公开(公告)号：US20110296925A1

公开(公告)日：2011-12-08

申请号：US12793459

申请日：2010-06-03

申请人： Keith A. Miesel ,  James M. Haase ,  Chris J. Paidosh ,  Darren A. Janzig ,  Timothy J. Denison

发明人： Keith A. Miesel ,  James M. Haase ,  Chris J. Paidosh ,  Darren A. Janzig ,  Timothy J. Denison

IPC分类号： G01L9/12 ,  H05K13/04

CPC分类号： G01L9/0072 ,  G01L19/142 ,  G01L19/143 ,  G01L19/147 ,  H01L2224/48472 ,  Y10T29/49002 ,  Y10T29/53265

摘要： The disclosure is directed to a capacitive pressure sensor, and the assembly of a capacitive pressure sensor, that may be used within an implantable medical pump. In one example, a housing ferrule that encloses one capacitive plate and includes at least one protrusion for attaching a support structure of the capacitive plate. The at least one protrusion defines a smaller inner diameter as a reference point for securing the support structure while the ferrule provides a larger inner diameter to allow the support structure to tilt inside the ferrule to orient the capacitive plate into a desired plane. Despite manufacturing irregularities, the capacitive plate can be mounted in the desired plane parallel to another capacitive plate, a diaphragm, mounted to an edge of the ferrule. In another example, an assembly tool provides a stage to orient the capacitive plate and support structure within the ferrule at a desired depth.

摘要翻译： 本公开涉及电容式压力传感器以及可在可植入医疗泵内使用的电容式压力传感器的组件。 在一个示例中，壳体套圈包围一个电容板并且包括用于附接电容板的支撑结构的至少一个突起。 所述至少一个突出部限定较小的内径作为用于固定支撑结构的参考点，同时套圈提供更大的内径以允许支撑结构在套圈内部倾斜以将电容板定向到期望的平面。 尽管制造不规则，但是电容板可以安装在平行于另一个电容板的所需平面中，该电容板安装在套圈的边缘上。 在另一示例中，组装工具提供了将电容板和支撑结构定位在套圈内的阶段，以期望的深度。

公开(公告)号：US20110267212A1

公开(公告)日：2011-11-03

申请号：US13182276

申请日：2011-07-13

申请人： Timothy J. Denison

发明人： Timothy J. Denison

IPC分类号： H03M99/00

CPC分类号： G01D5/24

摘要： This disclosure describes a capacitive interface circuit for a low power system. The capacitive interface circuit is configured to achieve very low noise sensing of capacitance-based transducers, such as a micro-electro-mechanical system (MEMS)-based sensor, with high resolution and low power. The capacitive interface circuit uses a differential amplifier and correlated triple sampling (CTS) to substantially eliminate, or at least reduce, kT/C noise, as well as amplifier offset and flicker (1/f) noise, from the output of the amplifier. The capacitive interface circuit may further include an output stage that reduces glitching, i.e., clock transients, in the output signal by allowing transients in the amplifier output to settle. In this manner, the circuit can be used in a low power system to produce a stable, low-noise output.

摘要翻译： 本公开描述了一种用于低功率系统的电容接口电路。 电容接口电路被配置为实现基于电容的换能器的非常低的噪声感测，例如具有高分辨率和低功率的基于微机电系统（MEMS）的传感器。 电容接口电路使用差分放大器和相关三倍采样（CTS）从放大器的输出基本上消除或至少降低kT / C噪声以及放大器偏移和闪烁（1 / f）噪声。 电容接口电路还可以包括通过允许放大器输出中的瞬变稳定来减少输出信号中的时钟瞬变的输出级。 以这种方式，电路可以用在低功率系统中以产生稳定的低噪声输出。

公开(公告)号：US08000789B2

公开(公告)日：2011-08-16

申请号：US11789453

申请日：2007-04-24

申请人： Timothy J. Denison

发明人： Timothy J. Denison

IPC分类号： A61N1/362

CPC分类号： G01D5/24

摘要： This disclosure describes a capacitive interface circuit for a low power system. The capacitive interface circuit is configured to achieve very low noise sensing of capacitance-based transducers, such as a micro-electro-mechanical system (MEMS)-based sensor, with high resolution and low power. The capacitive interface circuit uses a differential amplifier and correlated triple sampling (CTS) to substantially eliminate, or at least reduce, kT/C noise, as well as amplifier offset and flicker (1/f) noise, from the output of the amplifier. The capacitive interface circuit may further include an output stage that reduces glitching, i.e., clock transients, in the output signal by allowing transients in the amplifier output to settle. In this manner, the circuit can be used in a low power system to produce a stable, low-noise output.

摘要翻译： 本公开描述了一种用于低功率系统的电容接口电路。 电容接口电路被配置为实现基于电容的换能器的非常低的噪声感测，例如具有高分辨率和低功率的基于微机电系统（MEMS）的传感器。 电容接口电路使用差分放大器和相关三倍采样（CTS）从放大器的输出基本上消除或至少降低kT / C噪声以及放大器偏移和闪烁（1 / f）噪声。 电容接口电路还可以包括通过允许放大器输出中的瞬变稳定来减少输出信号中的时钟瞬变的输出级。 以这种方式，电路可以用在低功率系统中以产生稳定的低噪声输出。

公开(公告)号：US07847628B2

公开(公告)日：2010-12-07

申请号：US12121267

申请日：2008-05-15

申请人： Timothy J. Denison

发明人： Timothy J. Denison

IPC分类号： H03F1/02

CPC分类号： H03F3/38 ,  A61B5/04 ,  A61B5/053 ,  A61B5/7203 ,  A61B5/7217 ,  A61B5/7225 ,  A61B5/7228 ,  A61B5/7242

摘要： This disclosure describes a chopper stabilized instrumentation amplifier. The amplifier is configured to achieve stable measurements at low frequency with very low power consumption. The instrumentation amplifier uses a differential architecture and a mixer amplifier to substantially eliminate noise and offset from an output signal produced by the amplifier. Dynamic limitations, i.e., glitching, that result from chopper stabilization at low power are substantially eliminated through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the amplifier operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. The amplifier can be used in a low power system, such as an implantable medical device, to provide a stable, low-noise output signal.

摘要翻译： 本公开描述了一种斩波稳定仪表放大器。 放大器被配置为以低功耗实现稳定的低频测量。 仪表放大器使用差分架构和混频器放大器来基本上消除由放大器产生的输出信号的噪声和偏移。 通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除了在低功率下由斩波器稳定所产生的动态限制，即，短路。 放大器的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或外部信号的最小混叠进入信号通路。 该放大器可用于诸如可植入医疗设备的低功率系统中，以提供稳定的低噪声输出信号。

公开(公告)号：US20080211574A1

公开(公告)日：2008-09-04

申请号：US12121267

申请日：2008-05-15

申请人： Timothy J. Denison

发明人： Timothy J. Denison

IPC分类号： H03F1/02

CPC分类号： H03F3/38 ,  A61B5/04 ,  A61B5/053 ,  A61B5/7203 ,  A61B5/7217 ,  A61B5/7225 ,  A61B5/7228 ,  A61B5/7242

摘要： This disclosure describes a chopper stabilized instrumentation amplifier. The amplifier is configured to achieve stable measurements at low frequency with very low power consumption. The instrumentation amplifier uses a differential architecture and a mixer amplifier to substantially eliminate noise and offset from an output signal produced by the amplifier. Dynamic limitations, i.e., glitching, that result from chopper stabilization at low power are substantially eliminated through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the amplifier operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. The amplifier can be used in a low power system, such as an implantable medical device, to provide a stable, low-noise output signal.

摘要翻译： 本公开描述了一种斩波稳定仪表放大器。 放大器被配置为以低功耗实现稳定的低频测量。 仪表放大器使用差分架构和混频器放大器来基本上消除由放大器产生的输出信号的噪声和偏移。 通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除了在低功率下由斩波器稳定所产生的动态限制，即，短路。 放大器的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或外部信号的最小混叠进入信号通路。 该放大器可用于诸如可植入医疗设备的低功率系统中，以提供稳定的低噪声输出信号。

公开(公告)号：US09717439B2

公开(公告)日：2017-08-01

申请号：US12751508

申请日：2010-03-31

申请人： Jonathon E. Giftakis ,  Timothy J. Denison

发明人： Jonathon E. Giftakis ,  Timothy J. Denison

IPC分类号： A61B5/0476 ,  A61B5/11 ,  A61B5/00

CPC分类号： A61B5/0476 ,  A61B5/1116 ,  A61B5/4094 ,  A61B5/6823 ,  A61B5/6828 ,  A61B5/686 ,  A61B5/6868 ,  A61B5/742 ,  A61B5/7435 ,  A61B5/744 ,  A61B2560/0219 ,  A61B2562/043 ,  G06F19/00

摘要： The temporal correlation between a bioelectrical brain signal of a patient and patient motion data, such as a signal indicative of patient motion or a patient posture indicator, is displayed by a display device. In some examples, the patient posture indicator comprises a graphical representation of at least a portion of a body of the patient. In some examples, the temporal correlation between a bioelectrical brain signal, a signal indicative of patient motion, and a signal indicative of cardiac activity of the patient is displayed by the display device.

公开(公告)号：US09613184B2

公开(公告)日：2017-04-04

申请号：US12426065

申请日：2009-04-17

申请人： Jonathon E. Giftakis ,  Mark T. Rise ,  Paul H. Stypulkowski ,  Timothy J. Denison

发明人： Jonathon E. Giftakis ,  Mark T. Rise ,  Paul H. Stypulkowski ,  Timothy J. Denison

IPC分类号： A61N1/00 ,  G06F19/00 ,  A61M5/142 ,  A61N1/08 ,  A61N1/36 ,  A61M5/172 ,  A61N1/372

CPC分类号： G16H40/63 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/3561 ,  A61M2205/3592 ,  A61M2210/0693 ,  A61N1/08 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/37211 ,  G06F19/00 ,  G16H40/40

摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy dissipates. The washout period characteristic may include, for example, a duration of the washout period, an amplitude or a trend in a physiological signal during the washout period or a power level or a ratio of power levels in frequency bands of the physiological signal. In some embodiments, washout period characteristics associated with a plurality of therapy programs may be used to compare the programs. In other embodiments, a washout period characteristic may be used to determine a mood state of the patient and, in some cases, modify a therapy program. Monitoring a washout period may also be useful for timing therapy program trials.

公开(公告)号：US09072870B2

公开(公告)日：2015-07-07

申请号：US12238105

申请日：2008-09-25

申请人： Jianping Wu ,  Gregory F. Molnar ,  Gabriela C. Miyazawa ,  Timothy J. Denison

发明人： Jianping Wu ,  Gregory F. Molnar ,  Gabriela C. Miyazawa ,  Timothy J. Denison

IPC分类号： A61N1/00 ,  A61N1/08 ,  A61M21/02 ,  A61B5/00 ,  A61B5/04 ,  A61B5/048 ,  A61M21/00 ,  G06F19/00

CPC分类号： A61B5/4812 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/024 ,  A61B5/04014 ,  A61B5/04015 ,  A61B5/0402 ,  A61B5/0478 ,  A61B5/048 ,  A61B5/1116 ,  A61B5/1118 ,  A61B5/4082 ,  A61B5/4839 ,  A61M5/1723 ,  A61M21/02 ,  A61M2005/1726 ,  A61M2021/0072 ,  A61M2205/3523 ,  A61M2205/3553 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/04 ,  A61M2230/08 ,  A61M2230/10 ,  A61M2230/205 ,  A61M2230/30 ,  A61M2230/42 ,  A61M2230/50 ,  A61M2230/60 ,  A61M2230/63 ,  A61M2230/65 ,  A61N1/36078 ,  A61N1/36139 ,  G06F19/3481 ,  G16H40/63

摘要： Therapy delivery to a patient may be controlled based on a determined sleep stage of the patient. In examples, the sleep stage may be determined based on a frequency characteristic of a biosignal indicative of brain activity of the patient. A frequency characteristic may include, for example, a power level within one or more frequency bands of the biosignal, a ratio of the power level in two or more frequency bands, or a pattern in the power level of one or more frequency bands over time. A therapy program may be selected or modified based on the sleep stage determination. Therapy may be delivered during the sleep stage according to the selected or modified therapy program. In some examples, therapy delivery may be controlled after making separate determinations of a sleep stage based on the biosignal and another physiological parameter, and confirming that the sleep stage determinations are consistent.

摘要翻译： 可以基于患者的确定的睡眠阶段来控制对患者的治疗递送。 在实施例中，睡眠阶段可以基于指示患者的大脑活动的生物信号的频率特性来确定。 频率特性可以包括例如生物信号的一个或多个频带内的功率电平，两个或更多个频带中的功率电平的比率，或者一个或多个频带的功率电平中的模式随时间的变化 。 可以基于睡眠阶段确定来选择或修改治疗程序。 根据所选择或修改的治疗方案，治疗可以在睡眠阶段期间递送。 在一些实例中，可以在基于生物信号和另一生理参数进行睡眠阶段的单独测定以及确认睡眠阶段确定是一致的之后控制治疗递送。

公开(公告)号：US08594779B2

公开(公告)日：2013-11-26

申请号：US11799031

申请日：2007-04-30

申请人： Timothy J. Denison ,  Wesley A. Santa

发明人： Timothy J. Denison ,  Wesley A. Santa

IPC分类号： A61B5/04 ,  A61B5/00

CPC分类号： A61B5/053 ,  A61B5/024 ,  A61B5/0402 ,  A61B5/0478 ,  A61B5/0488 ,  A61B5/4094 ,  A61B5/4839 ,  A61B5/7203 ,  A61B5/7225 ,  A61B5/7228 ,  A61B5/7275 ,  A61N1/08 ,  A61N1/36025 ,  A61N1/36082 ,  G06F19/00

摘要： Seizure prediction systems and methods include measuring impedance and a potential within a brain of a patient to determine whether the brain is in a state indicative of a possibility of seizure. In some embodiments, at least one of the measured impedance or the measured potential may be used as a primary indication of the brain state indicative of a possibility of seizure. In one embodiment, if one of the measured impedance or the measured potential indicates a seizure, the other measurement (impedance or potential) may be used to validate whether the brain is in the state indicative of the possibility of seizure.

摘要翻译： 缉获预测系统和方法包括测量患者的脑中的阻抗和潜力，以确定大脑是否处于指示癫痫发作可能性的状态。 在一些实施例中，测量的阻抗或测量电位中的至少一个可以用作指示发作可能性的脑状态的主要指示。 在一个实施例中，如果所测量的阻抗或测量的电位之一表示发作，则可以使用另一测量（阻抗或电位）来验证大脑是否处于表示发作可能性的状态。

公开(公告)号：US08554325B2

公开(公告)日：2013-10-08

申请号：US13345397

申请日：2012-01-06

申请人： Gregory F. Molnar ,  Steven S. Gill ,  Keith A. Miesel ,  Mark S. Lent ,  Timothy J. Denison ,  Eric J. Panken ,  Carl D. Wahlstrand ,  Jonathan C. Werder

发明人： Gregory F. Molnar ,  Steven S. Gill ,  Keith A. Miesel ,  Mark S. Lent ,  Timothy J. Denison ,  Eric J. Panken ,  Carl D. Wahlstrand ,  Jonathan C. Werder

IPC分类号： A61N1/18

CPC分类号： A61B5/04014 ,  A61B5/0006 ,  A61B5/4082 ,  A61B5/6814 ,  A61N1/36003 ,  A61N1/36014 ,  A61N1/36025 ,  A61N1/36067 ,  A61N1/36082

摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.

摘要翻译： 基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。 在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。 运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。 在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。 在一些示例中，在检测到患者不再处于运动状态或患者已成功启动运动时，治疗递送被停用。 此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。