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745 条记录 (耗时 0.037 秒)

    Adamantane derivatives and process for producing the same
    61.
    发明授权
    Adamantane derivatives and process for producing the same 有权
    金刚烷衍生物及其制备方法

    公开(公告)号：US07528279B2

    公开(公告)日：2009-05-05

    申请号：US10588080

    申请日：2005-02-01

    申请人： Naoyoshi Hatakeyama ,  Shinji Tanaka ,  Hidetoshi Ono ,  Yasunari Okada

    发明人： Naoyoshi Hatakeyama ,  Shinji Tanaka ,  Hidetoshi Ono ,  Yasunari Okada

    IPC分类号： C07C69/54 ,  C07C67/29 ,  C07C303/28 ,  C07C303/44 ,  C07C309/66

    CPC分类号： C07C69/54 ,  C07C67/29 ,  C07C303/28 ,  C07C309/66 ,  C07C2603/74

    摘要： The present invention provides an adamantane derivative (I) having a structure represented by the general formula (I); an adamantane derivative (II) having a structure represented by the general formula (II); and a process for producing those adamantane derivatives. An alcohol form of an adamantane compound is reacted with a sulfonyl compound to obtain the adamantane derivative (II), which is then reacted with an alcohol to obtain the adamantane derivative (I). The adamantane derivative (I) and adamantane derivative (II) each having the structure represented by the general formula (I) and general formula (II), respectively, is a novel adamantyl(meth)acrylate compound and useful as a monomer for functional resins such as a photosensitive resin in the field of photolithography.

    摘要翻译： 本发明提供具有由通式（I）表示的结构的金刚烷衍生物（I）; 具有由通式（II）表示的结构的金刚烷衍生物（II）; 以及生产这些金刚烷衍生物的方法。 将金刚烷化合物的醇形式与磺酰基化合物反应，得到金刚烷衍生物（II），然后与醇反应得到金刚烷衍生物（I）。 分别具有由通式（I）和通式（II）表示的结构的金刚烷衍生物（I）和金刚烷衍生物（II）分别是新型金属（甲基）丙烯酸酯金属化合物，并且可用作功能性树脂的单体 例如光刻领域的感光性树脂。

    Benzoic acid derivatives as modulators of PPAR alpha and gamma
    62.
    发明授权
    Benzoic acid derivatives as modulators of PPAR alpha and gamma 失效

    公开(公告)号：US07521461B2

    公开(公告)日：2009-04-21

    申请号：US10518819

    申请日：2003-06-17

    申请人： Lanna Li

    发明人： Lanna Li

    IPC分类号： A61K31/47 ,  A61K31/44 ,  A61K31/426 ,  A61K31/4172 ,  A61K31/195 ,  C07C229/38

    CPC分类号： C07C59/68 ,  C07C233/78 ,  C07C235/34 ,  C07C275/30 ,  C07C309/66 ,  C07C311/13 ,  C07C323/62 ,  C07D213/38 ,  C07D217/06 ,  C07D233/54 ,  C07D307/68

    摘要： A compound of formula (I) wherein R1 represents aryl optionally substituted by a heterocyclic group or a heterocyclic group optionally substituted by aryl wherein each aryl or heterocyclic group is optionally substituted; the group —(CH2)m-T-(CH2)n—U—(CH2)p— is attached at either the 3 or 4 position in the phenyl ring as indicated by the numbers in formula (I) and represents a group selected from one or more of the following: O(CH2)2, O(CH2)3, NC(O)NR4(CH2)2, CH2S(O2)NR5(CH2)2, CH2N(R6)C(O)CH2, (CH2)2N(R6)C(O)(CH2)2, C(O)NR7CH2, C(O)NR7(CH2)2, and CH2N(R6)C(O)CH2O; V represents O, S, NR8 or a single bond; q represents 1, 2, or 3; W represents O, S, N(R9)C(O), NR10, or a single bond; R2 represents halo, a C1-4 alkyl group which is optionally substituted by one or more fluoro, a C1-4 alkoxy group which is optionally substituted by one or more fluoro, a C1-4 acyl group, aryl, an aryl C1-4 alkyl group, CN or NO2; r represents 0, 1, 2 or 3; R3 halo, a C1-4 alkyl group which is optionally substutited by one or more fluoro, a C1-4 alkoxy group which is optionally substituted by one or more fluoro, a C1-4 acyl group, aryl, an aryl C1-4 alkyl group, or CN; s represents 0, 1, 2 or 3; and R4, R5, R6, R7, R8, R9, and R10 independently represent H, a C1-10 alkyl group, aryl or an aryl C1-4 alkyl group or when m is O and T represents a group N(R6)C(O) or a group (R5)NS(O2) then R1 and R6 or R1 and R5 together with the nitrogen atom to which they are attached represent a heteroaryl group; with provisos and pharmaceutically acceptable salts thereof, processes for preparing such compounds, their utility in treating clinical conditions associated with insulin resistance, methods for their therapeutic use and pharmaceutical compositions containing them.

    Methods for producing cyclic benzamidine derivatives
    65.
    发明授权
    Methods for producing cyclic benzamidine derivatives 失效
    环苯甲脒衍生物的制备方法

    公开(公告)号：US07375236B2

    公开(公告)日：2008-05-20

    申请号：US11208289

    申请日：2005-08-18

    申请人： Naoyuki Shimomura ,  Manabu Sasho ,  Akio Kayano ,  Kazuhiro Yoshizawa ,  Masahiko Tsujii ,  Hiroshi Kuroda ,  Ken Furukawa

    发明人： Naoyuki Shimomura ,  Manabu Sasho ,  Akio Kayano ,  Kazuhiro Yoshizawa ,  Masahiko Tsujii ,  Hiroshi Kuroda ,  Ken Furukawa

    IPC分类号： C07D265/30 ,  C07D209/44 ,  C07C43/307

    CPC分类号： C07D295/096 ,  C07C43/225 ,  C07C43/315 ,  C07C255/54 ,  C07C255/56 ,  C07C303/28 ,  C07D209/44 ,  C07D209/48 ,  C07C309/66

    摘要： In the present invention, the methods of producing a fluorinated cyclic benzamidine derivative (A), or a salt thereof, comprise the step of reacting a specific novel compound with ammonia or imide.The methods of this invention for producing a morpholine-substituted phenacyl derivative (B), or a salt thereof, comprise reaction of a specific novel compound with morpholine, reaction of the product with a halogenating reagent, and deketalization of the product.The methods of this invention for a producing cyclic benzamidine derivative (C), or a salt thereof, comprise the step of coupling compound (A), or a salt thereof, with compound (B), or a salt thereof, in the presence of an ether or a hydrocarbon.The methods of this invention for recrystallizing a cyclic benzamidine derivative (C), or a salt thereof, comprise the steps of dissolving compound (C), or the salt thereof, in a mixed solvent comprising an alcohol and water, or a mixed solvent comprising an ether and water, and after dissolution, adding additional water to precipitate crystals of compound (C), or the salt thereof.

    摘要翻译： 在本发明中，制备氟化环状苯甲脒衍生物（A）或其盐的方法包括使特定的新化合物与氨或酰亚胺反应的步骤。 本发明用于生产吗啉取代的苯甲酰甲基衍生物（B）或其盐的方法包括特异性新化合物与吗啉的反应，产物与卤化试剂的反应和产物的脱缩合作用。 本发明的制备环状苯甲脒衍生物（C）或其盐的方法包括将化合物（A）或其盐与化合物（B）或其盐偶联的步骤在 醚或烃。 本发明用于环状苄脒衍生物（C）或其盐的重结晶的方法包括将化合物（C）或其盐溶解在包含醇和水的混合溶剂中的步骤或包含 醚和水，溶解后加入另外的水，使化合物（C）的结晶或其盐析出。

    Non-aqueous electrolytic solution and lithium secondary battery using the same
    67.
    发明授权
    Non-aqueous electrolytic solution and lithium secondary battery using the same 有权

    公开(公告)号：US07261975B2

    公开(公告)日：2007-08-28

    申请号：US10572571

    申请日：2004-09-17

    申请人： Koji Abe ,  Takaaki Kuwata

    发明人： Koji Abe ,  Takaaki Kuwata

    IPC分类号： H01M10/08

    CPC分类号： H01M10/0567 ,  C07C309/66 ,  H01M10/0525 ,  H01M2300/004

    摘要： The present invention provides a lithium secondary battery which is improved particularly in cycle characteristics. Disclosed is a lithium secondary battery which uses a non-aqueous electrolytic solution obtained by dissolving electrolyte salt in a non-aqueous solvent. The non-aqueous electrolytic solution further contains a pentafluorophenyloxy compound represented by the formula (I), and vinylene carbonate and/or 1,3-propanesultone. In the formula (I), R1 is a substituent selected from the group consisting of an alkylcarbonyl group having 2 to 12 carbon atoms, an alkoxycarbonyl group having 2 to 12 carbon atoms, an aryloxycarbonyl group having 7 to 18 carbon atoms, and an alkanesulfonyl group having 1 to 12 carbon atoms. At least one hydrogen atom of the substituent can be substituted with a halogen atom or an aryl group having 6 to 18 carbon atoms.