公开(公告)号：US20190297936A1

公开(公告)日：2019-10-03

申请号：US15940614

申请日：2018-03-29

Applicant: Jason Kang ,  Daniel Chu

Inventor： Jason Kang ,  Daniel Chu

IPC: A24C3/00 ,  A24C1/04 ,  A24C5/10 ,  A24C5/34 ,  A24C5/46 ,  A24C5/54 ,  A24F25/02 ,  A24F9/02

Abstract: The embodiments disclose a method including creating a blunt rolling device for rolling blunt smoking products, rolling a wrapper on a wrapper roller tube to create a blunt wrapper tube with a glass tip, tamping smoking material into the blunt wrapper tube at a user defined density, twisting, cutting and tucking wrapper excess into the glass tip, and controlling the operations of the blunt rolling device using a computer, wireless communications and a blunt rolling method and device program for sequencing processes, operating solenoid drive motors and humidity and temperature devices of a smoking material humidor, adjusting settings of devices using predetermined data stored in digital memory devices and accessed using digital processors.

公开(公告)号：US09354155B2

公开(公告)日：2016-05-31

申请号：US13483771

申请日：2012-05-30

Applicant: Daniel Chu ,  Eli A. Hefner ,  Yann Jouvenot

Inventor： Daniel Chu ,  Eli A. Hefner ,  Yann Jouvenot

IPC: G01N15/14 ,  G01N15/10

CPC classification number: G01N15/1463 ,  G01N2015/1006

Abstract: An automated system captures multiple digital images of a sample, from different viewing areas of the sample. The images are analyzed and a test result may be reported based on the count of cells in all of the digital images. The system may be especially applicable to the testing of samples having low cell concentrations, as the variability between tests may be reduced as compared with a system that bases its test results on only a single image of the sample. The system may count the cells in a first digital image of the sample, and may capture or analyze one or more additional digital images only when it is recognized that additional measurements are needed to ensure adequate accuracy and repeatability of the test.

Abstract translation: 自动化系统从样品的不同观察区域捕获样品的多个数字图像。 分析图像，并且可以基于所有数字图像中的单元的计数来报告测试结果。 该系统可能特别适用于具有低细胞浓度的样品的测试，因为与将其测试结果仅基于样品的单个图​​像的系统相比，可以减少测试之间的可变性。 系统可以对样本的第一数字图像中的单元进行计数，并且可以仅在认识到需要额外的测量以确保测试的足够的精度和可重复性时才捕获或分析一个或多个附加的数字图像。

公开(公告)号：US20130272048A1

公开(公告)日：2013-10-17

申请号：US13995172

申请日：2011-09-01

Applicant: Daniel Chu

Inventor： Daniel Chu

IPC: G11C5/06 ,  H03K19/00

CPC classification number: G11C5/06 ,  G11C7/109 ,  G11C7/20 ,  H01L24/73 ,  H01L2224/05554 ,  H01L2224/32145 ,  H01L2224/32245 ,  H01L2224/48147 ,  H01L2224/48247 ,  H01L2224/49175 ,  H01L2224/73265 ,  H01L2225/06562 ,  H03K19/00 ,  H01L2924/00012 ,  H01L2224/48145

Abstract: A multi-die memory package may have separate chip enable inputs for the respective memory dice. Individual chip enable inputs may be separated by other chip connections such as power and ground. The memory dice may include multiple chip enable inputs to allow easy wire bonding of the individual chip enable inputs to a die without requiring any jumpers within the package. Circuitry may be included so that undriven chip enable inputs are masked and driven chip enable inputs may be propagated to the memory die to enable memory accesses while a single chip enable input is only connected to the capacitance of a single bonding pad.

公开(公告)号：US20130137144A1

公开(公告)日：2013-05-30

申请号：US13487414

申请日：2012-06-04

Applicant: Daniel Chu ,  Paul Patt

Inventor： Daniel Chu ,  Paul Patt

IPC: B01L7/00

CPC classification number: B01L7/52 ,  B01L2200/025 ,  B01L2300/0816 ,  B01L2300/0829 ,  B01L2300/1822

Abstract: Rapid and uniform temperature changes in the wells of a microplate or any thin-walled plate that contains an array of reaction wells, or in the channels of a multi-channel microfluidics device, are achieved by the use of a thermal block with thermoelectric heating/cooling elements built into the block, or by the use of a thermal block with wedges protruding from its lower surface, with thermoelectric elements placed in surface contact with the angled sides of each wedge.

Abstract translation: 在微孔板或包含反应孔阵列的任何薄壁板或多通道微流体装置的通道中的孔中的快速和均匀的温度变化通过使用具有热电加热/ 或者通过使用具有从其下表面突出的楔形物的热块，其中热电元件与每个楔形物的倾斜侧面表面接触。

公开(公告)号：US07858631B2

公开(公告)日：2010-12-28

申请号：US10515434

申请日：2003-05-23

Applicant: Rustum S. Boyce ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith ,  Bryan Chang

Inventor： Rustum S. Boyce ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith ,  Bryan Chang

IPC: A61K31/519

CPC classification number: C07D253/08 ,  C07D217/24 ,  C07D239/88 ,  C07D239/90 ,  C07D239/91 ,  C07D239/96 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D417/04 ,  C07D471/04

Abstract: A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure of Formulas (IA), (IB), or (IC): where the values of the variable are defined herein.

Abstract translation: 提供了能够作为MC4-R激动剂的各种低分子量含胍基分子。 该化合物可用于治疗MC4-R介导的疾病。 化合物具有式（IA），（IB）或（IC）的结构：其中变量的值在本文中定义。

公开(公告)号：US20100105654A1

公开(公告)日：2010-04-29

申请号：US12605174

申请日：2009-10-23

Applicant: Rustum S. BOYCE ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith ,  Christopher R. Conlee ,  Brian D. Thompson ,  Judith de Armas Kuntz ,  David L. Musso ,  Kevin K. Barvian ,  Stephen A. Thomson ,  William R. Swain ,  Kien S. Du ,  Brian A. Chauder ,  Jason D. Speake ,  Michael J. Bishop

Inventor： Rustum S. BOYCE ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith ,  Christopher R. Conlee ,  Brian D. Thompson ,  Judith de Armas Kuntz ,  David L. Musso ,  Kevin K. Barvian ,  Stephen A. Thomson ,  William R. Swain ,  Kien S. Du ,  Brian A. Chauder ,  Jason D. Speake ,  Michael J. Bishop

IPC: A61K31/517 ,  C07D403/12 ,  C07D239/86 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10

CPC classification number: C07D217/24 ,  C07D239/91 ,  C07D239/95 ,  C07D239/96 ,  C07D253/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structures VA, VB, VIIA and VIIB where the values of the variables are defined herein.

Abstract translation: 提供了能够作为MC4-R激动剂的各种小分子，含胍分子。 当给予受试者时，这些化合物可用于治疗MC4-R介导的疾病。 化合物具有结构VA，VB，VIIA和VIIB，其中变量的值在本文中定义。

公开(公告)号：US20090131304A1

公开(公告)日：2009-05-21

申请号：US12268364

申请日：2008-11-10

Applicant: Daniel Chu ,  Yaohui Lei ,  Yu Bai ,  Zhi-Jie Ni ,  John Jian-Xin Wang

Inventor： Daniel Chu ,  Yaohui Lei ,  Yu Bai ,  Zhi-Jie Ni ,  John Jian-Xin Wang

IPC: A61K38/12 ,  C07K9/00

CPC classification number: C07K9/008 ,  A61K38/00

Abstract: Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of the desmethyl-vancomycin scaffold, in particular, acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. In addition, compounds of the invention include desmethyl-vancomycin scaffolds on which the acid moiety on the macrocyclic ring is converted to certain substituted amides and the amino substituent on the amino-substituted sugar moiety is alkylated with certain alkyl groups. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.

Abstract translation: 具有抗菌活性的半合成糖肽基于脱甲基万古霉素支架的修饰，特别是在该支架上具有某些酰基的氨基取代的糖部分上的氨基取代基的酰化; 和/或将该支架的大环上的酸部分转化为某些取代的酰胺。 此外，本发明的化合物包括去甲基 - 万古霉素支架，大环上的酸部分转化为某些取代的酰胺，氨基取代的糖部分上的氨基取代基被某些烷基烷基化。 还提供了合成化合物的方法，含有化合物的药物组合物，以及用于治疗和/或预防疾病，特别是细菌感染的化合物的使用方法。

公开(公告)号：US20060235019A1

公开(公告)日：2006-10-19

申请号：US10515434

申请日：2003-05-23

Applicant: Rustum Boyce ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith

Inventor： Rustum Boyce ,  Natalia Aurrecoechea ,  Daniel Chu ,  Aaron Smith

IPC: A61K31/53 ,  A61K31/525 ,  A61K31/519 ,  C07D487/02 ,  C07D475/02

CPC classification number: C07D253/08 ,  C07D217/24 ,  C07D239/88 ,  C07D239/90 ,  C07D239/91 ,  C07D239/96 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D417/04 ,  C07D471/04

Abstract: A variety of low molecular weight, guanidino-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The compounds have the structure of Formulas (IA), (IB), or (IC): where the values of the variable are defined herein.

Abstract translation: 提供了能够作为MC4-R激动剂的各种低分子量含胍基分子。 该化合物可用于治疗MC4-R介导的疾病。 化合物具有式（IA），（IB）或（IC）的结构：其中变量的值在本文中定义。

公开(公告)号：US20050101548A1

公开(公告)日：2005-05-12

申请号：US10940900

申请日：2004-09-13

Applicant: Xiaodong Lin ,  Daniel Chu

Inventor： Xiaodong Lin ,  Daniel Chu

IPC: A61K31/7048 ,  A61P31/04 ,  C07H17/08

CPC classification number: C07H17/08

Abstract: Antimicrobial compounds are provided having the formula (Q): as well as tautomers, stereoisomers, pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.

Abstract translation: 提供具有式（Q）的抗微生物化合物：以及互变异构体，立体异构体，其药学上可接受的盐，酯或前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。

公开(公告)号：US20050009764A1

公开(公告)日：2005-01-13

申请号：US10831749

申请日：2004-04-23

Applicant: Matthew Burger ,  Georgia Carroll ,  Daniel Chu ,  Xiaodong Lin ,  Jacob Plattner ,  Alice Rico

Inventor： Matthew Burger ,  Georgia Carroll ,  Daniel Chu ,  Xiaodong Lin ,  Jacob Plattner ,  Alice Rico

IPC: A61P31/04 ,  C07H17/08 ,  A61K31/7052

CPC classification number: C07H17/08

Abstract: Antimicrobial macrolide and ketolide compounds are provided having formulas XII: as well as pharmaceutically acceptable salts, esters or prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.

Abstract translation: 提供抗微生物大环内酯和酮内酯化合物，其具有式XII：及其药学上可接受的盐，酯或前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。