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1488 条记录 (耗时 0.032 秒)

    Polymer derivative of cytidine metabolic antagonist
    62.
    发明授权
    Polymer derivative of cytidine metabolic antagonist 有权
    胞苷代谢拮抗剂的聚合物衍生物

    公开(公告)号：US09018323B2

    公开(公告)日：2015-04-28

    申请号：US13884413

    申请日：2011-11-16

    申请人： Keiichirou Yamamoto ,  Manami Okazaki ,  Dai Kawamura

    发明人： Keiichirou Yamamoto ,  Manami Okazaki ,  Dai Kawamura

    IPC分类号： C08G81/00 ,  A61K31/513 ,  C07D407/04 ,  C08G69/40 ,  C08G69/48 ,  A61K31/77 ,  A61K31/785 ,  A61K47/48 ,  C08G85/00

    CPC分类号： C08G81/00 ,  A61K31/513 ,  A61K31/77 ,  A61K31/785 ,  A61K47/60 ,  A61K47/645 ,  C07D407/04 ,  C08G69/40 ,  C08G69/48

    摘要： [Problem]To provide a novel polymer derivative of a cytidine metabolic antagonist which allows release of a medicament irrespective of enzymes of the living body and is expected to have high therapeutic effects. [Solution]The polymer derivative of a cytidine metabolic antagonist in which a substituent represented by the general formula (I) or the general formula (II) [wherein R7 and R8 each independently represent a hydrogen atom or an optionally substituted (C1-C6)alkyl group, R6 represents a hydrogen atom, an optionally substituted (C1-C40)alkyl group, an optionally substituted (C1-C40)aralkyl group, an optionally substituted aromatic group, an amino acid residue in which the carboxy group is protected, or an optionally substituted sugar residue, CX—CY represents CH—CH or C═C (double bond), and A represents the residue of the cytidine metabolic antagonist except the amino group at the position 4] is bonded to the side-chain carboxy group of a block copolymer of a polyethylene-glycol structural moiety and a polymer having 10 or more carboxy groups.

    摘要翻译： [问题]提供一种胞苷代谢拮抗剂的新型聚合物衍生物，其允许不管生物体的酶释放药物并且预期具有高治疗效果。 [溶液]通式（I）或通式（II）表示的取代基的胞苷代谢拮抗剂的聚合物衍生物[其中，R7和R8各自独立地表示氢原子或可以具有取代基的（C1-C6） 烷基，R 6表示氢原子，任选取代的（C 1 -C 40）烷基，任选取代的（C 1 -C 40）芳烷基，任选取代的芳族基团，其中羧基被保护的氨基酸残基，或 任选取代的糖残基，CX-CY表示CH-CH或C = C（双键），A表示胞苷代谢拮抗剂的残基，除了位置4]上的氨基键合到侧链羧基 的聚乙二醇结构部分和具有10个或更多个羧基的聚合物的嵌段共聚物。

    Supramacromolecular polymer complexes providing controlled nitric oxide release for healing wounds
    63.
    发明授权
    Supramacromolecular polymer complexes providing controlled nitric oxide release for healing wounds 有权
    提供受控的一氧化氮释放用于愈合伤口的超分子聚合物复合物

    公开(公告)号：US08992945B2

    公开(公告)日：2015-03-31

    申请号：US12675498

    申请日：2008-08-20

    申请人： Ping I. Lee ,  Yan Li

    发明人： Ping I. Lee ,  Yan Li

    IPC分类号： A61K9/00 ,  A61K9/70 ,  C08G69/48 ,  A61K31/765 ,  A61K31/785 ,  A61K47/48 ,  A61L15/44 ,  A61L29/16 ,  A61L31/16 ,  C08L39/08 ,  C08L35/02

    CPC分类号： A61K31/785 ,  A61K47/58 ,  A61L15/44 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/114 ,  C08L35/02 ,  C08L39/08 ,  C08L2666/04

    摘要： A bio-adhesive supramacromolecular complex of the general formula: wherein R1 is independently selected from the group consisting of an alkane unsubstituted or substituted with alkoxy groups; R2 is independently selected from the group consisting of C1-6 alkyl; R3 and R4 are independently selected from the group consisting of optionally substituted aliphatic or aromatic alkyl; R5 is independently selected from the group consisting of H or C1-6 alkyl; W is a hydrogen-bond accepting functional group-containing entity; Y is a carboxylic acid ester or amide linkage; R is an independently selected peptide linking group; T1, T2, T3 and T4 are independently selected polymer residues; and m1, m2, m3, n1 and n2 are integers selected from at least 25; and wherein P has a molecular weight of about 1×103 to 1×107 and Q has a molecular weight of about 1×103 to 1×107. The complex provides controlled nitric oxide release over a longer period of time than prior art compounds in the locally delivery systems. Novel compositions, methods of preparation, apparatus including layer-by-layer assemblies coating, electrospinning and ultrasonic atomization, skin coverings containing and medical use of the complexes are described.

    摘要翻译： 一种具有以下通式的生物粘合剂超分子复合物：其中R 1独立地选自未被取代或被烷氧基取代的烷烃; R 2独立地选自C 1-6烷基; R3和R4独立地选自任选取代的脂族或芳族烷基; R 5独立地选自H或C 1-6烷基; W是含氢键接受官能团的实体; Y是羧酸酯或酰胺键; R是独立选择的肽连接基团; T1，T2，T3和T4是独立选择的聚合物残基; m1，m2，m3，n1和n2是从至少25中选择的整数; 其中P的分子量约为1×10 3〜1×10 7，Q的分子量约为1×10 3〜1×10 7。 该复合物在局部递送系统中比现有技术化合物在更长的时间内提供受控的一氧化氮释放。 描述了新型组合物，制备方法，包括逐层组合物涂布，静电纺丝和超声雾化的装置，包含复合物的医疗用途的皮肤覆盖物。

    Use of a polyamide chain-extending compound as a stabilizer
    66.
    发明申请
    Use of a polyamide chain-extending compound as a stabilizer 审中-公开
    使用聚酰胺链延长化合物作为稳定剂

    公开(公告)号：US20140309367A1

    公开(公告)日：2014-10-16

    申请号：US14232025

    申请日：2012-07-06

    申请人： Gerard Bradley

    发明人： Gerard Bradley

    IPC分类号： C08L77/00 ,  C08L51/00 ,  C08G69/48

    CPC分类号： C08L51/00 ,  C08G69/48 ,  C08K5/0008 ,  C08K5/005 ,  C08K7/14 ,  C08L77/00

    摘要： The invention relates to the use of a polyamide chain-extending compound as an agent for stabilizing the polyamide toward heat, light and/or bad weather. Polyamide compositions may comprise at least one of these polyamide chain-extending compounds and optionally reinforcing fillers and optionally impact modifiers.

    摘要翻译： 本发明涉及聚酰胺链增长化合物作为将聚酰胺稳定到热，光和/或恶劣天气的试剂的用途。 聚酰胺组合物可以包括这些聚酰胺链延伸化合物和任选的增强填料和任选的抗冲改性剂中的至少一种。

    Halogen-Free Polymer Blend
    68.
    发明申请
    Halogen-Free Polymer Blend 有权
    无卤聚合物共混物

    公开(公告)号：US20140227542A1

    公开(公告)日：2014-08-14

    申请号：US14129614

    申请日：2012-06-28

    申请人： Jukka Hillberg ,  Jukka Maki

    发明人： Jukka Hillberg ,  Jukka Maki

    IPC分类号： C08L77/00 ,  C08G69/48 ,  B32B27/34

    CPC分类号： C08L77/00 ,  B32B27/34 ,  C08G69/48 ,  C08K5/0066 ,  C08K5/0091 ,  C08K5/55 ,  C08L71/02 ,  C08L75/04 ,  C08L75/08 ,  Y10T428/31728

    摘要： The invention concerns a halogen-free polymeric blend capable of ionic conductivity comprising either one or more polyether-based polymers or copolymers that have favorable structures to facilitate polymer chain segmental motion and ion hopping environment, selected from the group of polyether-block-polymers and polyether-based polyurethanes, or said polyether based polymers or copolymers together with one or more ionomers formed by neutralization of ethylene acid co-polymers, as well as one or more specific halogen-free ionic complexes or salts comprising a weakly coordinating anion and a cation of an alkali metal or alkaline earth metal. Further, the invention concerns the use of said blend and a plastic material containing said blend as an additive.

    摘要翻译： 本发明涉及能够具有离子导电性的无卤素聚合物共混物，其包含一种或多种聚醚基聚合物或共聚物，其具有有利的结构以促进聚合物链段分段运动和离子跳跃环境，其选自聚醚嵌段聚合物和 聚醚基聚氨酯或所述聚醚基聚合物或共聚物与通过中和乙烯酸共聚物形成的一种或多种离聚物，以及一种或多种特定的无卤素离子络合物或包含弱配位阴离子和阳离子的盐 的碱金属或碱土金属。 此外，本发明涉及所述共混物和含有所述共混物作为添加剂的塑料材料的用途。