公开(公告)号：US20040217279A1

公开(公告)日：2004-11-04

申请号：US10736154

申请日：2003-12-13

Applicant: Nanostream, Inc.

Inventor： Steven E. Hobbs ,  Stephen D. O'Connor ,  Ronald C. Gamble

IPC: H01J049/00

CPC classification number: G01N30/6043 ,  B01L3/5027 ,  G01N30/6095 ,  G01N30/72 ,  H01J49/009 ,  H01J49/04

Abstract: Systems for analyzing multiple samples in parallel using mass spectrometric preferably coupled with fluid phase separation techniques are provided. A multi-analyzer mass spectrometer includes multiple inlets, multiple mass analyzers, and multiple transducers to conduct mass analyses of multiple samples in parallel. A modular mass analyzer may include a vacuum enclosure, a chassis, and multiple mass analysis modules disposed within the chassis. Modules are preferably disposed in a spatially compact two-dimensional array. A common multi-stage vacuum system may be utilized in conjunction with baffles or partitions disposed within and between modules to maintain differential vacuum conditions within the spectrometer utilizing a minimum number of pumps. Common control inputs may be provided to multiple modules or other components within a multi-analyzer spectrometer. Fluid phase separation devices for use with a multi-analyzer spectrometer may be microfluidic devices utilizing chromatographic, electrophoretic, or other separation methods.

Abstract translation: 提供了使用优选与流体相分离技术耦合的质谱分析多个样品的系统。 多分析仪质谱仪包括多个入口，多个质量分析仪和多个换能器，用于并行进行多个样品的质量分析。 模块化质量分析器可以包括真空外壳，底盘以及设置在底盘内的多个质量分析模块。 模块优选地设置在空间紧凑的二维阵列中。 共同的多级真空系统可以与设置在模块内和模块之间的挡板或隔板一起使用，以利用最少数量的泵来维持光谱仪内的差分真空条件。 通常的控制输入可以提供给多分析仪光谱仪中的多个模块或其他组件。 用于多分析仪光谱仪的流体相分离装置可以是利用色谱，电泳或其它分离方法的微流体装置。

公开(公告)号：US20040195498A1

公开(公告)日：2004-10-07

申请号：US10482022

申请日：2004-05-20

Inventor： Kazuhiko Omote

IPC: H01J049/00

CPC classification number: G01N23/20 ,  G01N23/201 ,  G01N23/203

Abstract: A non-uniform density sample analyzing method for analyzing distribution state of particle-like matter in a non-uniform density sample, wherein an actually measured X-ray scattering curve is an in-plane X-ray scattering curve obtained by in-plane diffraction measurement, wherein the fitting between the in-plane X-ray scattering curve and the simulated X-ray scattering curve is performed, and wherein the value of the fitting parameter when the simulated X-ray scattering curve agrees with the in-plane X-ray scattering curve serves to indicate the in-plane direction distribution sate of the particle-like matter in the non-uniform density sample. This method can analyze the in-plane direction distribution state of the particle-like matter in the anisotropic non-uniform density sample easily and accurately. Its device and system are also disclosed.

Abstract translation: 一种用于分析非均匀密度样品中颗粒状物质的分布状态的非均匀密度样品分析方法，其中实际测量的X射线散射曲线是通过面内衍射获得的平面内X射线散射曲线 测量，其中执行所述平面内X射线散射曲线与所述模拟X射线散射曲线之间的拟合，并且其中当所述模拟X射线散射曲线与所述平面内X射线散射曲线一致时所述拟合参数的值， 射线散射曲线用于表示非均匀密度样品中颗粒状物质的面内方向分布状态。 该方法可以方便，准确地分析各向异性密度样品中颗粒状物质的面内方向分布状态。 其设备和系统也被公开。

公开(公告)号：US20040188603A1

公开(公告)日：2004-09-30

申请号：US10464576

申请日：2003-06-19

Inventor： Robert Harold Bateman ,  James Ian Langridge ,  Therese McKenna ,  Keith Richardson

IPC: H01J049/00

CPC classification number: H01J49/0031 ,  H01J49/0027 ,  H01J49/0045 ,  H01J49/10 ,  H01J49/34

Abstract: A method of mass spectrometry is disclosed wherein a gas collision cell is repeatedly switched between a fragmentation and a non-fragmentation mode. Parent ions from a first sample are passed through the collision cell and parent ion mass spectra and fragmentation ion mass spectra are obtained. Parent ions from a second sample are then passed through the collision cell and a second set of parent ion mass spectra and fragmentation ion mass spectra are obtained. The mass spectra are then compared and if either certain parent ions or certain fragmentation ions in the two samples are expressed differently then further analysis is performed to seek to identify the ions which are expressed differently in the two different samples.

公开(公告)号：US20040173740A1

公开(公告)日：2004-09-09

申请号：US10485807

申请日：2004-02-04

Inventor： Scott A. McLuckey ,  Gavin E. Reid ,  James Mitchell Wells

IPC: H01J049/00

CPC classification number: H01J49/424 ,  H01J49/0063 ,  H01J49/0072 ,  H01J49/0077 ,  H01J49/04 ,  H01J49/42

Abstract: A method of inhibiting the reaction between ions of opposite polarity is disclosed. The method includes exposing a population of ions to a resonance excitation frequency during a mass-to-charge altering reaction between a first subpopulation of ions and a second subpopulation of ions, the resonance excitation frequency being tuned to inhibit the mass-to-charge altering reaction between an ion of the first subpopulation of ions having a predetermined mass-to-charge ratio and an ion of the second subpopulation of ions so that when an ion of the first subpopulation of ions attains the predetermined mass-to-charge ratio, the ion having the predetermined mass-to-charge ratio is selectively inhibited from reacting with ions of the second subpopulation of ions.

Abstract translation: 公开了抑制相反极性的离子之间的反应的方法。 该方法包括在离子的第一亚群和第二亚离子群之间的质量 - 电荷改变反应期间将离子群体暴露于共振激发频率，谐振激发频率被调谐以抑制质量 - 电荷改变 具有预定质荷比的第一亚群的离子与第二子离子群的离子之间的反应，使得当离子的第一亚群离子达到预定的质荷比时， 选择性地抑制具有预定质荷比的离子与第二亚离子群的离子反应。

公开(公告)号：US20040164240A1

公开(公告)日：2004-08-26

申请号：US10750915

申请日：2004-01-05

Applicant: Hitachi, Ltd.

Inventor： Akihiko Okumura ,  Izumi Waki

IPC: H01J049/00

CPC classification number: H01J49/401 ,  H01J49/0045 ,  H01J49/24 ,  H01J49/4215 ,  H01J49/424

Abstract: Disclosed is a mass spectrometer combining an ion trap and a TOFMS non-coaxially, wherein ion trapping efficiency, mass resolution, and CID efficiency can be maximized. The present invention relates to the mass spectrometer combining the ion trap and the TOFMS non-coaxially, having a mass filter disposed between an ion source and an ion trap and a controller for controlling the gas pressure inside the ion trap and the gas pressure inside the mass filter independently, wherein the gas pressure inside the ion trap is set to the level higher than that inside the mass filter.

Abstract translation: 公开了一种结合离子阱和TOFMS非同轴的质谱仪，其中离子捕获效率，质量分辨率和CID效率可以最大化。 本发明涉及将离子阱和TOFMS非同轴结合的质谱仪，其具有设置在离子源和离子阱之间的质量过滤器和用于控制离子阱内的气体压力的控制器和内部的气体压力 质量过滤器，其中离子阱内的气体压力设定为高于质量过滤器内部的气体压力。

公开(公告)号：US20040164238A1

公开(公告)日：2004-08-26

申请号：US10254749

申请日：2002-09-25

Inventor： Jun Xu ,  J. Michael Ramsey ,  William B. Whitten

IPC: H01J049/00

CPC classification number: H01J49/168 ,  G01N27/622

Abstract: A method and apparatus is disclosed for flowing a sample gas and a reactant gas (38, 43) past a corona discharge electrode (26) situated at a first location in an ion drift chamber (24), applying a pulsed voltage waveform comprising a varying pulse component and a dc bias component to the corona discharge electrode (26) to cause a corona which in turn produces ions from the sample gas and the reactant gas, applying a dc bias to the ion drift chamber (24) to cause the ions to drift to a second location (25) in the ion drift chamber (24), detecting the ions at the second location (25) in the drift chamber (24), and timing the period for the ions to drift from the corona discharge electrode to the selected location in the drift chamber.

Abstract translation: 公开了一种用于使样本气体和反应气体（38,43）流过位于离子漂移室（24）中的第一位置处的电晕放电电极（26）的方法和装置，施加包括变化的脉冲电压波形 脉冲分量和直流偏压分量，以产生电晕，该电晕又产生来自样品气体和反应气体的离子，向离子漂移室施加直流偏压以使离子进入 漂移到离子漂移室（24）中的第二位置（25），检测漂移室（24）中第二位置（25）处的离子，并使离子从电晕放电电极漂移到周期 漂移室中的选定位置。

公开(公告)号：US20040144916A1

公开(公告)日：2004-07-29

申请号：US10758511

申请日：2004-01-15

Applicant: University of Manitoba

Inventor： Andrew N. Krutchinsky ,  Alexandre V. Loboda ,  Victor L. Spicer ,  Werner Ens ,  Kenneth G. Standing

IPC: H01J049/00

CPC classification number: H01J49/063 ,  H01J49/04 ,  H01J49/164 ,  H01J49/401

Abstract: A method and apparatus are provided for providing an ion transmission device or interface between an ion source and a spectrometer. The ion transmission device can include a multipole rod set and includes a damping gas, to damp spatial and energy spreads of ions generated by a pulsed ion source. The multipole rod set has the effect of guiding the ions along an ion path, so that they can be directed into the inlet of a mass spectrometer. The invention has particular application to MALDI (matrix-assisted laser desorption/ionization) ion sources, which produce a small supersonic jet of matrix molecules and ions, which is substantially non-directional, and can have ions travelling in all available directions from the source and having a wide range of energy spreads. The ion transmission device can have a number of effects, including: substantially spreading out the generated ions along an ion axis to generate a quasi-continuous beam; reducing the energy spread of ions emitted from the source; and at least partially suppressing unwanted fragmentation of analyte ions. Consequently, a number of pulses of ions can be delivered to the time-of-flight or other spectrometer, for each cycle of the ion generation.

公开(公告)号：US20040124354A1

公开(公告)日：2004-07-01

申请号：US10693874

申请日：2003-10-28

Inventor： Robert Harold Bateman ,  Kevin Giles ,  John Brian Hoyes ,  Steve Pringle ,  Jason Lee Wildgoose

IPC: H01J049/00

CPC classification number: H01J49/4235

Abstract: A mass spectrometer is disclosed comprising a mass filter for separating ions according to their mass to charge ratio. The mass filter comprises a plurality of electrodes wherein ions are radially confined within the mass filter by the application of AC or RF voltages to the electrodes. One or more transient DC voltages or one or more transient DC voltage waveforms are progressively applied to the electrodes so that ions having a certain mass to charge ratio are separated from other ions having different mass to charge ratios which remain radially confined within the mass filter.

Abstract translation: 公开了一种质谱仪，其包括用于根据其质荷比分离离子的质量过滤器。 质量过滤器包括多个电极，其中通过向电极施加AC或RF电压，离子径向地限制在质量过滤器内。 一个或多个瞬态直流电压或一个或多个瞬态直流电压波形逐渐地施加到电极，使得具有一定质荷比的离子与具有不同质量与电荷比的其它离子分离，这些离子保持径向地限制在质量过滤器内。

公开(公告)号：US20040124351A1

公开(公告)日：2004-07-01

申请号：US10380025

申请日：2003-03-10

Inventor： Fernando J Pineda

IPC: H01J049/00

CPC classification number: H01J49/40 ,  H01J49/0009

Abstract: A method for calibrating time-of-flight mass spectrometers is provided. The method includes at least modeling a time-of-flight mass spectrometer as a composite operator in accordance with a state space approach. The model is used to perform both symbolic and numeric propagation. To perform symbolic propagation, the model is used to derive closed form equations for the time-of-flight, by symbolically propagating the state of one or more ions modeled as state vectors. To perform numeric propagation, the model is used to calculate the time-of-flight by numerically propagating the state vector representation of one or more ions.

Abstract translation: 提供了一种用于校准飞行时间质谱仪的方法。 该方法包括至少根据状态空间方法将飞行时间质谱仪建模为复合算子。 该模型用于执行符号和数字传播。 为了执行符号传播，该模型用于通过象征性地传播建模为状态向量的一个或多个离子的状态来导出飞行时间的闭合形式方程。 为了执行数字传播，该模型用于通过数值传播一个或多个离子的状态矢量表示来计算飞行时间。

公开(公告)号：US20040108450A1

公开(公告)日：2004-06-10

申请号：US10472917

申请日：2003-09-23

Inventor： Alexander Makarov ,  Mark E Hardman ,  Jae C. Schwartz ,  Michael W. Senko

IPC: H01J049/00

CPC classification number: H01J49/4225 ,  B82Y30/00 ,  H01J49/423 ,  H01J49/425

Abstract: A mass spectrometer 10 comprises an ion source 12 which generates nebulized ions which enter an ion cooler 20 via an ion source block 16. Ions within a window of m/z of interest are extracted via a quadrupole mass filter 24 and passed to a linear trap 30. Ions are trapped in a potential well in the linear trap 30 and are bunched at the bottom of the potential well adjacent an exit segment 50. Ions are gated out of the linear trap 30 into an electrostatic ion trap 130 and are detected by a secondary electron multiplier 10. By bunching the ions in the linear trap 30 prior to ejection, and by focussing the ions in time of flight (TOF) upon the entrance of the electrostatic trap 130, the ions arrive at the electrostatic trap 130 as a convolution of short, energetic packets of similar m/z. Such packets are particularly suited to an electrostatic trap because the FWHM of each packet's TOF distribution is less than the period of oscillation of those ions in the electrostatic trap.

Abstract translation: 质谱仪10包括离子源12，其产生经由离子源块16进入离子冷却器20的雾化离子。感兴趣的m / z窗口内的离子通过四极质量过滤器24提取并传递到线性阱 离子被捕获在线性阱30中的势阱中，并且在靠近出口段50的势阱的底部聚集。离子从门极捕获器30中门控成静电离子阱130，并由 二次电子倍增器10.通过在喷射之前聚束线性阱30中的离子，并且通过在静电捕获器130的入口处聚焦离子在飞行时间（TOF）上，离子作为卷积到达静电捕获器130 短的，精力充沛的类似m / z的包。 由于每个分组的TOF分布的FWHM小于静电阱中的那些离子的振荡周期，所以这样的分组特别适用于静电阱。