公开(公告)号：US11834663B2

公开(公告)日：2023-12-05

申请号：US17365260

申请日：2021-07-01

Applicant: Monash University

Inventor： Siew Yeen Chai ,  Robert Widdop ,  Tracey Gaspari ,  Huey Wen Lee

IPC: A61K31/395 ,  A61K31/351 ,  A61K31/4433 ,  A61P11/16 ,  A61P9/00 ,  A61P13/12 ,  C12N15/113 ,  A61K31/4709 ,  A61K31/55 ,  A61P1/16

CPC classification number: C12N15/1137 ,  A61K31/351 ,  A61K31/395 ,  A61K31/4433 ,  A61K31/4709 ,  A61K31/55 ,  A61P1/16 ,  A61P9/00 ,  A61P13/12 ,  C12N2310/14

Abstract: The present invention relates to compositions, methods and kits for the treatment of fibrosis. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment of cardiac fibrosis. The invention provides a method of treating fibrosis in an individual comprising administering an inhibitor of insulin-regulated aminopeptidase (IRAP), thereby treating fibrosis.

公开(公告)号：US11738087B2

公开(公告)日：2023-08-29

申请号：US15758633

申请日：2016-09-08

Applicant: Monash University

Inventor： Chris Porter ,  Jamie Simpson ,  Natalie Trevaskis ,  Tim Quach ,  Sifei Han ,  Luojuan Hu

IPC: A61K47/54 ,  A61K31/568 ,  A61K31/27 ,  A61K31/365 ,  A61K31/485 ,  A61K31/222 ,  A61K31/165 ,  A61K31/138 ,  A61K31/167 ,  C07C219/06 ,  C07C235/36 ,  C07D307/88 ,  C07C271/24 ,  C07D489/12 ,  C07J1/00 ,  A61K9/00 ,  A61K45/06

CPC classification number: A61K47/542 ,  A61K9/0053 ,  A61K31/138 ,  A61K31/165 ,  A61K31/167 ,  A61K31/222 ,  A61K31/27 ,  A61K31/365 ,  A61K31/485 ,  A61K31/568 ,  A61K45/06 ,  C07C219/06 ,  C07C235/36 ,  C07C271/24 ,  C07D307/88 ,  C07D489/12 ,  C07J1/0025 ,  C07J1/0029 ,  C07C2602/26 ,  A61K31/365 ,  A61K2300/00 ,  A61K31/485 ,  A61K2300/00 ,  A61K31/568 ,  A61K2300/00 ,  A61K31/222 ,  A61K2300/00 ,  A61K31/165 ,  A61K2300/00 ,  A61K31/27 ,  A61K2300/00

Abstract: The present invention relates to compounds and their uses, in particular, compounds in the form of prodrugs that pro mote transport of a pharmaceutical agent to the lymphatic system and subsequently enhance release of the parent drug.

公开(公告)号：US20220395513A1

公开(公告)日：2022-12-15

申请号：US17881458

申请日：2022-08-04

Applicant: PureTech LYT, Inc. ,  Monash University

Inventor： Daniel Kenneth Bonner ,  Rishab R. Shyam ,  Jamie Simpson ,  Christopher John Porter ,  Natalie Trevaskis ,  Tim Quach ,  Sifei Han ,  Luojuan Hu

IPC: A61K31/573 ,  A61K47/54

Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

公开(公告)号：US11387012B2

公开(公告)日：2022-07-12

申请号：US16610067

申请日：2018-04-24

Applicant: MONASH UNIVERSITY

Inventor： Wenlong Cheng ,  George P Simon ,  Yan Wang

IPC: H01B1/02 ,  H01B13/00 ,  B22F9/24 ,  B22F1/07 ,  B82Y30/00 ,  B82Y40/00

Abstract: An elastic conductor comprising: an elastomeric substrate, and an array of nanowires, wherein the nanowires are upstanding relative to the surface of the substrate.

公开(公告)号：US20220162550A1

公开(公告)日：2022-05-26

申请号：US17534594

申请日：2021-11-24

Applicant: Monash University

Inventor： Jose POLO ,  Xiaodong LIU ,  Jia Ping TAN

IPC: C12N5/0735

Abstract: The present invention relates to stem cells derived from a multi-layered cellular structure or blastocyst structure, compositions comprising the same, and methods for obtaining the same.

公开(公告)号：US20220152145A1

公开(公告)日：2022-05-19

申请号：US17348023

申请日：2021-06-15

Applicant: Monash University

Inventor： Michelle McIntosh ,  David Morton ,  Tomas Sou ,  Livesey Olerile ,  Richard Prankerd

IPC: A61K38/095 ,  A61K9/16 ,  A61K9/00 ,  C07K7/16

Abstract: This invention relates to drug delivery and in particular to the delivery of biologically active agents in the form of dry powders for inhalation. The invention also relates to methods for preparing such dry powder formulations and methods for their use.

公开(公告)号：US11335515B2

公开(公告)日：2022-05-17

申请号：US16644684

申请日：2018-04-26

Applicant: MONASH UNIVERSITY

Inventor： Parama Chakraborty Banerjee ,  Mainak Majumder ,  Derrek Evan Lobo ,  Abozar Akbarivakilabadi

IPC: H01G11/26 ,  H01G11/52 ,  H01G11/56

Abstract: The invention provides a capacitive energy storage device comprising: at least one porous film infiltrated with an electrolyte; and one or more pairs of separated electrodes disposed on top of a first surface of the porous film, each electrode comprising a capacitive electrode material in ionic communication with the underlying porous film, wherein the electrolyte provides ionic communication between the separated electrodes via the internal porosity of the porous film.

公开(公告)号：US11280875B2

公开(公告)日：2022-03-22

申请号：US17253607

申请日：2019-05-30

Applicant: MONASH UNIVERSITY

Inventor： Stefanie Cincotta ,  Adrian Neild ,  Jean Armstrong

IPC: G01S5/16 ,  G01S1/70 ,  H04B10/116

Abstract: A visible light positioning receiver arrangement for obtaining spatial position information of the receiver arrangement from a plurality of luminaires (5), at least one of the luminaires including at least one associated modulated light source for transmitting a light signal providing positional information of one or more reference points associated with the luminaire, said receiver arrangement including: an imaging receiver for capturing an image of the luminaires and associated said reference point(s); and a non-imaging receiver (7) for estimating an angle of arrival (AOA) of light from each said modulated light source, and for decoding the reference point positional information therefrom; wherein said AOA information and reference point positional information from the non-imaging receiver is matched to the image captured by the imaging receiver to obtain said spatial position information.

公开(公告)号：US20210244825A1

公开(公告)日：2021-08-12

申请号：US17155773

申请日：2021-01-22

Applicant: Monash University

Inventor： Charles Reay MACKAY ,  Di YU ,  Remy ROBERT

IPC: A61K47/68 ,  C07K16/24 ,  A61K38/20

Abstract: The invention relates to IL-21, to antibodies and related fragments thereof for binding to IL-21, to production of said antibodies and fragments and to use of said antibodies and fragments for detection and therapy of various conditions, in particular inflammation, infection and oncology.

公开(公告)号：US11065445B2

公开(公告)日：2021-07-20

申请号：US16092989

申请日：2017-04-10

Applicant: MONASH UNIVERSITY

Inventor： Paul B Fitzgerald ,  Caley M. Sullivan ,  Richard H. Thomson

IPC: A61N1/36 ,  A61B5/00 ,  A61B5/369 ,  A61B5/375 ,  A61N1/04 ,  A61B5/318 ,  A61B5/389

Abstract: Closed-loop transcranial stimulation and monitoring is disclosed that includes generating a stimulation signal having a set of first oscillation parameters; applying the stimulation signal transcranially to a patient; monitoring the stimulation signal as applied to the patient; receiving a brain activity signal from the patient; generating a feedback signal based on the monitored stimulation signal as applied to the patient; and generating a modified activity signal by subtracting the feedback signal from the brain activity signal; determining one or more second oscillation parameters of the modified activity signal; and adjusting the set of first oscillation parameters of the stimulation signal based on the one or more second oscillation parameters of the modified activity signal. Closed-loop transcranial stimulation and monitoring is also disclosed in which the patient is engaged in a cognitive task.