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68 条记录 (耗时 0.026 秒)

    Lymphotoxin-&agr;/&bgr; complexes and anti-lympotoxin-&bgr; receptor antibodies as anti-tumor agents
    61.
    发明授权
    Lymphotoxin-&agr;/&bgr; complexes and anti-lympotoxin-&bgr; receptor antibodies as anti-tumor agents 失效
    淋巴毒素-α/β复合物和抗淋巴毒素-β受体抗体作为抗肿瘤剂

    公开(公告)号：US06312691B1

    公开(公告)日：2001-11-06

    申请号：US08875560

    申请日：1998-06-05

    申请人： Jeffrey L. Browning ,  Werner Meier ,  Christopher D. Benjamin

    发明人： Jeffrey L. Browning ,  Werner Meier ,  Christopher D. Benjamin

    IPC分类号： A61K39395

    CPC分类号： A61K38/191 ,  A61K39/395 ,  A61K2039/505 ,  C07K14/525 ,  C07K14/715 ,  C07K16/2866 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S424/809 ,  A61K2300/00

    摘要： This invention relates to compositions and methods useful for activating LT-&bgr; receptor signaling, which in turn elicits potent anti-proliferative effects on tumor cells. More particularly, this invention relates to lymphotoxin heteromeric complexes formed between lymphotoxin-&agr; and multiple subunits of lymphotoxin-&bgr;, which induce cytotoxic effects on tumor cells in the presence of lymphotoxin-&bgr; receptor activating agents. Also within the scope of this invention are antibodies directed against the lymphotoxin-&bgr; receptor which act as lymphotoxin-&bgr; receptor activating agents alone or in combination with other lymphotoxin-&bgr; receptor activating agents either in the presence or absence of lymphotoxin-&agr;/&bgr; complexes. A screening method for selecting such antibodies is provided. This invention also relates to compositions and methods using cross-linked anti-lymphotoxin-&bgr; receptor antibodies either alone or in the presence of other lymphotoxin-&bgr; receptor activating agents to potentiate tumor cell cytotoxicity.

    摘要翻译： 本发明涉及用于激活LT-β受体信号传导的组合物和方法，其又引起对肿瘤细胞的有效的抗增殖作用。 更具体地，本发明涉及在淋巴毒素-α与淋巴毒素-β的多个亚基之间形成的淋巴毒素异聚体复合物，其在淋巴毒素-β受体活化剂存在下诱导对肿瘤细胞的细胞毒性作用。 也在本发明范围内的是针对淋巴毒素-β受体的抗体，其单独或与其它淋巴毒素-β受体活化剂组合起作用，即在存在或不存在淋巴毒素-α/β复合物的情况下作为淋巴毒素-β受体活化剂 。 提供了选择这种抗体的筛选方法。 本发明还涉及使用交联的抗淋巴毒素-β受体抗体单独或在其它淋巴毒素-β受体活化剂存在下增强肿瘤细胞毒性的组合物和方法。

    Vehicle engine ignition system utilizing light guides for protection against interference
    64.
    发明授权
    Vehicle engine ignition system utilizing light guides for protection against interference 失效
    汽车发动机点火系统利用光导来防止干扰

    公开(公告)号：US4380225A

    公开(公告)日：1983-04-19

    申请号：US235566

    申请日：1981-02-18

    申请人： Jurgen Wesemeyer ,  Georg Haubner ,  Werner Meier

    发明人： Jurgen Wesemeyer ,  Georg Haubner ,  Werner Meier

    IPC分类号： F02P3/045 ,  B60R25/045 ,  F02P3/04 ,  F02P3/055 ,  F02P5/145 ,  F02P7/073 ,  F02P15/00 ,  F02P1/00 ,  F02P5/04 ,  F02P5/06

    CPC分类号： B60R25/045 ,  F02P5/145 ,  F02P7/073 ,  Y02T10/46

    摘要： In order to mount the control circuit for the ignition system at a location remote from the spark plug and ignition coil, i.e. at a location not subject to electromagnetic or electrical interference, photoconductors are used to interconnect the control circuit with the final output stage. Photoconductors are also used to interconnect the basic synchronization unit, that is the unit which furnishes a pulse for each rotation of a shaft of the engine, to the input of the control circuit. A theft prevention device is also incorporated. Specifically, the control circuit compares a sequence stored in a microprocessor to the on/off pattern of a received light pulse sequence. The latter is applied from a light emitter through a convex lens and a photoconductor to a second input of the control unit. Only if the stored pattern corresponds to the received light pattern can control signals initiating a spark be generated.

    摘要翻译： 为了将点火系统的控制电路安装在远离火花塞和点火线圈的位置，即在不受电磁干扰或电气干扰的位置处，使用光电导体将控制电路与最终输出级相互连接。 光电导体还用于将基本同步单元（即，为发动机的轴的每个旋转提供脉冲的单元）连接到控制电路的输入。 还包括防盗装置。 具体地，控制电路将存储在微处理器中的序列与接收的光脉冲序列的开/关模式进行比较。 后者通过凸透镜和光电导体从光发射器施加到控制单元的第二输入端。 只有存储的图案对应于所接收的光图案才能控制产生引发火花的信号。

    Digital ignition control for a magnetopowered ignition system of an internal combustion engine
    65.
    发明授权
    Digital ignition control for a magnetopowered ignition system of an internal combustion engine 失效
    内燃机磁力点火系统的数字点火控制

    公开(公告)号：US4378769A

    公开(公告)日：1983-04-05

    申请号：US235758

    申请日：1981-02-18

    申请人： Georg Haubner ,  Jurgen Wesemeyer ,  Werner Meier ,  Hans Schrumpf

    发明人： Georg Haubner ,  Jurgen Wesemeyer ,  Werner Meier ,  Hans Schrumpf

    IPC分类号： F02P5/155 ,  F02P1/08 ,  F02P5/15 ,  F02P9/00 ,  F02P11/02 ,  F02P1/00 ,  F02P3/02 ,  F02P5/04

    CPC分类号： F02P5/1504 ,  F02P1/083 ,  F02P11/02 ,  F02P5/1502 ,  F02P9/005 ,  Y02T10/46

    摘要： In an ignition system for an internal combustion engine, a digital system for computing the timing advance is provided. Constants approximating the curve of timing advance v. engine speed are stored in a microprocessor. The positive half waves of primary current in the magneto generate the ignition energy and also generate a reference signal for controlling the actual ignition time. The sequence of reference signals is also used to generate a digital value indicative of engine speed. The latter is used to address the read only memory in which the constants for approximating the timing advance curve are stored. After each reference signal, the value read out from the read only memory is counted down by a counter. When the counter reaches the value of zero, ignition is started.

    摘要翻译： 在用于内燃机的点火系统中，提供了用于计算定时提前的数字系统。 将定时提前v。发动机转速曲线近似的常数存储在微处理器中。 磁电中初级电流的正半波产生点火能量，并产生用于控制实际点火时间的参考信号。 参考信号的序列也用于产生指示发动机转速的数字值。 后者用于寻址其中存储用于近似定时提前曲线的常数的只读存储器。 在每个参考信号之后，从只读存储器读出的值由计数器递减计数。 当计数器达到零值时，点火开始。

    Pregnane derivatives
    66.
    发明授权
    Pregnane derivatives 失效
    孕烯衍生物

    公开(公告)号：US4193921A

    公开(公告)日：1980-03-18

    申请号：US841430

    申请日：1977-10-12

    申请人： Andor Furst ,  Ludwig Labler ,  Werner Meier

    发明人： Andor Furst ,  Ludwig Labler ,  Werner Meier

    IPC分类号： C07J5/00 ,  C07J9/00 ,  C07J17/00 ,  C07J31/00 ,  C07J71/00

    CPC分类号： C07J31/006 ,  C07J17/00 ,  C07J71/001 ,  C07J9/00 ,  C07J9/005

    摘要： The present invention relates to pregnane derivatives of the formula ##STR1## wherein R.sup.1 and R.sup.3 are hydroxyl groups or readily cleavable etherified or esterified hydroxyl groups and R.sup.20 is hydroxymethyl or readily cleavable etherified or esterified hydroxy methyl, formyl, carboxyl or carbalkoxy useful as intermediates for the preparation of 1.alpha.-hydroxycholecalciferols. The present invention also relates to processes for the preparation of the pregnane derivatives and the intermediates thereof.

    摘要翻译： 本发明涉及式IMAGE的孕烷衍生物，其中R 1和R 3是羟基或易于切割的醚化或酯化的羟基，R 20是羟甲基或易裂解的醚化或酯化的羟甲基，甲酰基，羧基或烷氧羰基，可用作中间体 制备1α-羟基胆钙化醇。 本发明还涉及制备孕烷衍生物及其中间体的方法。

    9,10-Seco-steroids
    67.
    发明授权
    9,10-Seco-steroids 失效
    9,10-类固醇

    公开(公告)号：US4064173A

    公开(公告)日：1977-12-20

    申请号：US651763

    申请日：1976-01-23

    申请人： Jean-Marie Cassal ,  Andor Furst ,  Werner Meier

    发明人： Jean-Marie Cassal ,  Andor Furst ,  Werner Meier

    IPC分类号： C07C401/00 ,  C07C49/27

    CPC分类号： C07C205/45 ,  C07C2102/24

    摘要： A process for the preparation of 9,10-seco-steroids of the formula ##STR1## WHEREIN R.sup.1 and R.sup.2 independently are hydrogen, amino, OR.sup.5, OCOR.sup.6 or NHCOR.sup.5 wherein R.sup.5 is hydrogen or lower alkyl and R.sup.6 is lower alkyl or phenyl; R.sup.3 is lower alkyl; R.sup.4 is oxo, ##STR2## wherein R.sup.13 is lower alkyl, lower alkoxy -- lower alkylene, tetrahydropyranyl or tetrahydrofuryl, R.sup.14 is lower alkyl or aryl and R.sup.15 and R.sup.16 are lower alkyl or taken together form lower alkylene or arylene, and n is 1 or 2 is disclosed. The 9,10-seco-steroids of this invention are useful intermediates for the preparation of steroids.

    摘要翻译： 其中R 1和R 2独立地为氢，氨基，OR 5，OCOR 6或NHCOR 5，其中R 5为氢或低级烷基且R 6为低级烷基或苯基; R3是低级烷基; R4是氧代，其中R13是低级烷基，低级烷氧基 - 低级亚烷基，四氢吡喃基或四氢呋喃基，R14是低级烷基或芳基，R15和R16是低级烷基或一起形成低级亚烷基或亚芳基，n是1或 2。 本发明的9,10-秒类固醇是制备类固醇的有用中间体。

    Capacitor type magneto ignition system with diode-protected shutdown switch
    68.
    发明授权
    Capacitor type magneto ignition system with diode-protected shutdown switch 失效
    具有二极管保护关断开关的电容式磁点火系统

    公开(公告)号：US3964461A

    公开(公告)日：1976-06-22

    申请号：US527501

    申请日：1974-11-26

    申请人： Jurgen Wesemeyer ,  Hans Schrumpf ,  Werner Meier ,  Georg Haubner

    发明人： Jurgen Wesemeyer ,  Hans Schrumpf ,  Werner Meier ,  Georg Haubner

    IPC分类号： F02P1/08 ,  F02P11/02 ,  F02P1/00 ,  F02P9/00

    CPC分类号： F02P1/086 ,  F02P1/08 ,  F02P1/083 ,  F02P11/025

    摘要： An additional diode is provided in series with the charging diode through which the storage capacitor of a magneto ignition system is charged and the shutdown switch for the engine is connected between the common connection of the two diodes and the common connection of the magneto generator, and the capacitor diodes, because of their high back resistance, prevent any high positive or negative voltages from appearing across an open shutdown switch.

    摘要翻译： 与充电二极管串联提供一个额外的二极管，通过该充电二极管对磁点火系统的存储电容器进行充电，并且用于发动机的关断开关连接在两个二极管的公共连接和磁发电机的公共连接之间，以及 电容二极管由于具有较高的反向电阻，可防止任何高的正或负电压出现在开路关断开关上。