstract: Provided are a fluorescent probe, a preparation method therefor and a use thereof. The fluorescent probe responds to viscosity sensitively and specifically, can be used for the specific fluorescence labeling of proteins and can also be used in the quantification, detection or kinetic study of proteins and the imaging of cells, tissues and living bodies.

公开(公告)号：US10703938B2

公开(公告)日：2020-07-07

申请号：US16064235

申请日：2016-12-16

Applicant: KUNSHAN TIANYANG HOT MELT ADHESIVE CO., LTD. ,  SHANGHAI TIANYANG HOT MELT ADHESIVE CO., LTD. ,  EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Zuoxiang Zeng ,  Xingquan Ma ,  Zhelong Li

IPC: C09J5/06 ,  C09J11/06 ,  C09J11/08 ,  C08G69/26 ,  C08G69/36 ,  C09J177/06

Abstract: A novel hot-melt adhesive and a preparation method thereof are disclosed, and in particular a hot-melt adhesive for bonding aluminum, stainless steel or other metal materials and PVC plastics is disclosed. The specific nylon-type copolyamide is firstly prepared by designing specific raw materials and percentage thereof, and in combination with favorable bonding properties of the nylon-type copolyamide for metals and favorable bonding characteristics of the perchloroethylene resin for PVC, a double screw extruder is utilized to perform sufficient melt blending on the nylon-type copolyamide and the perchloroethylene resin under the synergistic actions of related aids, so that the obtained novel hot-melt adhesive has favorable bonding properties for both metals and PVC.

公开(公告)号：US10689469B2

公开(公告)日：2020-06-23

申请号：US16157974

申请日：2018-10-11

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  SHANGHAI FUYUAN RUBBER AND PLASTIC TECHNOLOGY LTD.

Inventor： Anna Zheng ,  Yong Guan ,  Dafu Wei ,  Xiang Xu ,  Pengfei Zhan ,  Weixing Liu ,  Han Shi

IPC: C08F220/14 ,  C08F2/10 ,  C08F212/08 ,  C08F265/06 ,  C08F287/00 ,  C08L25/14 ,  C08L35/06 ,  C08L77/06 ,  C08F2/01 ,  C08F2/44 ,  C08F212/10 ,  C08K5/00

Abstract: A method of reactive extrusion copolymerization of vinyl monomer consisting of (1) feeding vinyl monomer or at least one vinyl monomer together with an initiator into the first screw of twin-screw extruder, and modified resin into the subsequent screw section; (2) feeding the above monomer into the screw segment after auto-acceleration zone and feeding the initiator corresponding to the temperature of barrel and micro/nano inorganic modified fillers after the half-life period of the initiator; (3) feeding the antioxidant and anti-UV agent at the end of the polymerization, and then removing unpolymerized monomer and by-products by devolatilization of screw segment; (4) obtaining vinyl copolymer resin with a anticipated molecular weight of 5×102 to 6×105 from the reactive extrusion polymerization by controlling the temperature of different screw segments. The invention which overcomes the existing defects of the free radical polymerization by reactive extrusion technology, can not only meet the requirement of short stay time of reactive extrusion polymerization, combine the functionalization and high performance, but also make it possible to obtain high molecular weight polymers.

公开(公告)号：US10479798B2

公开(公告)日：2019-11-19

申请号：US15523058

申请日：2015-10-30

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Honglin Li ,  Hualiang Jiang ,  Yufang Xu ,  Jia Li ,  Zhenjiang Zhao ,  Jingya Li ,  Hongling Xu ,  Shiliang Li

IPC: C07D311/60 ,  C07D311/92 ,  C07D405/04 ,  C07D493/04 ,  A61K31/352 ,  A61K31/5377 ,  C07D221/10 ,  C07D335/04 ,  C07D417/04

Abstract: The present invention relates to six-membered ring benzo derivatives as a DPP-4 inhibitor and a use thereof. In particular, the present invention relates to a compound as shown in formula I, a pharmaceutical composition containing the compound as shown in formula I and a use of the compound in the preparation of drugs for treating DPP-4 related diseases or inhibiting DPP-4.

公开(公告)号：US20190264249A1

公开(公告)日：2019-08-29

申请号：US16310741

申请日：2016-06-16

Applicant: East China University Of Science And Technology

Inventor： Fengqing Wang ,  Liqin Xu ,  Yongjun Liu ,  Haohao Liu ,  Liangbin Xiong ,  Dongzhi Wei

IPC: C12P33/00 ,  C12R1/34 ,  C12R1/33 ,  C12R1/325 ,  C12N9/02

Abstract: The present invention relates to a genetically-engineered Mycobacterium strain and a use thereof in the preparation of steroidal compounds. The genetically-engineered Mycobacterium strain is a Mycobacteria which lacks of acyl-CoA dehydrogenase genes fadE31, fadE32 and fadE33, wherein acyl-CoA dehydrogenase genes fadE31, fadE32 and fadE33 respectively encode proteins as follows: having amino acid sequences according to SEQ ID NOs 4, 6 and 8; derived by substituting, deleting or inserting one or more amino acids in the amino acid sequence defined by preceding protein and having the same function as that of the preceding protein. The present invention constructs a genetically-engineered Mycobacterium strain and applies it in preparing steroidal compounds, thereby enriching the types of valuable intermediates, improving the production efficiency and product quality of steroid drugs, reducing energy consumption in the steroid drugs production, simplifying production steps, and reducing production costs.

公开(公告)号：US10351706B2

公开(公告)日：2019-07-16

申请号：US15756734

申请日：2016-08-30

Applicant: East China University of Science and Technology

Inventor： Youjun Yang ,  Xinran Li ,  Zuhai Lei ,  Yi Li

IPC: C07D491/22 ,  C07D311/96 ,  C09K11/06 ,  C09B11/10 ,  C07D491/20 ,  C09B11/24 ,  C09B23/01

Abstract: The invention relates to a near-infrared fluorescent dye and use thereof, and particularly relates to compounds represented by following Formulae A, B and C, wherein each group in the Formulae is described in the specification. Further provided are a dye composition comprising the compound represented by Formula A or Formula B, and a preparation method of the compound represented by Formula A or Formula B. The compound has a maximum absorption wavelength of 880 nm, considerably exceeding maximum absorption wavelengths of the majority of small-molecule near-infrared fluorescent dyes in the prior art. Moreover, the structure thereof does not aggregate even if the concentration thereof is excessively high, thereby having considerably high chemical stability and light stability.