公开(公告)号：US07897817B2

公开(公告)日：2011-03-01

申请号：US11885734

申请日：2005-12-01

Applicant: Yasuhiro Uozumi ,  Yoichi Yamada ,  Takayasu Arakawa

Inventor： Yasuhiro Uozumi ,  Yoichi Yamada ,  Takayasu Arakawa

IPC: C07C49/00

CPC classification number: C07C45/39 ,  B01J23/42 ,  B01J31/068 ,  B01J31/1658 ,  B01J31/1805 ,  B01J31/2291 ,  B01J31/4038 ,  B01J31/4069 ,  B01J35/0013 ,  B01J35/006 ,  B01J2231/70 ,  B01J2531/828 ,  C07C51/235 ,  Y02P20/584 ,  C07C49/413 ,  C07C49/217 ,  C07C49/78 ,  C07C49/04 ,  C07C49/76 ,  C07C57/44

Abstract: To provide a catalyst that has sufficient catalytic activity as a platinum catalyst and yet is readily separated from a target material and can be reused. A resin-supported platinum cluster catalyst containing a resin layer comprising a platinum particle core, the average diameter of which is from 1 nm to 10 nm, and a compound containing nitrogen (general formula R1NH2) surrounding the core. This catalyst can be obtained by forming a platinum complex from a compound containing nitrogen represented by the general formula R1NR22 (in the formula, R1 represents a carrier with a hydrophilic molecular chain and R2 represents a hydrogen atom, an alkyl group and the like) and a platinum compound represented by the general formula M(PtX4-nR3n)m (in the formula, M represents an alkali metal and the like, X represents a halogen atom and the like, R3 represents an unsaturated organic ligand, n represents an integer from zero to four and m represents an integer indicating the electrical charge of the metal, M) and allowing this platinum complex to react with a reducing agent in an aqueous solvent.

Abstract translation: 提供具有作为铂催化剂的足够的催化活性并且容易与目标材料分离并且可以重复使用的催化剂。 含有包含平均直径为1nm〜10nm的铂粒子核心的树脂层的树脂负载的铂簇催化剂和包含核的氮（通式R 1 NH 2）的化合物。 该催化剂可以通过由通式R1NR22表示的含氮化合物形成铂络合物（式中，R1表示具有亲水性分子链的载体，R2表示氢原子，烷基等）和 由通式M（PtX4-nR3n）m表示的铂化合物（式中，M表示碱金属等，X表示卤素原子等，R3表示不饱和有机配体，n表示来自 0至4，m表示金属的电荷的整数，M），并允许该铂络合物在水性溶剂中与还原剂反应。

公开(公告)号：US20090092560A1

公开(公告)日：2009-04-09

申请号：US12251310

申请日：2008-10-14

Applicant: Debasis Bagchi

Inventor： Debasis Bagchi

IPC: A61K8/49 ,  C07F11/00 ,  A61K31/28

CPC classification number: A61K31/4406 ,  A61K31/28 ,  A61K33/24 ,  A61K36/185 ,  A61K36/22 ,  A61K36/38 ,  A61K36/49 ,  A61K36/54 ,  A61K36/82 ,  C07C57/44 ,  C07C59/285 ,  C07C65/03 ,  C07C229/76 ,  A61K2300/00

Abstract: The present invention provides chromium compounds, specifically chromium dinicocysteinate, which possess the ability to improve insulin sensitization, glucose tolerance, bioavailability, efficacy, and safety, and methods for their use.

Abstract translation: 本发明提供具有改善胰岛素敏化，葡萄糖耐量，生物利用度，功效和安全性的能力的铬化合物，特别是二碳代二碳酸铬及其使用方法。

公开(公告)号：US20080125486A1

公开(公告)日：2008-05-29

申请号：US11839525

申请日：2007-08-15

Applicant: Pedro Cuevas Sanchez ,  Guillermo Gimenez Gallego ,  Inigo Saenz de Tejada Morgan ,  Javier Angulo Frutos ,  Rosa Maria Lozano Puerto ,  Antonio Romero Garrido ,  Serafin Valverde Lopez

Inventor： Pedro Cuevas Sanchez ,  Guillermo Gimenez Gallego ,  Inigo Saenz de Tejada Morgan ,  Javier Angulo Frutos ,  Rosa Maria Lozano Puerto ,  Antonio Romero Garrido ,  Serafin Valverde Lopez

IPC: A61K31/22 ,  A61K31/192 ,  A61K31/185

CPC classification number: A61K31/255 ,  A61K9/0014 ,  A61K31/095 ,  A61K31/10 ,  A61K31/185 ,  A61K31/192 ,  A61K31/216 ,  A61K31/222 ,  A61K31/225 ,  A61K31/235 ,  A61K45/06 ,  C07C57/44 ,  C07C59/68 ,  C07C65/03 ,  C07C65/19 ,  C07C69/017 ,  C07C69/84 ,  C07C309/24 ,  C07C309/42 ,  C07C309/68 ,  C07C309/75 ,  A61K2300/00

Abstract: The present invention refers to the use of the compound of Formula (I′) or pharmaceutically acceptable salt, solvate, isomer, or prodrug thereof for the treatment and/or prophylaxis of hematological dyscrasias, including myelodisplastic syndromes (MDSs) and for improving the efficacy of chemotherapy, radiation therapy and/or cancer immunotherapy. In addition, it relates to the use of a compound of formula (I″) for the treatment and/or prophylaxis of cancer of an organ.

Abstract translation: 本发明涉及式（I'）化合物或其药学上可接受的盐，溶剂合物，异构体或前体药物在治疗和/或预防血液恶化症中的用途，包括骨髓增生异常综合征（MDS）和用于改善功效 的化疗，放射治疗和/或癌症免疫治疗。 此外，它涉及式（I“）化合物用于治疗和/或预防器官癌症的用途。

公开(公告)号：US06867400B2

公开(公告)日：2005-03-15

申请号：US10064623

申请日：2002-07-31

Applicant: Michael John Collins ,  Michael John Collins, Jr. ,  Wyatt Price Hargett, Jr. ,  Edward Earl King ,  Gary Wilbert Busse

Inventor： Michael John Collins ,  Michael John Collins, Jr. ,  Wyatt Price Hargett, Jr. ,  Edward Earl King ,  Gary Wilbert Busse

IPC: B01J19/12 ,  C07C51/38 ,  C07C67/03 ,  C07C67/08 ,  C07C221/00 ,  C07C223/06 ,  H05B6/78 ,  H05B6/74

CPC classification number: H05B6/806 ,  B01J19/126 ,  B01J2219/0009 ,  B01J2219/00162 ,  B01J2219/1227 ,  B01J2219/1239 ,  C07C51/38 ,  C07C67/03 ,  C07C67/08 ,  C07C221/00 ,  C07C57/44 ,  C07C69/76 ,  C07C69/78 ,  C07C223/06

Abstract: The invention is a method and associated instrument for microwave assisted chemistry. The invention includes the steps of directing a continuous flow of fluid through a microwave cavity while applying microwave radiation to the cavity and to the continuous flow of materials therein, monitoring the pressure of the fluid in the cavity; and cooling the fluid in the cavity when the pressure exceeds a predetermined setpoint pressure.

公开(公告)号：US2802869A

公开(公告)日：1957-08-13

申请号：US32483052

申请日：1952-12-08

Applicant: DOW CHEMICAL CO

Inventor： MONTGOMERY ROBERT S

IPC: C07C51/08 ,  C07C51/377 ,  C07C57/44

CPC classification number: C07C57/44 ,  C07C51/08 ,  C07C51/377

公开(公告)号：US11731928B2

公开(公告)日：2023-08-22

申请号：US17306005

申请日：2021-05-03

Applicant: SyneuRx International (Taiwan) Corp.

Inventor： Guochuan Emil Tsai ,  Ching-Cheng Wang ,  Tien-Lan Hsieh ,  Yuan-Chun Lo

IPC: C07C63/08 ,  C07D213/55 ,  C07C57/10 ,  C07C57/44

CPC classification number: C07C63/08 ,  C07C57/10 ,  C07C57/44 ,  C07D213/55 ,  C07B2200/13

Abstract: Provided are co-crystals of a sodium benzoate compound and a co-former compound of Formula (I)




Also provided herein are methods of preparing the co-crystals and uses thereof in treating and/or reducing the risk for a neuropsychiatric disorder (e.g., schizophrenia, psychotic disorders, depressive disorders, or Alzheimer's disease) or a glucose or lipid metabolic disorder (e.g., obesity, diabetes, hypercholesterolemia, hypertension, or hyperlipidemia).

公开(公告)号：US20180200706A1

公开(公告)日：2018-07-19

申请号：US15919812

申请日：2018-03-13

Applicant: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

Inventor： Bassam El ALI ,  Mansur B. Ibrahim

IPC: B01J31/22 ,  C07C51/377 ,  B01J35/02

CPC classification number: B01J31/2295 ,  B01J21/08 ,  B01J35/023 ,  B01J35/026 ,  B01J2231/4261 ,  B01J2531/824 ,  C07C51/06 ,  C07C51/09 ,  C07C51/353 ,  C07C51/367 ,  C07C51/373 ,  C07C51/377 ,  C07C201/12 ,  C07C57/44 ,  C07C59/64 ,  C07C59/84 ,  C07C205/53

Abstract: A solid-supported palladium(II) complex which catalyzes the Mizoroki-Heck coupling reaction efficiently and a method of employing the solid-supported palladium(II) complex to synthesize cinnamic acid and derivatives thereof. The solid-supported palladium(II) complex is also stable and can be recycled without significantly losing catalytic activity.

公开(公告)号：US20180200705A1

公开(公告)日：2018-07-19

申请号：US15919669

申请日：2018-03-13

Applicant: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

Inventor： Bassam El ALI ,  Mansur B. IBRAHIM

IPC: B01J31/22 ,  C07C51/377 ,  B01J35/02

CPC classification number: B01J31/2295 ,  B01J35/026 ,  B01J2231/4261 ,  B01J2531/824 ,  C07C51/06 ,  C07C51/09 ,  C07C51/353 ,  C07C51/367 ,  C07C51/373 ,  C07C51/377 ,  C07C201/12 ,  C07C57/44 ,  C07C59/64 ,  C07C59/84 ,  C07C205/53

Abstract: A solid-supported palladium(II) complex which catalyzes the Mizoroki-Heck coupling reaction efficiently and a method of employing the solid-supported palladium(II) complex to synthesize cinnamic acid and derivatives thereof. The solid-supported palladium(II) complex is also stable and can be recycled without significantly losing catalytic activity.

公开(公告)号：US20180065117A1

公开(公告)日：2018-03-08

申请号：US15257466

申请日：2016-09-06

Applicant: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

Inventor： Bassam El ALI ,  Mansur B. IBRAHIM

IPC: B01J31/22 ,  C07C51/377 ,  B01J35/02

CPC classification number: B01J31/2295 ,  B01J35/026 ,  B01J2231/4261 ,  B01J2531/824 ,  C07C51/06 ,  C07C51/09 ,  C07C51/353 ,  C07C51/367 ,  C07C51/373 ,  C07C51/377 ,  C07C201/12 ,  C07C57/44 ,  C07C59/64 ,  C07C59/84 ,  C07C205/53

Abstract: A solid-supported palladium(II) complex which catalyzes the Mizoroki-Heck coupling reaction efficiently and a method of employing the solid-supported palladium(II) complex to synthesize cinnamic acid and derivatives thereof. The solid-supported palladium(II) complex is also stable and can be recycled without significantly losing catalytic activity.

公开(公告)号：US09179675B2

公开(公告)日：2015-11-10

申请号：US14587929

申请日：2014-12-31

Applicant: Marrone Bio Innovations, Inc.

Inventor： Huazhang Huang ,  Ratnakar Asolkar

IPC: A01N37/02 ,  A01N37/06 ,  A01N37/10 ,  A01N37/18 ,  A01N43/36 ,  A01N43/40 ,  A01N43/46 ,  C07C233/05 ,  C07C233/06 ,  C07C233/11 ,  C07D295/185 ,  C07C57/42 ,  C07D207/06 ,  C07D211/16 ,  C07D233/04 ,  C11B1/00 ,  C07C57/44 ,  C07C69/587 ,  C07C233/08

CPC classification number: A01N43/36 ,  A01N37/02 ,  A01N37/06 ,  A01N37/10 ,  A01N37/18 ,  A01N43/40 ,  A01N43/46 ,  C07C57/42 ,  C07C57/44 ,  C07C69/587 ,  C07C233/05 ,  C07C233/06 ,  C07C233/08 ,  C07C233/11 ,  C07C2601/08 ,  C07D207/06 ,  C07D211/16 ,  C07D223/04 ,  C07D233/04 ,  C07D295/185 ,  C11B1/00

Abstract: Methods and compositions for controlling plant pests, particularly weeds and/or plant phytopathogens using sarmentine and/or analogs thereof are disclosed.