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97 条记录 (耗时 0.052 秒)

    Error checking in blood analyzer
    65.
    发明授权
    Error checking in blood analyzer 失效
    血液分析仪检查错误

    公开(公告)号：US5590052A

    公开(公告)日：1996-12-31

    申请号：US227554

    申请日：1994-04-14

    申请人： Anne R. Kopf-Sill ,  Steven N. Buhl ,  Glenda L. Choate ,  Lloyd A. Schick ,  Robert E. Nagle ,  Jenq C. Chang ,  Daniel Bernstein ,  Wayne A. Britt

    发明人： Anne R. Kopf-Sill ,  Steven N. Buhl ,  Glenda L. Choate ,  Lloyd A. Schick ,  Robert E. Nagle ,  Jenq C. Chang ,  Daniel Bernstein ,  Wayne A. Britt

    IPC分类号： G01N21/25 ,  G01N35/00 ,  G01N35/02 ,  G01N21/17

    CPC分类号： G01N35/00594 ,  G01N21/253 ,  G01N35/025 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165

    摘要： The present invention provides various methods for detecting errors in a blood analysis system. The system includes a blood analyzer and a molded plastic rotor with a series of chambers and capillary channels through which blood is processed and distributed to cuvettes which contain lyophilized reagents. The rotor is placed in the analyzer which spins the rotor, and an optical system reads the cuvettes as light is flashed through the cuvettes. The invention provides checks for: confirming the presence of a reagent in the cuvettes before a sample is applied to the cuvettes; determining whether a fluid sample has been properly distributed to the cuvettes of the rotor; determining whether an adequate amount of fluid sample was applied to the analytical rotor; determining whether a fluid sample has been properly distributed to a cuvette of an analytical rotor; determining whether a reaction chemistry in a cuvette has reached an end point; checking the noise level and non-linearity of a reaction rate in a cuvette; determining whether an adequate amount of diluent was delivered to the cuvettes of an analytical rotor; determining dilution systematic failure when measuring different reaction chemistries in the cuvettes of the rotor; determining whether a blood sample in a cuvette is hemolyzed, lipemic, or icteric; determining the degradation of a reagent in a cuvette; determining proper light source and light detector operation; and determining proper motor function and cuvette mark detection.

    摘要翻译： 本发明提供了用于检测血液分析系统中的错误的各种方法。 该系统包括血液分析仪和具有一系列腔室和毛细通道的模制塑料转子，通过血液分析器和毛细管通道将血液加工并分配到含有冻干试剂的比色皿。 将转子放置在旋转转子的分析仪中，当光通过反应杯闪烁时，光学系统读取比色皿。 本发明提供了以下检查：在将样品施加到比色杯之前，确认试剂在试管中的存在; 确定流体样品是否已经被适当地分配到转子的比色杯中; 确定足够量的流体样品是否被施加到分析转子; 确定流体样品是否已经被适当地分配到分析转子的比色杯中; 确定比色皿中的反应化学物质是否达到终点; 检查反应杯中的反应速率的噪声水平和非线性; 确定足够量的稀释剂是否被输送到分析转子的比色杯中; 测量转子的比色杯中的不同反应化学物质时的稀释系统失效; 确定比色皿中的血液样品是否溶血，脂肪或黄疸; 确定试剂在试管中的降解; 确定适当的光源和光检测器的操作; 并确定适当的运动功能和比色皿标记检测。

    Microfluidic devices and systems for performing inefficient fast PCR
    70.
    发明授权
    Microfluidic devices and systems for performing inefficient fast PCR 有权
    用于执行无效快速PCR的微流体装置和系统

    公开(公告)号：US06524830B2

    公开(公告)日：2003-02-25

    申请号：US09943070

    申请日：2001-08-29

    申请人： Anne R. Kopf-Sill

    发明人： Anne R. Kopf-Sill

    IPC分类号： C12P1934

    CPC分类号： B01L7/52 ,  B01L2400/0415 ,  C12Q1/686 ,  C12Q2565/629 ,  C12Q2537/143

    摘要： Methods of performing fast polymerase mediated reactions are provided. These reactions can be used in an inefficient fashion in the cycles of the polymerase mediated reactions to produce product at a much faster rate than conventional polymerase mediated reaction methods. Integrated systems for performing these methods are also provided.

    摘要翻译： 提供了进行快速聚合酶介导的反应的方法。 这些反应可以在聚合酶介导的反应循环中以低效的方式使用，以比常规聚合酶介导的反应方法快得多的速率产生产物。 还提供了用于执行这些方法的集成系统。