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61.发明申请公开(公告)号：US20170175206A1
公开(公告)日：2017-06-22
申请号：US15396115
申请日：2016-12-30
Inventor： Jianfeng Xu , William B. Isaacs , Henrik Grönberg
CPC classification number: C12Q1/6886 , C12Q2600/156 , G16B30/00 , G16B50/00
Abstract: The present invention provides a method of identifying a subject as having an increased risk of having or developing aggressive prostate cancer, comprising detecting in the subject the presence of various polymorphisms associated with an increased risk of having or developing aggressive prostate cancer.
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62.发明申请METHODS AND COMPOSITIONS FOR TREATMENT OF CHLAMYDIAL INFECTION AND RELATED DISEASES AND DISORDERS 审中-公开治疗鳞状细胞感染及相关疾病和病症的方法和组合公开(公告)号：US20170067059A1
公开(公告)日：2017-03-09
申请号：US15153401
申请日：2016-05-12
Applicant: Wake Forest University Health Sciences
Inventor： Allen W. Tsang , Cristina M. Furdui
IPC: C12N15/113 , C07K16/28 , C07K16/32 , A61K39/395 , G01N33/574 , A61K31/5377 , A61K31/7088 , C12Q1/68 , G01N33/68 , G01N33/569 , A61K45/06 , A61K31/517
CPC classification number: C12N15/1138 , A61K31/517 , A61K31/5377 , A61K31/7088 , A61K31/712 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C12N2310/11 , C12N2320/31 , C12Q1/6883 , C12Q1/689 , C12Q2600/154 , C12Q2600/158 , G01N33/56927 , G01N33/57492 , G01N33/6893 , G01N2333/485 , G01N2333/71 , G01N2800/26 , G01N2800/52 , A61K2300/00
Abstract: The present invention provides compositions and methods of use in the treatment/prevention of chlamydial infection and/or diseases and disorders associated with chlamydial infection in a subject.
Abstract translation: 本发明提供了用于治疗/预防衣原体感染和/或与受试者中衣原体感染相关的疾病和病症的组合物和方法。
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公开(公告)号：US09566089B2
公开(公告)日：2017-02-14
申请号：US14714678
申请日：2015-05-18
Applicant: Wake Forest University Health Sciences
Inventor： Lawrence X. Webb , Louis C. Argenta , Michael J. Morykwas
CPC classification number: A61B17/66 , A61B17/60 , A61B17/864 , A61B17/866 , A61B17/8685 , A61B2017/00544
Abstract: An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.
Abstract translation: 外部固定组件包括插入患者骨骼中的多个中空销。 每个销具有内孔和从孔延伸穿过销壁的多个孔。 销可以联接到真空压力源，可操作以在围绕销的组织中产生减小的压力。 一个盖被放置在销的周围并被密封以提供一个流体密封的外壳，其保持围绕销的减压。 使用上述固定销来施加外部固定的方法包括以下步骤：将每个销插入皮肤开口，将销孔定位在所选组织附近，用密封的外壳覆盖皮肤开口，将销连接到真空压力源 并且激活真空压力源以在患者的组织中在骨骼处或骨附近产生减压。
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公开(公告)号：US09557251B2
公开(公告)日：2017-01-31
申请号：US14410707
申请日：2013-06-25
Applicant: Wake Forest University Health Sciences
Inventor： Shaozhou Ken Tian , Kim R. Geisinger
CPC classification number: B01L3/5021 , B01L2300/042 , B01L2300/047 , B01L2300/0851 , B01L2300/0858 , C12Q1/24 , G01N1/36
Abstract: Cell tubes that can be used both for pathology collection and subsequent cell processing include a tube with a cell bed at a lower portion of the tube. The tube can include a base member that can be detachable from the tube body. The tubes can be used to form cell (cytology) blocks that incorporate the cell bed. The cell bed can be an inert cell bed of paraffin.
Abstract translation: 可以用于病理学收集和随后的细胞处理的细胞管包括在管的下部具有细胞床的管。 管可以包括能够从管体拆卸的基部构件。 管可以用于形成结合细胞床的细胞（细胞学）块。 细胞床可以是石蜡的惰性细胞床。
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65.发明授权Methods for making a tissue engineered muscle repair (TEMR) construct in vitro for implantation in vivo 有权用于体外植入组织工程肌肉修复（TEMR）构建体的方法用于体内植入公开(公告)号：US09556418B2
公开(公告)日：2017-01-31
申请号：US13765104
申请日：2013-02-12
Applicant: Wake Forest University Health Sciences
Inventor： George J. Christ , Benjamin T. Corona
CPC classification number: A61L27/3895 , A61F2/08 , A61F2002/0894 , A61K35/12 , A61K35/34 , A61L27/3826 , A61L27/3873 , C12M35/02 , C12N5/0658 , C12N5/0697 , C12N2527/00 , C12N2533/54 , C12N2533/90
Abstract: Provided herein are methods of culturing organized skeletal muscle tissue from precursor muscle cells by cyclically stretching and relaxing said muscle cells on a support in vitro for a time sufficient to produce said organized skeletal muscle tissue, including reseeding said organized skeletal muscle tissue by contacting additional precursor muscle cells to said organized skeletal muscle tissue on said solid support, and then repeating said step of cyclically stretching and relaxing said muscle cells in said support in vitro for time sufficient to enhance the density (i.e., increased number of nuclei and/or number of multinucleated cells) of said organized skeletal muscle tissue on said support.
Abstract translation: 本文提供的方法是通过在体外在载体上循环拉伸和松弛所述肌肉细胞足以产生所述有组织的骨骼肌组织的时间，包括通过使另外的前体接触来重新接合所述组织的骨骼肌组织，从前体肌细胞培养有组织的骨骼肌组织 将肌细胞移动到所述固体支持物上的所述有组织的骨骼肌组织，然后重复所述在体外循环拉伸和松弛所述支持体中所述肌肉细胞的时间足以提高密度（即增加的细胞核数量和/或数量） 所述组织的骨骼肌组织在所述支持体上的多核细胞）。
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Patent Agency Ranking
公开(公告)号：US20160374938A1
公开(公告)日：2016-12-29
申请号：US15262344
申请日：2016-09-12
Applicant: Wake Forest University Health Sciences
Inventor： Benjamin S. Harrison , Steve J. Hodges
CPC classification number: A61K9/0014 , A61J1/05 , A61K9/06 , A61K9/14 , A61K31/17 , A61K31/327 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/44 , A61M5/178 , A61K2300/00
Abstract: A topical wound treatment composition comprises a hydrogen peroxide generator; alkaline powder; not more than 5 percent by weight of water; additional topical active agent if desired, and emollient (preferably hygroscopic emollient) to balance. When topically applied to a wound and water from the surrounding environment diffuses into the composition, the hydrogen peroxide generator and/or the alkaline compound diffuse into one another, causing a chemical reaction that generates treatment-effective amounts of oxygen to occur. The oxygen can then diffuse out of the composition and aid in wound treatment or healing.
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67.发明授权Vessel encoded arterial spin labeling using fourier encoding suitable for vascular territory mapping 有权血管编码动脉自旋标记使用适用于血管区域映射的傅里叶编码公开(公告)号：US09468394B2
公开(公告)日：2016-10-18
申请号：US13780323
申请日：2013-02-28
Applicant: Wake Forest University Health Sciences
Inventor： Youngkyoo Jung
CPC classification number: A61B5/055 , A61B5/0263 , A61B5/7257 , A61B5/7425 , A61B2576/026 , G01R33/5608 , G01R33/56366 , G06T7/0012 , G06T2207/10088 , G06T2207/30016 , G06T2207/30104
Abstract: Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional color blood flow map that combines X and Y encoded primary and secondary peak data of 1-dimensional Inverse Fourier Transform images to visually indicate (i) anterior/posterior and right/left directional components of respective feeding arteries using defined colors and (ii) brightness to indicate an amount of blood flow associated with each voxel, with increased brightness associated with increased blood flow.
Abstract translation: 方法，系统，计算机程序，电路和工作站被配置为生成至少一个二维彩色血流图，其组合了X维和Y编码的一维傅里叶逆变换图像的主峰数据和次峰值数据，以在视觉上指示（i） （ii）明亮度以指示与每个体素相关联的血流量，具有与增加的血液流量相关联的增加的亮度。
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公开(公告)号：US20160262893A1
公开(公告)日：2016-09-15
申请号：US15164192
申请日：2016-05-25
Applicant: Wake Forest University Health Sciences
Inventor： Ryan P. Terlecki
IPC: A61F2/26
CPC classification number: A61F2/26 , A61F2230/0065 , A61F2240/001 , A61F2240/004 , B29C45/00 , B29C2045/0093 , B29K2083/00 , B29L2031/7532 , Y10T29/49826
Abstract: Rear tip extenders include a tether attached to a collar that can be mounted onto a respective cylinder forward of a fluid line (that communicates with a scrotal pump) to prevent full separation or detachment from the cylinder during a revision procedure.
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公开(公告)号：US09433495B2
公开(公告)日：2016-09-06
申请号：US14162351
申请日：2014-01-23
Applicant: Wake Forest University Health Sciences
Inventor： Keith Andrew Walter , Kurt Weber
CPC classification number: A61F2/148 , A61F2/0095 , A61F2/142 , A61F9/007
Abstract: Systems, devices and methods for performing small incision DLEK include providing a corneal transplantation donor tissue graft; then forming the tissue graft into an implantable configuration using the flexible substrate. Related medical kits and tools for forming a compact or rolled donor tissue graft are also described.
Abstract translation: 用于进行小切口DLEK的系统，装置和方法包括提供角膜移植供体组织移植物; 然后使用柔性基底将组织移植物形成可植入构型。 还描述了用于形成紧密或轧制的供体组织移植物的相关医疗试剂盒和工具。
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70.发明申请Flagellin Fusion Proteins and Use Thereof to Induce Immune Responses Against Pseudomonas aeruginosa 审中-公开鞭毛蛋白融合蛋白及其用途可诱导对铜绿假单胞菌的免疫反应公开(公告)号：US20160193319A1
公开(公告)日：2016-07-07
申请号：US14989588
申请日：2016-01-06
Applicant: Wake Forest University Health Sciences
Inventor： Steven B. Mizel , Daniel J. Wozniak , Eric T. Weimer
IPC: A61K39/104 , C07K14/21
CPC classification number: A61K39/104 , A61K2039/55516 , A61K2039/572 , A61K2039/575 , A61K2039/6068 , C07K14/21 , C07K16/1214 , C07K2317/34 , C07K2319/00 , C07K2319/40 , C12N15/62 , C12N15/63
Abstract: The invention provides compositions and fusion proteins comprising a flagellin adjuvant and a Pseudomonas aeruginosa antigen. The invention further provides pharmaceutical formulations and methods for inducing an immune response against P. aeruginosa (e.g., to prevent and/or treat P. aeruginosa infection).
Abstract translation: 本发明提供了包含鞭毛蛋白佐剂和铜绿假单胞菌抗原的组合物和融合蛋白。 本发明还提供用于诱导针对铜绿假单胞菌的免疫应答的药物制剂和方法（例如，以预防和/或治疗铜绿假单胞菌感染）。
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