公开(公告)号：US06340686B1

公开(公告)日：2002-01-22

申请号：US09571215

申请日：2000-05-16

申请人： Shuichi Furuya ,  Nobuhiro Suzuki ,  Nobuo Choh ,  Yoshi Nara

发明人： Shuichi Furuya ,  Nobuhiro Suzuki ,  Nobuo Choh ,  Yoshi Nara

IPC分类号： A61K31519

CPC分类号： C07D495/04

摘要： A compound of the formula: wherein R1 and R2 each is hydrogen, hydroxy, C1-4 alkoxy, C1-4 alkoxy-carbonyl or C1-4 alkyl which may be substituted; R3 is hydrogen, halogen, hydroxy or C1-4 alkoxy which may be substituted; or adjacent two R3 may form C1-4 alkylenedioxy; R4 is hydrogen or C1-4 alkyl; R6 is C1-4 alkyl which may be substituted or a group of the formula: wherein R5 is hydrogen or R4 and R5 may form heterocycle; and n is 0-5, or a salt thereof, has an excellent GnRH-antagonizing activity, and is useful for preventing or treating sex hormone-dependent diseases.

摘要翻译： 下式化合物：其中R 1和R 2各自为氢，羟基，C 1-4烷氧基，C 1-4烷氧羰基或可被取代的C 1-4烷基; R3是氢，卤素，羟基或可被取代的C1-4烷氧基; 或相邻的两个R 3可以形成C 1-4亚烷基二氧基; R4是氢或C1-4烷基; R6是可以被取代的C1-4烷基或下式的基团：其中R5是氢或R4和R5可以形成杂环; 并且n为0-5或其盐具有优异的GnRH拮抗活性，并且可用于预防或治疗性激素依赖性疾病。

公开(公告)号：USD451644S1

公开(公告)日：2001-12-04

申请号：US29126961

申请日：2000-07-26

申请人： Soichi Fujimoto ,  Shigeki Kuroda ,  Nobuhiro Suzuki

设计人： Soichi Fujimoto ,  Shigeki Kuroda ,  Nobuhiro Suzuki

公开(公告)号：US6015789A

公开(公告)日：2000-01-18

申请号：US894317

申请日：1997-08-14

申请人： Nobuhiro Suzuki ,  Shuichi Furuya

发明人： Nobuhiro Suzuki ,  Shuichi Furuya

IPC分类号： A61K38/09 ,  A61K31/44 ,  A61K31/505

CPC分类号： A61K38/09

摘要： The present invention relates to a pharmaceutical luteinizing hormone releasing hormone agonist in combination with a luteinizing hormone releasing hormone antagonist. By using a luteinizing hormone releasing hormone agonist and a luteinizing hormone releasing hormone antagonist in combination, the transient exacerbation with elevation of serum testosterone and estrogen owing to the pituitary-gonadotropic action (acute action) manifested immediately following an initial dose of the luteinizing hormone releasing hormone agonist can be successfully obviated.

摘要翻译： PCT No.PCT / JP97 / 01459 Sec。 371日期1997年8月14日 102（e）日期1997年8月14日PCT 1997年4月25日PCT公布。 公开号WO97 / 40846 日期1997年11月6日本发明涉及一种与黄体生成激素释放激素拮抗剂组合的药物黄体生成激素释放激素激动剂。 通过组合使用促黄体激素释放激素激动剂和黄体生成激素释放激素拮抗剂，随着促黄体生成激素释放的初始剂量，立即表现出由于垂体促性腺激素作用（急性作用）引起的血清睾酮和雌激素升高的短暂加重 激素激动剂可以顺利消除。

公开(公告)号：US5981977A

公开(公告)日：1999-11-09

申请号：US110834

申请日：1998-07-06

申请人： Chisato Furukawa ,  Hideto Sugawara ,  Masayuki Ishikawa ,  Nobuhiro Suzuki

发明人： Chisato Furukawa ,  Hideto Sugawara ,  Masayuki Ishikawa ,  Nobuhiro Suzuki

IPC分类号： H01L33/12 ,  H01L33/14 ,  H01L33/32 ,  H01L33/44 ,  H01S5/00 ,  H01S5/227 ,  H01S5/323 ,  H01L33/00

CPC分类号： H01L33/32 ,  H01L33/007 ,  H01S5/227 ,  H01S5/2272 ,  H01S5/32341

摘要： A nitride compound semiconductor light emitting element comprises a substrate, a nitride compound semiconductor n-type layer, a mask layer having a predetermined opening, a nitride compound semiconductor buffer layer epitaxially grown on said n-type layer exclusively at said opening. The buffer layer has a recess on its top face so that a thickness of said buffer layer is thinner above a central portion of the opening and thicker above edge portions of the opening. A nitride compound semiconductor active layer is selectively formed on the recess of the buffer layer to be thicker at the central portion of the recess and thinner at the edges of the recess. A nitride compound semiconductor burying layer overlays the mask layer and the active layer to cover the active layer. By selectively growing the buffer layer and the active layer in the opening of the mask layer formed on the substrate and by growing additional layers to bury the entire structure and to flatten the surface, a planar-type, stripe-buried structure is realized. The active layer has a distribution of refractive index due to the distribution of thickness resulting from the selective growth and can confine light with high efficiency. Additionally, by using an insulation film, highly efficient confinement of current is realized to provide a light emitting element for a shorter wavelength with a high luminous intensity and a low oscillation threshold value.

摘要翻译： 氮化物半导体发光元件包括衬底，氮化物化合物半导体n型层，具有预定开口的掩模层，仅在所述开口处在所述n型层上外延生长的氮化物化合物半导体缓冲层。 缓冲层在其顶面上具有凹部，使得所述缓冲层的厚度在开口的中心部分上方更薄，并且在开口的边缘部分较厚。 在缓冲层的凹部上选择性地形成氮化物化合物半导体活性层，使其在凹部的中央部较厚，在凹部的边缘处变薄。 氮化物化合物半导体掩埋层覆盖掩模层和有源层以覆盖有源层。 通过在衬底上形成的掩模层的开口中选择性地生长缓冲层和活性层，并且通过生长附加层以埋入整个结构并使表面变平，实现了平面型条纹埋层结构。 活性层由于选择性生长导致的厚度分布而具有折射率分布，并且可以高效地限制光。 此外，通过使用绝缘膜，实现电流的高效限制，以提供具有高发光强度和低振荡阈值的较短波长的发光元件。

公开(公告)号：US5977132A

公开(公告)日：1999-11-02

申请号：US762125

申请日：1996-12-09

申请人： Nobuhiro Suzuki ,  Hirokazu Matsumoto ,  Shuichi Furuya

发明人： Nobuhiro Suzuki ,  Hirokazu Matsumoto ,  Shuichi Furuya

IPC分类号： A61K31/4365 ,  A61K31/519 ,  C07D495/04 ,  A61K31/47

CPC分类号： C07D495/04 ,  A61K31/4365 ,  A61K31/519

摘要： The prolactin production inhibition agent of the present invention containing a condensed cyclic compound, which is characterized by containing a condensed bicyclic structure of an optionally substituted homo or hetero 5- to 7-membered ring with an optionally substituted homo or hetero 5- to 7-membered ring, or a salt thereof, can be used, as a medicine, for the prophylaxis or therapy of diseases accompanied with an excess prolactin production or diseases having enhanced reactivity with prolactin, or is useful for inhibiting puerperal lactation, and also useful as a prophylactic or therapeutic agent of galactorrhea, hyperprolactinemic ovulation disturbance, amenorrhea-galactorrhea syndrome, prolactinoma, and besides, interbrain tumor, and acromegaly, pituitary gigantism.

摘要翻译： 含有缩合环状化合物的本发明的催乳激素产生抑制剂，其特征在于含有任选取代的同价或杂原子5-至7-元环的稠合双环结构，任选取代的同位或异或5-至7-元环， 可以用作预防或治疗伴随过量催乳素生成的疾病或与催乳素具有增强反应性的疾病，或用于抑制产后泌乳的药物，也可用作 乳酸溢液的预防或治疗，高泌乳素血症，闭经 - 乳溢综合征，催乳素瘤，以及脑内肿瘤，肢端肥大症，垂体巨细胞症等。

公开(公告)号：US5230999A

公开(公告)日：1993-07-27

申请号：US555081

申请日：1990-07-18

申请人： Nobuhiro Suzuki ,  Hirokazu Matsumoto

发明人： Nobuhiro Suzuki ,  Hirokazu Matsumoto

IPC分类号： C07K16/26 ,  C12P21/08

CPC分类号： C07K16/26

摘要： Disclosed are monoclonal antibodies having an affinity for endothelin-3 or a precursor thereof; a hybridoma cell which produces the monoclonal antibody; and an immunoassay of endothelin-3 and big endothelin-3, a precursor of endothelin-3, by a sandwich method or a competitive method. The monoclonal antibodies can be used as strong antagonists for endothelin-3 in various endothelin-3-related diseases, and the immunoassays make it possible to determine endothelin-3 and big endothelin-3 with high sensitivity.

公开(公告)号：US5150027A

公开(公告)日：1992-09-22

申请号：US634503

申请日：1990-12-27

申请人： Nobuhiro Suzuki

发明人： Nobuhiro Suzuki

IPC分类号： A63H30/04 ,  H02P7/29 ,  H03M1/66

CPC分类号： A63H30/04

摘要： A motor drive circuit for a radio-controlled model capable of readily varying any desired part of inclination of the input-output characteristics with a highly simplified circuit arrangement. The motor drive circuit includes an element for converting a signal corresponding to control condition into a digital signal and subjecting the digital signal to weighing processing for every bit thereof.

摘要翻译： 一种用于无线电控制模型的电动机驱动电路，其能够以高度简化的电路布置容易地改变输入 - 输出特性的任何所需部分倾斜度。 电动机驱动电路包括用于将对应于控制条件的信号转换为数字信号的元件，并对其数字信号进行称重处理。

公开(公告)号：US4816390A

公开(公告)日：1989-03-28

申请号：US721901

申请日：1985-04-10

申请人： Koichi Kondo ,  Nobuhiro Suzuki

发明人： Koichi Kondo ,  Nobuhiro Suzuki

IPC分类号： C07K16/30 ,  G01N33/535 ,  G01N33/53

CPC分类号： C07K16/3007 ,  G01N33/535 ,  Y10S435/81 ,  Y10S436/813

摘要： An immunochemical assay of human carcinoembryonic antigen (CEA), comprising the use of an antibody supported on a carrier and an antibody labelled with peroxidase by coupling by means of a compound of the formula: ##STR1## wherein n is an integer of 0 to 5 and R is a chemical bond or a divalent 6-membered cyclic hydrocarbon residue, in which at least one of said antibodies is a monoclonal antibody. The assay can be conducted with high sensitivity by simple and easy operation in clinical laboratories.

摘要翻译： 一种人癌胚抗原（CEA）的免疫化学测定法，其包括使用负载在载体上的抗体和用过氧化物酶标记的抗体，通过下式化合物偶联：其中n为0-5的整数 并且R是化学键或二价的6元环烃残基，其中至少一种所述抗体是单克隆抗体。 通过在临床实验室中简单易用的操作，可以高灵敏度地进行测定。

公开(公告)号：US4473852A

公开(公告)日：1984-09-25

申请号：US412001

申请日：1982-08-27

申请人： Yasuo Kominami ,  Kazuo Watanabe ,  Fumihiko Yokogawa ,  Nobuhiro Suzuki

发明人： Yasuo Kominami ,  Kazuo Watanabe ,  Fumihiko Yokogawa ,  Nobuhiro Suzuki

IPC分类号： H04B1/62 ,  G11B20/04 ,  G11B20/24 ,  H03G9/02 ,  H04B1/64 ,  G11B5/47 ,  G11B5/02

CPC分类号： H03G9/025

摘要： Conventional Dolby B-type or C-type noise reduction systems respond sensitively to an A.C. bias signal during recording onto a magnetic tape. As a result, the system might exhibit a large encode error. In order to reduce such encode error, the gain - frequency characteristic control sensitivity of a side chain in the system to the A.C. bias signal to be supplied to a recording head is set at a value smaller than that of the gain - frequency characteristic control sensitivity of the side chain to an encode input signal at an audio frequency. Such a reduction of the encode error is achieved by connecting a bias trap circuit to a gain control amplifier included in the side chain.

摘要翻译： 传统的杜比B型或C型降噪系统在记录到磁带上时敏感地响应于A.C.偏差信号。 因此，系统可能会出现较大的编码错误。 为了减少这种编码误差，系统中侧链的增益 - 频率特性控制灵敏度被提供给记录头的AC偏置信号被设置为小于增益 - 频率特性控制灵敏度 的侧链到音频的编码输入信号。 通过将偏置捕获电路连接到侧链中包括的增益控制放大器来实现编码误差的这种减少。

公开(公告)号：US08372670B2

公开(公告)日：2013-02-12

申请号：US12841812

申请日：2010-07-22

申请人： Rintaro Koda ,  Takahiro Arakida ,  Satoshi Taniguchi ,  Yuji Masui ,  Nobuhiro Suzuki ,  Tomoyuki Oki ,  Chiyomi Uchiyama ,  Kayoko Kikuchi

发明人： Rintaro Koda ,  Takahiro Arakida ,  Satoshi Taniguchi ,  Yuji Masui ,  Nobuhiro Suzuki ,  Tomoyuki Oki ,  Chiyomi Uchiyama ,  Kayoko Kikuchi

IPC分类号： G01R31/26 ,  H01L21/66

CPC分类号： H01S5/18311 ,  H01L33/0079 ,  H01L33/44 ,  H01L33/62 ,  H01L33/647 ,  H01L2924/0002 ,  H01S5/0207 ,  H01S5/0215 ,  H01S5/0216 ,  H01S5/0217 ,  H01S5/02272 ,  H01S5/0425 ,  H01L2924/00

摘要： A method for making a light-emitting element assembly including a support substrate having a first surface, a second surface facing the first surface, a recessed portion, and a conductive material layer formed over the first surface and the inner surface of the recessed portion, and a light-emitting element. The light-emitting element has a laminated structure including a first compound semiconductor layer, a light-emitting portion, and a second compound semiconductor layer, at least the second compound semiconductor layer and the light-emitting portion constituting a mesa structure. The light-emitting element further includes an insulating layer formed, a second electrode, and a first electrode. The mesa structure is placed in the recessed portion so that the conductive material layer and the second electrode are in at least partial contact with each other, and light emitted from the light-emitting portion is emitted from the second surface side of the first compound semiconductor layer.

摘要翻译： 一种制造发光元件组件的方法，包括：具有形成在所述凹部的所述第一表面和所述内表面上的第一表面，面向所述第一表面的第二表面，凹陷部分和导电材料层的支撑基板， 和发光元件。 发光元件具有包括第一化合物半导体层，发光部和第二化合物半导体层的层叠结构，至少第二化合物半导体层和构成台面结构的发光部。 发光元件还包括形成的绝缘层，第二电极和第一电极。 台面结构被放置在凹部中，使得导电材料层和第二电极彼此至少部分接触，并且从发光部分发射的光从第一化合物半导体的第二表面侧发射 层。