公开(公告)号：US10137198B2

公开(公告)日：2018-11-27

申请号：US15171088

申请日：2016-06-02

申请人： LIPIDOR AB

发明人： Anders Carlsson ,  Jan Holmback

IPC分类号： A61K47/24 ,  A01N25/02 ,  A61K8/34 ,  A61K8/37 ,  A61K8/55 ,  A61K8/63 ,  A61K8/891 ,  A61K9/08 ,  A61K47/14 ,  A61Q7/00 ,  A61Q19/00 ,  A01N37/18 ,  A61K8/49 ,  A61K8/89 ,  A61K9/00 ,  A61K31/167 ,  A61K31/245 ,  A61K31/4174 ,  A61K31/573 ,  A61K38/13 ,  A61K47/10 ,  A61K47/34 ,  A61Q17/02

摘要： A lipid layer forming composition comprises a volatile silicone oil of a boiling point above 180° C., a polar lipid, optionally a C2-C4 aliphatic alcohol, optionally a pharmacologically or cosmetically active agent or a protective agent. The lipid layer forming composition can be applied to a biological surface by spraying, dipping or brushing to form a stable polar lipid layer on the surface.

公开(公告)号：US20180303869A1

公开(公告)日：2018-10-25

申请号：US15823996

申请日：2017-11-28

申请人： Clarus CLS Holdings, LLC

发明人： C. Michael SAMSON ,  Bo LIANG ,  Joseph A. CAPRIOTTI

IPC分类号： A61K31/79 ,  A61K47/38 ,  A61K9/00 ,  A61K47/34 ,  A61K47/02 ,  A61K31/24 ,  A61K33/18 ,  A61K31/80 ,  A61K31/407 ,  A61K31/245 ,  A61K47/18 ,  A61K31/192 ,  A61K31/196 ,  A61K31/4535 ,  A61K31/56 ,  A61K31/573 ,  A61K45/06

CPC分类号： A61K31/79 ,  A61K9/0048 ,  A61K31/192 ,  A61K31/196 ,  A61K31/24 ,  A61K31/245 ,  A61K31/407 ,  A61K31/4535 ,  A61K31/56 ,  A61K31/573 ,  A61K31/80 ,  A61K33/18 ,  A61K45/06 ,  A61K47/02 ,  A61K47/183 ,  A61K47/34 ,  A61K47/38 ,  A61K2300/00

摘要： A topical ophthalmic composition comprised of povidone-iodine 0.01% to 10.0% combined with a steroid or non-steroidal anti-inflammatory drug. This solution is useful in the treatment of active infections of at least one tissue of the eye (e.g., conjunctiva and cornea) from bacterial, mycobacterial, viral, fungal, or amoebic causes, as well as treatment to prevent such infections in appropriate clinical settings (e.g. corneal abrasion, postoperative prophylaxis, post-LASIK/LASEK prophylaxis). Additionally the solution is effective in the prevention of infection and inflammation in the post-operative ophthalmic patient.

公开(公告)号：US10039830B2

公开(公告)日：2018-08-07

申请号：US15061281

申请日：2016-03-04

申请人： CETYLITE INDUSTRIES, INC.

发明人： Garry Gwozdz

IPC分类号： A61K31/245 ,  A61K47/10 ,  A61M11/00 ,  A61C19/08 ,  A61K9/00 ,  A61K47/26 ,  A61M19/00

摘要： A topical anesthetic composition comprising benzocaine, pharmaceutically acceptable salt thereof, amide thereof and/or ester thereof; tetracaine and/or pharmaceutically acceptable salt thereof; ethanol; polyethylene glycol; propylene glycol; water; and benzyl alcohol is provided. Also provided is method for dispensing the above topical anesthetic composition to a desired site such by spraying the topical anesthetic from a pump actuated metered dose spray device. The topical anesthetic composition can also be administered subgingivally with a syringe and applicator tip. A product comprising the above topical anesthetic spray composition contained in a pump actuated metered dose spray device.

公开(公告)号：US10034943B2

公开(公告)日：2018-07-31

申请号：US15036183

申请日：2014-11-06

申请人： LIPIDOR AB

发明人： Bengt Herslöf ,  Jan Holmbäck

IPC分类号： A61K8/58 ,  A61K47/14 ,  A61K8/34 ,  A61K47/24 ,  A61K8/37 ,  A61K47/10 ,  A61K9/08 ,  A61K8/55 ,  A61Q19/00 ,  A61K9/12 ,  A61K8/365 ,  A61K8/42 ,  A61K8/49 ,  A61K9/00 ,  A61K31/137 ,  A61K31/165 ,  A61K31/192 ,  A61K31/196 ,  A61K31/245 ,  A61K31/351 ,  A61K31/4174 ,  A61K31/506 ,  A61K31/573 ,  A61K31/59 ,  A61K31/593 ,  A61K31/60 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  A61Q7/00

摘要： A pharmaceutical or cosmetic carrier for topical administration substantially consists of phosphatidylcholine, monoglyceride, fatty acid ester of C1-C3 alcohol; volatile solvent selected from ethanol and its combinations with C3-C4 alcohol and/or volatile silicone oil. Also disclosed are pharmaceutical and cosmetic compositions comprising the carrier and pharmaceutically or cosmetically active agent(s).

公开(公告)号：US10028929B2

公开(公告)日：2018-07-24

申请号：US13005902

申请日：2011-01-13

申请人： Raffaella Scorza

发明人： Raffaella Scorza

IPC分类号： A61K31/245

摘要： The subject of the present invention is the use of aminaphtone for the preparation of a medicament for treating arteriophaties, in particular arteriophaties of a degenerative inflammatory type. Preferably, said medicament is formulated for oral administration.

公开(公告)号：US10028920B2

公开(公告)日：2018-07-24

申请号：US15350938

申请日：2016-11-14

申请人： UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE ,  CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS C.S.I.C.

发明人： Carlos Belmonte Martínez ,  Juana Gallar Martínez ,  Antonio Ferrer Montiel ,  Asia Fernández Carvajal ,  Félix Viana De La Iglesia

IPC分类号： A61K31/045 ,  A61K45/06 ,  A61K31/00 ,  A61K31/047 ,  A61K31/075 ,  A61K31/16 ,  A61K31/164 ,  A61K31/167 ,  A61K31/17 ,  A61K31/196 ,  A61K31/215 ,  A61K31/22 ,  A61K31/221 ,  A61K31/245 ,  A61K31/27 ,  A61K31/352 ,  A61K31/357 ,  A61K31/381 ,  A61K31/4025 ,  A61K31/4164 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/505 ,  A61K31/55 ,  A61K31/662 ,  A61K31/7105 ,  A61K31/713 ,  A61K45/00 ,  A61K9/00 ,  A61K31/07 ,  A61K31/4178 ,  A61K38/13

摘要： The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand. Furthermore, the invention relates to therapeutic compositions for the treatment of epiphora, more specifically to compositions comprising a TRPM8 receptor antagonist.

公开(公告)号：US20180193394A1

公开(公告)日：2018-07-12

申请号：US15914064

申请日：2018-03-07

申请人： Ronald D. SEKURA ,  Roscoe M. MOORE

发明人： Ronald D. SEKURA ,  Roscoe M. MOORE

IPC分类号： A61K36/185 ,  A61K36/61 ,  A61K36/00 ,  A61K31/045 ,  A61K31/235 ,  A61K31/047 ,  A61K31/245 ,  A61K31/085 ,  A61K31/573 ,  A61K31/352 ,  A61K31/05 ,  A61K9/00 ,  A61K45/06 ,  A61K47/12 ,  A61K9/06 ,  A61K9/08 ,  A61K47/44 ,  A61K8/49 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q19/00 ,  A61K31/12 ,  A61K31/618

CPC分类号： A61K36/185 ,  A61K8/498 ,  A61K9/0014 ,  A61K9/0034 ,  A61K9/0043 ,  A61K9/06 ,  A61K9/08 ,  A61K31/045 ,  A61K31/047 ,  A61K31/05 ,  A61K31/085 ,  A61K31/12 ,  A61K31/235 ,  A61K31/245 ,  A61K31/352 ,  A61K31/573 ,  A61K31/618 ,  A61K36/00 ,  A61K36/61 ,  A61K45/06 ,  A61K47/12 ,  A61K47/44 ,  A61P17/06 ,  A61Q5/006 ,  A61Q5/02 ,  A61Q19/00 ,  A61Q19/001 ,  A61K2300/00

摘要： A topical formulation comprising a Cannabis derived botanical drug product, wherein the concentration of tetrahydrocannabinol, cannabidiol, or both in the topical formulation is greater than 2 milligrams per kilogram.

公开(公告)号：US20180177707A1

公开(公告)日：2018-06-28

申请号：US15739616

申请日：2016-06-29

申请人： Merz Pharma GmbH & Co. KGaA

发明人： Lubin BELKOVI ,  Franck VILLAIN ,  Alexander LINKO ,  Frank PLEIS

IPC分类号： A61K8/73 ,  A61K8/04 ,  A61K31/167 ,  A61K31/245 ,  A61Q19/08 ,  C08B37/08

CPC分类号： A61K8/735 ,  A61K8/042 ,  A61K31/167 ,  A61K31/245 ,  A61K31/728 ,  A61K2800/10 ,  A61K2800/594 ,  A61K2800/805 ,  A61K2800/91 ,  A61K2800/95 ,  A61Q19/00 ,  A61Q19/08 ,  C08B37/0072 ,  C08J3/005 ,  C08J2305/08 ,  C08J2405/08 ,  C08L5/08 ,  C08L2205/025 ,  A61K2300/00

摘要： The invention relates to a method of preparing a composition, the composition comprising a crosslinked first polymer, optionally a second polymer, which may be crosslinked or non-crosslinked, and water, wherein the first and the second polymer are selected from a pollysaccharide, comprising at least steps (i) to (iv): (i) crosslinking a mixture comprising the first polymer and water; (ii) subsequent to the crosslinking in step (i), terminating the crosslinking; (iii) optionally blending the product obtained in step (ii) with the second polymer; (iv) subjecting the product obtained in step (iii) to dialysis.

公开(公告)号：US10005720B2

公开(公告)日：2018-06-26

申请号：US14782415

申请日：2014-04-04

申请人： NORTH CAROLINA CENTRAL UNIVERSITY ,  The University of North Carolina at Chapel Hill

发明人： Jonathan Z. Sexton ,  Jay E. Brenman ,  David L. Musso

IPC分类号： C07C235/64 ,  A61K45/06 ,  C07C255/60 ,  C07C233/66 ,  C07C233/81 ,  C07C235/68 ,  C07D213/75 ,  C07D213/82 ,  C07D249/08 ,  C07D257/04 ,  C07D271/06 ,  C07D295/155 ,  A61K31/167 ,  A61K31/196 ,  A61K31/245 ,  A61K31/277 ,  A61K31/40 ,  A61K31/44 ,  A61K31/5375 ,  C07C45/46 ,  C07C67/39 ,  C07C231/02 ,  C07C253/30 ,  C07D207/34

CPC分类号： C07C235/64 ,  A61K31/167 ,  A61K31/196 ,  A61K31/245 ,  A61K31/277 ,  A61K31/40 ,  A61K31/44 ,  A61K31/5375 ,  A61K45/06 ,  C07C45/46 ,  C07C67/39 ,  C07C231/02 ,  C07C233/66 ,  C07C233/81 ,  C07C235/68 ,  C07C253/30 ,  C07C255/60 ,  C07C2601/14 ,  C07D207/34 ,  C07D213/75 ,  C07D213/82 ,  C07D249/08 ,  C07D257/04 ,  C07D271/06 ,  C07D295/155

摘要： The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

公开(公告)号：US20180125874A1

公开(公告)日：2018-05-10

申请号：US15542380

申请日：2016-01-08

申请人： The Johns Hopkins University

发明人： Franco D'Alessio ,  Benjamin David Singer ,  Landon King ,  Neil Raj Aggarwal

IPC分类号： A61K31/7068 ,  A61K31/502 ,  A61K31/245 ,  A61K31/166 ,  A61K31/353 ,  A61P29/00 ,  A61P11/00 ,  A61P31/16

CPC分类号： A61K31/7068 ,  A61K31/166 ,  A61K31/245 ,  A61K31/353 ,  A61K31/502 ,  A61K31/706 ,  A61P11/00 ,  A61P29/00 ,  A61P31/16

摘要： The present invention provides methods and compositions for treatment of acute inflammatory diseases or disorders and/or for treatment of lung injury. Certain exemplary methods involve administering an IL-4 polypeptide or fragment thereof possessing cytokine activity or an IL-4 agonist systemically to a subject having an inflammatory disease or disorder and/or a lung injury. Other exemplary methods involve administering an inhibitor of DNA methylation systemically to a subject and/or administering an inhibitor of DNA methylation to a cell population comprising T cells (e.g., Treg cells) for introduction/re-introduction to a subject having an inflammatory disease or disorder and/or a lung injury. Compositions and cells for use in such methods are also provided.