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公开(公告)号：US07285411B1
公开(公告)日：2007-10-23
申请号：US09721508
申请日：2000-11-22
CPC分类号： B01L3/502784 , B01J19/0093 , B01L3/5025 , B01L3/502761 , B01L2200/0647 , B01L2200/0673 , B01L2300/0816 , B01L2300/0861 , B01L2400/0415 , G01N33/5008 , G01N33/5304 , G01N33/57415 , G01N35/08
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
摘要翻译： 本发明提供了可用于进行高通量筛选测定的新型微流体装置和方法。 特别地，本发明的装置和方法可用于筛选大量不同的化合物，因为它们对多种化学品，优选生物化学体系的影响。
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2.发明授权Apparatus and methods for correcting for variable velocity in microfluidic systems 有权用于校正微流体系统中可变速度的装置和方法公开(公告)号：US06703205B2
公开(公告)日：2004-03-09
申请号：US10102149
申请日：2002-03-19
申请人： Anne R. Kopf-Sill , Andrea W. Chow , Claudia B. Cohen , Steven A. Sundberg , John Wallace Parce
发明人： Anne R. Kopf-Sill , Andrea W. Chow , Claudia B. Cohen , Steven A. Sundberg , John Wallace Parce
IPC分类号： G01N33558
CPC分类号： G01N33/557 , B01J19/0093 , B01J2219/0095 , B01J2219/0097 , B01J2219/00995 , B01L3/5027 , B01L3/50273 , B01L3/502746 , B01L3/563 , B01L9/527 , B01L2200/14 , B01L2200/143 , B01L2300/0627 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , G01N27/447 , G01N27/44726 , G01N27/44791 , Y10S435/81 , Y10S436/805 , Y10S436/809
摘要： Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and products in a reaction in electrokinetic microfluidic devices are also provided. These microfluidic devices can have substrates with channels, depressions, and/or wells for moving, mixing and monitoring precise amounts of analyte fluids.
摘要翻译： 提供了具有用于校正电动效果的计算机的电动装置。 还提供了通过在电动微流体装置中确定反应物和产物在反应中的速度来校正电动效应的方法。 这些微流体装置可以具有用于移动，混合和监测精确量的分析物流体的通道，凹陷和/或孔的基底。
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公开(公告)号：US06517234B1
公开(公告)日：2003-02-11
申请号：US09705062
申请日：2000-11-02
IPC分类号： B81B100
CPC分类号： G01N27/44791 , B01F13/0059 , B01J19/0093 , B01J2219/00783 , B01J2219/0086 , B01J2219/00889 , B01L3/502707 , B01L3/502746 , B01L3/502776 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , B01L2400/084 , Y10S366/01 , Y10S366/02 , Y10S366/03 , Y10T436/2575
摘要： The present invention is generally directed to improved microfluidic devices, systems and methods of using same, which incorporate channel profiles that impart significant benefits over previously described systems. In particular, the presently described devices and systems employ channels having, at least in part, depths that are varied over those which have been previously described. These varied channel depths provide numerous beneficial and unexpected results.
摘要翻译： 本发明一般涉及改进的微流体装置，系统和使用方法，其结合了相对于先前描述的系统具有显着益处的通道分布。 特别地，目前描述的装置和系统采用至少部分地具有比之前描述的深度变化的深度的通道。 这些不同的通道深度提供了许多有益和意想不到的结果。
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公开(公告)号：US06406893B1
公开(公告)日：2002-06-18
申请号：US09718140
申请日：2000-11-20
IPC分类号： C12P1934
CPC分类号： B01L3/0262 , B01F13/0059 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0605 , B01L2200/0673 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2300/18 , B01L2300/1833 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , C12Q1/6869 , G01N2035/1053 , G01N2035/1058
摘要： Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.
摘要翻译： 提供了用于进行生物化学分析的综合系统，设备，软件和方法，包括DNA测序，基因组筛选，核酸和其他生物组分的纯化以及药物筛选。 提供了用于使用这些装置和系统进行各种流体操作的微流体装置，系统和方法。 这些装置和系统用于执行需要大量迭代，连续或平行流体操作的流体操作，其以微型或密封且容易自动的格式。
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5.发明授权Method for in situ concentration and/or dilution of materials in microfluidic systems 有权在微流体系统中原位浓缩和/或稀释材料的方法公开(公告)号：US06475441B1
公开(公告)日：2002-11-05
申请号：US09654601
申请日：2000-09-01
IPC分类号： B01L300
CPC分类号： B01L3/5027 , B01F5/0475 , B01F13/0059 , B01J19/0093 , B01J2219/00783 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00889 , B01J2219/00905 , B01L3/502753 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/088 , B01L2300/0887 , B01L2400/0418 , B01L2400/0421 , G01N1/38 , G01N1/40 , G01N27/44743 , G01N27/44791 , Y10T436/117497 , Y10T436/25625 , Y10T436/2575
摘要： The present invention is generally directed to methods, apparatus and systems for use in performing in situ dilution or concentration of a particular subject material in a microfluidic device or system. These methods and apparatus may generally be integrated with other microfluidic operations and/or systems, to perform a number of different manipulations, wherein dilution or concentration, carried out within the context of the microfluidic device or system, is just one part.
摘要翻译： 本发明一般涉及用于在微流体装置或系统中进行原位稀释或浓缩特定主题材料的方法，装置和系统。 这些方法和装置通常可以与其它微流体操作和/或系统集成，以执行许多不同的操作，其中在微流体装置或系统的上下文中执行的稀释或浓缩只是一部分。
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公开(公告)号：US06465257B1
公开(公告)日：2002-10-15
申请号：US09308440
申请日：1999-11-15
IPC分类号： G01N110
CPC分类号： B01L3/50273 , B01L3/5025 , B01L3/502753 , B01L2300/0816 , B01L2300/0864 , B01L2400/0418 , B01L2400/0421 , G01N27/44791 , Y10T436/2575
摘要： The present invention generally provides microfluidic devices (200) and systems that utilize electrokinetic material transport systems to selectively control and direct the transport of materials through and among complex arrangements of integrated microscale channels (for example, 202 and 208+2n, where n=0, 1, . . . 8) disposed within integrated body structures.
摘要翻译： 本发明通常提供微流体装置（200）和利用电动材料输送系统来选择性地控制和指导材料通过整合微量通道（例如，202和208 + 2n，其中n = 0 ，1，...，8）。
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公开(公告)号：US06447727B1
公开(公告)日：2002-09-10
申请号：US08971854
申请日：1997-11-17
IPC分类号： B01L300
CPC分类号： B01L3/50273 , B01L3/5025 , B01L3/502753 , B01L2200/10 , B01L2300/0645 , B01L2300/0809 , B01L2300/0816 , B01L2300/0864 , B01L2400/0418 , B01L2400/0421 , B01L2400/0688 , G01N27/44791 , Y10T436/2575
摘要： The present invention generally provides microfluidic devices and systems that utilize electrokinetic material transport systems to selectively control and direct the transport of materials through and among complex arrangements of integrated, interconnected microscale channels disposed within integrated body structures.
摘要翻译： 本发明通常提供微流体装置和系统，其利用电动材料传输系统来选择性地控制和引导材料的输送通过设置在一体化身体结构内的集成的互连微通道的复杂布置。
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8.发明授权Apparatus for in situ concentration and/or dilution of materials in microfluidic systems 有权用于在微流体系统中原位浓缩和/或稀释材料的装置
公开(公告)号：US06149870A
公开(公告)日：2000-11-21
申请号：US407756
申请日：1999-09-28
CPC分类号： B01L3/5027 , B01F13/0059 , B01F5/0475 , B01J19/0093 , B01L3/502753 , G01N1/38 , G01N1/40 , G01N27/44743 , G01N27/44791 , B01J2219/00783 , B01J2219/00826 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00889 , B01J2219/00905 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/088 , B01L2300/0887 , B01L2400/0418 , B01L2400/0421 , B01L3/502784 , Y10T436/117497 , Y10T436/25625 , Y10T436/2575
摘要： The present invention is generally directed to methods, apparatus and systems for use in performing in situ dilution or concentration of a particular subject material in a microfluidic device or system. These methods and apparatus may generally be integrated with other microfluidic operations and/or systems, to perform a number of different manipulations, wherein dilution or concentration, carried out within the context of the microfluidic device or system, is just one part.
摘要翻译： 本发明一般涉及用于在微流体装置或系统中进行原位稀释或浓缩特定主题材料的方法，装置和系统。 这些方法和装置通常可以与其它微流体操作和/或系统集成，以执行许多不同的操作，其中在微流体装置或系统的上下文中执行的稀释或浓缩只是一部分。
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公开(公告)号：US07238323B2
公开(公告)日：2007-07-03
申请号：US10314092
申请日：2002-12-05
CPC分类号： C12Q1/6869 , B01F13/0059 , B01L3/0262 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502784 , B01L7/52 , B01L2200/027 , B01L2200/0605 , B01L2200/0673 , B01L2200/10 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/0421 , G01N2035/1053 , G01N2035/1058 , C12Q2565/629
摘要： Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.
摘要翻译： 提供了用于进行生物化学分析的综合系统，设备，软件和方法，包括DNA测序，基因组筛选，核酸和其他生物组分的纯化以及药物筛选。 提供了用于使用这些装置和系统进行各种流体操作的微流体装置，系统和方法。 这些装置和系统用于执行需要大量迭代，连续或平行流体操作的流体操作，其以微型或密封且容易自动的格式。
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公开(公告)号：US06670133B2
公开(公告)日：2003-12-30
申请号：US10197724
申请日：2002-07-17
IPC分类号： G01M3100
CPC分类号： C12Q1/6869 , B01F13/0059 , B01L3/0262 , B01L3/5025 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L3/502784 , B01L7/52 , B01L2200/027 , B01L2200/0605 , B01L2200/0673 , B01L2200/10 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/0867 , B01L2300/1827 , B01L2400/0406 , B01L2400/0415 , B01L2400/0421 , G01N2035/1053 , G01N2035/1058 , C12Q2565/629
摘要： Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and methods for using these devices and systems for performing a wide variety of fluid operations are provided. The devices and systems of are used in performing fluid operations which require a large number of iterative, successive or parallel fluid manipulations, in a microscale, or sealed and readily automated format.
摘要翻译： 提供了用于进行生物化学分析的综合系统，设备，软件和方法，包括DNA测序，基因组筛选，核酸和其他生物组分的纯化以及药物筛选。 提供了用于使用这些装置和系统进行各种流体操作的微流体装置，系统和方法。 这些装置和系统用于执行需要大量迭代，连续或平行流体操作的流体操作，其以微型或密封且容易自动的格式。
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