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71.发明申请Methods and Materials Relating to CD84-like Polypeptides and Polynucleotides 审中-公开与CD84样多肽和多核苷酸相关的方法和材料公开(公告)号：US20080260747A1
公开(公告)日：2008-10-23
申请号：US12100870
申请日：2008-04-10
申请人： Chiaoyun Kuo , Bryan J. Boyle , Jian-Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
发明人： Chiaoyun Kuo , Bryan J. Boyle , Jian-Rui Wang , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/70503 , C07K14/70596 , C07K14/715 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted CD84-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human spleen (Hyseq clone identification numbers 2938352 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted CD84-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供由对应于新的人分泌的CD84样多肽的这种多核苷酸和突变体或其变体编码的新的多核苷酸和多肽。 这些多核苷酸包含从人脾cDNA文库中分离的核酸序列（Hyseq克隆鉴定号2938352（SEQ ID NO：1））。 本发明的其它方面包括含有生产新的人分泌的CD84样多肽的方法的载体和对这些多肽特异的抗体。
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72.发明申请Methods and materials relating to novel stem cell growth factor-like polypeptides and polynucleotides 审中-公开与新型干细胞生长因子样多肽和多核苷酸相关的方法和材料公开(公告)号：US20080241207A1
公开(公告)日：2008-10-02
申请号：US11985996
申请日：2007-11-19
申请人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy Mize , Mitsuo Nishikawa , Cheng-Chi Chao
发明人： Y. Tom Tang , Ivan Labat , Radoje T. Drmanac , Nancy Mize , Mitsuo Nishikawa , Cheng-Chi Chao
IPC分类号： A61L27/54 , C12Q1/68 , C07K16/22 , C12N5/02 , G01N33/53 , C40B40/08 , A61P43/00 , A61K35/12 , A61K38/18 , A61K31/711 , C12N5/00 , C12N5/22
CPC分类号： C07K14/475 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K16/00 , C07K2319/00 , C12N9/16 , C12N9/6432 , C12Y304/21006 , Y10S435/81 , Y10S435/975
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。 这些多核苷酸包含从人胎儿皮肤（Hyseq克隆鉴定号15375176），成年脾（Hyseq克隆鉴定号14856094）和人内皮细胞的人睾丸细胞（Hyseq克隆鉴定号2880984和2881695）的cDNA文库中分离的核酸序列 （Hyseq克隆鉴定号13804756,13687487,13804756）。 本发明的其它方面包括含有生产新型人类干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。
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公开(公告)号：US20080200388A1
公开(公告)日：2008-08-21
申请号：US12080212
申请日：2008-04-01
申请人： Bryan J. Boyle , Peter C.R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
发明人： Bryan J. Boyle , Peter C.R. Emtage , Walter Funk , Y. Tom Tang , Jingsong Zhao
IPC分类号： A61K38/16 , C07H21/04 , C12N15/00 , C12N5/00 , C07K14/00 , C12P21/06 , C12Q1/68 , G01N33/53 , G01N33/00 , C12N5/02
摘要： The invention relates to pharmaceutical compositions comprising gastrointestinal proliferative factor SCFA2, SCFA4 or SCFA4v polynucleotides and polypeptides. The invention further relates to the therapeutic use of SCFA2, SCFA4 or SCFA4v to prevent or treat conditions or disorders associated with the degeneration of the epithelial mucosa.
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74.发明授权公开(公告)号：US07411052B2
公开(公告)日：2008-08-12
申请号：US10488423
申请日：2002-08-30
申请人： Y. Tom Tang
发明人： Y. Tom Tang
CPC分类号： C07K14/475
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
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公开(公告)号：US07317099B2
公开(公告)日：2008-01-08
申请号：US10168365
申请日：2000-12-23
申请人： Ivan Labat , Y. Tom Tang , Radoje T. Drmanac , Chenghua Liu , Juhi Lee , Nancy K. Mize , John Childs , Cheng-Chi Chao
发明人： Ivan Labat , Y. Tom Tang , Radoje T. Drmanac , Chenghua Liu , Juhi Lee , Nancy K. Mize , John Childs , Cheng-Chi Chao
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505 , C07K14/475
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供由这样的多核苷酸编码的新型多核苷酸和多肽，其对应于新型人分泌的干细胞生长因子样多肽的突变体或其变体。 这些多核苷酸包含从人胎肝脾，卵巢，成人脑，肺肿瘤，脊髓，子宫颈，卵巢，内皮细胞，脐带，淋巴细胞，肺成纤维细胞，胎儿脑和睾丸制备的cDNA文库中分离的核酸序列。 本发明的其它方面包括含有用于产生新的人分泌的干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。
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公开(公告)号：US20070009886A1
公开(公告)日：2007-01-11
申请号：US10534578
申请日：2003-11-10
申请人： Narinder Chawla , Y. Tom Tang , Jennifer Griffin , Yonghong Yang , Jayalaxmi Ramkumar , Reena Khare , Thomas Richardson , Shanya Becha , Uyen Tran , Amy Kable , Anita Swarnakar , Bridget Warren , Vicki Elliott , Joseph Marquis , April Hafalia
发明人： Narinder Chawla , Y. Tom Tang , Jennifer Griffin , Yonghong Yang , Jayalaxmi Ramkumar , Reena Khare , Thomas Richardson , Shanya Becha , Uyen Tran , Amy Kable , Anita Swarnakar , Bridget Warren , Vicki Elliott , Joseph Marquis , April Hafalia
CPC分类号： C07K14/47 , C07K14/4726
摘要： Various embodiments of the invention provide human carbohydrate-associated proteins (CHOP) and polynucleotides which identify and encode CHOP. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of CHOP.
摘要翻译： 本发明的各种实施方案提供了识别和编码CHOP的人碳水化合物相关蛋白（CHOP）和多核苷酸。 本发明的实施方案还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 其他实施方案提供用于诊断，治疗或预防与CHOP异常表达相关的障碍的方法。
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公开(公告)号：US06818754B1
公开(公告)日：2004-11-16
申请号：US10461791
申请日：2003-06-12
申请人： Bryan J. Boyle , George Yeung , Matthew C. Arterburn , Nancy K. Mize , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
发明人： Bryan J. Boyle , George Yeung , Matthew C. Arterburn , Nancy K. Mize , Y. Tom Tang , Chenghua Liu , Radoje T. Drmanac
IPC分类号： C12Q168
CPC分类号： C12N9/6432 , A61K38/00 , C07K14/4703 , C07K14/70503 , C07K14/715 , C07K16/00 , C12N9/16 , C12Y304/21006
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted semaphorin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal liver-spleen (Hyseq clone identification numbers 5688868 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted semaphorin-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译： 本发明提供了由这样的多核苷酸编码的新型多核苷酸和多肽，其与对应于新型人分泌的信号素样多肽的突变体或其变体。 这些多核苷酸包含从胎儿肝脾cDNA文库分离的核酸序列（Hyseq克隆鉴定号5688868（SEQ ID NO：1））。 本发明的其它方面包括含有用于产生新的人分泌的信号素样多肽的方法的载体和对这些多肽具有特异性的抗体。
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公开(公告)号：US06743619B1
公开(公告)日：2004-06-01
申请号：US09774528
申请日：2001-01-30
申请人： Y. Tom Tang , Ping Zhou , Ryle Goodrich , Chenghua Liu , Vinod Asundi , Feiyan Ren , Jie Zhang , Qing A. Zhao , Yonghong Yang , Aidong J. Xue , Tom Wehrman , Jian-Rui Wang , Dunrui Wang , Radoje T. Drmanac
发明人： Y. Tom Tang , Ping Zhou , Ryle Goodrich , Chenghua Liu , Vinod Asundi , Feiyan Ren , Jie Zhang , Qing A. Zhao , Yonghong Yang , Aidong J. Xue , Tom Wehrman , Jian-Rui Wang , Dunrui Wang , Radoje T. Drmanac
IPC分类号： C12N990
CPC分类号： C07K14/47 , G01N2500/00
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
摘要翻译： 本发明提供了新的核酸，由这些核酸编码的新的多肽序列及其用途。
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公开(公告)号：US06610536B2
公开(公告)日：2003-08-26
申请号：US09808701
申请日：2001-03-14
申请人： Y. Tom Tang , Ryle Goodrich , Vinod Asundi , Radoje T. Drmanac
发明人： Y. Tom Tang , Ryle Goodrich , Vinod Asundi , Radoje T. Drmanac
IPC分类号： C12N502
CPC分类号： C07K14/47 , A61K38/00 , C07K14/8107
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US06569662B1
公开(公告)日：2003-05-27
申请号：US09620312
申请日：2000-07-19
申请人： Y. Tom Tang , Ping Zhou , Radoje T. Drmanac
发明人： Y. Tom Tang , Ping Zhou , Radoje T. Drmanac
IPC分类号： C12N900
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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