公开(公告)号：US07774047B2

公开(公告)日：2010-08-10

申请号：US11371916

申请日：2006-03-10

申请人： Yuichi Yamashita ,  Atsushi Maki ,  Hideaki Koizumi

发明人： Yuichi Yamashita ,  Atsushi Maki ,  Hideaki Koizumi

IPC分类号： A61B6/00

CPC分类号： A61B5/14546 ,  A61B5/14553 ,  A61B2562/0233 ,  A61B2562/0242 ,  A61B2562/046 ,  G01N21/35 ,  G01N21/4795

摘要： An optical measurement instrument for a living body to measure dynamic change of blood of a brain includes light incident units for irradiating light on a head of a subject, a light detector for detecting a light irradiated from the light incident units and reflected within the subject, a signal processing unit for calculating a spacious distribution of signals from the subject to be measured from a signal detected by the light detector, and a display for displaying the spacious distribution of signals from the subject to be measured. Measurement points are arranged about a middle of the light incident units and the light detector, and the light incident units and the light detector are arranged such that the measurement points are arranged to form a lattice whose circumference is square.

摘要翻译： 用于测量大脑血液动态变化的生物体的光学测量仪器包括用于照射被检体头部的光入射单元，用于检测从光入射单元照射并在被检体内反射的光的光检测器， 信号处理单元，用于根据由光检测器检测到的信号计算来自待测对象的信号的宽敞分布;以及显示器，用于显示来自待测对象的信号的宽敞分布。 测量点围绕光入射单元和光检测器的中间布置，并且光​​入射单元和光检测器被布置成使得测量点被布置成形成圆周为正方形的格子。

公开(公告)号：US07645983B2

公开(公告)日：2010-01-12

申请号：US10139241

申请日：2002-05-07

申请人： Atsumu Hirabayashi ,  Minoru Sakairi ,  Yasuaki Takada ,  Hideaki Koizumi ,  Kaoru Umemura

发明人： Atsumu Hirabayashi ,  Minoru Sakairi ,  Yasuaki Takada ,  Hideaki Koizumi ,  Kaoru Umemura

IPC分类号： H01J49/00

CPC分类号： H01J49/045

摘要： An ion source includes a body having a gas passage and an orifice. A capillary is inserted into the gas passage so that a tip portion of the capillary extends into the orifice. A gas supplier supplies a gas into the gas passage to form a gas flow through the gas passage along the capillary and through the orifice past a tip of the capillary so that the gas flow sprays a sample solution flowing through the capillary from the tip of the capillary. A flow controller regulates a pressure of the gas in the gas passage to adjust a characteristic value F/S to a predetermined value, where F is a flow rate of the gas flow at standard conditions (20° C., 1 atmosphere), and S is a difference between a cross section of the orifice and a cross section of the tip portion of the capillary in the orifice.

摘要翻译： 离子源包括具有气体通道和孔的主体。 毛细管插入到气体通道中，使得毛细管的尖端部分延伸到孔中。 气体供应商将气体供应到气体通道中以形成沿着毛细管的气体通道的气流，并且通过孔经过毛细管的尖端，使得气流从其中的尖端喷射流过毛细管的样品溶液 毛细管。 流量控制器调节气体通道中的气体的压力，以将特征值F / S调节到预定值，其中F是在标准条件（20℃，1个大气压）下气流的流量，以及 S是孔口的截面与孔口中的毛细管的尖端部分的横截面之间的差异。

公开(公告)号：US07440794B2

公开(公告)日：2008-10-21

申请号：US11037282

申请日：2005-01-19

申请人： Atsushi Maki ,  Hideaki Koizumi ,  Fumio Kawaguchi ,  Yuichi Yamashita ,  Yoshitoshi Ito

发明人： Atsushi Maki ,  Hideaki Koizumi ,  Fumio Kawaguchi ,  Yuichi Yamashita ,  Yoshitoshi Ito

IPC分类号： A61B5/00

CPC分类号： A61B5/0059 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/14552 ,  A61B5/14553 ,  A61B5/18 ,  A61B5/6814 ,  A61B5/7207 ,  A61B5/7228 ,  A61B6/03 ,  A61B6/507 ,  A61B2562/0219 ,  A61B2562/0233 ,  A61B2562/046

摘要： In an optical measurement system and imaging method adapted to measure in vivo information in a living body without harming the living body, light rays of a plurality of wavelengths which are modulated in intensity with a plurality of different frequencies are irradiated on a plurality of irradiation positions on the surface of a living body, and time-variable changes in living body transmitting light intensity levels corresponding to the respective wavelengths and the respective irradiation positions are measured at different positions on the surface of the living body. Light is utilized to image the results of the measurements, in which the measuring time is shortened by estimating fluctuation attributable to the living body, and the presence or absence of a change in measured signal can be decided easily by displaying an estimation signal and a measured signal at a time.

摘要翻译： 在适于测量活体内的体内信息而不损害生物体的光学测量系统和成像方法中，以多个不同频率强度调制的多个波长的光线照射在多个照射位置 在生物体的表面上，在生物体的表面的不同位置测量发射对应于各个波长和各个照射位置的光强度水平的生物体的随时间变化。 光被用于对测量结果进行成像，其中通过估计归因于生物体的波动来缩短测量时间，并且可以通过显示估计信号和测量的信号来容易地确定测量信号的变化的存在或不存在 信号一次。

公开(公告)号：US07359825B2

公开(公告)日：2008-04-15

申请号：US11378448

申请日：2006-03-20

申请人： Atsushi Maki ,  Yuuichi Yamashita ,  Tsuyoshi Yamamoto ,  Hideaki Koizumi

发明人： Atsushi Maki ,  Yuuichi Yamashita ,  Tsuyoshi Yamamoto ,  Hideaki Koizumi

IPC分类号： G01C17/00

CPC分类号： G01N21/49 ,  A61B5/0042 ,  A61B5/14553 ,  A61B5/7435

摘要： In order to provide an optical measurement system and an optical measurement method which is suitable for optically measuring a body to be inspected and easily obtaining an image of a desired item based on information obtained by the measurement, an optical measurement method including an initial display process for selectively instructing any one of selection of optical measurement, analysis of said optical measurement result and completion of a program; a process for inputting items of condition including a measurement mode; a process for displaying a light irradiation position and a light detection position and a state expressing measurement position relationship together with said mode; a process for instructing to form a file for storing said optical measurement result; a process for instructing a measurement condition to detect light signals from the inside of a body to be inspected which is irradiated by a multi-wavelength multi-channel; and a process for displaying said signals for each channel detected according to said instructed result.

摘要翻译： 为了提供一种光学测量系统和光学测量方法，该光学测量系统和光学测量方法适合于光学测量待检查的物体，并且基于通过测量获得的信息容易地获得期望项目的图像，包括初始显示处理 用于选择性地指示光学测量的选择，所述光学测量结果的分析和程序的完成中的任何一个; 用于输入包括测量模式的条件项目的处理; 用于显示光照射位置和光检测位置以及表示测量位置关系的状态与所述模式的过程; 用于指示形成用于存储所述光学测量结果的文件的处理; 用于指示测量条件从多波长多通道照射的被检体的内部检测光信号的处理; 以及用于显示根据所述指示结果检测的每个通道的所述信号的处理。

公开(公告)号：US07072700B2

公开(公告)日：2006-07-04

申请号：US10148991

申请日：2000-11-29

申请人： Tsuyoshi Yamamoto ,  Atsushi Maki ,  Hideaki Koizumi ,  Fumio Kawaguchi ,  Michiyuki Fujiwara ,  Mikihiro Kaga

发明人： Tsuyoshi Yamamoto ,  Atsushi Maki ,  Hideaki Koizumi ,  Fumio Kawaguchi ,  Michiyuki Fujiwara ,  Mikihiro Kaga

IPC分类号： A61B5/00

CPC分类号： A61B5/14546 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/14553 ,  A61B2562/0233 ,  A61B2562/046

摘要： The invention provides a biological photometric device characterized by a method of disposing a light source and a light detector, capable of measuring a distribution of concentrations at different depths and changes in the concentration in the case of measuring and forming an image of the concentration of metabolites in an organ and changes in the concentration. The light sources and light detectors are disposed on the subject so that, in the case of measuring a concentration of metabolites in an organ and changes in the concentration in a shallow portion in the subject by using an about midpoint position between each of the light sources and each of the light detectors as a sampling point, measurement is performed by using a sampling point of a pair of the light source and said light detector which are disposed at a small interval. In the case of measurement in a deep portion in the subject, a sampling point of a pair of the light source and the light detector which are disposed at a large interval is used.

公开(公告)号：US07047149B1

公开(公告)日：2006-05-16

申请号：US09674008

申请日：1999-04-26

申请人： Atsushi Maki ,  Yuuichi Yamashita ,  Tsuyoshi Yamamoto ,  Hideaki Koizumi

发明人： Atsushi Maki ,  Yuuichi Yamashita ,  Tsuyoshi Yamamoto ,  Hideaki Koizumi

IPC分类号： G01C17/00

CPC分类号： G01N21/49 ,  A61B5/0042 ,  A61B5/14553 ,  A61B5/7435

摘要： An optical measurement system for optically measuring a body to be inspected and obtaining an image of a desired item based on information obtained by the measurement includes means for displaying a number of measurement points, means for indicating a light irradiation position and a light detecting position and means for displaying a measurement position and a state of allocating a number to the measurement position. The system further includes means for displaying measuring time sequence data, means for setting a condition of acquiring data, means for displaying a status of acquiring the data, means for instructing control of measurement and means for marking a mark at a position measuring time sequence data.

摘要翻译： 一种光学测量系统，用于光学测量待检查的物体，并且基于通过测量获得的信息获得期望项目的图像，包括显示多个测量点的装置，用于指示光照射位置和光检测位置的装置，以及 用于显示测量位置和向测量位置分配数字的状态的装置。 该系统还包括用于显示测量时间序列数据的装置，用于设置获取数据的条件的装置，用于显示获取数据的状态的装置，用于指示测量的控制的装置和用于在测量时间序列数据的位置处标记标记的装置 。

公开(公告)号：US06901284B1

公开(公告)日：2005-05-31

申请号：US09913323

申请日：2000-02-18

申请人： Atsushi Maki ,  Tsuyoshi Yamamoto ,  Hideaki Koizumi ,  Yuichi Yamashita

发明人： Atsushi Maki ,  Tsuyoshi Yamamoto ,  Hideaki Koizumi ,  Yuichi Yamashita

IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B6/00 ,  G01N21/17

CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B5/7445 ,  A61B2562/0233 ,  A61B2562/046

摘要： An optical measuring apparatus for optically measuring a sample includes a plurality of parts for applying light beams to the sample, a plurality of detecting parts for detecting light beams from the light applying parts which come through the sample, a memory part which receives signals from the detecting parts, converts them into digital signals and stores the digital signals as measuring positions between the light applying part and the light detecting part. Further, there is provided a first display part which shows a relationship between positions on the sample and measuring positions corresponding to the positions of the detecting parts on the sample, and a second display part which shows a relationship between positions on the sample and measuring positions corresponding to the positions of the detecting parts which are shown on the first display part.

摘要翻译： 用于光学测量样品的光学测量装置包括用于向样品施加光束的多个部件，用于检测来自样品的光施加部分的光束的多个检测部分， 检测部件将它们转换为数字信号，并将数字信号存储在光施加部分和光检测部分之间的测量位置。 此外，提供了示出样品上的位置与样品上检测部位的位置对应的测量位置之间的关系的第一显示部分和示出样品和测量位置之间的关系的第二显示部分 对应于在第一显示部分上示出的检测部件的位置。

公开(公告)号：US06787017B1

公开(公告)日：2004-09-07

申请号：US09806913

申请日：2001-04-06

申请人： Atsumu Hirabayashi ,  Yukiko Hirabayashi ,  Akihiko Okumura ,  Hideaki Koizumi

发明人： Atsumu Hirabayashi ,  Yukiko Hirabayashi ,  Akihiko Okumura ,  Hideaki Koizumi

IPC分类号： G01N27447

CPC分类号： G01N27/44791 ,  G01N27/44704

摘要： The capillary electrophoresis system includes a wafer-shaped part having passages filled with a buffer solution for introducing sample solutions; a body having a configuration suitable to removably hold and to move the wafer-shaped part. The body includes first and second electrodes for applying a voltage across both ends of passages of the wafer-shaped part to separate and remove the sample solution. The body also includes first and second buffer reservoirs conductive to passages of the wafer-shaped part at specific positions for filling buffer solution around the first and second electrodes. The system according to the present invention facilitates washing of electrophoresis passages and reduces the time and labor costs required for replacement of the fused-silica wafers and simplifies operation by allowing a plurality of sample solutions to be analyzed more quickly.

摘要翻译： 毛细管电泳系统包括具有填充有用于引入样品溶液的缓冲溶液的通道的晶片状部件; 具有适于可移除地保持和移动晶片形部分的构造的本体。 本体包括第一和第二电极，用于跨晶片形部分的通道的两端施加电压以分离和去除样品溶液。 身体还包括第一和第二缓冲储存器，其导电到晶片状部分在特定位置处的通道，用于在第一和第二电极周围填充缓冲溶液。 根据本发明的系统有助于电泳通道的洗涤，并且减少了更换熔凝石英晶片所需的时间和人力成本，并且通过允许更快速地分析多个样品溶液来简化操作。

公开(公告)号：US06774359B1

公开(公告)日：2004-08-10

申请号：US09762276

申请日：2001-02-06

申请人： Yukiko Hirabayashi ,  Atsumu Hirabayashi ,  Akihiko Okumura ,  Hideaki Koizumi

发明人： Yukiko Hirabayashi ,  Atsumu Hirabayashi ,  Akihiko Okumura ,  Hideaki Koizumi

IPC分类号： G01N2306

CPC分类号： H01J49/04 ,  B01F5/0413 ,  B01F13/0059 ,  B01L3/5027 ,  G01N35/085

摘要： In a sample-introduction tool in which an end of a passage is connected to a reservoir for storing a mobile phase solution, a sample-dropping orifice is provided at the passage and the mobile phase solution and a sample running off from the other end of the passage are introduced into a mass spectrometer by generating a high-speed gas stream around the other end of the passage. The mobile phase solution and the sample are nebulized by the high-speed gas stream, and the injected sample is ionized.

摘要翻译： 在其中通道的端部连接到用于存储流动相溶液的储存器的样品引入工具中，在通道和流动相溶液处提供了一个抽样孔，并且从另一端流出的样品 通过在通道的另一端周围产生高速气流将通道引入质谱仪。 流动相溶液和样品被高速气流雾化，注入的样品离子化。

公开(公告)号：US06542763B1

公开(公告)日：2003-04-01

申请号：US09697327

申请日：2000-10-27

申请人： Yuichi Yamashita ,  Atsushi Maki ,  Tsuyoshi Yamamoto ,  Hideaki Koizumi ,  Fumio Kawaguchi

发明人： Yuichi Yamashita ,  Atsushi Maki ,  Tsuyoshi Yamamoto ,  Hideaki Koizumi ,  Fumio Kawaguchi

IPC分类号： A61B500

CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B5/0059 ,  A61B2562/02 ,  A61B2562/0233 ,  A61B2562/046

摘要： In a system for performing imaging measurement of a test object by mounting many optical fibers to the test object, incident positions of the test object on which to illuminate light, detection positions of the test object from which to detect light and measurement positions which are determined from a positional relationship between the incident positions and the detection positions are displayed as graphic elements on a display unit. A state of detection signal level or a change in the state is displayed as a change in color or in pattern of the graphic element. Further, incident optical fibers for illuminating light to the test object and detection optical fibers for detecting light from the test object are mounted to the test object, and light emitting elements are mounted to probes to be mounted to the test object and interlocked with the change of the graphic elements.

摘要翻译： 在用于通过将许多光纤安装到测试对象上来进行测试对象的成像测量的系统中，用于照亮光的测试对象的入射位置，检测光的测试对象的检测位置和确定的测量位置 根据入射位置与检测位置之间的位置关系在显示单元上显示为图形元素。 检测信号电平状态或状态变化被显示为图形元素的颜色或图案的变化。 此外，将用于向测试对象照射光的入射光纤和用于检测来自测试对象的光的检测光纤安装在测试对象上，并且将发光元件安装到要安装到测试对象上的探针并与变化互锁 的图形元素。