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    Tris(trimethyl siloxyl)silane vinylic monomers and uses thereof
    71.
    发明授权
    Tris(trimethyl siloxyl)silane vinylic monomers and uses thereof 有权
    三（三甲基甲硅烷氧基）硅烷乙烯基单体及其用途

    公开(公告)号：US09475827B2

    公开(公告)日：2016-10-25

    申请号：US14651539

    申请日：2013-12-13

    Applicant: Novartis AG ,  Shin-Etsu Chemical Company, Ltd.

    Inventor： Frank Chang ,  Mamoru Hagiwara ,  Shoji Ichinohe

    IPC: C08L101/14 ,  C07F7/08 ,  C08F287/00 ,  G02B1/04

    CPC classification number: C07F7/0889 ,  C07F7/0834 ,  C07F7/0838 ,  C08F287/00 ,  G02B1/043 ,  C08L83/04 ,  C08L51/085 ,  C08L101/14 ,  C08L33/08

    Abstract: The invention provides a TRIS-containing vinylic monomer which comprises one sole (meth)acryloyloxy group and a tris(trimethylsiloxy)silyl group covalently linked to the ethylenically-unsaturated group through a polyoxyethylene linker. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from a TRIS-containing vinylic monomer of the invention. In addition, the invention provides a method for making a TRIS-containing vinylic monomer of the invention.

    Abstract translation: 本发明提供了一种含TRIS的乙烯基单体，其包含一个唯一的（甲基）丙烯酰氧基和通过聚氧乙烯接头与烯属不饱和基团共价连接的三（三甲基甲硅烷氧基）甲硅烷基。 本发明还涉及包含衍生自本发明的含TRIS的乙烯基单体的单体单元的聚合物，可光化交联的含硅氧烷的预聚物，硅氧烷水凝胶聚合物材料或硅氧水凝胶隐形眼镜。 此外，本发明提供了制备本发明的含TRIS的乙烯基单体的方法。

    WATER-PROCESSABLE SILICONE-CONTAINING PREPOLYMERS AND USES THEREOF
    72.
    发明申请
    WATER-PROCESSABLE SILICONE-CONTAINING PREPOLYMERS AND USES THEREOF 有权
    含水硅油的预处理剂及其用途

    公开(公告)号：US20160033683A1

    公开(公告)日：2016-02-04

    申请号：US14883142

    申请日：2015-10-14

    Applicant: Novartis AG

    Inventor： Jinyu Huang ,  Frank Chang ,  Robert Scott ,  Arturo Norberto Medina ,  Venkat Shankar ,  Selma Kuyu ,  Dawn Alison Smith ,  Daqing Wu

    IPC: G02B1/04 ,  C08J3/075

    CPC classification number: G02B1/043 ,  C08G77/20 ,  C08G77/42 ,  C08G77/442 ,  C08J3/075 ,  C08J2343/04 ,  C08J2383/08 ,  C08L83/10 ,  C08L101/14 ,  C08L83/04

    Abstract: The invention provide a class of water-processable polymerizable prepolymers which comprises (1) siloxane-containing monomeric units derived at least one siloxane containing monomer having one hydrophilic group or chain and/or polysiloxane-containing crosslinking units derived from at least one hydrophilized polysiloxane or chain-extended polysiloxane crosslinker; (2) hydrophilic monomeric units derived from one or more hydrophilic vinylic monomers; and (3) from about 0.05% to about 5% by weight of polymerizable units each having a pendant or terminal, ethylenically-unsaturated group and free of any polysiloxane segment. The prepolymer comprises from about 20% to about 50% by weight of silicone relative to the total weight of the prepolymer and has a high water solubility or dispersibility of at least about 5% by weight in water and suitable for making silicone hydrogel contact lenses.

    Abstract translation: 本发明提供了一类可水加工的可聚合预聚物，其包含（1）衍生自至少一种含有一个含硅氧烷的单体的含硅氧烷的单体单元，所述单体具有一个亲水基团或链和/或含聚硅氧烷的交联单元，其衍生自至少一种亲水化聚硅氧烷或 链延长聚硅氧烷交联剂; （2）衍生自一种或多种亲水乙烯基单体的亲水单体单元; 和（3）约0.05％至约5％重量的各自具有侧基或末端的可聚合单元，烯属不饱和基团并且不含任何聚硅氧烷链段。 预聚物相对于预聚物的总重量包含约20重量％至约50重量％的硅氧烷，并且在水中具有至少约5重量％的高水溶性或分散性，并且适于制备硅酮水凝胶隐形眼镜。

    Polymerizable chain-extended polysiloxanes with pendant hydrophilic groups
    73.
    发明授权
    Polymerizable chain-extended polysiloxanes with pendant hydrophilic groups 有权
    具有侧链亲水基团的可聚合的延伸链的聚硅氧烷

    公开(公告)号：US09109091B2

    公开(公告)日：2015-08-18

    申请号：US14618135

    申请日：2015-02-10

    Applicant: Novartis AG

    Inventor： Frank Chang ,  Jinyu Huang ,  Laura Ann Sanders

    IPC: A01N25/10 ,  A61K47/34 ,  A01P1/00 ,  A61P27/02 ,  C08F290/06 ,  C08G77/46 ,  G02B1/04

    CPC classification number: C08G77/28 ,  C08F290/068 ,  C08G77/20 ,  C08G77/48 ,  G02B1/043 ,  C08L83/14 ,  C08L83/12

    Abstract: The invention provide a class of chain-extended polysiloxane crosslinkers which comprises (1) at least two polylsiloxane segments, wherein each pair of adjacent polysiloxane segments is linked by one divalent organic radical which includes at least one pendant hydrophilic group (hydroxyl and/or carboxyl groups) or at least one dangling hydrophilic polymer chain and a di-thioether linkage —S-DR-S— in which DR is a divalent organic radical; and (2) two terminal ethylenically unsaturated groups. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer.

    Abstract translation: 本发明提供一类链延长聚硅氧烷交联剂，其包含（1）至少两个聚硅氧烷链段，其中每对相邻的聚硅氧烷链段通过一个二价有机基团连接，所述二价有机基团包括至少一个侧链亲水基团（羟基和/或羧基 基团）或至少一个悬浮的亲水性聚合物链和二硫醚键-S-DR-S-，其中DR是二价有机基团; 和（2）两个末端烯属不饱和基团。 本发明还涉及包含衍生自本发明的链延长聚硅氧烷交联剂的交联单元和包含这种聚合物的眼用透镜的聚合物。

    Amphiphilic polysiloxane prepolymers and uses thereof
    74.
    发明授权
    Amphiphilic polysiloxane prepolymers and uses thereof 有权
    两亲性聚硅氧烷预聚物及其用途

    公开(公告)号：US08987403B2

    公开(公告)日：2015-03-24

    申请号：US14014631

    申请日：2013-08-30

    Applicant: Novartis AG

    Inventor： Frank Chang ,  Robert Scott ,  Jinyu Huang ,  Arturo N. Medina ,  Dawn A. Smith ,  Laura A. Sanders ,  John Dallas Pruitt

    IPC: C08G77/06 ,  C08G77/388 ,  C08G77/458 ,  G02B1/04 ,  C08F290/06

    CPC classification number: G02B1/043 ,  C08F290/068 ,  C08G77/388 ,  C08G77/458 ,  C08G2210/00 ,  C08L2205/02 ,  C08L83/04 ,  C08L51/085 ,  C08L101/14 ,  C08F220/56 ,  C08F220/28

    Abstract: The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses.

    Abstract translation: 本发明提供一种两亲性聚硅氧烷预聚物，其包含衍生自至少一种亲水乙烯基单体的亲水性单体单元，衍生自至少一种具有至少两个末端烯属不饱和基团的聚硅氧烷交联剂的聚硅氧烷交联单元，悬浮聚硅氧烷链各自被终止 具有一个烯键式不饱和基团，以及衍生自除RAFT试剂之外的链转移剂的链转移单元。 本发明的预聚物适用于制备水凝胶隐形眼镜。 本发明还涉及由本发明的两亲聚硅氧烷预聚物制成的水凝胶隐形眼镜以及制备本发明的两亲性聚硅氧烷预聚物和制备硅酮水凝胶隐形眼镜的方法。

    METHOD FOR DETERMINING THE SURFACE CONCENTRATION OF CARBOXYL GROUPS ON A LENS
    75.
    发明申请
    METHOD FOR DETERMINING THE SURFACE CONCENTRATION OF CARBOXYL GROUPS ON A LENS 有权
    确定镜片上羧基组合物表面浓度的方法

    公开(公告)号：US20140356965A1

    公开(公告)日：2014-12-04

    申请号：US14289046

    申请日：2014-05-28

    Applicant: Novartis AG

    Inventor： Xinming Qian ,  Frank Chang ,  Troy Vernon Holland ,  Yongxing Qiu ,  Venkat Shankar

    IPC: G01N33/44

    CPC classification number: B29D11/00865 ,  B29D11/00951 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14 ,  C08L33/26

    Abstract: The invention is related to a method for qualifying and quantifying carboxyl groups on the surfaces of a silicone hydrogel contact lens. The method of the invention comprises the steps of: (a) obtaining silicone hydrogel contact lenses each of which comprises a silicone hydrogel lens body (i.e., bulk material) and a coating thereon, wherein the silicone hydrogel lens body is obtained from a lens formulation free of any polymerizable component including one or more carboxyl groups, wherein the coating comprises a polymer having carboxyl groups; (b) immersing a given number of the silicone hydrogel contact lenses in a fixed volume of a C1-C4 alcohol solution of a positively-charged dye having acetate as counter anion at a given initial concentration for a time period sufficient to stain the silicone hydrogel contact lens; and (c) determining the concentration of carboxyl groups per each silicone hydrogel contact lens and/or the thickness of the coating on the silicone hydrogel contact lens.

    Abstract translation: 本发明涉及硅胶水凝胶隐形眼镜表面上的羧基的合格和定量的方法。 本发明的方法包括以下步骤：（a）获得硅酮水凝胶隐形眼镜，每个硅胶水凝胶隐形眼镜包括硅酮水凝胶镜片主体（即散装材料）及其上的涂层，其中硅酮水凝胶镜片主体由透镜制剂 不含任何包含一个或多个羧基的可聚合组分，其中该涂层包含具有羧基的聚合物; （b）将给定数量的硅酮水凝胶隐形眼镜浸入固定体积的具有乙酸盐作为抗衡阴离子的带正电荷的染料的C1-C4醇溶液中，所述正电荷染料在给定的初始浓度下持续一段足以染色硅酮水凝胶 隐形眼镜; 和（c）确定每个硅氧水凝胶隐形眼镜的羧基浓度和/或硅氧水凝胶隐形眼镜上涂层的厚度。

    Polymers
    77.
    发明授权
    Polymers 有权
    聚合物

    公开(公告)号：US08703875B2

    公开(公告)日：2014-04-22

    申请号：US13778882

    申请日：2013-02-27

    Applicant: Novartis AG

    Inventor： Frank Chang ,  Norberto Arturo Medina

    IPC: C08F30/08

    CPC classification number: C07C231/12 ,  C07C67/00 ,  C08F8/00 ,  C08F220/06 ,  C08F220/26 ,  C08F220/56 ,  C08F230/08 ,  C08F2220/286 ,  C08F2800/20 ,  C08F2810/20 ,  C08F2810/30 ,  C08G77/442 ,  C08J3/075 ,  C08J3/28 ,  C08J2433/04 ,  C08J2483/04 ,  G02B1/043 ,  C08L51/085 ,  C08F290/068 ,  C08F285/00

    Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least two different hydrophilic monomers selected from the group consisting of N,N-dimethyl acrylamide (DMA), 2-hydroxyethyl acrylate (HEA), glycidyl methacrylate (GMA), N-vinylpyrrolidone (NVP), acrylic acid (AA) and a C1-C4-alkoxy polyethylene glycol(meth)acrylate having a weight average molecular weight of from 200 to 1500, and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group.

    Abstract translation: 本发明涉及可通过（a）共聚选自N，N-二甲基丙烯酰胺（DMA），丙烯酸2-羟基乙酯（HEA），甲基丙烯酸缩水甘油酯（GMA））的至少两种不同亲水性单体的新型可交联共聚物， ，N-乙烯基吡咯烷酮（NVP），丙烯酸（AA）和重均分子量为200〜1500的C1-C4-烷氧基聚乙二醇（甲基）丙烯酸酯，以及至少一种包含两种或更多种烯键式不饱和双 在具有官能团的链转移剂的存在下进行键合; 和（b）使所得共聚物的一种或多种官能团与具有烯属不饱和基团的有机化合物反应。

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