公开(公告)号：US06924478B1

公开(公告)日：2005-08-02

申请号：US10848516

申请日：2004-05-18

申请人： Roman Zubarev ,  Gökhan Baykut ,  Matthias Witt

发明人： Roman Zubarev ,  Gökhan Baykut ,  Matthias Witt

IPC分类号： G01N27/62 ,  H01J49/00 ,  H01J49/02 ,  H01J49/38 ,  H01J49/40 ,  H01J49/42

CPC分类号： H01J49/424 ,  H01J49/0054 ,  H01J49/38

摘要： Multiply charged ions are trapped and accumulated in a spatially limited region before being injected into an ion trap mass spectrometer such as a Fourier transform ion cyclotron resonance mass spectrometer (FTICR MS). In the ion trap electron capture dissociation (ECD) and vibrational excitation dissociation are sequentially applied on ions of the same ion ensemble. The first dissociation process does not fragment all primary ions. Following the detection of the dissociation products, the primary ions that remain undissociated undergo the vibrational excitation and again, a part of them dissociate, and the fragments are detected. Thus, the same ion ensemble is used for two fragmentation processes. During these processes, further ions generated in the external ion source are accumulated in the spatially limited region for subsequent analyses.

摘要翻译： 倍增电荷的离子被俘获并积聚在空间有限的区域中，然后被注入离子阱质谱仪如傅里叶变换离子回旋共振质谱仪（FTICR MS）。 在离子阱中，电子捕获离解（ECD）和振动激发解离依次施加在相同离子组合的离子上。 第一个解离过程不会破坏所有的初级离子。 在解离产物的检测之后，保持未解离的主离子经历振动激发，并且再次部分解离，并检测碎片。 因此，相同的离子组合用于两个分段过程。 在这些过程中，在外部离子源中产生的另外的离子被积聚在空间有限的区域中用于随后的分析。

公开(公告)号：US06903332B2

公开(公告)日：2005-06-07

申请号：US10303661

申请日：2002-11-25

申请人： Gerhard Weiss ,  Carsten Stoermer ,  Oliver Räther

发明人： Gerhard Weiss ,  Carsten Stoermer ,  Oliver Räther

IPC分类号： H01J49/16 ,  H01J49/40 ,  H01J49/00 ,  B01D54/44

CPC分类号： H01J49/401 ,  H01J49/06

摘要： The invention relates to the construction and operation of a slit diaphragm pulser for a time-of-flight mass spectrometer with orthogonal injection of the ions to be examined. The invention includes switching three diaphragm potentials during a transition from a filling phase to an acceleration phase in order to maintain a potential along the axis of the injected ion beam at a constant level, to prevent any penetration by the accelerating fields during the filling phase and to obtain extremely high mass resolution in the acceleration phase through a lens effect.

摘要翻译： 本发明涉及正交注射待检离子的飞行时间质谱仪的狭缝隔膜脉冲发生器的结构和操作。 本发明包括在从填充阶段到加速阶段的过渡期间切换三个隔膜电位，以便沿着注入的离子束的轴线保持恒定水平的电位，以防止在填充阶段期间加速场的任何穿透;以及 通过透镜效应在加速阶段获得极高的质量分辨率。

公开(公告)号：US20050116985A1

公开(公告)日：2005-06-02

申请号：US10975027

申请日：2004-10-27

申请人： Martin Schurenberg

发明人： Martin Schurenberg

IPC分类号： B01L3/02 ,  B05B1/02 ,  B41J2/165 ,  G01N35/10

CPC分类号： B01L3/0268 ,  B01L2300/0838 ,  B01L2300/0867 ,  B01L2400/02 ,  B01L2400/0487 ,  G01N35/1011 ,  G01N2035/1041

摘要： A liquid droplet dispenser generates very small droplets of regular size and high velocity by means of shock waves in a liquid-filled capillary. The droplets are ejected from an ejection capillary. The ejection capillary is surrounded by one or more capillary tubes, which create liquid surfaces that allow the droplets to be ejected on a stable path along the axis of the ejection capillary. A system of multiple ejection capillaries may be used that may be fed from a common liquid reservoir. The dispenser may be used for surface coating, as well as other applications.

摘要翻译： 液滴分配器通过充满液体的毛细管中的冲击波产生规则尺寸和高速度的非常小的液滴。 液滴从喷射毛细管喷出。 喷射毛细管由一个或多个毛细管围绕，其产生允许液滴沿着喷射毛细管的轴线在稳定的路径上喷射的液体表面。 可以使用可以从公共液体储存器供给的多个喷射毛细管的系统。 分配器可用于表面涂层以及其它应用。

公开(公告)号：US20050006579A1

公开(公告)日：2005-01-13

申请号：US10818778

申请日：2004-04-06

申请人： Jochen Franzen

发明人： Jochen Franzen

IPC分类号： H01J49/00 ,  H01J49/06 ,  H01J49/42

CPC分类号： H01J49/066

摘要： An ion funnel screen ions from a gas stream flowing into a differential pump stage of a mass spectrometer, transfers them to a subsequent differential pump stage. The ion funnel uses apertured diaphragms between which gas escapes easily. Holders for the apertured diaphragms are also provided that offer little resistance to the escaping gas while, at the same time, serving to feed the RF and DC voltages.

摘要翻译： 离子漏斗屏幕从流入质谱仪的差分泵级的气流离子，将其转移到随后的差动泵级。 离子漏斗使用多孔隔膜，气体易于逸出。 还提供用于有孔隔膜的支架，其对逸出气体几乎没有阻力，同时用于馈送RF和DC电压。

公开(公告)号：US20040094703A1

公开(公告)日：2004-05-20

申请号：US10298169

申请日：2002-11-15

申请人： Bruker Daltonik GMBH

发明人： Armin Holle

IPC分类号： H01J049/40

CPC分类号： H01J49/405

摘要： The invention relates to an energy-focusing and space-angle focusing reflector for time-of-flight mass spectrometers. The invention consists in producing an adjustable space-angle focusing system by means of an adjustably weaker field with curved equipotential lines at the end of the reflector instead of a fully homogeneous electrical reflection field.

摘要翻译： 本发明涉及一种用于飞行时间质谱仪的能量聚焦和空间角聚焦反射器。 本发明在于通过在反射器的末端具有弯曲的等电位线的可调节较弱的场来产生可调节的空间角度聚焦系统，而不是完全均匀的电反射场。

公开(公告)号：US20030136903A1

公开(公告)日：2003-07-24

申请号：US10316173

申请日：2002-12-10

申请人： Bruker Daltonik GMBH

发明人： Gerhard Weiss ,  Carsten Stoermer ,  Oliver Rather

IPC分类号： H01J049/40

CPC分类号： H01J49/401

摘要： The invention relates to time-of-flight mass spectrometers, equipped with ion reflector and ion detector, with orthogonal ion injection and outpulsing of a segment of the ion beam perpendicular to the direction of injection in a pulser. The invention is directed to a time-of-flight mass spectrometer in which a reflector and an ion detector each have an angular offset about an axis that is perpendicular to the respective directions of injection and deflection. This allows a large distance to be used between the pulser and detector with the highest possible utilization of ions.

摘要翻译： 本发明涉及配备有离子反射器和离子检测器的飞行时间质谱仪，其具有与脉冲发生器中的注射方向垂直的离子束的正交离子注入和脉冲。 本发明涉及一种飞行时间质谱仪，其中反射器和离子检测器各自具有围绕垂直于各个注射和偏转方向的轴线的角度偏移。 这允许在脉冲发生器和检测器之间使用较大的距离，以最大限度地利用离子。

公开(公告)号：US20030066802A1

公开(公告)日：2003-04-10

申请号：US10244826

申请日：2002-09-16

申请人： Bruker Daltonik GmbH

发明人： Bernd Jastorff ,  Reinhold Stormann ,  Andreas Germanus ,  Jochen Franzen

IPC分类号： B01D015/08

CPC分类号： G16C20/10 ,  G01N30/6095 ,  G01N30/7233 ,  G01N33/48714 ,  G16C20/20

摘要： The invention relates to the elucidation of the breakdown of foreign substance in the metabolism of a liquid, chemical or biological reaction system by the analytical determination of the breakdown products (metabolites) produced. It is common practice for this elucidation to be carried out nullblindnull, i.e. without systematic prediction of the breakdown substances, by comparison and subtraction of analytical data sets, which are obtained by, for example, separating the substances in the liquid using liquid chromatography and measuring them using mass spectrometry before and after the foreign substance has been added. Unlike the current method, the invention consists of first calculating a nullvirtualnull breakdown of the foreign substance, taking into account all the possible branches of the breakdown path according to a set of breakdown rules, which can be determined beforehand, so that the predicted potential breakdown products can be looked for selectively by using a more finally tuned method of measurement.

摘要翻译： 本发明涉及通过生产的分解产物（代谢物）的分析测定来阐明液体，化学或生物反应体系的代谢中外来物质的分解。 通过比较和减去分析数据集，通过例如使用液相色谱法分离液体中的物质而获得的这种解析数据集是通常的做法，即通过实施“盲目”，即没有系统地预测分解物质 并且在添加异物之前和之后使用质谱法测量它们。 本发明与现有方法不同，首先计算异物的“虚拟”故障，考虑到可以预先确定的一组故障规则，将故障路径的所有可能的分支考虑在内，从而预测 可以通过使用更加最终调谐的测量方法来选择性地寻找潜在的分解产物。

公开(公告)号：USRE36906E

公开(公告)日：2000-10-10

申请号：US975058

申请日：1997-11-20

申请人： Jochen Franzen ,  Yang Wang

发明人： Jochen Franzen ,  Yang Wang

IPC分类号： H01J49/42

CPC分类号： H01J49/424

摘要： An ion trap is provided in which higher multipole field fractions can be switched on and off and, in addition, can be electrically tuned. Specifically, the electrodes of an ideally shaped ion trap are divided into rotationally symmetrical component electrodes positioned facing the interior of the ion trap on a hyperboloidal surface with rotationally symmetry.

摘要翻译： 提供了一种离子阱，其中可以打开和关闭更高的多极场分数，并且另外可以电调谐离子阱。 具体地说，理想形状的离子阱的电极被分成旋转对称的分量电极，其位于面向离子阱内部的旋转对称的双曲面上。

公开(公告)号：US11802833B2

公开(公告)日：2023-10-31

申请号：US17167155

申请日：2021-02-04

申请人： Bruker Daltonik GmbH

发明人： Thomas Maier ,  Norman Mauder

IPC分类号： G01N21/3563 ,  C12Q1/04 ,  G01N21/27 ,  G01N21/31 ,  G01N1/31 ,  G01N1/38 ,  G01N21/35 ,  G01N1/28

CPC分类号： G01N21/3563 ,  C12Q1/04 ,  G01N1/312 ,  G01N1/38 ,  G01N21/278 ,  G01N21/31 ,  G01N21/35 ,  G01N2001/2893 ,  G01N2001/386 ,  G01N2021/3572 ,  G01N2021/3595

摘要： The invention relates to a microbial test standard for use in infrared spectrometry which has at least two resealable vessels which are liquid-tight when closed, each of which contains a predefined amount of dried biomass of a microorganism. The microorganisms in the different vessels differ in at least one characteristic, which is selected in particular from the group comprising species, subspecies, strain, serovar, pathovar, toxivar and variety, and the difference manifests itself in a predefined intermicrobial spectral distance. The disclosure furthermore comprises a method of using the microbial test standard.

公开(公告)号：US11721534B2

公开(公告)日：2023-08-08

申请号：US17186650

申请日：2021-02-26

申请人： Bruker Daltonik GmbH

发明人： Tobias Boskamp

IPC分类号： H01J49/00 ,  G01N33/483

CPC分类号： H01J49/0036 ,  G01N33/4833

摘要： The disclosure relates to a method for processing a mass spectrum, comprising: (i) providing the mass spectrum which contains a plurality of data pairs, each data pair being representative of a mass value or mass-related value on a mass scale or mass-related scale and an abundance value or abundance-related value associated with the respective mass value or mass-related value, (ii) selecting a plurality of intervals on the mass scale or mass-related scale, each interval containing a multitude of the said data pairs, (iii) for each interval, applying a first mathematical-statistical analysis to the said data pairs contained in the respective interval in order to derive an interval-specific peak width, and (iv) using the said interval-specific peak widths to determine an estimated peak width for each mass value or mass-related value on the mass scale or mass-related scale.