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公开(公告)号：US20080262360A1
公开(公告)日：2008-10-23
申请号：US11736058
申请日：2007-04-17
IPC分类号： A61B5/0205
CPC分类号： A61B5/0205 , A61B5/0816 , A61B5/1116 , A61B5/4818 , A61B5/686 , A61N1/3627
摘要： Systems and methods for diagnosing one or more respiration distress manifestations by implantably recognizing their occurrence and evaluating information about the same to provide an indication of present or impending worsening heart failure are discussed. Using information produced by an implantable respiration sensor circuit and an implantable physiological sensor circuit, such as at least one of a physical activity sensor circuit or a posture sensor circuit, an implantable or external processor circuit may detect a respiration disturbance and an associated subsequent arousal from stable state occurrence and thereafter evaluate over time arousal from stable state occurrences to provide the indication of present or impending worsening heart failure. In one example, information about a fluid level within a subject is used in determining the indication of worsening heart failure. In various examples, a regimen is initiated or adjusted in response to the indication of present or impending worsening heart failure.
摘要翻译： 讨论了通过可植入地识别其发生并评估关于其的信息来诊断一种或多种呼吸困扰表现的系统和方法，以提供现在或即将恶化的心力衰竭的指征。 使用由可植入呼吸传感器电路和植入式生理传感器电路产生的信息，例如物理活动传感器电路或姿势传感器电路中的至少一个，可植入或外部处理器电路可以检测呼吸障碍和相关联的随后的唤醒 稳定状态发生，然后评估来自稳定状态发生的随着时间的兴奋，以提供目前或即将恶化的心力衰竭的指征。 在一个示例中，关于受试者内的液位水平的信息用于确定恶化的心力衰竭的指示。 在各种实例中，响应于目前或即将恶化的心力衰竭的指征开始或调整方案。
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公开(公告)号：US07252640B2
公开(公告)日：2007-08-07
申请号：US10309770
申请日：2002-12-04
申请人： Quan Ni , John D. Hatlestad , Jesse W. Hartley , Jeff E. Stahmann , Jaeho Kim , Kent Lee
发明人： Quan Ni , John D. Hatlestad , Jesse W. Hartley , Jeff E. Stahmann , Jaeho Kim , Kent Lee
IPC分类号： A61B5/02
CPC分类号： A61B5/4818 , A61B5/0205 , A61B5/4806 , A61B5/4809 , A61B5/7264
摘要： Devices and methods for detecting disordered breathing involve determining that the patient is asleep and sensing one or more signals associated with disordered breathing indicative of sleep-disordered breathing while the patient is asleep. Sleep-disordered breathing is detected using the sensed signals associated with disordered breathing. The sensed signals associated with disordered breathing may also be used to acquire a respiration pattern of one or more respiration cycles. Characteristics of the respiration pattern are determined. The respiration pattern is classified as a disordered breathing episode based on the characteristics of the respiration pattern. One or more processes involved in the detection of disordered breathing are performed using an implantable device.
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公开(公告)号：US09943234B2
公开(公告)日：2018-04-17
申请号：US11736058
申请日：2007-04-17
IPC分类号： A61B5/08 , A61B5/0205 , A61B5/11 , A61B5/00 , A61N1/362
CPC分类号： A61B5/0205 , A61B5/0816 , A61B5/1116 , A61B5/4818 , A61B5/686 , A61N1/3627
摘要： Systems and methods for diagnosing one or more respiration distress manifestations by implantably recognizing their occurrence and evaluating information about the same to provide an indication of present or impending worsening heart failure are discussed. Using information produced by an implantable respiration sensor circuit and an implantable physiological sensor circuit, such as at least one of a physical activity sensor circuit or a posture sensor circuit, an implantable or external processor circuit may detect a respiration disturbance and an associated subsequent arousal from stable state occurrence and thereafter evaluate over time arousal from stable state occurrences to provide the indication of present or impending worsening heart failure. In one example, information about a fluid level within a subject is used in determining the indication of worsening heart failure. In various examples, a regimen is initiated or adjusted in response to the indication of present or impending worsening heart failure.
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64.发明授权公开(公告)号：US09814429B2
公开(公告)日：2017-11-14
申请号：US12341590
申请日：2008-12-22
申请人： Kent Lee , John D. Hatlestad , Qingsheng Zhu , Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni
发明人： Kent Lee , John D. Hatlestad , Qingsheng Zhu , Jeffrey E. Stahmann , Jesse W. Hartley , Quan Ni
IPC分类号： A61B5/08 , A61B5/00 , A61B5/0205 , A61B5/113 , A61B5/0476 , A61B5/0478 , A61B5/0488 , A61B5/0496 , A61B5/11
CPC分类号： A61B5/7264 , A61B5/0031 , A61B5/0205 , A61B5/0476 , A61B5/0478 , A61B5/0488 , A61B5/0496 , A61B5/08 , A61B5/0809 , A61B5/11 , A61B5/113 , A61B5/1135 , A61B5/4818
摘要： Disordered breathing events may be classified as central, obstructive or a combination of central an obstructive in origin based on patient motion associated with respiratory effort. Central disordered breathing is associated with disrupted respiration with reduced respiratory effort. Obstructive disordered breathing is associated with disrupted respiration accompanied by respiratory effort. A disordered breathing classification system includes a disordered breathing detector and a respiratory effort motion sensor. Components of the disordered breathing classification system may be fully or partially implantable.
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公开(公告)号：US08831716B2
公开(公告)日：2014-09-09
申请号：US11853590
申请日：2007-09-11
CPC分类号： A61B5/053 , A61B5/0535 , A61B5/0537 , A61B5/08 , A61B5/0809 , A61B5/416 , A61B5/6846 , A61N1/36521
摘要： Systems and methods for monitoring pulmonary edema or other thoracic fluid status in a subject use thoracic impedance histogram information. An internal or external processor circuit receives the thoracic impedance histogram information and uses it to compute and provide a lung fluid status indication. The thoracic impedance histogram information can include a count, mean or median of a histogram bin or subrange of bins within the histogram range.
摘要翻译： 用于监测受试者的肺水肿或其他胸腔液状态的系统和方法使用胸阻抗直方图信息。 内部或外部处理器电路接收胸部阻抗直方图信息并使用它来计算和提供肺液体状态指示。 胸廓阻抗直方图信息可以包括直方图区块的计数，平均值或中值或直方图范围内的区域的子范围。
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66.发明授权公开(公告)号：US08801636B2
公开(公告)日：2014-08-12
申请号：US11780411
申请日：2007-07-19
CPC分类号： A61B5/1112 , A61B5/1116 , A61B5/686
摘要： An example method includes monitoring a first posture including a first lateral decubitus posture (LDP), recording a first LDP record based on the first LDP, computing a first posture trend based on the first LDP record and determining and providing a wellness indication based on the first posture trend.
摘要翻译： 一种示例性方法包括监视包括第一侧卧位姿势（LDP）的第一姿势，基于第一LDP记录第一LDP记录，基于第一LDP记录计算第一姿态趋势，并基于该第一LDP记录确定并提供健康指示 第一姿势趋势。
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公开(公告)号：US08753276B2
公开(公告)日：2014-06-17
申请号：US13415281
申请日：2012-03-08
申请人： John D. Hatlestad , Imad Libbus , Aaron Lewicke
发明人： John D. Hatlestad , Imad Libbus , Aaron Lewicke
CPC分类号： A61B5/1116 , A61B5/0031 , A61B5/021 , A61B5/02405 , A61B5/076 , A61B5/686 , A61B2562/0219 , A61N1/05
摘要： In an embodiment, an implantable medical device includes a controller circuit, a posture sensing circuit, and a physiological sensing circuit. The controller circuit senses a change in a physiological signal as a result of a change in posture, and generates a response as a function of that change. In another embodiment, the controller circuit identifies a heart failure condition as a function of the change in the physiological signal.
摘要翻译： 在一个实施例中，可植入医疗装置包括控制器电路，姿势感测电路和生理感测电路。 控制器电路作为姿势变化的结果感测生理信号的变化，并产生作为该变化的函数的响应。 在另一个实施例中，控制器电路根据生理信号的变化来识别心力衰竭状况。
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公开(公告)号：US08738119B2
公开(公告)日：2014-05-27
申请号：US12576453
申请日：2009-10-09
申请人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
发明人： Yi Zhang , Jeffrey E. Stahmann , Krzysztof Z. Siejko , Ramesh Wariar , Julie A. Thompson , John D. Hatlestad , Kenneth C. Beck
IPC分类号： A61B5/02
CPC分类号： A61B5/02055 , A61B5/0008 , A61B5/0031 , A61B5/01 , A61B5/02028 , A61B5/0205 , A61B5/0215 , A61B5/026 , A61B5/029 , A61B5/042 , A61B5/0452 , A61B5/0531 , A61B5/0538 , A61B5/0816 , A61B5/085 , A61B5/1118 , A61B5/121 , A61B5/14542 , A61B5/686 , A61B5/6869 , A61B5/7275 , A61B7/04 , A61N1/36585 , G06F19/00
摘要： An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.
摘要翻译： 一种装置包括多个传感器和一个处理器。 每个传感器提供包括生理信息的传感器信号，并且至少一个传感器是可植入的。 处理器包括生理变化事件检测模块，其从传感器信号检测生理变化事件，并产生一个或多个检测到的生理变化事件的发生的指示，以及心力衰竭（HF）检测模块。 HF检测模块使用第一规则确定检测到的生理变化事件是否指示受试者的HF状态的变化，使用第二规则确定是否覆盖第一规则HF确定，并且声明HF的变化 状态根据第一和第二规则发生。
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公开(公告)号：US08660638B2
公开(公告)日：2014-02-25
申请号：US12616536
申请日：2009-11-11
IPC分类号： A61B5/0402
CPC分类号： A61B5/02028 , A61B5/0031 , A61B5/0205 , A61B5/0215 , A61B5/02405 , A61B5/0402 , A61B5/0476 , A61B5/11 , A61B5/1116 , A61B5/145 , A61B5/14532 , A61B5/14546 , A61N1/362 , A61N1/37247 , G06F19/00 , G06F19/3418 , G06F19/3481 , G16H40/63
摘要： Methods and systems are directed to acquiring and organizing information associated with at least one syncope event. A syncope event may be a suspected syncope event, a verified syncope event or a syncope event that is suspected and verified. Automated processes are used to collect information associated with at least one syncope event and organize the information as a syncope log entry. At least one of acquiring the information and organizing the information is performed at least in part implantably.
摘要翻译： 方法和系统旨在获取和组织与至少一个晕厥事件相关联的信息。 晕厥事件可能是疑似晕厥事件，经过验证的晕厥事件或怀疑和验证的晕厥事件。 自动进程用于收集与至少一个晕厥事件相关的信息，并将该信息组织为晕厥日志条目。 至少部分地可植入地执行获取信息和组织信息中的至少一个。
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70.发明申请MONITORING OF CHRONOBIOLOGICAL RHYTHMS FOR DISEASE AND DRUG MANAGEMENT USING ONE OR MORE IMPLANTABLE DEVICE 审中-公开使用一个或多个可植入装置监测疾病和药物管理的血液生殖系统公开(公告)号：US20130226078A1
公开(公告)日：2013-08-29
申请号：US13845398
申请日：2013-03-18
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G16H20/10 , G16H20/40 , G16H50/20 , G16H50/30
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译： 使用至少一个可植入装置自动评价或预测受试者的健康状况。 在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。 也可以使用昼夜节律以外的其他时间生理节律。 可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。 预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。 还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。
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