公开(公告)号：US20210186876A1

公开(公告)日：2021-06-24

申请号：US17190537

申请日：2021-03-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob KLEIN ,  Ronit GOLDBERG ,  Jasmine SEROR ,  Weifeng LIN ,  Reut MASHIACH

IPC: A61K9/127 ,  A61K9/00 ,  A61K47/32 ,  A61K47/10 ,  A61K47/36 ,  A61K9/08 ,  A61K31/728 ,  A61K31/77 ,  A61K31/79 ,  B65D35/00 ,  B65D75/36

Abstract: A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.

公开(公告)号：US20210172077A1

公开(公告)日：2021-06-10

申请号：US16771243

申请日：2018-12-10

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Ronny NEUMANN ,  Alexander KHENKiN ,  Miriam SOMEKH

IPC: C25B3/23 ,  B01J23/78 ,  C25B3/07 ,  C25B1/02

Abstract: The invention relates to electrocatalytic processes for the formation of formate esters using at least one catalyst or pre-catalyst; wherein the formate ester can be further hydrolyzed.

公开(公告)号：US20210154261A1

公开(公告)日：2021-05-27

申请号：US16633175

申请日：2018-07-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yardena SAMUELS ,  Rand ARAFEH ,  Karen FLORES ,  Rony SEGER ,  Ehud WAINSTEIN

IPC: A61K38/10 ,  A61K31/519 ,  A61K31/4184 ,  A61P35/00

Abstract: An article of manufacture is disclosed which comprises: (i) a peptide agent which is capable of preventing extracellular signal-regulated kinase1/2 (ERK) translocation into the nucleus; and (ii) a MEK inhibitor. Uses thereof are also disclosed.

公开(公告)号：US20210142905A1

公开(公告)日：2021-05-13

申请号：US17151232

申请日：2021-01-18

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran SEGAL ,  Eran ELINAV

IPC: G16H50/20 ,  G06N20/00 ,  G16H10/60 ,  G16H50/70 ,  G16H20/60

Abstract: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.

公开(公告)号：US11002735B2

公开(公告)日：2021-05-11

申请号：US16748001

申请日：2020-01-21

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. Cohen ,  Eytan Domany ,  Francisco Javier Quintana ,  Guy Hed ,  Gad Getz

IPC: G16B40/00 ,  G01N33/564 ,  G16B20/00 ,  G01N33/68

Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.

公开(公告)号：US10938486B2

公开(公告)日：2021-03-02

申请号：US16643862

申请日：2018-08-20

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Ulf Leonhardt

IPC: H04B10/80 ,  G02B6/43 ,  H04B10/25

Abstract: An optical bus for multi-core processing providing optical data transfer between cores through a single planar waveguide employing a variable-thickness, light-propagation layer having a progressively changing effective refractive index in accordance with lateral position within the light-propagation layer such that light emission from a single light emitter in communication with one core is focused on each of multiple photodetectors in communication with its respective processer core.

公开(公告)号：US10933124B2

公开(公告)日：2021-03-02

申请号：US15744881

申请日：2016-07-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair Reisner ,  Noga Or-Geva ,  Eran Ophir ,  Yaki Eidelstein ,  Rotem Gidron Budovsky

IPC: A61K35/17 ,  A61P31/00 ,  A61P35/04 ,  A61K39/00 ,  C12N5/078 ,  C12N5/0783 ,  A61K39/395 ,  C07K16/28 ,  A61K35/12

Abstract: A method of transplantation is disclosed. The method comprising administering to a subject in need of transplantation of cells in suspension, a therapeutically effective amount of anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, said anti-third party cells being tolerance-inducing cells and capable of homing to the lymph nodes following transplantation, wherein said cells in suspension comprise non-hematopoietic cells or hematopoietic cells which are not stem cells. Methods of treating and kits are also provided.

公开(公告)号：US10933122B2

公开(公告)日：2021-03-02

申请号：US16521622

申请日：2019-07-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit Sagi ,  Eitan Wong ,  Ran Afik

IPC: C12N9/64 ,  A61K38/48

Abstract: A method of treating an inflammatory disease is disclosed. The method comprises administering to the subject a therapeutically effective amount of a polypeptide comprising a pro-domain of TNF-alpha converting enzyme (TACE), said polypeptide being devoid of a catalytic domain of said TACE, said polypeptide comprising a modification at a site selected from the group consisting of R58, R56 and K57 which renders said polypeptide resistant to furin degradation said polypeptide being capable of downregulating an activity of TACE, thereby treating the inflammatory disease.

公开(公告)号：US10923230B2

公开(公告)日：2021-02-16

申请号：US16412538

申请日：2019-05-15

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran Segal ,  Eran Elinav

IPC: G16H50/20 ,  G16H50/70 ,  G06N20/00 ,  G06F19/00 ,  G16H20/60

Abstract: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.

公开(公告)号：US10920192B2

公开(公告)日：2021-02-16

申请号：US14259997

申请日：2014-04-23

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yaqub Hanna ,  Noa Novershtern ,  Yoach Rais

IPC: C12N5/0735 ,  C12N5/074

Abstract: Provided is an isolated human naive pluripotent stem cell (PSC), wherein: (i) when the naive PSC is a female PSC, then said naive female PSC has two unmethylated alleles of an X-inactive specific transcript (XIST) gene; and (ii) when said naive PSC is a male PSC, then said naive male PSC has an unmethylated allele of said XIST gene. Also provided is a culture medium which comprises an ERK1/2 inhibitor, a GSK3beta inhibitor, a p38 inhibitor, a JNK inhibitor, a STAT3 activator and at least one agent selected from the group consisting of: bFGF, TGFbeta 1, a PKC inhibitor, a ROCK inhibitor and a NOTCH inhibitor; or at least agent selected from the group consisting of: a TGFR inhibitor, a FGFR inhibitor, a PKC inhibitor, a ROCK inhibitor and a NOTCH inhibitor.