公开(公告)号：US06966979B2

公开(公告)日：2005-11-22

申请号：US10772340

申请日：2004-02-06

Applicant: Renato Pedrazzi

Inventor： Renato Pedrazzi

IPC: A61M1/16 ,  A61M1/34 ,  A61M1/36 ,  A61M39/28 ,  B01D61/00 ,  B01D65/00

CPC classification number: A61M1/342 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3669 ,  A61M39/28 ,  A61M2230/30

Abstract: An infusion control device controls infusion of a liquid in an extracorporeal blood circuit having an arterial pipe connected to an inlet of a blood compartment of a filter and a venous pipe connected to an outlet of the blood compartment. The arterial pipe is also connected to a pre-dilution pipe of an infusion circuit, and the venous pipe is also connected to a post-dilution pipe of said infusion circuit. The infusion control device regulates and distributes an infusion flow rate in the arterial and venous pipes based on a monitoring of quantities that are directly correlated with the operating conditions of the filter.

Abstract translation: 输液控制装置控制在体外血液循环中的液体输注，其具有连接到过滤器的血液室的入口的动脉管和连接到血液室的出口的静脉管。 动脉管还连接到输注电路的预稀释管，静脉管也连接到所述输注电路的后稀释管。 输液控制装置基于与过滤器的操作条件直接相关的量的监测来调节和分配动脉和静脉管中的输注流速。

公开(公告)号：US20050247203A1

公开(公告)日：2005-11-10

申请号：US10518787

申请日：2003-05-26

Applicant: Jacques Chevallet ,  Nicolas Semenzato ,  Alain Frugier

Inventor： Jacques Chevallet ,  Nicolas Semenzato ,  Alain Frugier

IPC: A61M1/34 ,  A61M1/36 ,  B01D19/00 ,  B01F5/00 ,  B04C5/103

CPC classification number: B01D19/0057 ,  A61M1/3437 ,  A61M1/3627 ,  A61M1/3639 ,  A61M1/3641 ,  A61M1/3676 ,  A61M2205/3382 ,  A61M2206/16 ,  B01F5/0057 ,  B04C5/103

Abstract: A description is given of a gas separation device for a physiological fluid, comprising a containing body (6) having at least a first inlet aperture (7) for a physiological fluid, positioned with a tangential direction of access, at least one outlet aperture (9) for the said fluid, spaced apart from the said inlet aperture, and a guide element (17) housed within the said body. The guide element (17) has a continuous active surface (15) designed to contact and guide the said fluid and delimits, together with the containing body (6), a first annular chamber (20) into which the first inlet aperture (7) opens directly.

Abstract translation: 给出了用于生理流体的气体分离装置的描述，其包括容纳体（6），该容纳体具有至少一个用于生理流体的第一入口孔（7），定位在切向方向上，至少一个出口孔 所述流体与所述入口孔间隔开，以及容纳在所述主体内的引导元件（17）。 引导元件（17）具有设计成接触和引导所述流体并与容纳体（6）一起界定的连续有效表面（15），第一环形室（20），第一入口孔（7） 直接打开

公开(公告)号：US20050131332A1

公开(公告)日：2005-06-16

申请号：US10982170

申请日：2004-11-04

Applicant: Thomas Kelly ,  Robert Childers ,  Don Busby ,  Rodolfo Roger ,  Waleed Mutasem Sayyid ,  Shahid Din

Inventor： Thomas Kelly ,  Robert Childers ,  Don Busby ,  Rodolfo Roger ,  Waleed Mutasem Sayyid ,  Shahid Din

IPC: A61M1/16 ,  A61M1/34 ,  B01D61/58 ,  A61M37/00

CPC classification number: A61M1/3621 ,  A61M1/1006 ,  A61M1/101 ,  A61M1/1012 ,  A61M1/1037 ,  A61M1/1039 ,  A61M1/1062 ,  A61M1/1081 ,  A61M1/1086 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1607 ,  A61M1/1613 ,  A61M1/1621 ,  A61M1/1629 ,  A61M1/1633 ,  A61M1/1635 ,  A61M1/1656 ,  A61M1/166 ,  A61M1/1668 ,  A61M1/167 ,  A61M1/1672 ,  A61M1/1696 ,  A61M1/267 ,  A61M1/288 ,  A61M1/341 ,  A61M1/3417 ,  A61M1/342 ,  A61M1/3427 ,  A61M1/3431 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3444 ,  A61M1/3451 ,  A61M1/3458 ,  A61M1/3465 ,  A61M1/3468 ,  A61M1/3472 ,  A61M1/3486 ,  A61M1/3624 ,  A61M1/3626 ,  A61M1/3627 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/3647 ,  A61M1/3649 ,  A61M1/365 ,  A61M1/3652 ,  A61M1/3656 ,  A61M2202/0413 ,  A61M2205/12 ,  A61M2205/13 ,  A61M2205/15 ,  A61M2205/18 ,  A61M2205/276 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3327 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3337 ,  A61M2205/3344 ,  A61M2205/3368 ,  A61M2205/3379 ,  A61M2205/3393 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3584 ,  A61M2205/502 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2205/75

Abstract: A system, method and apparatus for performing a renal replacement therapy is provided. In one embodiment, two small high flux dialyzers are connected in series. A restriction is placed between the two dialyzers in the dialysate flow path. The restriction is variable and adjustable in one preferred embodiment. The restriction builds a positive pressure in the venous dialyzer, causing a high degree of intentional backfiltration. That backfiltration causes a significant flow of dialysate through the high flux venous membrane directly into the patient's blood. That backfiltered solution is subsequently ultrafiltered from the patient from the arterial dialyzer. The diffusion of dialysate into the venous filter and removal of dialysate from the arterial dialyzer causes a convective transport of toxins from the patient. Additionally, the dialysate that does not diffuse directly into the patient but instead flows across the membranes of both dialyzers provides a diffusive clearance of waste products.

Abstract translation: 提供了一种用于进行肾脏替代疗法的系统，方法和装置。 在一个实施例中，两个小型高通量透析器串联连接。 在透析液流动路径中的两个透析器之间进行限制。 在一个优选实施例中，限制是可变的和可调节的。 限制在静脉透析器中产生正压，导致高度有意的反渗透。 该回流导致透析液通过高通量静脉膜直接流入患者血液中。 随后从动脉透析器将患者的过滤后的溶液进行超滤。 透析液扩散到静脉过滤器中，从动脉透析器中除去透析液会导致患者的毒素对流运输。 另外，透析液不直接扩散到患者体内，而是穿过两个透析器的膜，从而提供废物的扩散清除。

公开(公告)号：US20050098500A1

公开(公告)日：2005-05-12

申请号：US10949731

申请日：2004-09-24

Applicant: Gregory Collins ,  James Summerton ,  Edward Spence

Inventor： Gregory Collins ,  James Summerton ,  Edward Spence

IPC: A61M1/16 ,  A61M1/34 ,  B01D61/14 ,  B01D61/24 ,  B01D61/26

CPC classification number: A61M1/342 ,  A61M1/1656 ,  A61M1/1666 ,  A61M1/1668 ,  A61M1/1676 ,  A61M1/3413 ,  A61M1/3417 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3458 ,  A61M1/3462 ,  A61M1/3465 ,  A61M1/3472 ,  B01D61/142 ,  B01D61/243

Abstract: A dual-stage system and methods for using the same include first and second filtration cartridges is provided and is particularly suited for hemodiafiltration and/or hemodialysis. As fluid enters the first filtration cartridge, the hydroxyl ion concentration and hence pH is increased by exposing it to either a strong base or a salt of a weak acid across a filter membrane. This stage allows for improved removal of certain toxins in the fluid, such as protein-bound substances that disassociate more readily from proteins at higher pH. As the filtered fluid enters the second filtration cartridge, the pH of the fluid is restored to normal levels prior to infusion to a patient.

Abstract translation: 提供双阶段系统及其使用方法包括第一和第二过滤筒，并且特别适用于血液透析和/或血液透析。 当流体进入第一过滤筒时，通过将其暴露于过滤膜上的弱酸的强碱或弱酸，使羟基离子浓度和因此的pH增加。 该阶段允许改善流体中某些毒素的去除，例如在较高pH下更容易与蛋白质分离的蛋白质结合物质。 当过滤的流体进入第二过滤筒时，在输注到患者之前，流体的pH恢复到正常水平。

公开(公告)号：US06814864B1

公开(公告)日：2004-11-09

申请号：US10111771

申请日：2002-04-29

Applicant: Olivier Favre ,  Francesco Di Lella

Inventor： Olivier Favre ,  Francesco Di Lella

IPC: B01D6128

CPC classification number: A61M1/3441 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3639 ,  A61M1/3663 ,  A61M1/3672 ,  A61M2205/707 ,  A61M2205/7563 ,  Y10S210/929

Abstract: An extra-corporeal blood purification device includes a blood filter, and elements for measuring at least one parameter affected by filter resistance to liquid flow, elements for determining at least a threshold value of the parameter, elements for comparing the parameter with the threshold value, exchange control elements for calculating the distribution between the respective flow rates through connecting ducts, capable of reducing the difference between the value of the measured parameter and the threshold value.

Abstract translation: 一种体外血液净化装置包括血液过滤器和用于测量受到对液体流动的过滤阻力影响的至少一个参数的元件，用于确定参数的至少阈值的元件，用于将参数与阈值进行比较的元件， 交换控制元件，用于计算通过连接管道的相应流量之间的分布，能够减小测量参数的值与阈值之间的差异。

公开(公告)号：US20040199099A1

公开(公告)日：2004-10-07

申请号：US10826736

申请日：2004-04-16

Inventor： James R. Matson ,  Patrice A. Lee

IPC: A61M037/00 ,  B01D039/00

CPC classification number: A61M1/3472 ,  A61M1/3437 ,  A61M1/3475 ,  A61M1/3486

Abstract: A hemofiltration system for a mammal is provided with a hemofilter and an adsorbent device. The hemofilter removes ultrafiltrate from a blood stream extracted from the mammal to create a filtered blood stream and an ultrafiltrate stream. The adsorbent device has one or more adsorbent materials and is used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilter removing inflammatory mediators that cause inflammatory mediator related disease, sepsis, and SIRS/MODS/MOSF to create a post adsorption ultrafiltrate stream. The post adsorption ultrafiltrate stream is selectively combined with the filtered blood stream and together with the filtered blood stream is returned to the mammal.

公开(公告)号：US20040089594A1

公开(公告)日：2004-05-13

申请号：US10433845

申请日：2003-10-27

Inventor： Gregory R. Collins ,  James Summerton ,  Edward Spence

IPC: C02F009/00

CPC classification number: A61M1/3624 ,  A61L2/24 ,  A61M1/16 ,  A61M1/34 ,  A61M1/3413 ,  A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3465 ,  A61M1/3635 ,  A61M1/367 ,  A61M2205/3331 ,  A61M2205/3344 ,  A61M2205/3351 ,  A61M2205/3355

Abstract: A method and an apparatus are provided for preventing retrograde flow of fluid, e.g., blood products, into a source of sterile substitution fluid (50). The apparatus of the present invention includes a controllable pinch valve member (110) that is placed on a section of a conduit (90) which carries sterile substitution fluid to an extracorporeal circuit (30). In one embodiment, control over the valve member (110) is based on a control unit (120) using fluid pressures that are sensed upstream and downstream of the valve member (110) by upstream sensor (121) and downstream pressure (122) respectively. The valve member (110) is preferably opened only when the upstream pressure is greater than the downstream pressure. This assures that the substitution fluid flows only in a single direction when the pinch valve member (110) completely occludes the conduit (90) when in a closed position. Therefor, blood will not contaminate the sterile fluid by being drawn into the conduit (90) due to pressure differences.

Abstract translation: 提供了一种用于防止流体（例如血液制品）逆流流入无菌置换流体源（50）的方法和装置。 本发明的装置包括可控制的夹紧阀构件（110），其被放置在导管（90）的一部分上，导管（90）将无菌替代流体运送到体外回路（30）。 在一个实施例中，对阀构件（110）的控制是基于控制单元（120），其使用通过上游传感器（121）和下游压力（122）在阀构件（110）的上游和下游感测的流体压力 。 阀构件（110）优选仅在上游压力大于下游压力时打开。 这确保当处于关闭位置时夹紧阀构件（110）完全封闭导管（90）时，替代流体仅沿单个方向流动。 因此，血液不会由于压力差而被吸入导管（90）而污染无菌流体。

公开(公告)号：US20040057949A1

公开(公告)日：2004-03-25

申请号：US10252228

申请日：2002-09-23

Inventor： Potito U. DePaolis ,  Saleh Salehmoghaddam

IPC: A61K039/395 ,  C02F001/44 ,  A61K031/715

CPC classification number: B01D61/243 ,  A61K31/715 ,  A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3458 ,  B01D61/022 ,  B01D61/04 ,  B01D2311/04 ,  B01D2311/12 ,  B01D2311/18

Abstract: An improved method for hemodialysis employing reverse osmosis raises the pH of the blood to preserve the activity of the enzyme lysozyme to improve immune function and reduce the risk of infection in dialysis. In general, this method comprises: (1) removing arterial blood from a patient in need of hemodialysis; (2) increasing the pH of the arterial blood to a value of about 7.8 by adding a sufficient quantity of a 5% solution of sodium chloride buffered to a pH value of 7.9; (3) passing the arterial blood from step (b) through a dialyzer operating by reverse osmosis; (4) adding a pH-reducing agent selected from the group consisting of acetate buffer and dextran sulfate to reduce the pH of the blood to its normal value; (5) passing the blood from step (4) through a dialyzer operating by reverse osmosis to remove antigen; and (6) returning the blood to the patient.

Abstract translation: 使用反渗透的血液透析改进方法提高了血液的pH值，以保持酶溶菌酶的活性，从而改善免疫功能，降低透析感染的风险。 一般来说，该方法包括：（1）从需要血液透析的患者中除去动脉血; （2）通过加入足够量的缓冲至pH值为7.9的氯化钠的5％溶液将动脉血的pH值提高至约7.8; （3）将来自步骤（b）的动脉血通过反渗透操作的透析器; （4）添加选自乙酸盐缓冲液和硫酸葡聚糖的pH降低剂，将血液的pH值降低至正常值; （5）将来自步骤（4）的血液通过反渗透操作的透析器除去抗原; 和（6）将血液返回给患者。

公开(公告)号：US06635026B1

公开(公告)日：2003-10-21

申请号：US09705740

申请日：2000-11-06

Applicant: Bernard Béné

Inventor： Bernard Béné

IPC: A61M3500

CPC classification number: A61M1/3462 ,  A61M1/1607 ,  A61M1/1647 ,  A61M1/166 ,  A61M1/1672 ,  A61M1/342 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3458 ,  Y10S210/929

Abstract: A haemofiltration machine designed to work with a haemofilter comprises two compartments separated by a semipermeable membrane, one compartment having an inlet connected to a withdrawing tube for taking blood from the patient and an outlet connected to a blood return tube, the other having an outlet connected to a tube for removing used liquid. The machine itself comprises a solution generator for preparing a first injectable solution from at least one concentrated solution; a circulation pump for injecting the first solution at a flow rate of Qpre into the withdrawing tube; an infusion pump for injecting a patient with a second solution containing a ionic substance [A] with a fixed concentration [A]post different from its concentration [A]pre in the first solution; and a control unit for determining an infusion flow rate Q(post) for the second solution such that the concentration of the ionic substance [A] inside the patient tends towards a required concentration [A]des, as a function of [A]post, [A]des, Qpre, and the blood flow rate QB.

Abstract translation: 设计用于与血液滤膜一起工作的血液滤膜机包括由半透膜隔开的两个隔间，一个隔室具有连接到用于从患者取血的抽出管的入口和连接到血液回流管的出口，另一个具有出口连接 到用于除去二手液体的管。 机器本身包括用于从至少一个浓缩溶液制备第一可注射溶液的溶液发生器; 用于将Qpre流量的第一溶液注入到抽出管中的循环泵; 输液泵，用于向患者注射含有固定浓度[A]的离子物质[A]的第二溶液，其不同于其在第一溶液中的浓度[A] pre; 以及用于确定第二溶液的输注流量Q（post）的控制单元，使得患者内的离子物质[A]的浓度趋于所需浓度[A] des，作为[A]柱的函数 ，[A] des，Qpre和血流量QB。

公开(公告)号：US06582385B2

公开(公告)日：2003-06-24

申请号：US09027301

申请日：1998-02-19

Applicant: Jeffrey H Burbank ,  C David Finch ,  James M Brugger

Inventor： Jeffrey H Burbank ,  C David Finch ,  James M Brugger

IPC: A61M3700

CPC classification number: A61M1/3472 ,  A61M1/28 ,  A61M1/3437 ,  A61M1/3458 ,  A61M1/3482 ,  A61M1/3486 ,  A61M2205/3306 ,  A61M2205/3389 ,  Y10S210/90

Abstract: A hemofiltration system is provided in which ultrafiltrate is purified by reverse osmosis for reinfusion. Non-sterile infusate concentrate is dialyzed into the purified ultrafiltrate and combined with cleared blood which is returned to the patient. In another system, a hemofilter is used to sterilize essentially pure, non-sterile water for dilution of sterile infusate concentrate, then the hemofilter is used to filter blood, the infusate concentrate being combined with cleared blood for return to the patient.

Abstract translation: 提供了一种血液滤过系统，其中超滤液通过反渗透纯化用于再灌注。 将非无菌灌注浓缩物透析至纯化的超滤液中，并与清除的血液结合并返回给患者。 在另一个系统中，使用血液过滤器对基本上纯净的非无菌水进行灭菌以稀释无菌灌注浓缩物，然后使用血液滤膜来过滤血液，将输注的浓缩物与清除的血液结合以返回给患者。