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公开(公告)号：US20140315742A1
公开(公告)日：2014-10-23
申请号：US14348275
申请日：2012-09-28
Applicant: MESO SCALE TECHNOLOGIES, LLC , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
Inventor： William F Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
IPC: G01N33/566
CPC classification number: G01N33/56972 , G01N33/566 , G01N33/6893 , G01N2333/70535 , G01N2333/70578 , G01N2800/40 , G01N2800/60 , G01T1/00 , G01T1/02
Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
Abstract translation: 本发明涉及用于评估电离辐射吸收剂量和/或患者辐射组织损伤严重程度的方法和试剂盒。 本发明还涉及用于基于在辐射暴露的情况下相对于正常对照改变的多个生物标志物的生物标志物测量来计算辐射的吸收剂量的算法。
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公开(公告)号：US20140315189A1
公开(公告)日：2014-10-23
申请号：US14357653
申请日：2012-11-09
Applicant: Meso Scale Technologies, LLC
Inventor： Eli N. Glezer , George Sigal
CPC classification number: C12Q1/70 , C12Q1/6813 , C12Q1/6834 , G01N33/542 , G01N33/54333 , C12Q2563/179
Abstract: The present invention is directed to methods for reducing cross-reactivity between species employed in multiplexed immunoassays.
Abstract translation: 本发明涉及降低多重免疫测定中使用的物种之间的交叉反应性的方法。
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公开(公告)号：US20140191109A1
公开(公告)日：2014-07-10
申请号：US14147216
申请日：2014-01-03
Applicant: Meso Scale Technologies, LLC
Inventor： Ian Chamberlin , Charles M. Clinton , Eli N. Glezer , Bandele Jeffrey-Coker , Manish Kochar , Sandor Kovacs , D.T. Le , Aaron Leimkuehler , George Sigal , Leo Tabakin , Jon Willoughby
CPC classification number: G02B7/36 , G01N21/253 , G01N21/6452 , G01N35/028
Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.
Abstract translation: 描述了用于进行测定的装置，系统，方法，试剂和试剂盒及其制备方法。 它们特别适用于以多孔板测定方式进行自动化分析。
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公开(公告)号：US12203937B2
公开(公告)日：2025-01-21
申请号：US17264489
申请日：2019-12-23
Applicant: Meso Scale Technologies, LLC.
Inventor： Alexander K. Tucker-Schwartz , George Sigal
Abstract: The present disclosure provides compositions, reagents, kits, systems, system components, and methods for performing assays. More particularly, the disclosure relates to an assay composition for detecting luminescence, which comprises an alkyl diethanolamine, for example, N-butyldiethanolamine (BDEA). In embodiments, the assay composition comprises 2-dibutylaminoethanol (BDAE).
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公开(公告)号：US11982871B2
公开(公告)日：2024-05-14
申请号：US17492187
申请日：2021-10-01
Applicant: Meso Scale Technologies, LLC.
Inventor： Ian Chamberlin , Charles M. Clinton , Eli N. Glezer , Bandele Jeffrey-Coker , Manish Kochar , Sandor Kovacs , D. T. Le , Aaron Leimkuehler , George Sigal , Leo Tabakin , Jon Willoughby
CPC classification number: G02B7/36 , G01N21/253 , G01N21/6452 , G01N35/028
Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.
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Patent Agency Ranking
公开(公告)号：US11967410B2
公开(公告)日：2024-04-23
申请号：US15902597
申请日：2018-02-22
Applicant: Meso Scale Technologies, LLC. , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
Inventor： William F Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
CPC classification number: G16H20/40 , G01N27/3273 , G01N33/6893 , G01N35/00 , G01T1/00 , G01T1/02 , G01N2333/70535 , G01N2333/70578 , G01N2800/40 , G01N2800/60
Abstract: Methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. Also, algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
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公开(公告)号：US11892455B2
公开(公告)日：2024-02-06
申请号：US17061095
申请日：2020-10-01
Applicant: Meso Scale Technologies, LLC
Inventor： Charles M. Clinton , Eli N. Glezer , Bandele Jeffrey-Coker , Sandor L. Kovacs , Sudeep M. Kumar , George Sigal , Carl Stevens , Michael Vock
IPC: G01N35/10 , B67B7/00 , G01N33/58 , G01N21/64 , G01N21/66 , G01N33/53 , G01N35/02 , B01L3/00 , G01N35/04
CPC classification number: G01N33/582 , B01L3/5085 , B01L3/50255 , B67B7/24 , G01N21/6452 , G01N21/66 , G01N33/5302 , G01N35/028 , G01N35/1011 , G01N35/1079 , G01N35/1081 , G01N35/1002 , G01N35/109 , G01N2035/0405 , G01N2035/0425 , G01N2035/1025 , Y10T83/9314
Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.
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公开(公告)号：US11686739B2
公开(公告)日：2023-06-27
申请号：US17412688
申请日：2021-08-26
Applicant: Meso Scale Technologies, LLC.
Inventor： Manish Kochar , Peter J. Bosco , Ian D. Chamberlin , Bandele Jeffrey-Coker , Eric M. Jones , Aaron H. Leimkuehler , Kim-Xuan Nguyen , Pankaj Oberoi , Louis W. Pang , Jennifer Parker , Victor Pellicier , Nicholas Sammons , George Sigal , Jacob N. Wohlstadter , Stanley T. Smith , Carl C. Stevens , Rodger D. Osborne , Kenneth E. Page
IPC: G01N35/00 , B01L3/00 , B01L9/00 , G16H40/67 , G16H10/40 , G16H40/40 , F24F11/30 , G06K7/14 , G06Q10/087 , G06Q10/10 , H04B1/3827
CPC classification number: G01N35/0099 , B01L3/50853 , B01L9/523 , F24F11/30 , G06K7/1413 , G06Q10/087 , G06Q10/10 , G16H10/40 , G16H40/40 , G16H40/67 , B01L2200/143 , B01L2300/021 , G01N2035/00356 , G05B2219/40269 , H04B1/3827
Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such data in the conduct of an assay by an assay system. The present invention also relates to consumables (e.g., kits and reagent containers), software, data deployable bundles, computer-readable media, loading carts, instruments, systems, and methods, for performing automated biological assays.
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公开(公告)号：US20220397579A1
公开(公告)日：2022-12-15
申请号：US17773896
申请日：2020-11-04
Applicant: MESO SCALE TECHNOLOGIES, LLC.
Inventor： Sunsanee Kanjananimmanont , Sudeep Kumar , Navaratnam Manjula , Simone Barbero , Martin Stengelin , George Sigal
IPC: G01N33/68 , G01N33/543
Abstract: The invention relates to methods and kits for quantitating radiation exposure in a subject exposed to radiation, at risk of exposure to radiation or suspected of having been exposed to radiation. In embodiments, the present disclosure provides multiplexed immunoassays for quantifying amounts of biomarkers for assessing radiation exposure in a sample. Also provided herein are kits for performing the multiplexed assays.
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公开(公告)号：US20220283157A1
公开(公告)日：2022-09-08
申请号：US17531868
申请日：2021-11-22
Applicant: Meso Scale Technologies, LLC.
Inventor： Eli N. Glezer , Mikayla Higgins , John Kenten , George Sigal
IPC: G01N33/564
Abstract: The present disclosure relates to multiplexed assay formats configured to measure the level of a plurality of biomarkers that include a protein array for detecting autoreactive antibody levels against autoantigens.
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