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    Osteoporosis treatment with anti-IL-11 antibody
    72.
    发明授权
    Osteoporosis treatment with anti-IL-11 antibody 失效
    用抗IL-11抗体进行骨质疏松症治疗

    公开(公告)号：US06998123B1

    公开(公告)日：2006-02-14

    申请号：US09491982

    申请日：2000-01-27

    申请人： Stephen Shaughnessy ,  Richard Carl Austin

    发明人： Stephen Shaughnessy ,  Richard Carl Austin

    IPC分类号： A61K39/395

    CPC分类号： C07K16/2866 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/5431 ,  C07K14/70503 ,  C07K14/7155 ,  C07K16/244 ,  C07K2317/76

    摘要： There is disclosed a process of treating or alleviating the symptoms of pathological conditions in which bone density is decreased, which comprises inhibiting, in a mammalian patient suffering from such a condition, the formation in vivo of a tertiary complex of IL-11, its cell surface membrane receptor and the cell surface glycoprotein gp130. Examples of such substances are recombinant soluble IL-11 receptor mutants modified, as compared with native IL-11 receptor, at their gp130 binding site, and peptides which can interact with IL-11. The process of the invention not only inhibits bone resorption and hence bone loss, but also increases the process of bone formation to increase bone density.

    摘要翻译： 公开了治疗或减轻其中骨密度降低的病理状况的症状的方法，其包括在患有这种病症的哺乳动物患者体内抑制IL-11的三级复合物，其细胞 表面膜受体和细胞表面糖蛋白gp130。 这些物质的实例是与天然IL-11受体在其gp130结合位点相比修饰的重组可溶性IL-11受体突变体，以及可与IL-11相互作用的肽。 本发明的方法不仅抑制骨吸收并因此抑制骨丢失，而且增加骨形成过程以增加骨密度。

    Off-resonance mid-IR laser desorption ionization
    73.
    发明授权
    Off-resonance mid-IR laser desorption ionization 失效
    非共振中红外激光解吸电离

    公开(公告)号：US06977370B1

    公开(公告)日：2005-12-20

    申请号：US10804723

    申请日：2004-03-19

    申请人： Scot R. Weinberger

    发明人： Scot R. Weinberger

    IPC分类号： G01N33/48 ,  G01N33/50 ,  G01N33/68

    CPC分类号： G01N33/6851 ,  Y10T436/11 ,  Y10T436/143333 ,  Y10T436/24 ,  Y10T436/25

    摘要： Methods for producing a preponderance of gas phase ions having higher order charge states during laser desorption ionization of an analyte are presented, the methods comprising irradiating the analyte in the presence of energy absorbing molecules at a mid-IR wavelength that is offset from an IR absorption maximum of the energy absorbing molecules.

    摘要翻译： 提出了在分析物的激光解吸电离期间产生具有较高阶电荷状态的气相离子优势的方法，所述方法包括在能量吸收分子的存在下以与IR吸收偏离的中红外波长的方式照射分析物 最大能量吸收分子。

    Gradient insensitive split-core digital to analog converter
    77.
    发明授权
    Gradient insensitive split-core digital to analog converter 有权
    梯度不敏感的分裂芯数转换器

    公开(公告)号：US06937178B1

    公开(公告)日：2005-08-30

    申请号：US10440080

    申请日：2003-05-15

    申请人： William C. Rempfer ,  Hassan Malik ,  James L. Brubaker

    发明人： William C. Rempfer ,  Hassan Malik ,  James L. Brubaker

    IPC分类号： H03M1/06 ,  H03M1/76 ,  H03M1/78

    CPC分类号： H03M1/0678 ,  H03M1/0643 ,  H03M1/765

    摘要： Digital to analog converter circuits and methods are provided for producing an analog output voltage indicative of a digital input signal with at least partial insensitivity to error gradients. Described are split-core resistive elements, which include a plurality of one-dimensional or multi-dimensional resistive strings, that may be used to reduce or substantially eliminate the effects that error gradients have on the linearity of the analog output voltages of a resistive string or interpolating amplifier DACs. The resistor strings that make up the split-core resistive elements are configured in such a manner that combining respective output voltages from each of the resistor strings results in an analog output voltage that is at least partially insensitive to the effects of error gradients.

    摘要翻译： 提供数模转换器电路和方法用于产生表示对错误梯度至少部分不敏感的数字输入信号的模拟输出电压。 描述的是分离电阻元件，其包括多个一维或多维电阻串，其可用于减少或基本上消除误差梯度对电阻串的模拟输出电压的线性的影响 或内插放大器DAC。 构成分离电阻元件的电阻串以这样的方式配置，即组合来自每个电阻器串的各个输出电压导致对误差梯度的影响至少部分不敏感的模拟输出电压。

    Increasing drive strength and reducing propagation delays through the use of feedback
    79.
    发明授权
    Increasing drive strength and reducing propagation delays through the use of feedback 失效
    通过使用反馈来增加驱动强度并减少传播延迟

    公开(公告)号：US06909308B2

    公开(公告)日：2005-06-21

    申请号：US10228172

    申请日：2002-08-26

    申请人： Kenneth S. Hunt

    发明人： Kenneth S. Hunt

    IPC分类号： H03K19/017 ,  H03K19/094

    CPC分类号： H03K19/01721

    摘要： Techniques of increasing drive strength and reducing propagation delays of a digital logic circuit through the use of feedback are presented. Logic circuitry operative to receive an input signal of the digital logic circuit and a delayed version of an output signal of the digital logic circuit turns “ON” a supplemental drive transistor for a digital state transition of the output signal. The supplemental drive transistor provides supplemental drive current to the digital logic circuit during the output signal digital state transition, thus advantageously reducing propagation delay and increasing fan-out capability. The logic circuitry turns “OFF” the drive transistor once the output signal digital state transition is complete.

    摘要翻译： 提出了通过使用反馈来提高数字逻辑电路的驱动强度和减少传播延迟的技术。 逻辑电路可操作以接收数字逻辑电路的输入信号，并且数字逻辑电路的输出信号的延迟版本将“ON”为输出信号的数字状态转换的补充驱动晶体管。 补充驱动晶体管在输出信号数字状态转换期间向数字逻辑电路提供辅助驱动电流，从而有利于减少传播延迟并增加扇出能力。 一旦输出信号数字状态转换完成，逻辑电路将驱动晶体管“关”。