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    System and method for a two piece spray nozzle
    61.
    发明授权
    System and method for a two piece spray nozzle 有权
    两件式喷嘴的系统和方法

    公开(公告)号：US06796510B2

    公开(公告)日：2004-09-28

    申请号：US10729745

    申请日：2003-12-05

    Applicant: Daniel Py

    Inventor： Daniel Py

    IPC: B05B1700

    CPC classification number: B05B11/0067 ,  B05B1/3436 ,  B05B11/00412 ,  B05B11/007 ,  B05B11/0072 ,  B05B11/3004 ,  B05B11/3074 ,  B05B11/3077 ,  B05B11/3094

    Abstract: An aerosol tip mechanism for an aerosol-type dispenser for dispensing liquid content has a flexible outer shell, a rigid cap portion composed of lower and upper portions, and a rigid nozzle portion having a rigid shaft received within the outlet portion of the flexible outer shell. The rigid shaft interfaces the outlet portion of the outer shell, forming a first normally-closed one-way valve. The lower and upper portions of the rigid cap portion form boots adapted to receive an outlet portion of the flexible outer shell, the boots thereby constraining a lateral motion of the outlet portion of the outer shell, and symmetrically centering the outlet portion around the rigid shaft of the nozzle. The rigid nozzle portion includes a plurality of liquid channels for delivering liquid from a reservoir to a swirling chamber defined within the rigid cap portion, which liquid channels are configured to minimize energy losses of the liquid and promote a more homogeneous fluid particle size in the dispensed aerosol. The aerosol tip mechanism provides for long-term sterility of the stored fluid, which in turn allows for preservation of the sterility of non-chemically preserved formulations, which may be in the form of suspension or liquid gels.

    Abstract translation: 用于分配液体内容物的气溶胶型分配器的气溶胶喷嘴机构具有柔性外壳，由下部和上部组成的刚性盖部分，以及刚性喷嘴部分，其具有容纳在柔性外壳的出口部分内的刚性轴 。 刚性轴与外壳的出口部分接合，形成第一常闭单向阀。 刚性盖部分的下部和上部形成适于容纳柔性外壳的出口部分的靴子，靴子因此约束外壳的出口部分的横向运动，并且将出口部分对称地对准刚性轴 的喷嘴。 刚性喷嘴部分包括多个液体通道，用于将液体从储存器输送到限定在刚性盖部分内的旋转室，该液体通道被配置为使液体的能量损失最小化，并促使在分配的液体中更均匀的流体颗粒尺寸 气雾剂。 气溶胶末端机构提供储存的流体的长期无菌性，这又允许保持非化学保存的制剂的无菌性，其可以是悬浮液或液体凝胶的形式。

    System and method for application of medicament into the nasal passage
    64.
    发明授权
    System and method for application of medicament into the nasal passage 失效
    将药物应用于鼻通道的系统和方法

    公开(公告)号：US06505622B2

    公开(公告)日：2003-01-14

    申请号：US09927272

    申请日：2001-08-09

    Applicant: Daniel Py

    Inventor： Daniel Py

    IPC: A61M1508

    CPC classification number: B05B11/3066 ,  A61M11/001 ,  A61M11/06 ,  A61M15/0025 ,  A61M15/0026 ,  A61M15/0065 ,  A61M2205/073 ,  A61M2206/16 ,  B05B1/341 ,  B05B1/3436 ,  B05B11/0038 ,  B05B11/00412 ,  B05B11/007 ,  B05B11/0072 ,  B05B11/0075 ,  B05B11/3001 ,  B05B11/3011 ,  B05B11/3074 ,  B05B11/3076 ,  B05B11/3077 ,  B05B11/309 ,  B05B11/3092 ,  B05B11/3095

    Abstract: A pump-type dispenser for dispensing predetermined doses of medicament in droplets or in spray form to the nasal area incorporates a rigid vial for medicament, an expandable pouch located within the rigid vial, a nasal screen, a one-way actuation mechanism, a one-way valve mechanism in the nozzle area and a spring element, both the valve mechanism and the spring element being formed as integral portions of the pump body. The one-way valve mechanism in the nozzle area ensures a one-way movement of medicament from the dispenser, thereby preserving substantially perfect sterility of the medicament in the dispenser, without requiring the use of preservatives. The one-way actuation mechanism enables the user to load and dispense a uniform quantity of medicament with a uniform actuation force and speed via a single continuous motion of the actuation mechanism. The rigid vial/expandable-pouch combination facilitates improved long term use, as well as uniformity of dosage independent of the pump orientation.

    Abstract translation: 用于将液滴或喷雾形式的预定剂量的药剂分配到鼻区域的泵型分配器包括用于药物的刚性小瓶，位于刚性小瓶内的可膨胀袋，鼻屏，单向致动机构，一个 在喷嘴区域中具有一个阀门机构和一个弹簧元件，阀机构和弹簧元件都形成为泵体的整体部分。 喷嘴区域中的单向阀机构确保药物从分配器的单向运动，从而在分配器中保持药物基本上完美的无菌性，而不需要使用防腐剂。 单向致动机构使得用户能够通过致动机构的单一连续运动以均匀的致动力和速度来加载和分配均匀量的药物。 刚性小瓶/可膨胀袋组合有助于改善长期使用，以及独立于泵取向的剂量均匀性。

    Process for filling a sealed receptacle under aseptic conditions
    65.
    发明授权
    Process for filling a sealed receptacle under aseptic conditions 失效
    在无菌条件下填充密封容器的方法

    公开(公告)号：US5641004A

    公开(公告)日：1997-06-24

    申请号：US424932

    申请日：1995-04-19

    Applicant: Daniel Py

    Inventor： Daniel Py

    IPC: B67C3/00 ,  A61J3/07 ,  B65B3/00 ,  B65B31/08 ,  B65B55/02 ,  B65B1/04 ,  B65B3/04

    CPC classification number: B65B3/003 ,  B65B31/08 ,  B65B55/02

    Abstract: An automated process for filling a sealed receptacle (1) with a fluid under aseptic conditions is disclosed. The sealed receptacle has at least one part (2B) made of a material capable of being pierced by a hollow needle (8R) and sufficiently flexible to close itself up again after removal of the hollow needle. In the automated process, the part (2B) of the sealed receptacle is pierced using a hollow filling needle (8R) which is in contact with the fluid to be channeled into the receptacle (1). During the process of filling the receptacle (1), the perforating end of the hollow filling needle (8R) is maintained under aseptic conditions by means of laminar gas flow.

    Abstract translation: 公开了一种用于在无菌条件下用流体填充密封容器（1）的自动化过程。 密封容器具有由能够被中空针（8R）刺穿的材料制成的至少一个部分（2B），并且在去除中空针之后足够柔性以再次闭合。 在自动化过程中，密封容器的部分（2B）使用与要引导到容器（1）中的流体接触的中空填充针（8R）进行穿孔。 在填充容器（1）的过程中，空心填充针（8R）的穿孔端通过层流气流保持在无菌条件下。

    Intraocular prosthesis
    66.
    发明授权
    Intraocular prosthesis 失效

    公开(公告)号：US5300115A

    公开(公告)日：1994-04-05

    申请号：US978645

    申请日：1992-11-19

    Applicant: Daniel Py

    Inventor： Daniel Py

    IPC: A61F2/14

    CPC classification number: A61F2/142 ,  A61F2/14

    Abstract: A prosthesis for implanting in an eye has a lens member and a double interface member which is coupled to the periphery of the lens member. The double interface member is comprised of a more superficial branch and a deeper branch which project out from the lens member. The double interface member has a plurality of pores for permitting the ingrowth of tissue to anchor the prosthesis to the eye. The double interface member also has an anatomical structure into which eye tissue is inserted, so as to become an immediate anchor to the eye and an immediate barrier to external pathogens.

    Ocular vial
    67.
    发明授权
    Ocular vial 失效
    眼小瓶

    公开(公告)号：US5163929A

    公开(公告)日：1992-11-17

    申请号：US601944

    申请日：1990-10-22

    Applicant: Daniel Py

    Inventor： Daniel Py

    IPC: A61F9/00 ,  A61J1/00 ,  A61J1/20 ,  A61M11/00 ,  B65D25/08 ,  B65D81/32

    CPC classification number: A61J1/2093 ,  A61F9/0008 ,  A61M11/00 ,  B65D25/08 ,  B65D81/3222 ,  A61J1/2027

    Abstract: An ocular treatment apparatus for applying medicament into an eye has a vial defining a vial cavity for holding medicament. A nozzle is attached over an opening in the vial and is in fluid communication with the vial cavity for releasing drops of medicament. A piston member is suspended within the vial and slideably engaged within the vial cavity for displacing a substantially predetermined volume of medicament through the nozzle for release into the eye.

    Abstract translation: 用于将药物施用到眼睛中的眼部治疗装置具有限定用于保持药物的小瓶腔的小瓶。 喷嘴连接在小瓶中的开口上并且与小瓶腔流体连通以释放药液滴。 活塞构件悬挂在小瓶内并可滑动地接合在小瓶腔内，用于使基本上预定量的药物通过喷嘴移动以释放到眼睛中。

    Ocular treatment apparatus
    68.
    发明授权
    Ocular treatment apparatus 失效
    眼部治疗仪

    公开(公告)号：US4981479A

    公开(公告)日：1991-01-01

    申请号：US452782

    申请日：1989-12-19

    Applicant: Daniel Py

    Inventor： Daniel Py

    IPC: A61F9/00 ,  B05B11/00

    CPC classification number: A61F9/0026 ,  A61F9/0008 ,  B05B11/307

    Abstract: An apparatus for applying medicament to an eye has an inner casing and an outer casing coupled to the inner casing and moveable relative thereto. An eyecup is supported on one end of the inner casing. The eyecup defines a surface shaped to conformably engage the facial tissue surrounding an eye. An ocular vial is supported within the inner casing. The ocular vial holds medicament for release into an eye. An eyelid displacing member is coupled to the outer casing and slideably mounted through the inner casing. The eyelid displacing member includes a depresser tab adapted to engage the facial tissue below an eye. The depresser tab engages the facial tissue upon moving the outer casing toward the inner casing, thus displacing the lower eyelid to expose the ocular cul-de-sac. A dispensing member is supported by the outer casing. The dispensing member is adapted to actuated the ocular vial upon moving the outer casing toward the inner casing, to release medicament onto the exposed ocular cul-de-sac of the eye.

    Abstract translation: 将药物施用于眼睛的装置具有内壳和外壳，所述内壳和外壳联接到所述内壳并且可相对于所述内壳移动。 内壳的一端支撑着眼罩。 眼罩定义了一个表面，其形状适合地与眼睛周围的面部组织接合。 内窥镜支撑在内壳内。 眼小瓶保持用于释放到眼睛中的药物。 眼睑移位构件联接到外壳并且可滑动地安装穿过内壳。 眼睑移位构件包括适于接合眼睛下方的面部组织的按压片。 当将外壳移动到内壳时，按压片接合面巾纸，从而使下眼皮移位以露出眼部凹陷。 分配构件由外壳支撑。 分配构件适于在将外壳移动到内壳时致动眼用小瓶，以将药剂释放到眼睛的暴露的眼睛凹陷上。

    Ocular treatment apparatus
    69.
    发明授权
    Ocular treatment apparatus 失效
    眼部治疗仪

    公开(公告)号：US4946452A

    公开(公告)日：1990-08-07

    申请号：US267526

    申请日：1988-11-04

    Applicant: Daniel Py

    Inventor： Daniel Py

    IPC: A61F9/00

    CPC classification number: A61F9/0026

    Abstract: An ocular treatment apparatus for applying medicament into an eye has an inner housing member with an eyepiece on a free end thereof. The eyepiece defines an opening in one end thereof, and the opening has a peripheral edge shaped for engagement with the facial tissue surrounding an eye. A body portion of the inner housing member is coupled to the eyepiece and is dimensioned to receive a vial of medicament for application to the eye. An outer housing member of the apparatus has an open free end, which is slidably engaged over the inner housing member. The outer housing member has a displacement rod that projects inwardly from a closed end thereof in the axial direction of the apparatus. The displacement rod is engageable with a flexible vial supported within the body portion of the inner housing member. The displacement rod flexes the vial inwardly to dispense medicament therefrom into an eye. A flexible bar is mounted to the outer housing member, and the free end of the flexible bar is adapted to be engaged with the facial tissue below an eye to displace the facial tissue, and thus displace the lower eyelid, to direct the medicament into the exposed ocular cul-de-sac of the eye. The flexible member is engaged with the facial tissue by moving the outer housing member toward the eyepiece, which simultaneously displaces the lower eyelid and allows the medicament dispensed from the vial to fall into the exposed ocular cul-de-sac of the eye.

    Abstract translation: 用于将药物施用到眼睛中的眼部治疗装置具有在其自由端上具有目镜的内部壳体构件。 目镜在其一端限定一个开口，并且该开口具有形状成与眼睛周围的面部组织接合的周边边缘。 内部壳体构件的主体部分联接到目镜，并且其尺寸被设计成接收用于施用于眼睛的药物小瓶。 该装置的外部壳体构件具有敞开的自由端，其可滑动地接合在内部壳体构件上。 外壳构件具有从设备的轴向的封闭端向内突出的位移杆。 位移杆可与支撑在内壳体构件的主体部分内的柔性小瓶接合。 位移杆向内弯曲小瓶，以将药物从其中分配到眼睛中。 柔性杆被安装到外部壳体构件上，并且柔性杆的自由端适于与眼睛下方的面部组织接合以移位面部组织，并且因此移位下眼睑，以将药物引导到 暴露眼睛的眼睛死亡。 柔性构件通过将外壳构件朝向目镜移动而与面巾组合，其同时移动下眼睑并允许从小瓶分配的药物落入眼睛的暴露的眼睛凹陷中。

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