公开(公告)号：US08812131B2

公开(公告)日：2014-08-19

申请号：US12824663

申请日：2010-06-28

申请人： Jordi Parramon ,  Rafael Carbunaru ,  Matt I. Haller

发明人： Jordi Parramon ,  Rafael Carbunaru ,  Matt I. Haller

IPC分类号： A61N1/36

CPC分类号： A61N1/36171 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/36 ,  A61N1/36071 ,  A61N1/36125 ,  A61N1/36175 ,  A61N1/36178 ,  A61N1/37235

摘要： A method for configuring stimulation pulses in an implantable stimulator device having a plurality of electrodes is disclosed, which method is particularly useful in adjusting the electrodes by current steering during initialization of the device. In one aspect, a set of ideal pulses for patient therapy is determined, in which at least two of the ideal pulses are of the same polarity and are intended to be simultaneous applied to corresponding electrodes on the implantable stimulator device during an initial duration. These pulses are reconstructed into fractionalized pulses, each comprised of pulse portions. The fractionalized pulses are applied to the corresponding electrodes on the device during a final duration, but the pulse portions of the fractionalized pulses are not simultaneously applied during the final duration.

摘要翻译： 公开了一种用于在具有多个电极的可植入刺激器装置中配置刺激脉冲的方法，该方法在装置的初始化期间通过电流转向来调节电极特别有用。 在一个方面，确定用于患者治疗的一组理想脉冲，其中至少两个理想脉冲具有相同的极性并且旨在在初始持续时间期间同时施加到可植入刺激器装置上的对应电极。 这些脉冲被重建成分数脉冲，每个脉冲包括脉冲部分。 分数脉冲在最后的持续时间内施加到器件上的对应电极，但分数脉冲的脉冲部分在最后的持续时间内不被同时施加。

公开(公告)号：US08731686B2

公开(公告)日：2014-05-20

申请号：US12630761

申请日：2009-12-03

申请人： Courtney Lane ,  Jesse Geroy ,  James C. Makous ,  Todd Whitehurst ,  Matthew Flowers ,  John Michael Barker ,  Terry Ferrell ,  John Swoyer ,  Brett Schleicher ,  Jeff Gagnon ,  Andrew DiGiore ,  Ellis Garai ,  Kristen Jaax ,  Rafael Carbunaru

发明人： Courtney Lane ,  Jesse Geroy ,  James C. Makous ,  Todd Whitehurst ,  Matthew Flowers ,  John Michael Barker ,  Terry Ferrell ,  John Swoyer ,  Brett Schleicher ,  Jeff Gagnon ,  Andrew DiGiore ,  Ellis Garai ,  Kristen Jaax ,  Rafael Carbunaru

IPC分类号： A61N1/00

CPC分类号： A61B17/0057 ,  A61B90/10 ,  A61B2090/103 ,  A61N1/0534 ,  A61N1/0539

摘要： A burr hole plug comprises a plug base configured for being mounted around a burr hole. The plug base includes an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base. The retainer further includes first and second slidable clamping mechanisms configured for securing the medical devices therebetween within the aperture of the plug base. A method comprises introducing the medical device through the burr hole, mounting a plug base around the burr hole, such that the medical device extends through the plug base aperture, mounting the retainer within the aperture of the plug base, and sliding the first and second clamping mechanisms secure the medical device therebetween.

摘要翻译： 毛刺孔塞包括构造成围绕钻孔安装的塞子基座。 插头基座包括一个孔，通过该孔可以使离开钻孔的细长医疗装置通过。 毛刺孔塞还包括保持器，其构造成用于安装在插头基座的孔内。 保持器还包括第一和第二可滑动夹紧机构，其被构造用于将医疗装置固定在插头基座的孔内。 一种方法包括：通过毛刺孔引导医疗装置，将插头基座安装在毛刺孔周围，使得医疗装置延伸穿过插头基座孔口，将保持器安装在插头基座的孔内，并将第一和第二 夹紧机构将医疗装置固定在其间。

公开(公告)号：US08676322B2

公开(公告)日：2014-03-18

申请号：US12358073

申请日：2009-01-22

申请人： Todd K. Whitehurst ,  Kristen N. Jaax ,  Rafael Carbunaru ,  Greg Baldwin ,  Brett Schleicher ,  Andrew DiGiore ,  Roger Hastings

发明人： Todd K. Whitehurst ,  Kristen N. Jaax ,  Rafael Carbunaru ,  Greg Baldwin ,  Brett Schleicher ,  Andrew DiGiore ,  Roger Hastings

IPC分类号： A61N1/05

CPC分类号： A61N1/36007 ,  A61N1/0551 ,  A61N1/36071 ,  A61N1/37205 ,  A61N1/37252

摘要： Methods and systems of treating a patient with pancreatitis pain include providing a stimulator, configuring one or more stimulation parameters to treat pancreatitis pain, programming the stimulator with the one or more stimulation parameters, generating a stimulus configured to treat pancreatitis pain with the stimulator in accordance with the one or more stimulation parameters, and applying the stimulus with the stimulator to one or more stimulation sites in accordance with the one or more stimulation parameters.

摘要翻译： 治疗患有胰腺炎疼痛的患者的方法和系统包括提供刺激器，配置一个或多个刺激参数以治疗胰腺炎疼痛，用所述一个或多个刺激参数编程所述刺激器，产生被配置为按照所述刺激器治疗胰腺炎疼痛的刺激 与所述一个或多个刺激参数相关联，并且根据所述一个或多个刺激参数将刺激器刺激施加到一个或多个刺激位点。

公开(公告)号：US20120197352A1

公开(公告)日：2012-08-02

申请号：US13442913

申请日：2012-04-10

申请人： Rafael Carbunaru ,  Robert D. Ozawa ,  Kenneth A. McGiboney

发明人： Rafael Carbunaru ,  Robert D. Ozawa ,  Kenneth A. McGiboney

IPC分类号： A61N1/36

CPC分类号： A61N1/37276 ,  A61N1/36007 ,  A61N1/3605 ,  A61N1/37205 ,  A61N1/37217 ,  A61N1/37223 ,  A61N1/37229 ,  A61N1/37235 ,  A61N1/3727 ,  A61N1/375 ,  A61N1/3787 ,  H01L2224/45144 ,  H01L2224/45147 ,  H01L2224/48465 ,  H01L2224/49175 ,  H01L2924/00011 ,  H01L2924/1461 ,  H01L2924/19105 ,  H01L2924/19107 ,  H01L2924/3011 ,  H01L2924/30111 ,  H02J7/025 ,  H02J7/345 ,  H04B5/0037 ,  H04B5/0081 ,  H04L27/02 ,  H04L27/10 ,  Y10T29/4902 ,  Y10T29/49071 ,  Y10T29/49073 ,  Y10T29/49128 ,  Y10T29/4913 ,  Y10T29/49155 ,  Y10T29/49169 ,  Y10T29/49826 ,  Y10T29/49945 ,  Y10T29/49968 ,  Y10T428/12264 ,  Y10T428/12271 ,  Y10T428/12347 ,  Y10T428/12375 ,  Y10T428/12396 ,  Y10T428/12535 ,  Y10T428/12806 ,  H01L2924/00 ,  H01L2924/01005 ,  H01L2924/01033

摘要： A system and method are provided for both recharging and communicating with a stimulator having a rechargeable battery, which stimulator is implanted deeply in the body, in particular where the stimulator is a microstimulator, the system includes a base station and an external device, for instance a chair pad. The chair pad may contain an antenna/charging coil and a booster coil. The antenna/charging coil can be used for charging the rechargeable battery and also for communicating with the stimulator using frequency shift keying and on-off keying. The booster coil can be used to recharge a battery depleted to zero volts. The base station connected to the chair pad may be used to power the antenna/charging coil and the booster coil.

摘要翻译： 提供了一种系统和方法，用于对具有可再充电电池的刺激器进行再充电和通信，该刺激器将刺激器深深地植入人体内，特别是在刺激器是微型激励器的情况下，系统包括基站和外部设备，例如 一把椅子。 椅垫可以包含天线/充电线圈和升压线圈。 天线/充电线圈可用于对可充电电池充电，并且还可以使用频移键控和开关键控与刺激器通信。 升压线圈可用于为耗尽零伏特的电池充电。 连接到椅垫的基站可用于为天线/充电线圈和升压线圈供电。

公开(公告)号：US08224460B2

公开(公告)日：2012-07-17

申请号：US13207876

申请日：2011-08-11

申请人： Brett Schleicher ,  Andrew DiGiore ,  Rafael Carbunaru ,  Courtney Lane ,  Kristen N. Jaax

发明人： Brett Schleicher ,  Andrew DiGiore ,  Rafael Carbunaru ,  Courtney Lane ,  Kristen N. Jaax

IPC分类号： A61N1/00

CPC分类号： A61N1/0558

摘要： A nerve stimulation lead has a distal end, a proximal end, and a longitudinal length. The nerve stimulation lead includes a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and a plurality of conductive wires electrically coupling the plurality of electrodes electrically to the plurality of terminals. The nerve stimulation lead also includes at least one anchoring unit disposed on the nerve stimulation lead. The at least one anchoring unit is configured and arranged for anchoring the nerve stimulation lead against a bony structure.

摘要翻译： 神经刺激引线具有远端，近端和纵向长度。 神经刺激引线包括设置在远端的多个电极，设置在近端的多个端子，以及将多个电极电连接到多个端子的多个导线。 神经刺激引线还包括设置在神经刺激引线上的至少一个锚定单元。 所述至少一个锚定单元被配置和布置成用于将神经刺激引线抵靠骨结构锚定。

公开(公告)号：US08214042B2

公开(公告)日：2012-07-03

申请号：US12471626

申请日：2009-05-26

申请人： Robert Dai Ozawa ,  Rafael Carbunaru

发明人： Robert Dai Ozawa ,  Rafael Carbunaru

IPC分类号： A61N1/378

CPC分类号： A61N1/3787 ,  A61F2250/0001 ,  A61N1/08 ,  H02J7/025 ,  H02J50/10

摘要： Disclosed are charging algorithms implementable in an external charger for controlling the charging of both an external battery in the external charger and an implant battery in an implantable medical device. Because full-powered simultaneous charging of both batteries can generate excessive heat in the external charger, the various charging algorithms are designed to ensure that both batteries are ultimately charged, but in a manner considerate of heat generation. In some embodiments, the charging algorithms prevent simultaneous charging of both batteries by arbitrating which battery is given charging precedence at a given point in time. In other embodiments, the charging algorithms allow for simultaneous charging of both batteries, but with at least one of the batteries being only weakly charged at low power levels. In other embodiments, the temperature generated in the external charger is monitored and used to control the charging algorithm. In these embodiments, if a safe temperature is exceeded, then the charging algorithms change to new temperature-reducing schemes which still allow for both batteries to be ultimately charged.

摘要翻译： 公开了可在外部充电器中实现的充电算法，用于控制外部充电器中的外部电池和可植入医疗装置中的植入物电池的充电。 因为两个电池的全功率同时充电可能在外部充电器中产生过多的热量，所以各种充电算法被设计成确保两个电池最终被充电，但是以一种考虑发热的方式。 在一些实施例中，充电算法通过仲裁给定电池在给定的时间点给予充电优先级来防止两个电池的同时充电。 在其他实施例中，充电算法允许两个电池同时充电，但是至少一个电池在低功率电平下仅为弱充电。 在其他实施例中，监视在外部充电器中产生的温度并用于控制充电算法。 在这些实施例中，如果超过安全温度，则充电算法变为新的降温方案，这仍然允许两个电池最终被充电。

公开(公告)号：US08019443B2

公开(公告)日：2011-09-13

申请号：US12413081

申请日：2009-03-27

申请人： Brett Schleicher ,  Andrew DiGiore ,  Rafael Carbunaru ,  Courtney Lane ,  Kristen N. Jaax

发明人： Brett Schleicher ,  Andrew DiGiore ,  Rafael Carbunaru ,  Courtney Lane ,  Kristen N. Jaax

IPC分类号： A61N1/00

CPC分类号： A61N1/0558

摘要： A nerve stimulation lead has a distal end, a proximal end, and a longitudinal length. The nerve stimulation lead includes a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and a plurality of conductive wires electrically coupling the plurality of electrodes electrically to the plurality of terminals. The nerve stimulation lead also includes at least one anchoring unit disposed on the nerve stimulation lead. The at least one anchoring unit is configured and arranged for anchoring the nerve stimulation lead against a bony structure.

摘要翻译： 神经刺激引线具有远端，近端和纵向长度。 神经刺激引线包括设置在远端的多个电极，设置在近端的多个端子，以及将多个电极电连接到多个端子的多个导线。 神经刺激引线还包括设置在神经刺激引线上的至少一个锚定单元。 所述至少一个锚定单元被配置和布置成用于将神经刺激引线抵靠骨结构锚定。

公开(公告)号：US20110166546A1

公开(公告)日：2011-07-07

申请号：US13050836

申请日：2011-03-17

申请人： Kristen N. Jaax ,  Todd K. Whitehurst ,  Rafael Carbunaru

发明人： Kristen N. Jaax ,  Todd K. Whitehurst ,  Rafael Carbunaru

IPC分类号： A61N1/36 ,  A61M5/142

CPC分类号： A61N1/36082 ,  A61N1/37205

摘要： Methods of treating a medical condition include applying at least one stimulus to a motor cortex within a brain of a patient with an implanted system control unit in accordance with one or more stimulation parameters. Systems for treating a medical condition include a system control unit implanted within the patient that is configured to apply at least one stimulus to a motor cortex within a brain of a patient in accordance with one or more stimulation parameters.

摘要翻译： 治疗医疗状况的方法包括根据一个或多个刺激参数，用植入的系统控制单元向患者的脑内的运动皮质施加至少一种刺激。 用于治疗医疗状况的系统包括植入患者体内的系统控制单元，其被配置为根据一个或多个刺激参数将至少一个刺激施加到患者脑内的运动皮质。

公开(公告)号：US20110160796A1

公开(公告)日：2011-06-30

申请号：US12976658

申请日：2010-12-22

申请人： Courtney Lane ,  Rafael Carbunaru ,  David K.L. Peterson ,  Andrew DiGiore

发明人： Courtney Lane ,  Rafael Carbunaru ,  David K.L. Peterson ,  Andrew DiGiore

IPC分类号： A61N1/08 ,  A61N1/36

CPC分类号： A61N1/36139 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36082 ,  A61N1/37282

摘要： Neurostimulation systems and methods for providing therapy to a patient suffering from a symptom of a disease that latently responds to electrical stimulation therapy are provided. First electrical stimulation energy is conveyed to or from a tissue region of the patient in accordance with a first set of stimulation parameters, thereby affecting the symptom. A predetermined period of time estimated for the symptom to resolve in response to electrical stimulation therapy is allowed to elapse. Second electrical stimulation energy is conveyed to or from the tissue region in accordance with a second set of stimulation parameters different from the first set of stimulation parameters.

摘要翻译： 提供了神经刺激系统和用于向患有潜在的电刺激治疗反应的疾病症状的患者提供治疗的方法。 根据第一组刺激参数将第一电刺激能量传送到患者的组织区域或从患者的组织区域传送，从而影响症状。 对于电刺激治疗反应的症状的预定时间段被允许经过。 根据与第一组刺激参数不同的第二组刺激参数将第二电刺激能量传送到组织区域或从组织区域传送。

公开(公告)号：US20110137372A1

公开(公告)日：2011-06-09

申请号：US12959890

申请日：2010-12-03

申请人： James Makous ,  Brett Schleicher ,  Rafael Carbunaru ,  Kristen Jaax ,  Andrew DiGiore

发明人： James Makous ,  Brett Schleicher ,  Rafael Carbunaru ,  Kristen Jaax ,  Andrew DiGiore

IPC分类号： A61N1/36

CPC分类号： A61N1/36139 ,  A61N1/0534

摘要： A system and method for applying stimulation to a target stimulation site within a patient, while avoiding undesirable eye movement side effects of the stimulation, are provided. The method includes determining whether eye movement, sensed by internal or external electrodes, is a side effect of a conveyed electrical stimulus. If the eye movement is a side effect, the electrical current distribution of the stimulus is modified in order to steer a locus of the electrical stimulus from one tissue region of the patient to another different tissue region of the patient, thereby mitigating the eye movement side effects. For example, the locus of the electrical stimulus may be steered away from the oculomotor nerve. Eye movement side effects of DBS treatment may include apraxia of lid opening, downward movement and adduction of only one eyeball, and/or continuous deviation of both eyeballs.

摘要翻译： 提供了一种用于将刺激应用于患者内的目标刺激部位同时避免刺激的不期望的眼睛运动副作用的系统和方法。 该方法包括确定由内部或外部电极感测的眼睛运动是否是所传送的电刺激的副作用。 如果眼睛运动是副作用，则刺激的电流分布被修改以便将电刺激的轨迹从患者的一个组织区域引导到患者的另一不同组织区域，从而减轻眼睛运动侧 效果。 例如，电刺激的轨迹可以被转向离开眼动神经。 DBS治疗的眼睛运动副作用可能包括盖开口的不适，仅有一只眼球的向下运动和内收，和/或两只眼球的连续偏差。