公开(公告)号：US07309359B2

公开(公告)日：2007-12-18

申请号：US10645006

申请日：2003-08-21

申请人： Hai H. Trieu ,  William F. McKay ,  Michael C. Sherman ,  Jon C. Serbousek

发明人： Hai H. Trieu ,  William F. McKay ,  Michael C. Sherman ,  Jon C. Serbousek

IPC分类号： A61F2/44

CPC分类号： A61L27/3683 ,  A61F2/08 ,  A61F2/442 ,  A61F2002/30075 ,  A61F2002/30214 ,  A61F2002/30224 ,  A61F2002/30293 ,  A61F2002/30448 ,  A61F2002/30459 ,  A61F2002/30461 ,  A61F2002/30677 ,  A61F2002/30971 ,  A61F2002/4435 ,  A61F2002/444 ,  A61F2002/445 ,  A61F2210/0061 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0091 ,  A61L27/3604 ,  A61L27/3612 ,  A61L27/3658 ,  A61L2430/38 ,  Y10S623/908 ,  Y10S623/919 ,  Y10S623/923

摘要： Allogenic or xenogenic materials are used to provide intervertebral disc nucleus implants and/or annular plugs. The allogenic or xenogenic materials comprise natural disc annulus material, which may have a portion of the anterior longitudinal ligament attached. The tissue may be used “as is” without an additional core or covering, or it may be used in combination with other materials. The material may be rolled, folded, layered and/or sutured, stapled, or glued to provide a solid plug of natural biological material. The implant may be provided as a dehydrated, substantially rod-shaped segment having a diameter less than the diameter of the hydrated material, and may have one or more ends of the dehydrated rod terminate with a further reduced diameter portion, preferably a point.

摘要翻译： 同种异体或异种材料用于提供椎间盘核植入物和/或环形塞。 同种异体或异种材料包括天然椎间盘环形材料，其可以具有连接的前纵韧带的一部分。 组织可以“原样”使用而没有附加的芯或覆盖物，或者可以与其它材料组合使用。 该材料可以被卷起，折叠，分层和/或缝合，缝合或胶合以提供天然生物材料的固体塞子。 植入物可以被提供为具有直径小于水合材料直径的脱水的，基本上为棒状的段，并且可以具有脱水杆的一个或多个端部以另外的直径缩小部分，优选地点终止。

公开(公告)号：US20070259018A1

公开(公告)日：2007-11-08

申请号：US11595087

申请日：2006-11-09

申请人： William F. McKay

发明人： William F. McKay

IPC分类号： A61K38/18 ,  A61F2/02

CPC分类号： A61L27/227 ,  A61K9/0024 ,  A61L27/24 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/604 ,  C08L89/06

摘要： The present invention relates to the design and composition of a depot implant for optimal delivery of growth factors to treat bone avascular necrosis, in that such depot implant is constructed to be in a cylinder (rod) or sphere shape and have a natural or synthetic polymer scaffold with or without impregnated calcium phosphate particles. The density of the depot is higher than a typical BMP sponge carrier to facilitate it's implantation and slower release of the growth factor. The scaffold is such that it has adequate porosity and pore size to facilitate growth factor seeding and diffusion throughout the whole of the bone structure resulting in increased new blood vessel growth and density in the avascular necrotic bone. In addition, the shape of the depot implant allows for delivery through a cannula or large bore needle.

摘要翻译： 本发明涉及用于最佳递送生长因子以治疗骨无血管性坏死的贮库植入物的设计和组成，因为这种储存植入物构造为圆柱体（棒）或球形，并且具有天然或合成聚合物 含有或不含浸渍磷酸钙颗粒的支架。 仓库的密度高于典型的BMP海绵载体，以便于其植入和较慢释放生长因子。 支架具有足够的孔隙度和孔径以促进整个骨结构中的生长因子接种和扩散，导致无血管坏死骨中新血管生长和密度增加。 此外，储库植入物的形状允许通过套管或大孔针进行输送。

公开(公告)号：US06890728B2

公开(公告)日：2005-05-10

申请号：US10116729

申请日：2002-04-04

申请人： Victor D. Dolecek ,  Jeffery C. Marx ,  William F. McKay

发明人： Victor D. Dolecek ,  Jeffery C. Marx ,  William F. McKay

IPC分类号： C12N15/09 ,  A61K35/12 ,  A61K35/14 ,  A61K35/15 ,  A61K35/19 ,  A61K48/00 ,  A61L27/00 ,  A61M1/02 ,  A61M1/36 ,  A61P19/10 ,  B04B5/00 ,  B04B5/04 ,  B04B11/02 ,  C12N5/08 ,  C12N5/10 ,  G01N1/30 ,  A01N1/02

CPC分类号： A61K35/19 ,  A61K35/15 ,  A61M1/3616 ,  A61M1/3618 ,  A61M1/3693 ,  A61M1/3696 ,  A61M2202/045 ,  A61M2202/10 ,  B04B5/0428 ,  B04B5/0442 ,  B04B2005/045

摘要： Methods and apparatuses for the separation a predetermined cellular component from a bodily fluid or tissue by centrifugation are provided. More specifically, this invention provides a method for the separation and isolation of one or more components, such as stem cells, buffy coat, bone marrow cells, erythrocytes, leukocytes, thrombocytes, serum, fluorescently labeled cells, and magnetically labeled cells, from whole blood, bone marrow, buffy coat, fat tissue, muscle tissue, and nerve tissue by centrifugation, wherein the components are isolated while the centrifuge is rotating.

摘要翻译： 提供了通过离心从体液或组织分离预定的细胞组分的方法和装置。 更具体地说，本发明提供了从整体分离和分离一种或多种组分如干细胞，血沉棕黄层，骨髓细胞，红细胞，白细胞，血小板，血清，荧光标记细胞和磁性标记细胞的方法 血液，骨髓，血沉棕黄层，脂肪组织，肌肉组织和神经组织，其中在离心机旋转时分离组分。

公开(公告)号：US06780192B2

公开(公告)日：2004-08-24

申请号：US10040154

申请日：2001-10-22

申请人： William F. McKay ,  Bradley T. Estes

发明人： William F. McKay ,  Bradley T. Estes

IPC分类号： A61B1790

CPC分类号： A61F2/4611 ,  A61B2090/062 ,  A61F2/442 ,  A61F2/446 ,  A61F2/4601 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30225 ,  A61F2002/30329 ,  A61F2002/30405 ,  A61F2002/30616 ,  A61F2002/30785 ,  A61F2002/30797 ,  A61F2002/3082 ,  A61F2002/3085 ,  A61F2002/4602 ,  A61F2002/4623 ,  A61F2002/4627 ,  A61F2002/4662 ,  A61F2220/0025 ,  A61F2230/0069 ,  A61F2250/0064

摘要： An osteogenic material packing device is used to pack osteogenic material onto a spinal fusion device. The packing device has a cavity defined therein, which is adapted to receive the spinal fusion device. The packing device further includes an access port, which intersects the cavity to receive the osteogenic material. A cannula is coupled to the packing device and an inserter is coupled to the fusion device in order to insert the fusion device into the packing device. Osteogenic material is packed through the access port around the fusion device. The fusion device then is slid through the cannula and inserted in the intervertebral space between adjacent vertebrae.

公开(公告)号：US06398811B1

公开(公告)日：2002-06-04

申请号：US09873025

申请日：2001-06-01

申请人： William F. McKay

发明人： William F. McKay

IPC分类号： A61F244

CPC分类号： A61L27/3608 ,  A61F2/30724 ,  A61F2/3094 ,  A61F2/30965 ,  A61F2/442 ,  A61F2/446 ,  A61F2/4465 ,  A61F2/447 ,  A61F2/4611 ,  A61F2/4644 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/2839 ,  A61F2002/30004 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30228 ,  A61F2002/30235 ,  A61F2002/30271 ,  A61F2002/30583 ,  A61F2002/30596 ,  A61F2002/30617 ,  A61F2002/30733 ,  A61F2002/30772 ,  A61F2002/30785 ,  A61F2002/30789 ,  A61F2002/30795 ,  A61F2002/3082 ,  A61F2002/30822 ,  A61F2002/30823 ,  A61F2002/30827 ,  A61F2002/3085 ,  A61F2002/4475 ,  A61F2002/4649 ,  A61F2210/0085 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2250/0014 ,  A61F2250/0097 ,  A61F2310/00011 ,  A61F2310/00179 ,  A61F2310/00293 ,  A61F2310/00353 ,  A61L27/14 ,  A61L27/36 ,  A61L27/3658 ,  A61L27/54 ,  A61L2430/38

摘要： Described are intervertebral spacer assemblies having reinforcing members or space-filling members. Also described are methods for fabricating intervertebral spacers, as well as methods for fusing adjacent vertebrae utilizing intervertebral spacers of the present invention.

摘要翻译： 描述的是具有加强构件或空间填充构件的椎间间隔件组件。 还描述了用于制造椎间隔垫的方法，以及利用本发明的椎间间隔件来融合相邻椎骨的方法。

公开(公告)号：US5984967A

公开(公告)日：1999-11-16

申请号：US603674

申请日：1996-02-19

申请人： Thomas Zdeblick ,  William F. McKay

发明人： Thomas Zdeblick ,  William F. McKay

IPC分类号： A61B17/56 ,  A61B17/16 ,  A61B17/58 ,  A61B17/70 ,  A61B17/88 ,  A61F20060101 ,  A61F2/00 ,  A61F2/28 ,  A61F2/30 ,  A61F2/44 ,  A61F2/46 ,  A61L27/00 ,  A61L27/22 ,  A61L31/04

CPC分类号： A61B17/1671 ,  A61F2/4455 ,  A61F2/446 ,  A61F2/4611 ,  A61F2/4637 ,  A61L27/227 ,  A61L31/047 ,  A61B17/8883 ,  A61B17/8891 ,  A61F2/30744 ,  A61F2/30767 ,  A61F2/442 ,  A61F2002/2835 ,  A61F2002/30136 ,  A61F2002/30143 ,  A61F2002/30153 ,  A61F2002/30158 ,  A61F2002/3021 ,  A61F2002/30217 ,  A61F2002/30504 ,  A61F2002/30774 ,  A61F2002/30777 ,  A61F2002/30785 ,  A61F2002/3082 ,  A61F2002/3085 ,  A61F2002/30858 ,  A61F2002/30874 ,  A61F2002/4475 ,  A61F2002/448 ,  A61F2002/464 ,  A61F2002/4641 ,  A61F2220/0025 ,  A61F2230/0004 ,  A61F2230/0017 ,  A61F2230/0019 ,  A61F2230/0026 ,  A61F2230/0067 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00095 ,  A61F2310/00131 ,  A61F2310/00161 ,  A61F2310/00179 ,  A61F2310/00796 ,  A61L2430/38

摘要： An interbody fusion device in one embodiment includes a tapered body defining a hollow interior for receiving bone graft or bone substitute material. The body defines exterior threads which are interrupted over portions of the outer surface of the device. The fusion device includes truncated side walls so that on end view the body takes on a cylindrical form. The side walls are provided with vascularization openings, and the body wall device includes opposite bone ingrowth slots extending through the interrupted thread portion of the body. In another embodiment, the tapered body is solid and formed of a porous biocompatible material having sufficient structural integrity to maintain the intradiscal space and normal curvature. The material is preferably a porous tantalum having fully interconnected pores to facilitate complete bone tissue ingrowth into the implant. In further embodiments, the fusion devices are provided with osteogenic material to facilitate bone ingrowth. The osteogenic material can include bone morphogenic proteins in a suitable carrier determined by the configuration of the fusion device.

摘要翻译： 在一个实施例中的体内融合装置包括限定用于接收骨移植物或骨替代材料的中空内部的锥体。 主体限定了在装置的外表面的部分上被中断的外螺纹。 融合装置包括截顶侧壁，使得在端部视图上，身体呈圆柱形。 侧壁设置有血管化开口，并且身体壁装置包括延伸穿过身体的中断螺纹部分的相对的骨向内生长槽。 在另一个实施例中，锥形体是固体的并由具有足够结构完整性的多孔生物相容性材料形成，以保持椎间盘内空间和正常曲率。 该材料优选是具有完全相互连接的孔的多孔钽，以促进完整的骨组织向植入物中向内生长。 在另外的实施方案中，融合装置设有成骨材料以促进骨向内生长。 成骨材料可包括通过融合装置的构型确定的合适载体中的骨形态发生蛋白。

公开(公告)号：US5885291A

公开(公告)日：1999-03-23

申请号：US939791

申请日：1997-09-29

申请人： Peter A. Moskovitz ,  Scott Boden ,  William F. McKay ,  Joseph Moctezuma

发明人： Peter A. Moskovitz ,  Scott Boden ,  William F. McKay ,  Joseph Moctezuma

IPC分类号： A61B17/00 ,  A61B17/02 ,  A61B17/16 ,  A61B17/32 ,  A61B18/14 ,  A61F2/00 ,  A61F2/02 ,  A61F2/28 ,  A61F2/44 ,  A61F2/46

CPC分类号： A61F2/4611 ,  A61B17/02 ,  A61B17/0206 ,  A61B17/025 ,  A61B17/1604 ,  A61B17/1606 ,  A61B17/1608 ,  A61B17/1637 ,  A61F2/4455 ,  A61F2/4601 ,  A61B18/1442 ,  A61B2017/00261 ,  A61B2017/0042 ,  A61B2017/0256 ,  A61B2017/320044 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30153 ,  A61F2002/30261 ,  A61F2002/4623 ,  A61F2002/4635 ,  A61F2002/4649 ,  A61F2210/0004 ,  A61F2230/0019 ,  A61F2230/0082 ,  A61F2310/00293 ,  Y10S606/907

摘要： Minimally invasive spinal surgical techniques and tools are provided. The methods include separating the iliocostalis lumborum muscle from the anterior leaf of the thoracolumbar fascia to create a channel from the patient's skin to the intertransverse interval. In one embodiment, the method also includes delivering graft material through the channel to the intertransverse interval. A device according to one aspect of the present invention includes a retraction portion having a flattened plate configured to atraumatically retract tissue to create a working space within an endosurgical site and a curved shaft attached to the retraction portion. The shaft includes a bend having a radius of preferably 160 degrees. A gripping portion is attached to the shaft and is configured for manually gripping and manipulating the device.

摘要翻译： 提供微创脊柱外科技术和工具。 这些方法包括从胸腰肌筋膜前叶分离髂骨肌肉肌肉，以创建从患者皮肤到横向间隔的通道。 在一个实施方案中，该方法还包括将移植材料通过该通道输送到跨越间隔。 根据本发明的一个方面的装置包括具有扁平板的收缩部分，所述扁平板被构造成无损伤地收缩组织以在外科手术部位内产生工作空间，以及附接到所述缩回部分的曲轴。 轴包括具有优选为160度的半径的弯曲部。 抓握部分附接到轴上并被构造成手动地夹持和操纵装置。

公开(公告)号：US5741261A

公开(公告)日：1998-04-21

申请号：US670351

申请日：1996-06-25

申请人： Peter A. Moskovitz ,  Scott Boden ,  William F. McKay ,  Joseph Moctezuma

发明人： Peter A. Moskovitz ,  Scott Boden ,  William F. McKay ,  Joseph Moctezuma

IPC分类号： A61B17/00 ,  A61B17/02 ,  A61B17/16 ,  A61B17/32 ,  A61B18/14 ,  A61F2/00 ,  A61F2/02 ,  A61F2/28 ,  A61F2/44 ,  A61F2/46 ,  A61B17/56

CPC分类号： A61F2/4611 ,  A61B17/02 ,  A61B17/0206 ,  A61B17/025 ,  A61B17/1604 ,  A61B17/1606 ,  A61B17/1608 ,  A61B17/1637 ,  A61F2/4455 ,  A61F2/4601 ,  A61B18/1442 ,  A61B2017/00261 ,  A61B2017/0042 ,  A61B2017/0256 ,  A61B2017/320044 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30153 ,  A61F2002/30261 ,  A61F2002/4623 ,  A61F2002/4635 ,  A61F2002/4649 ,  A61F2210/0004 ,  A61F2230/0019 ,  A61F2230/0082 ,  A61F2310/00293 ,  Y10S606/907

摘要： Minimally invasive spinal surgical techniques and tools are provided. The methods include separating the iliocostalis lumborum muscle from the anterior leaf of the thoracolumbar fascia to create a channel from the patient's skin to the intertransverse interval. In one embodiment, the method also includes delivering graft material through the channel to the intertransverse interval. A device according to one aspect of the present invention includes a retraction portion having a flattened plate configured to atraumatically retract tissue to create a working space within an endosurgical site and a curved shaft attached to the retraction portion. The shaft includes a bend having a radius of preferably 160 degrees. A gripping portion is attached to the shaft and is configured for manually gripping and manipulating the device.

公开(公告)号：US4459985A

公开(公告)日：1984-07-17

申请号：US472335

申请日：1983-03-04

申请人： William F. McKay ,  Peter B. Van Syckle

发明人： William F. McKay ,  Peter B. Van Syckle

IPC分类号： A61F2/46 ,  A61B17/00 ,  A61B17/18

CPC分类号： A61F2/461 ,  A61F2002/4619 ,  A61F2002/4628

摘要： An extractor for dislodging an implanted tibial prosthesis comprising substantially parallel upper and lower members joined by a yoke, with the lower member comprising a pair of forked blades to insert under the tibial component and the upper member being adapted to receive means for applying upward dislodging force.

摘要翻译： 一种用于移除植入的胫骨假体的提取器，包括由轭架连接的基本上平行的上部和下部构件，下部构件包括一对叉形叶片以插入到胫骨部件下方，并且上部构件适于接收用于施加向上移动力的装置 。

公开(公告)号：US09655994B2

公开(公告)日：2017-05-23

申请号：US13557819

申请日：2012-07-25

申请人： William F. McKay

发明人： William F. McKay

IPC分类号： A61L27/36 ,  A61L27/54 ,  A61L27/38 ,  A61L27/50

CPC分类号： A61L27/3608 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/414 ,  A61L2430/02

摘要： A delivery system comprising a covering having at least two compartments is provided. A first compartment contains a first therapeutic agent and the second compartment can be unfilled and is configured to receive a second therapeutic agent. The first compartment and the second compartment are separated by at least one removable separation member, for example a drawstring, that can be pulled to allow the first and second therapeutic agents to mix prior to delivery at a selected surgical site. Either the first or second compartment of the covering define an opening further comprising a pre-attached sealing member, which can be a flap sealable by heat, sutures, pressing or interference fittings. The opening of the empty compartment can be configured to receive a filling member, such as a funnel fitted with a spring loaded clip for temporary attachment to the covering. A method of treating a bone defect in a patient utilizing the delivery system is also provided.