公开(公告)号：US09439869B2

公开(公告)日：2016-09-13

申请号：US14086907

申请日：2013-11-21

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Florian N. Ludwig ,  Stephen D. Pacetti ,  Syed F. A. Hossainy ,  Dariush Davalian

IPC: A61K9/50 ,  A61K9/51 ,  A61K38/44 ,  A61K41/00 ,  A61K47/48 ,  A61L31/16 ,  B01J13/02 ,  B22F1/02 ,  B82Y5/00 ,  A61K9/00

CPC classification number: A61K9/5031 ,  A61K9/0004 ,  A61K9/0019 ,  A61K9/5115 ,  A61K9/5138 ,  A61K38/446 ,  A61K41/0052 ,  A61K47/6923 ,  A61K47/6925 ,  A61K47/6929 ,  A61K47/6931 ,  A61L31/16 ,  A61L2300/00 ,  A61L2400/06 ,  A61L2400/12 ,  B01J13/02 ,  B22F1/025 ,  B82Y5/00 ,  Y10S977/773 ,  Y10S977/906 ,  Y10T428/2991 ,  Y10T428/2998

Abstract: Nano-constructs comprising nanoshells and methods of using the nano-constructs for treating or ameliorating a medical condition are provided.

公开(公告)号：US09439792B2

公开(公告)日：2016-09-13

申请号：US14053019

申请日：2013-10-14

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti ,  Cameron K. Kerrigan

IPC: A61F2/91 ,  A61F2/915

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2230/0013 ,  A61F2250/0068 ,  B33Y80/00 ,  Y10T29/49826

Abstract: A prosthesis for intraluminal drug delivery can comprise a plurality of interconnected struts that form a tubular scaffold structure. The struts include through-holes with an inner surface configured to retain a bioabsorbable depot. The bioabsorbable depot includes a drug-polymer composition that hydrolytically degrades upon implantation. The inner surface of the through-hole can be an entirely smooth and continuous area that is concave or convex, with no geometric discontinuities. The inner surface of the through-hole can include any number of constricted and distended regions to form grooves of a size and shape carefully selected to engage a corresponding geometric feature of the bioabsorbable depot.

Abstract translation: 用于管腔内药物递送的假体可以包括形成管状支架结构的多个互连的支柱。 支柱包括具有被构造成保持生物可吸收储库的内表面的通孔。 生物可吸收贮库包括在植入时水解降解的药物 - 聚合物组合物。 通孔的内表面可以是一个完全平滑和连续的凹或凸的区域，没有几何不连续。 通孔的内表面可以包括任何数量的收缩和扩张区域，以形成仔细选择以与生物可吸收储库的相应几何特征接合的尺寸和形状的凹槽。

公开(公告)号：US20160184120A1

公开(公告)日：2016-06-30

申请号：US14979297

申请日：2015-12-22

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： John E. Papp ,  Hung T. Nguyen ,  Justin K. Elerath ,  Dion I. Herabadi ,  Michael T. Martins ,  Kirsten S. King ,  Scott H. Mueller ,  Coeta K. Peloquin ,  Stephen D. Pacetti

IPC: A61F2/958 ,  A61F2/915 ,  A61F2/91 ,  A61F2/966 ,  A61F2/844

CPC classification number: A61F2/958 ,  A61F2/844 ,  A61F2/91 ,  A61F2/915 ,  A61F2/966 ,  A61F2002/826 ,  A61F2002/9583 ,  A61F2210/0076 ,  A61F2250/0019 ,  A61F2250/0039

Abstract: Segmented scaffolds composed of disconnected scaffold segments are delivered to an implant site on a delivery balloon. The segments are crimped to the balloon and separated from each other by gaps. When the balloon is inflated the gaps between the disconnected scaffold segments stay constant. Pillowed or banded balloons are used to deliver the segments.

Abstract translation: 由断开的支架段组成的分段支架被输送到输送球囊上的植入部位。 这些片段被卷曲到球囊并且通过间隙彼此分离。 当气囊膨胀时，断开的支架段之间的间隙保持不变。 枕头或带状气球用于交付细分。

公开(公告)号：US09364350B2

公开(公告)日：2016-06-14

申请号：US13937984

申请日：2013-07-09

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti ,  Richard Rapoza

IPC: A61F2/82 ,  A61F2/89 ,  A61F2/915

CPC classification number: A61F2/89 ,  A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/9155 ,  A61F2230/0054 ,  Y10T29/49995

Abstract: An implantable stent includes a plurality of rings. At least a distal end ring has an eased corner feature formed in the polymer substrate at a radially outward, distal-facing corner of the ring while relatively sharp corners of the polymer substrate are maintained in radially inward corners of the ring.

Abstract translation: 可植入支架包括多个环。 至少一个远端环具有形成在聚合物基底中位于环的径向向外的远侧面角处的易折角特征，而聚合物基底的相对尖锐的角保持在环的径向向内的拐角处。

公开(公告)号：US20160158046A1

公开(公告)日：2016-06-09

申请号：US15015945

申请日：2016-02-04

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti ,  Yunbing Wang

IPC: A61F2/958 ,  A61M25/10

CPC classification number: A61F2/958 ,  A61M5/16877 ,  A61M25/10184 ,  A61M25/10185 ,  A61M25/104 ,  A61M39/24 ,  A61M2039/2413

Abstract: An apparatus and method for controlling inflation pressure, pressurization rate, and volumetric flow rate of a balloon during deployment of a stent or scaffold is disclosed.

公开(公告)号：US20160081828A1

公开(公告)日：2016-03-24

申请号：US14958060

申请日：2015-12-03

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Stephen D. Pacetti

IPC: A61F2/915 ,  B65B31/04

CPC classification number: A61F2/915 ,  A61F2/86 ,  A61F2/88 ,  A61F2240/002 ,  A61F2250/0068 ,  A61F2250/0069 ,  B65B3/003 ,  B65B31/04

Abstract: An apparatus for loading material into a stent strut can comprise a chamber capable of maintaining an internal pressure below pressure external to the chamber. The chamber carries within it the stent and the material to be loaded into a lumen within the stent strut. Pressure within the chamber is decreased. The decreased pressure can draw the material into lumen. The decreased pressure can draw air out of the lumen so that, after a subsequent increase in pressure in the chamber, the material is drawn into the lumen.

Abstract translation: 用于将材料装载到支架支柱中的装置可以包括能够将内部压力保持在室外的压力的室。 腔室内承载支架和待装载到支架支架内腔内的材料。 室内的压力降低。 降低的压力可将材料吸入内腔。 减小的压力可以将空气抽出管腔，使得在腔室中随后的压力增加之后，材料被吸入管腔中。

公开(公告)号：US20160081827A1

公开(公告)日：2016-03-24

申请号：US14859170

申请日：2015-09-18

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Rommel Lumauig ,  Stephen D. Pacetti ,  Ni Ding ,  Joel Harrington ,  Xiao Ma ,  James P. Oberhauser ,  Jill McCoy ,  Chad J. Abunassar ,  Senthil Eswaran ,  Diem Ta

IPC: A61F2/915 ,  B29C71/02 ,  A61F2/844 ,  C08G63/08

CPC classification number: A61F2/915 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61L31/06 ,  A61L31/14 ,  A61L31/148 ,  B29C71/0009 ,  B29C71/02 ,  B29C2035/046 ,  B29C2035/048 ,  B29C2035/0811 ,  B29C2035/0822 ,  B29C2035/0855 ,  B29C2035/0861 ,  B29C2071/022 ,  B29K2067/046 ,  B29K2995/006 ,  B29L2031/7534 ,  C08G63/08 ,  C08L67/04

Abstract: Methods are disclosed including thermally processing a scaffold to increase the radial strength of the scaffold when the scaffold is deployed from a crimped state to a deployed state such as a nominal deployment diameter. The thermal processing may further maintain or increase the expansion capability of the scaffold when expanded beyond the nominal diameter.

Abstract translation: 公开的方法包括当支架从卷曲状态展开到展开状态（例如标称展开直径）时，热处理支架以增加支架的径向强度。 热处理可以进一步维持或增加支架在膨胀超过公称直径时的膨胀能力。

公开(公告)号：US20160000985A1

公开(公告)日：2016-01-07

申请号：US14322826

申请日：2014-07-02

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Paul Consigny ,  Erik Eli ,  Stephen D. Pacetti ,  Mikael Trollsas ,  John Stankus

IPC: A61M1/30

CPC classification number: A61M1/3655 ,  A61B2017/1107 ,  A61B2017/1135

Abstract: A medical device includes a curved tubular body configured for being used as an extravascular device to support vein maturation following the formation of an arteriovenous fistula. The tubular body is curved. The tubular body has an entrance angle of less than about 40 degrees to improve blood flow from the artery into the vein. And the tubular body includes a cuff or edge at the proximal end to stabilize the tubular body at the fistula.

公开(公告)号：US20150289875A1

公开(公告)日：2015-10-15

申请号：US14253719

申请日：2014-04-15

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Paul Consigny ,  Erik Eli ,  Stephen D. Pacetti ,  Mikael Trollsas ,  John Stankus ,  Julia Fox

IPC: A61B17/11 ,  A61F2/91 ,  A61F2/958

CPC classification number: A61B17/11 ,  A61B2017/1107 ,  A61B2017/1135 ,  A61F2/064 ,  A61F2/848 ,  A61F2/856 ,  A61F2/89 ,  A61F2/91 ,  A61F2/954 ,  A61F2/958 ,  A61F2/966 ,  A61F2002/821 ,  A61F2002/828 ,  A61F2002/91575 ,  A61F2002/9583 ,  A61M1/3655

Abstract: Medical devices and methods for forming an arteriovenous (AV) fistula include a stent having an arterial tubular portion and vein supporting tongue connected by a pre-shaped connector and a venous frustoconical stent having a distal end for maintaining a take-off angle for the venous portion of the AV fistula. Also disclosed is an angled balloon for assisting with the formation of the AV fistula. The medical devices disclosed herein support an AV fistula formation having a desired take off angle of about 30 degrees, or between about 15 and 45 degrees.

Abstract translation: 用于形成动静脉（AV）瘘的医疗装置和方法包括具有动脉管状部分和通过预形连接器连接的静脉支撑舌片的支架和具有用于维持静脉的起飞角度的远端的静脉截头圆锥形支架 部分AV瘘。 还公开了一种用于辅助AV瘘形成的成角度的球囊。 本文公开的医疗装置支持AV瘘形成，其具有约30度或约15度至45度的期望的脱离角度。

公开(公告)号：USRE45744E1

公开(公告)日：2015-10-13

申请号：US14074543

申请日：2013-11-07

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： David C. Gale ,  Bin Huang ,  Anthony Abbate ,  Stephen D. Pacetti

IPC: A24B5/00 ,  A61F2/958 ,  A61L31/10 ,  A61L31/14 ,  B29B13/02 ,  B29C65/00 ,  B29C65/76 ,  B29C65/56 ,  B29C35/08 ,  B29C71/02 ,  B29K1/00 ,  B29K23/00 ,  B29K27/06 ,  B29K27/00 ,  B29K29/00 ,  B29K31/00 ,  B29K33/00 ,  B29K33/20 ,  B29K55/02 ,  B29K63/00 ,  B29K75/00 ,  B29K77/00 ,  B29K83/00 ,  B29L31/00 ,  A61F2/95

CPC classification number: A61F2/958 ,  A61F2002/9522 ,  A61L31/06 ,  A61L31/10 ,  A61L31/14 ,  B29B13/024 ,  B29C65/56 ,  B29C65/76 ,  B29C66/71 ,  B29C66/73117 ,  B29C66/9121 ,  B29C66/91431 ,  B29C66/91641 ,  B29C66/919 ,  B29C66/91921 ,  B29C66/91941 ,  B29C66/91945 ,  B29C2035/0822 ,  B29C2071/022 ,  B29K2001/00 ,  B29K2001/12 ,  B29K2023/00 ,  B29K2023/083 ,  B29K2023/086 ,  B29K2027/06 ,  B29K2027/08 ,  B29K2027/16 ,  B29K2029/00 ,  B29K2031/00 ,  B29K2033/08 ,  B29K2033/20 ,  B29K2055/02 ,  B29K2063/00 ,  B29K2075/00 ,  B29K2077/00 ,  B29K2083/00 ,  B29L2031/7542 ,  Y10T29/49865 ,  Y10T428/24942 ,  Y10T428/3154 ,  Y10T428/31544 ,  Y10T428/31855 ,  B29K2079/08 ,  B29K2071/00 ,  B29K2069/00 ,  B29K2067/04 ,  B29K2067/00 ,  B29K2059/00 ,  B29K2033/12 ,  B29K2025/08 ,  B29K2023/18 ,  B29K2023/08 ,  C08L67/04

Abstract: This disclosure describes a method for crimping a polymeric stent onto a catheter for percutaneous transluminal coronary angioplasty or other intraluminal interventions. The method comprises crimping the stent onto a catheter when the polymer is at a target temperature other than ambient temperature. The polymer can optionally comprise drug(s).

Abstract translation: 本公开描述了一种用于将聚合物支架卷曲到用于经皮冠状动脉腔内冠状动脉成形术或其他管腔内干预的导管上的方法。 该方法包括当聚合物处于不同于环境温度的目标温度时将支架卷曲到导管上。 聚合物可任选地包含药物。