公开(公告)号：US12050227B2

公开(公告)日：2024-07-30

申请号：US16386804

申请日：2019-04-17

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  NARA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ayyalusamy Ramamoorthy ,  Thirupathi Ravula ,  Bikash Sahoo ,  Kazuma Yasuhara ,  Jin Arakida ,  Jun-Ichi Kikuchi

IPC: G01N33/92 ,  A61K9/127 ,  C08F220/14 ,  C08F220/18

CPC classification number: G01N33/92 ,  A61K9/1273 ,  C08F220/14 ,  G01N2333/575 ,  G01N2405/00

Abstract: The disclosure generally relates generally to lipid nanodiscs, in particular to lipid nanodiscs formed from acryloyl-based copolymers. A lipid nanodisc according to the disclosure includes a lipid bilayer having a first hydrophilic face and a second hydrophilic face opposing the first hydrophilic face, and a hydrophobic edge between the opposing hydrophilic faces, and an acryloyl-based copolymer encircling the hydrophobic edge of the lipid bilayer. The acryloyl-based copolymer includes a first monomer unit having a pendant hydrophobic group and a second monomer unit having a pendant hydrophilic group. Methods of making and characterizing the lipid nanodiscs are also disclosed.

公开(公告)号：US11276194B2

公开(公告)日：2022-03-15

申请号：US17042481

申请日：2019-03-28

Applicant: NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Keita Tomochika ,  Takuya Kiyokawa ,  Tsukasa Ogasawara ,  Jun Takamatsu ,  Ming Ding

IPC: G06T7/70

Abstract: Provided are a method and a device that can efficiently generate a training dataset. Object information is associated with a visual marker, a training dataset generation jig that is configured from a base part and a marker is used, said base part being provided with an area that serves as a guide for positioning a target object and said marker being fixed on the base part, the target object is positioned using the area as a guide and in this condition an image group of the entire object including the marker is acquired, the object information that was associated with the visual marker is acquired from the acquired image group, a reconfigured image group is generated from this image group by performing a concealment process on a region corresponding to the visual marker or the training dataset generation jig, a bounding box is set in the reconfigured image group on the basis of the acquired object information, information relating to the bounding box, the object information, and estimated target object position information and posture information are associated with a captured image, and a training dataset for performing object recognition and position/posture estimation for the target object is generated.

公开(公告)号：US11123324B2

公开(公告)日：2021-09-21

申请号：US16326127

申请日：2017-08-17

Applicant: NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  NOSTER INC.

Inventor： Reiko Shinkura ,  Kota Yamamoto

IPC: A61K31/365 ,  A61K31/407 ,  A61P37/08 ,  A61K45/00 ,  A61P11/06 ,  A61P27/02 ,  A61P43/00 ,  A61P17/00 ,  A61P37/02 ,  A61P17/04 ,  A61P11/02 ,  A61K39/39 ,  A61P1/04

Abstract: The present invention provides a pharmaceutical composition to be used for the treatment or prophylaxis of allergic diseases. More specifically, the present invention provides a pharmaceutical composition to be used for the treatment or prophylaxis of allergic diseases, which contains a substance that induces selective IgA class switching in B cells. As a substance that induces selective IgA class switching in B cells, a PKC activator can be used. In addition, a composition containing a substance that induces selective IgA class switching in B cells can also be useful as a mucosal adjuvant.

公开(公告)号：US11119451B2

公开(公告)日：2021-09-14

申请号：US16537526

申请日：2019-08-10

Applicant: Yokogawa Electric Corporation ,  NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Takamitsu Matsubara ,  Yunduan Cui ,  Lingwei Zhu ,  Hiroaki Kanokogi ,  Morihiro Fujisaki ,  Go Takami ,  Yota Furukawa

IPC: G05B13/02 ,  G06N20/10 ,  F01K23/10 ,  G06N5/00

Abstract: Provided is an apparatus including a plurality of agents that each set some devices among a plurality of devices provided in a facility to be target devices, wherein each of the plurality of agents includes a state acquiring section that acquires state data indicating a state of the facility; a control condition acquiring section that acquires control condition data indicating a control condition of each target device; and a learning processing section that uses learning data including the state data and the control condition data to perform learning processing of a model that outputs recommended control condition data indicating a control condition recommended for each target device in response to input of the state data.

公开(公告)号：US20210246462A1

公开(公告)日：2021-08-12

申请号：US16980266

申请日：2019-03-14

Applicant: MEDICAGO INC. ,  NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  MITSUBISHI TANABE PHARMA CORPORATION

Inventor： Pierre-Oliver LAVOIE ,  Marc-Andre D'AOUST ,  Ko KATO ,  Shotaro YAMASAKI

IPC: C12N15/82 ,  C12N15/86

Abstract: An isolated expression enhancer active in a plant, portion of a plant or plant cell, the expression enhancer is provided. The isolated expression enhancer may be selected from the group consisting of nbMT78 (SEQ ID NO:1); nbATL75 (SEQ ID NO:2); nbDJ46 (SEQ ID NO:3); nbCHP79 (SEQ ID NO:4); nbEN42 (SEQ ID NO:5); atHSP69 (SEQ ID NO:6); atGRP62 (SEQ ID NO:7); atPK65 (SEQ ID NO:8); atRP46 (SEQ ID NO:9); nb30S72 (SEQ ID NO:10); nbGT61 (SEQ ID NO:11); nbPV55 (SEQ ID NO:12); nbPPI43 (SEQ ID NO:13); nbPM64 (SEQ ID NO:14); and nbH2A86 (SEQ ID NO:15). Methods for using the isolated expression enhancer are also provided.

公开(公告)号：US20190277739A1

公开(公告)日：2019-09-12

申请号：US16319329

申请日：2017-07-21

Applicant: NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Takahito AOTO ,  Yasuhiro MUKAIGAWA

IPC: G01N3/36 ,  G01N3/06

Abstract: To provide a method whereby viscoelasticity of an object can be measured nondestructively and in non-contact fashion in a short time. By this method, elastic waves and light are radiated to an object and the viscoelasticity of an object is measured nondestructively and in non-contact fashion using a shadow change based on a change in the direction of a line normal to the surface of the object. Specifically, the present invention has an elastic wave transmission step for pressurizing or exciting the object by elastic waves and causing a minute displacement of the object surface shape, a photoirradiation step for radiating light to the minutely displaced object surface, an image acquisition step for acquiring a shadow change based on a change in the direction of a line normal to the object surface, and a viscoelasticity estimation step for processing an image of the acquired shadow change and calculating a viscoelasticity.

公开(公告)号：US20190193741A1

公开(公告)日：2019-06-27

申请号：US16227465

申请日：2018-12-20

Applicant: DENSO CORPORATION ,  NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Kentaro HITOMI ,  Kazuhito TAKENAKA ,  Masataka MORI ,  Kazushi IKEDA ,  Takatomi KUBO ,  Hiroaki SASAKI

IPC: B60W40/06 ,  G06K9/00 ,  H04W4/46 ,  G08G1/0967

CPC classification number: B60W40/06 ,  G06K9/00791 ,  G08G1/096791 ,  H04W4/46

Abstract: In an apparatus for detecting an anomaly of an evaluation target condition of a road, a storage stores a reference data set correlating to a predetermined attribute and being comprised of reference data samples. An anomaly level calculator obtains, from target vehicles, an evaluation data set correlating to the predetermined attribute and being comprised of evaluation data samples. The evaluation data samples are collected from the respective target vehicles as target driving data items at the predetermined attribute under the evaluation target condition of the road. The target driving data item for each of the target vehicles represents at least one driving operation of the corresponding one of the target vehicles. The anomaly level calculator compares the reference data set with the evaluation data set to thereby calculate an anomaly level of the evaluation target condition of the road.

公开(公告)号：US09611461B2

公开(公告)日：2017-04-04

申请号：US14777880

申请日：2014-03-14

Applicant: National University Corporation Nara Institute of Science and Technology

Inventor： Iwao Ohtsu ,  Takeshi Nakatani ,  Ai Tamakoshi ,  Sayo Takahashi ,  Hiroshi Takagi

IPC: C12P13/12 ,  C12N1/20 ,  C12N9/10 ,  C12N15/70

CPC classification number: C12N9/1085 ,  C12N15/70 ,  C12P13/12 ,  C12Y205/01047

Abstract: L-cysteine can be produced inexpensively and efficiently by using a bacterium belonging to the family Enterobacteriaceae modified to reduce activity of O-acetylserine sulfhydrylase B thereof, the bacterium being modified so that the C terminal region of its thiosulfate-binding protein is deleted, and the bacterium having an increased ability to produce L-cysteine in the presence of a sulfate.

公开(公告)号：US09480837B2

公开(公告)日：2016-11-01

申请号：US14763331

申请日：2014-02-12

Applicant: NATIONAL UNIVERSITY CORPORATION NARA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Toshihiko Noda ,  Takashi Tokuda ,  Kiyotaka Sasagawa ,  Jun Ohta

IPC: A61N1/00 ,  A61N1/05 ,  A61B5/0478 ,  A61B5/0492 ,  A61B5/00

CPC classification number: A61N1/0529 ,  A61B5/0478 ,  A61B5/0492 ,  A61B5/4064 ,  A61B5/686 ,  A61B2562/046 ,  A61N1/0531 ,  A61N1/0543

Abstract: Providing an electrode structure capable of realizing an electrode array which allows each of the electrodes to be individually controlled while allowing them to be densely arranged and placed in a living body. According to the present invention, an electrode control circuit electrically connected to an electrode body is fixed to a rear portion of the electrode body within a front-viewed contour of the electrode body. This electrode control circuit may be contained in a recess formed in the rear portion of the electrode body, or it may be fixed to the back face of the electrode body. Conversely, an electrically conductive material layer covering the electrode control circuit may be used as the electrode body. A plurality of such bioelectrodes may be arranged in a two-dimensional form on a substrate or connected by a connection line including an electrical wire. Such configurations allow the bioelectrodes to be densely arranged.

Abstract translation: 提供能够实现电极阵列的电极结构，其允许每个电极被单独控制，同时允许它们被密集地布置并放置在生物体中。 根据本发明，电连接到电极体的电极控制电路在电极体的前视图轮廓内固定到电极体的后部。 该电极控制电路可以容纳在形成在电极体的后部的凹部中，也可以固定在电极体的背面。 相反，可以使用覆盖电极控制电路的导电材料层作为电极体。 多个这样的生物电极可以以二维形式布置在基板上或者通过包括电线的连接线连接。 这种构造允许生物电极密集地布置。

公开(公告)号：US08999854B2

公开(公告)日：2015-04-07

申请号：US13658583

申请日：2012-10-23

Applicant: Sumitomo Electric Industries, Ltd. ,  National University Corporation Nara Institute of Science and Technology

Inventor： Takeyoshi Masuda ,  Tomoaki Hatayama

IPC: H01L21/302 ,  H01L29/861 ,  H01L29/78 ,  H01L29/06 ,  H01L29/868 ,  H01L29/739 ,  H01L21/308 ,  H01L21/3065 ,  H01L29/12 ,  H01L21/02 ,  H01L29/16

CPC classification number: H01L29/8613 ,  H01L21/02529 ,  H01L21/02576 ,  H01L21/0262 ,  H01L21/0475 ,  H01L21/3065 ,  H01L21/3083 ,  H01L29/045 ,  H01L29/06 ,  H01L29/0615 ,  H01L29/0619 ,  H01L29/0623 ,  H01L29/0661 ,  H01L29/12 ,  H01L29/1608 ,  H01L29/4236 ,  H01L29/4238 ,  H01L29/66068 ,  H01L29/739 ,  H01L29/78 ,  H01L29/7813 ,  H01L29/861 ,  H01L29/868 ,  Y10S438/931

Abstract: On a substrate, a silicon carbide layer provided with a main surface is formed. A mask is formed to cover a portion of the main surface of the silicon carbide layer. The main surface of the silicon carbide layer on which the mask is formed is thermally etched using chlorine-based gas so as to provide the silicon carbide layer with a side surface inclined relative to the main surface. The step of thermally etching is performed in an atmosphere in which the chlorine-based gas has a partial pressure of 50% or smaller.

Abstract translation: 在基板上形成具有主表面的碳化硅层。 形成掩模以覆盖碳化硅层的主表面的一部分。 利用氯系气体对其上形成有掩模的碳化硅层的主表面进行热蚀刻，从而为碳化硅层提供相对于主表面倾斜的侧表面。 热蚀刻步骤在氯系气体的分压为50％以下的气氛中进行。