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公开(公告)号：US5959078A
公开(公告)日：1999-09-28
申请号：US972498
申请日：1997-11-18
CPC分类号： C12N9/1081 , A61K38/00
摘要： Isolated nucleic acid molecules encoding polysialyl transferases, and the polysialyl transferases themselves are disclosed. SEQ ID NOS: 1, 2, 7 and 8 present examples of these. The nucleic acid molecules and the proteins can be used diagnostically or therapeutically. Additionally, antisense oligonucleotides and antibodies are described, which can also be used diagnostically or therapeutically.
摘要翻译： 公开了分离的编码聚唾液酸转移酶的核酸分子，以及唾液酸转移酶本身。 图1，图2，图7和图8示出了这些实施例。 核酸分子和蛋白质可以在诊断上或治疗上使用。 另外，描述了反义寡核苷酸和抗体，其也可以在诊断上或治疗上使用。
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62.发明授权Antibodies to human I-branching beta-1,6-N-acetylglucosaminyltransferase 失效人I支链β-1,6-N-乙酰葡糖胺基转移酶的抗体
公开(公告)号：US5731420A
公开(公告)日：1998-03-24
申请号：US486196
申请日：1995-06-07
CPC分类号： C12N9/1051 , A61K38/00
摘要： The present invention provides an isolated nucleic acid molecule encoding both a soluble and membrane-bound human .beta.-1,6-N-acetylglucosaminyltransferase, the I-branching enzyme (IGnT). The invention also provides vectors containing the isolated nucleic acid molecule encoding human IGnT as well as recombinant host cells transformed with the vectors. The invention further provides a method of preparing a membrane-bound form of human IGnT and methods of preparing and purifying soluble human IGnT and active fragments of either form. Also provided are antisense oligonucleotides complementary to a nucleic acid molecule encoding a human IGnT or an active fragment thereof, antibodies directed to the human IGnT, pharmaceutical compositions related to the human IGnT and transgenic nonhuman mammals expressing DNA encoding normal or mutant human IGnT. Also provided are methods for regulating the expression of human IGnT and methods for modifying a biological function mediated by the regulatory activity of human IGnT. Methods of detecting the presence of linear polylactosaminoglycans expressing i antigenic determinants on a cell surface also are provided.
摘要翻译： 本发明提供了编码可溶性和膜结合的人β-1,6-N-乙酰葡糖胺基转移酶I-分支酶（IGnT）的分离的核酸分子。 本发明还提供含有编码人IGnT的分离的核酸分子以及用载体转化的重组宿主细胞的载体。 本发明还提供了制备人IGnT的膜结合形式的方法，以及制备和纯化可溶性人IGnT和任一种形式的活性片段的方法。 还提供了与编码人IGnT或其活性片段的核酸分子互补的反义寡核苷酸，针对人IGnT的抗体，与人IGnT相关的药物组合物和表达编码正常或突变型人IGnT的DNA的转基因非人哺乳动物。 还提供了调节人IGnT的表达的方法和用于修饰由人IGnT的调节活性介导的生物功能的方法。 还提供了检测在细胞表面上表达i抗原决定簇的线性多糖胺聚糖存在的方法。
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公开(公告)号：US5646248A
公开(公告)日：1997-07-08
申请号：US73807
申请日：1993-06-08
申请人： Ritsuko Sawada , John B. Lowe , Minoru Fukuda
发明人： Ritsuko Sawada , John B. Lowe , Minoru Fukuda
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C07K14/435 , C12N15/12
CPC分类号： C07K14/705 , C07K14/47 , A61K38/00
摘要： The present invention provides novel purified human lysosomal membrane sialoglycoproteins. These novel human proteins, lamp-1 and lamp-2, are highly glycosylated and are the major carriers of polylactosaminoglycan, when expressed on the cell surface participate in various cellular adhesion interactions.
摘要翻译： 本发明提供新型纯化的人溶酶体膜唾液酸糖蛋白。 这些新型人类蛋白质灯1和灯2高度糖基化，并且是在细胞表面上表达时参与多种细胞粘附相互作用的聚乳糖胺聚糖的主要载体。
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公开(公告)号：US5360733A
公开(公告)日：1994-11-01
申请号：US955041
申请日：1992-10-01
IPC分类号： C12N15/09 , C07K14/47 , C07K14/705 , C07K16/40 , C12N1/21 , C12N5/10 , C12N9/10 , C12N15/54 , C12N15/64 , C12P21/02 , C12R1/91 , C12P19/18
CPC分类号： C07K16/40 , C07K14/705 , C07K14/70596 , C12N15/64 , C12N9/1051
摘要： The present invention provides a novel .beta.1.fwdarw.6 N-acetylglucosaminyltransferase, which forms core 2 oligosaccharide structures in O-glycans, and a novel acceptor molecule, leukosialin, CD43, for core 2 .beta.1.fwdarw.6 N-acetylglucosaminyltransferase activity. The amino acid sequences and nucleic acid sequences encoding these molecules, as well as active fragments thereof, also are disclosed. A method for isolating nucleic acid sequences encoding proteins having enzymatic activity is disclosed, using CHO cells that support replication of plasmid vectors having a polyoma virus origin of replication. A method to obtain a suitable cell line that expresses an acceptor molecule also is disclosed.
摘要翻译： 本发明提供了一种在O-聚糖中形成核心寡糖结构的新颖的β1-6N-乙酰氨基葡糖转移酶，以及用于核心2β1-> 6 N-乙酰葡糖胺基转移酶活性的新受体分子白细胞介素，CD43。 还公开了编码这些分子的氨基酸序列和核酸序列，以及其活性片段。 使用支持具有多瘤病毒复制起点的质粒载体的复制的CHO细胞来公开分离编码具有酶活性的蛋白质的核酸序列的方法。 公开了获得表达受体分子的合适细胞系的方法。
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65.发明授权
公开(公告)号：US4829187A
公开(公告)日：1989-05-09
申请号：US80513
申请日：1987-07-08
摘要： A UV-ray sensitive composition, comprising a photo activator forming a free radical by the irradiation of UV-rays, a discoloring agent which exhibits a color change in visible region of spectrum through the action of this free radical, and a UV-ray absorber.
摘要翻译： PCT No.PCT / JP86 / 00572 Sec。 371日期1987年7月8日第 102（e）日期1987年7月8日PCT提交1986年11月11日PCT公布。 出版物WO87 / 03086 日期：1987年5月21日。一种紫外线敏感性组合物，其包含通过照射紫外线形成自由基的光致敏剂，通过该自由基的作用展现出可见光谱范围的颜色变化的变色剂， 和紫外线吸收剂。
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公开(公告)号：US4788665A
公开(公告)日：1988-11-29
申请号：US75986
申请日：1987-07-21
CPC分类号： G11C16/10 , G11C2216/14
摘要： An electrically programmable read only memory is equipped with latch circuits for sequentially introducing series signals which are fed through external terminals. The converter includes sequentially operated switch elements and latch circuits in order to convert the series signals into parallel signals. The thus converted parallel signals are written simultaneously in a memory array via address decoder operated selection switch elements. According to this method, the writing operations into the memory array can be conducted at a high speed even when one writing operation is relatively long as a result of the parallel signal action.
摘要翻译： 电可编程只读存储器配备有用于顺序地引入通过外部端子馈送的串联信号的锁存电路。 转换器包括顺序操作的开关元件和锁存电路，以将串联信号转换为并行信号。 这样转换的并行信号通过地址译码器操作的选择开关元件同时写入存储器阵列。 根据这种方法，即使当并行信号动作的结果是一个写入操作相对较长时，也可以高速地进行对存储器阵列的写入操作。
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公开(公告)号：US4691298A
公开(公告)日：1987-09-01
申请号：US770576
申请日：1985-08-29
CPC分类号： G11C16/10 , G11C2216/14
摘要： An electrically programmable read only memory is equipped with latch circuits for sequentially introducing series signals which are fed through external terminals. The converter includes sequentially operated switch elements and latch circuits in order to convert the series signals into parallel signals. The thus converted parallel signals are written simultaneously in a memory array via address decoder operated selection switch elements. According to this method, the writing operations into the memory array can be conducted at a high speed even when one writing operation is relatively long as a result of the parallel signal action.
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68.发明授权Photosensitive resin containing a combination of diphenyl-imiazolyl dimer and a heterocyclic mercaptan 失效含有二苯基 - 亚氨基二聚体和杂环硫醇的组合的光敏树脂
公开(公告)号：US4410621A
公开(公告)日：1983-10-18
申请号：US250805
申请日：1981-04-03
申请人： Minoru Wada , Minoru Fukuda
发明人： Minoru Wada , Minoru Fukuda
CPC分类号： G03F7/031 , Y10S430/121 , Y10S430/123
摘要： A photosensitive resin composition which comprises (1) an ethylenically unsaturated compound which can be addition polymerized to form a high molecular compound, said addition polymerization being initiated by a free radical and chain-propagating, (2) a 2-polycyclic aryl-4,5-diphenylimidazolyl dimer wherein the polycyclic aryl group at the 2-position comprises at least two benzene rings condensed each other and (3) a heterocyclic mercaptan compound, said photosensitive resin composition being excellent in having a high photopolymerization initiation potency.
摘要翻译： 一种感光性树脂组合物，其包含（1）可以加成聚合以形成高分子化合物的烯属不饱和化合物，所述加成聚合由自由基引发和链增长，（2）2-多环芳基-4， 5-二苯基咪唑基二聚体，其中2-位的多环芳基包含至少两个彼此稠合的苯环和（3）杂环硫醇化合物，所述感光性树脂组合物具有优异的光聚合引发效力。
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69.发明授权Field effect transistor Miller integrator oscillator with temperature compensating impedance 失效具有温度补偿阻抗的场效应晶体管MILLER积分器振荡器
公开(公告)号：US4001721A
公开(公告)日：1977-01-04
申请号：US627281
申请日：1975-10-30
申请人： Minoru Fukuda
发明人： Minoru Fukuda
CPC分类号： H03K3/3545 , H03K4/94 , Y10S323/907
摘要： In an oscillation circuit wherein three or a greater odd number of inverters each of which is composed of a load FET and a driving FET are connected in cascade, a capacitor is connected between the input and output of at least one of the inverters so as to construct a Miller integrator, and the output of the final-stage inverter is connected to the input of the first-stage inverter, the improvement comprising the fact that impedance means, such as resistance, which has a positive temperature coefficient is connected in series with the capacitor, whereby the oscillation frequency of the oscillation circuit is prevented from fluctuating due to a change of the ambient temperature.
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公开(公告)号：US08952633B2
公开(公告)日：2015-02-10
申请号：US14236463
申请日：2012-07-10
IPC分类号： H05B37/02 , H05B41/24 , H05B41/288 , H05B41/292
CPC分类号： H05B41/24 , H05B41/2887 , H05B41/2928 , Y02B20/202 , Y02B20/208
摘要： In a lighting apparatus containing a high pressure discharge lamp, an alternating current supplied to the discharge lamp at the time of steady lighting of the frequency (basic frequency) selected from a range between 60 and 1000 Hz and a low frequency having a frequency selected from a range between 5 and 200 Hz lower than the basic frequency is generated alternately. The frequency of the low frequency wave is changed in response to the change of the lighting voltage of the discharge lamp. The supply period of the basic frequency is increased and decreased little by little by every predetermined time.
摘要翻译： 在包含高压放电灯的照明装置中，在从60Hz和1000Hz之间的频率选择的频率（基本频率）的稳定点亮时提供给放电灯的交流电流和频率选自 交替地产生比基本频率低5〜200Hz的范围。 响应于放电灯的点亮电压的变化，低频波的频率发生变化。 基本频率的供给周期每隔预定时间逐渐增加和减少。
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