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公开(公告)号：US20130011882A1
公开(公告)日：2013-01-10
申请号：US13472058
申请日：2012-05-15
Applicant: LUIS G. CASCÃO-PEREIRA , JAMES T. KELLIS, JR. , BRADLEY A. PAULSON , SCOTT D. POWER , SANDRA W. RAMER , VIVEK SHARMA , ANDREW SHAW , JAYARAMA K. SHETTY , DONALD E. WARD
Inventor： LUIS G. CASCÃO-PEREIRA , JAMES T. KELLIS, JR. , BRADLEY A. PAULSON , SCOTT D. POWER , SANDRA W. RAMER , VIVEK SHARMA , ANDREW SHAW , JAYARAMA K. SHETTY , DONALD E. WARD
CPC classification number: C11D3/38681 , C11D3/386 , C12N9/2417 , D06M16/003
Abstract: Disclosed are compositions comprising variants of alpha-amylase that have alpha-amylase activity and which exhibit altered properties relative to a parent AmyS-like alpha-amylase from which they are derived. The compositions comprise an additional enzyme such as a phytase. Also disclosed are methods of using the compositions, and kits related thereto.
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公开(公告)号：US20120014885A1
公开(公告)日：2012-01-19
申请号：US11919717
申请日：2006-04-25
Applicant: Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita Van Kimmenade , Gudrun Vogtentanz
Inventor： Katherine D. Collier , Anthony Day , Hans de Nobel , David A. Estell , Grant C. Ganshaw , Marc Kolkman , Raj Lad , Jeffrey V. Miller , Christopher J. Murray , Scott D. Power , Brian Schmidt , Anita Van Kimmenade , Gudrun Vogtentanz
IPC: A61K8/64 , A61Q17/04 , A61Q5/00 , A61Q1/02 , A61Q19/10 , A61Q1/10 , A61K38/08 , A61K38/16 , A61Q7/02 , C07K19/00 , A61Q15/00 , A61Q1/06
CPC classification number: A61K8/64 , A61K8/66 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q7/02 , A61Q9/00 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/04 , A61Q19/10 , C07K7/06
Abstract: The present invention provides peptides and supported peptides for treating various diseases and conditions. In particularly preferred embodiments, the present invention provides compositions and methods for personal care. In some embodiments, the present invention provides compositions for use in skin and/or hair care, as well as cosmetic compositions. In alternative particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold protein comprises BBI.
Abstract translation: 本发明提供用于治疗各种疾病和病症的肽和负载肽。 在特别优选的实施方案中，本发明提供用于个人护理的组合物和方法。 在一些实施方案中，本发明提供用于皮肤和/或头发护理以及化妆品组合物的组合物。 在替代的特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载的肽，例如红斑痤疮。 在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。 在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。 在一些最优选的实施方案中，支架蛋白包含BBI。
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公开(公告)号：US20100221780A1
公开(公告)日：2010-09-02
申请号：US12779793
申请日：2010-05-13
Applicant: Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
Inventor： Neelam S. Amin , Katherine D. Collier , Melodie Estabrook , David A. Estell , Bryan P. Fox , Scott D. Power , Brian F. Schmidt , Gudrun Vogtentanz
IPC: C12P21/00
CPC classification number: C07K14/811 , A61K8/64 , A61Q7/02
Abstract: The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.
Abstract translation: 本发明涉及包含结合靶蛋白的肽的修饰变体Bowman Birk蛋白酶抑制剂蛋白（BBPI），并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。 本发明包括多核苷酸构建体和含有编码修饰变体BBPI的多核苷酸序列的表达载体，表达和产生修饰变体BBPI的转化宿主细胞，修饰变体BBPI蛋白，包含修饰变体BBPI的组合物和制备方法 并在个人护理中使用修改后的变体BBPI。
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公开(公告)号：US20090258832A1
公开(公告)日：2009-10-15
申请号：US12404063
申请日：2009-03-13
Applicant: Scott D. Power , Fiona A. Harding
Inventor： Scott D. Power , Fiona A. Harding
CPC classification number: G01N33/6878 , A61K38/00 , C07K14/505 , C07K14/524 , C07K14/565 , C07K14/7151 , G01N33/505 , G01N33/56972 , G01N33/6863
Abstract: The present invention provides methods for the identification of CD4+ T-cell epitopes in the sequences of various proteins, namely, human cytokines and cytokine receptors, as well as the production of peptides which when incorporated into the protein sequence, are no longer capable of initiating the CD4+ T-cell response. In some embodiments, the present invention provides means and compositions suitable for reducing the immunogenicity of cytokines and cytokines receptors such as interferon-β, soluble tumor necrosis factor receptor-1, erythropoietin, and thrombopoietin.
Abstract translation: 本发明提供了鉴定各种蛋白质序列中的CD4 + T细胞表位的方法，即人类细胞因子和细胞因子受体，以及当其并入蛋白质序列时不再能起始的肽的产生 CD4 + T细胞应答。 在一些实施方案中，本发明提供适于降低细胞因子和细胞因子受体如干扰素-β，可溶性肿瘤坏死因子受体-1，促红细胞生成素和血小板生成素的免疫原性的方法和组合物。
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Patent Agency Ranking
公开(公告)号：US07524816B2
公开(公告)日：2009-04-28
申请号：US10984270
申请日：2004-11-08
Applicant: Anthony G. Day , David A. Estell , Christopher J. Murray , Scott D. Power
Inventor： Anthony G. Day , David A. Estell , Christopher J. Murray , Scott D. Power
IPC: A61K38/16
CPC classification number: C07K14/81 , A61K38/00 , C07K7/06 , C07K14/811 , C07K2319/00 , C12N15/62
Abstract: The present invention provides peptides and supported peptides for treating proliferative diseases. In particularly preferred embodiments, the present invention provides peptides and supported peptides for treating diseases of the skin, such as rosacea. In some particularly preferred embodiments, the supported peptides of the present invention are anti-VEGF peptides. In alternative particularly preferred embodiments, the anti-VEGF peptides are expressed on a scaffold protein. In some most preferred embodiments, the scaffold proteins is BBI.
Abstract translation: 本发明提供用于治疗增殖性疾病的肽和负载肽。 在特别优选的实施方案中，本发明提供用于治疗皮肤疾病的肽和负载肽，例如红斑痤疮。 在一些特别优选的实施方案中，本发明的负载型肽是抗VEGF肽。 在替代的特别优选的实施方案中，抗VEGF肽在支架蛋白上表达。 在一些最优选的实施方案中，支架蛋白是BBI。
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公开(公告)号：US20080131932A1
公开(公告)日：2008-06-05
申请号：US11848213
申请日：2007-08-30
Applicant: Hans De Nobel , David A. Estell , Wei Liu , Scott D. Power , Brian Schmidt , Huaming Wang
Inventor： Hans De Nobel , David A. Estell , Wei Liu , Scott D. Power , Brian Schmidt , Huaming Wang
CPC classification number: C12N15/80 , C07K14/811
Abstract: Described herein are protease inhibitors, variants thereof and methods for their production.
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公开(公告)号：US06297037B1
公开(公告)日：2001-10-02
申请号：US08194664
申请日：1994-02-10
Applicant: Christopher C. Barnett , Colin Mitchinson , Scott D. Power , Carol A. Requadt
Inventor： Christopher C. Barnett , Colin Mitchinson , Scott D. Power , Carol A. Requadt
IPC: C12N928
CPC classification number: C12N9/2417 , C11D3/386 , C12N15/75 , C12P19/14
Abstract: Novel alpha-amylase mutants derived from the DNA sequences of naturally occurring or recombinant alpha-amylases are disclosed. The mutant alpha-amylases, in general, are obtained by in vitro modifications of a precursor DNA sequence encoding the naturally occurring or recombinant alpha-amylase to generate the substitution (replacement) or deletion of one or more oxidizable amino acid residues in the amino acid sequence of a precursor alpha-amylase. Such mutant alpha-amylases have altered oxidative stability and/or altered pH performance profiles and/or altered thermal stability as compared to the precursor. Also disclosed are detergent and starch liquefaction compositions comprising the mutant amylases, as well as methods of using the mutant amylases.
Abstract translation: 公开了衍生自天然存在或重组α-淀粉酶的DNA序列的新型α-淀粉酶突变体。 通常，通过体外修饰编码天然存在或重组α-淀粉酶的前体DNA序列以产生氨基酸中一个或多个可氧化氨基酸残基的取代（置换）或缺失，获得突变体α-淀粉酶 前体α-淀粉酶的序列。 与前体相比，这种突变型α-淀粉酶具有改变的氧化稳定性和/或改变的pH性能特征和/或改变的热稳定性。 还公开了包含突变淀粉酶的洗涤剂和淀粉液化组合物，以及使用突变淀粉酶的方法。
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公开(公告)号：US5871550A
公开(公告)日：1999-02-16
申请号：US924440
申请日：1997-08-26
Applicant: Frits Goedegebuur , Scott D. Power , Deborah Winetzky , Anita Van Kimmenade , Mee-Young Yoon
Inventor： Frits Goedegebuur , Scott D. Power , Deborah Winetzky , Anita Van Kimmenade , Mee-Young Yoon
CPC classification number: C11D3/38645 , A23K10/14
Abstract: A mutant cellulase obtainable from Thermomonospora spp is provided which differs from a precursor cellulase in that it has been genetically engineered to introduce a substitution, deletion or addition of an amino acid residue to said precursor cellulase which provided improved activity in a detergent. Preferably, the substitution is at a residue corresponding to T140 in Thermomonospora fusca.
Abstract translation: 提供了可从热带菌属（Thermomonospora spp）获得的突变纤维素酶，其与前体纤维素酶不同，因为其已被遗传工程化以向所述前体纤维素酶中引入氨基酸残基的取代，缺失或添加，其提供了改善的洗涤剂活性。 优选地，取代是在热带孢霉菌中相当于T140的残基。
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公开(公告)号：US5389536A
公开(公告)日：1995-02-14
申请号：US705052
申请日：1991-05-23
Applicant: Gregory L. Gray , Scott D. Power , Ayrookaran J. Poulose
Inventor： Gregory L. Gray , Scott D. Power , Ayrookaran J. Poulose
CPC classification number: C12N9/18
Abstract: A substantially enzymatically pure hydrolase is provided which is secreted by and isolatable from Pseudomonas mendocina ATCC 53552. Cloning the gene expressing the hydrolase into a suitable expression vector and culturing, such as fermenting the E. coli strain JM101 harboring a plasmid designated pSNtacII, has been found to provide surprisingly high yields of the hydrolase.
Abstract translation: 提供了基本上酶的纯水解酶，其由门氏假单胞菌ATCC 53552分泌和分离。将表达水解酶的基因克隆到合适的表达载体中并培养，例如发酵含有命名为pSNtacII的质粒的大肠杆菌JM101 发现提供令人惊讶的高产率的水解酶。
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