公开(公告)号：US11266839B1

公开(公告)日：2022-03-08

申请号：US17095240

申请日：2020-11-11

申请人： Michael Sasha John

发明人： Michael Sasha John

IPC分类号： A61N1/36 ,  A61N1/372 ,  A61N1/05 ,  A61M5/142 ,  A61M5/172 ,  A61N1/04

摘要： Stimulation treatments for various medical disorders, such as neurological disorders, comprise novel systems, strategies, and methods for providing TMS, electrical, magnetic, optical and other stimulation modalities. Some stimulation methods comprise varying the stimulation parameters to improve the therapeutic efficacy of stimulation, and decrease risk of habituation and side-effects such as interference with normal brain, sensory, motor, and cognitive processes. The creation, and subsequent variation, of stimulation parameters can use sensed data in order to match, adjust, or avoid matching characteristics of the stimulation therapy relative to certain endogenous brain activities. Novel methods are described for choosing, creating and subsequently stimulating with partial signals which summate to produce therapeutic vector fields having unique temporal patterns and low- or high-frequency spectral content. Improvements for the treatment of pain are disclosed.

公开(公告)号：US20200222628A1

公开(公告)日：2020-07-16

申请号：US16820634

申请日：2020-03-16

申请人： Michael Sasha John

发明人： Michael Sasha John

IPC分类号： A61M5/168 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61M25/00 ,  A61M5/14 ,  G16H20/17

摘要： A drug delivery system provides for controlled dispensing of drug. When designed for mixing of drugs, at least one mixing chamber may be used. Flow controllers guide drugs into single or multiple catheters, enabling a single lumen catheter to dispense multiple drugs, diluting a concentrated drug to provide varying drug concentration. A buffer fluid can deliver precise drug amounts or can separate drugs within a catheter. A patient's bodily fluid can serve as a diluent or buffer fluid. A drug testing/filler apparatus may be used to facilitate filling of multiple reservoirs or other delivery. Bolus or continuous delivery of drug to selected distal locations can occur at independent rates. New catheter systems, hub assemblies, and uses therefore are also described. New methods for promotion of healthy pregnancy and treatment of a developing fetus are disclosed.

公开(公告)号：US20180165682A9

公开(公告)日：2018-06-14

申请号：US15404184

申请日：2017-01-11

申请人： Michael Sasha John

发明人： Michael Sasha John

IPC分类号： G06Q20/40

CPC分类号： G06Q20/4016 ,  G06F21/32 ,  G06F21/35 ,  G06F21/606 ,  G06F21/6263 ,  G06Q20/123 ,  G06Q20/382 ,  G06Q20/4012 ,  G06Q20/40145 ,  G06Q20/405 ,  G06Q20/409 ,  G06Q20/425 ,  G06Q30/06 ,  G06Q30/0601 ,  G06Q30/0613 ,  G06Q40/00

摘要： Systems and methods are described for providing fraud deterrents during payment card transactions especially for e-commerce and e-transactions. Fraud deterrents may be selected and configured by a client, bank, or other third-party and provided to a client in customized manners which may be configured on a client's authorized device Or otherwise as defined in an e-profile associated with a payment card. Fraud deterrent options may be contingent upon transaction features including a client's profile, transaction value, or other preferences. The deterrent features may be customized by the client and include use of conceptual passwords.

公开(公告)号：US20150018758A1

公开(公告)日：2015-01-15

申请号：US14070522

申请日：2013-11-02

申请人： Michael Sasha John

发明人： Michael Sasha John

IPC分类号： A61M5/168 ,  A61M5/14 ,  A61M25/00 ,  A61M5/142 ,  A61M5/172

CPC分类号： A61M5/16809 ,  A61B5/14532 ,  A61B5/412 ,  A61M5/1408 ,  A61M5/14276 ,  A61M5/16827 ,  A61M5/172 ,  A61M5/1723 ,  A61M25/00 ,  A61M25/0026 ,  A61M25/003 ,  A61M25/0097 ,  A61M2005/14208 ,  A61M2025/0002 ,  A61M2025/0036 ,  A61M2025/0037 ,  A61M2025/004 ,  A61M2205/3523 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17

摘要： A drug delivery system provides for controlled mixing of drugs, using flow controllers to guide drugs into single or multiple catheters, enabling a single lumen catheter to dispense multiple drugs, diluting a concentrated drug to provide varying drug concentration, using a buffer fluid to deliver precise amounts of drug or to separate drugs within a catheter, and using a patient's bodily fluid as a diluent or buffer fluid. A drug testing/filler apparatus may be used prior to system use to facilitate filling of multiple reservoirs and may also be used for refilling. The system can provide bolus or continuous delivery and enable the measured delivery of drug to selected distal locations at independent rates. New types of catheter systems, catheter hub assemblies, and uses therefore are also described. New methods for promotion of healthy pregnancy and treatment of a developing fetus are disclosed.

摘要翻译： 药物递送系统提供药物的受控混合，使用流量控制器将药物引导至单个或多个导管，使得单腔导管能够分配多种药物，稀释浓缩的药物以提供不同的药物浓度，使用缓冲液来递送精确的 药物的量或在导管内分开药物，并使用患者的体液作为稀释剂或缓冲液。 可以在系统使用之前使用药物测试/填充装置以便于填充多个储存器，并且还可以用于再填充。 该系统可以提供推注或连续递送，并使得能够以独立的速率测量药物递送到选定的远端位置。 因此，还描述了新型的导管系统，导管毂组件和用途。 公开了促进健康怀孕和治疗发育中的胎儿的新方法。

公开(公告)号：US08452404B1

公开(公告)日：2013-05-28

申请号：US12624506

申请日：2009-11-24

申请人： David R. Fischell ,  Michael Sasha John ,  David Keenan

发明人： David R. Fischell ,  Michael Sasha John ,  David Keenan

IPC分类号： A61N1/00 ,  A61B5/0402

CPC分类号： A61B5/04525 ,  A61B5/0031 ,  A61B5/0456 ,  A61B5/0468 ,  A61B5/0472 ,  A61B5/1112 ,  A61N1/368

摘要： A device for detecting cardiac ischemia is disclosed. The device includes a processor that is configured to operate in three different modes according to relative frequency of different beat types. If beats of a first beat type, such as ventricularly paced beats, are predominant, the processor ignores other beat types and performs ischemia detection only on ventricularly paced beats. Conversely, if beats of a second beat type, such as sinus or atrially paced beats, are predominant, the processor ignores ventricularly paced beats and performs ischemia detection only on sinus or atrially paced beats. If there is a mixture of beat types such that neither predominates, the processor performs ischemia detection on both beat types.

摘要翻译： 公开了一种用于检测心脏缺血的装置。 该装置包括处理器，其配置为根据不同拍子类型的相对频率在三种不同模式下操作。 如果头部节拍类型（例如心室起搏节拍）占优势，则处理器忽略其他节拍类型，仅针对心室起搏节拍进行缺血检测。 相反，如果第二节拍类型的节拍（例如窦性或高发性节拍）是主要的，则处理器忽略心室起搏节拍，并且仅对窦性或心率起搏节拍进行缺血检测。 如果没有优势的节拍类型的混合，则处理器对两种节拍类型执行缺血检测。

公开(公告)号：US08353837B2

公开(公告)日：2013-01-15

申请号：US12700692

申请日：2010-02-04

申请人： Michael Sasha John ,  Benjamin D. Pless ,  Brett Wingeier

发明人： Michael Sasha John ,  Benjamin D. Pless ,  Brett Wingeier

IPC分类号： A61B8/06

CPC分类号： A61N1/36139 ,  A61B5/0031 ,  A61B5/02 ,  A61B5/0476 ,  A61B5/14553 ,  A61B5/1459 ,  A61B5/4094 ,  A61B5/6868 ,  A61B5/7217 ,  A61B8/06 ,  A61B8/12 ,  A61B8/488 ,  A61F7/00 ,  A61F7/12 ,  A61N1/36057 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/36135 ,  A61N2/006 ,  A61N2/02 ,  A61N5/0622 ,  A61N7/00 ,  A61N2007/0043

摘要： A system including an implantable neurostimulator device capable of modulating cerebral blood flow to treat epilepsy and other neurological disorders. In one embodiment, the system is capable of modulating cerebral blood flow (also referred to as cerebral perfusion) in response to measurements and other observed conditions. Perfusion may be increased or decreased by systems and methods according to the invention as clinically required.

公开(公告)号：US08269634B2

公开(公告)日：2012-09-18

申请号：US12461876

申请日：2009-08-27

申请人： David R. Fischell ,  Michael Sasha John

发明人： David R. Fischell ,  Michael Sasha John

IPC分类号： G08B23/00

CPC分类号： A61B5/0031 ,  A61N1/37258 ,  G16H40/67

摘要： Alarm tests are disclosed which use alarm test signals to assess alarms provided by medical devices. Especially relevant are implanted devices that monitor cardiac activity and provide notification in response to medically relevant events. Alarm tests can occur periodically, or in response to a patient, doctor, or remote party initiating the alarm test. Alarm tests can also occur during the actual alarms issued to detected medical events. Alarm tests lead to pass or fail results, which in turn may cause operations to contingently occur. Alarm test failure in the auditory, visual, or tactile modality, may cause an alternatively defined alarm signal to be used as back-up. Alarm test logs can store alarm test results, including quantification of the measured alarm signal. Rapid alarm tests are described, as are various methods of accurately measuring characteristics of the test signal in ambulatory patients, which are especially relevant to a vibration alarm.

摘要翻译： 公开了报警测试，其使用报警测试信号来评估由医疗设备提供的警报。 特别相关的是监测心脏活动的植入装置，并响应医疗相关事件提供通知。 报警测试可以周期性地发生，或者响应于启动报警测试的病人，医生或远程方。 在检测到的医疗事件发生的实际警报中也可能发生报警测试。 报警测试导致通过或失败结果，这反过来可能导致操作偶然发生。 在听觉，视觉或触觉模式中的报警测试失败可能导致备用定义的报警信号用作备份。 报警测试记录可以存储报警测试结果，包括测量报警信号的量化。 描述了快速报警测试，以及精确测量门诊患者测试信号特性的各种方法，这些特征与振动报警特别相关。

公开(公告)号：US08115448B2

公开(公告)日：2012-02-14

申请号：US12131886

申请日：2008-06-02

申请人： Michael Sasha John

发明人： Michael Sasha John

IPC分类号： H01M10/46

CPC分类号： H02J7/025 ,  A61N1/37223 ,  A61N1/37252 ,  A61N1/3785 ,  A61N1/3787 ,  H02J5/005 ,  H02J50/10 ,  H02J50/20 ,  H02J50/50 ,  H02J50/70 ,  H02J50/80 ,  H04B1/40 ,  H04B5/0037 ,  H04B5/0062

摘要： The present invention is a wireless power system which includes components which can be recharged by harvesting wireless power, wireless power transmitters for transmitting the power, and devices which are powered from the components. Features such as temperature monitoring, tiered network protocols including both data and power communication, and power management strategies related to both charging and non-charging operations, are used to improve performance of the wireless network. Rechargeable batteries which are configured to be recharged using wireless power have unique components specifically tailored for recharging operations rather than for providing power to a device. A wireless power supply for powering implanted devices benefits from an external patient controller which contains features for adjusting both power transmission and harvesting provided by other components of the wireless power network.

摘要翻译： 本发明是一种无线电力系统，其包括能够通过收集无线电力进行再充电的组件，用于发送电力的无线电力发射机以及由组件供电的设备。 使用诸如温度监测，分层网络协议（包括数据和电力通信）以及与充电和非充电操作相关的电源管理策略等功能来提高无线网络的性能。 被配置为使用无线电力再充电的可充电电池具有专门用于再充电操作而不是向设备供电的专用组件。 用于为植入装置供电的无线电源受益于外部患者控制器，该外部患者控制器包含用于调整由无线电力网络的其他部件提供的电力传输和收获的功能。

公开(公告)号：US08027730B2

公开(公告)日：2011-09-27

申请号：US11309835

申请日：2006-10-09

申请人： Michael Sasha John

发明人： Michael Sasha John

IPC分类号： A61N1/18

CPC分类号： A61N1/36017 ,  A61N1/0529 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36025 ,  A61N1/36082 ,  G06F19/00 ,  G16H50/50

摘要： The present invention involves methods and systems for treatment of brain disorders using neuromodulation of brain networks. Treatment of one or more brain networks associated with a brain disorder is realized with a consideration of network dynamics and coupling effects such as indirect stimulation of non-target regions. A brain modulation system (BMS) increases, decreases, or otherwise modulates network regional activity in a differential manner. Therapy may aim to maintain electrical or chemical (relative) characteristics within a specified range. Therapy is initiated/adjusted using network functional imaging data including the use of brain network modeling. Linking rules may guide in the setting and subsequent adjusting of the therapy related to regions of brain network. Novel techniques are described for deterring the emergence of neural adaptation and of unintentional/indirect modulation arising from connectivity between network structures.

摘要翻译： 本发明涉及使用脑网络神经调节来治疗脑部疾病的方法和系统。 通过考虑网络动力学和耦合效应（例如非目标区域的间接刺激）来实现与脑紊乱相关的一个或多个脑网络的治疗。 脑调制系统（BMS）以差别方式增加，减少或以其他方式调制网络区域活动。 治疗可能旨在将电气或化学（相对）特性保持在指定范围内。 使用网络功能成像数据（包括使用脑网络建模）启动/调整治疗。 连接规则可以指导与脑网络区域相关治疗的设置和随后的调整。 描述了新技术，用于阻止网络结构之间的连接引起的神经适应和无意/间接调制的出现。

公开(公告)号：US08002701B2

公开(公告)日：2011-08-23

申请号：US11684801

申请日：2007-03-12

申请人： Michael Sasha John ,  David R. Fischell

发明人： Michael Sasha John ,  David R. Fischell

IPC分类号： A61B5/04 ,  A61N1/08

CPC分类号： A61B5/04 ,  A61B5/0031 ,  A61B5/02028 ,  A61B5/7264 ,  A61B2560/0295 ,  A61N1/08 ,  G06F19/00 ,  G06F19/3418 ,  Y10S128/903

摘要： A medical alarm communications system comprises a pager like device to be kept near a patient. The pager like device communicates medical alerts regarding the patient to a remote central station, which can provide therapeutic and/or diagnostic assistance by communicating to the pager like device. When the pager like device determines that an alert should be sent to the central station, it attempts to establish communication with the central station according to a primary communication protocol. If this attempt is unsuccessful according to some predetermined criteria (e.g. too much time has elapsed before communication is established), then the pager like device generates a message to the patient indicative of the failure, and The attempts to establish communication with the central station according to a secondary communication protocol.

摘要翻译： 医疗报警通信系统包括要保持在患者附近的寻呼机装置。 寻呼机设备将关于患者的医疗警报传达到远程中心站，其可以通过与寻呼机类设备通信来提供治疗和/或诊断辅助。 当寻呼机设备确定警报应发送到中心站时，它尝试根据主要通信协议与中心站建立通信。 如果根据某些预定标准（例如在建立通信之前经过了太多时间），则该尝试不成功，那么寻呼机类设备就向患者生成指示故障的消息，并且尝试与中心站建立通信 到次要通信协议。