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公开(公告)号:US08603521B2
公开(公告)日:2013-12-10
申请号:US12761588
申请日:2010-04-16
申请人: David J. Loury , Joseph J. Buggy , Tarak D. Mody , Erik J. Verner , Norbert Purro , Sriram Balasubramanian
发明人: David J. Loury , Joseph J. Buggy , Tarak D. Mody , Erik J. Verner , Norbert Purro , Sriram Balasubramanian
IPC分类号: A61K9/22
CPC分类号: A61N5/10 , A61K9/205 , A61K9/2054 , A61K9/2826 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/501 , A61K9/5026 , A61K31/166 , A61K31/343 , A61K31/35 , A61K31/381 , A61K31/40 , A61K31/4184 , A61K31/47 , A61K31/497 , A61K31/573 , A61K31/69 , A61K31/704 , A61K38/05 , A61K45/05 , A61K45/06 , A61K47/02 , A61K47/12 , C07D307/85
摘要: Dosing regimens, methods of treatment, controlled release formulations, and combination therapies that include an HDAC inhibitor, or a pharmaceutically acceptable salt thereof, are described.
摘要翻译: 描述了给药方案,治疗方法,控制释放制剂和包括HDAC抑制剂或其药学上可接受的盐的组合疗法。
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72.Combined administration of mitogenic immumo stimulator and a thymomimetic 失效
标题翻译: 有丝分裂免疫刺激剂和胸腺模拟物的联合施用公开(公告)号:US5846548A
公开(公告)日:1998-12-08
申请号:US506046
申请日:1995-07-24
申请人: Stefan Bartos
发明人: Stefan Bartos
IPC分类号: A61K36/18 , A61K35/55 , A61K36/00 , A61K36/26 , A61K38/00 , A61K38/16 , A61K38/20 , A61K38/32 , A61K38/36 , A61K45/00 , A61K45/06 , A61P35/00 , G01N33/53 , G01N33/574 , A61K31/00 , A61K39/385 , A01N65/00
摘要: A method of tumor therapy involves controlling the immune system by co-administration of a mitogenic immuno-stimulating substance and a thymomimetic substance.
摘要翻译: 肿瘤治疗的方法包括通过共同施用有丝分裂免疫刺激物质和胸腺嘧啶霉素物质来控制免疫系统。
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公开(公告)号:US5798090A
公开(公告)日:1998-08-25
申请号:US394431
申请日:1995-02-24
IPC分类号: A61K35/14 , A61K38/17 , A61K39/00 , A61K45/00 , A61K47/48 , C07K14/705 , A01N63/00 , A61K39/38
CPC分类号: A61K47/4833 , A61K39/0011 , A61K45/05 , C07K14/705
摘要: DTH-Effector cells are primed with carbohydrate antigens and used to enhance the cellular immune response. Tumors have been inhibited by DTH-Effector cells primed with epiglycanin and with synthetic T and Tn antigens. Either the DTH-Effector cells, or these tumor-associated carbohydrate antigens directly, may be used for tumor prophylaxis and therapy.
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74.
公开(公告)号:US5346891A
公开(公告)日:1994-09-13
申请号:US747633
申请日:1991-08-20
摘要: Novel LPS having the following physical properties, novel bacilli providing those LPS, and novel immunity stimulators, anagesics, and antiwithdrawal agents, and novel veterinary immunity stimulators, analgesics, and antiwithdrawal agents containing LPS selected from the group consisting of those LPSs and mixtures thereof.LPS1 Dominant molecular weight: 5,000.+-.1,000 as determined by______________________________________ SDS-PAGE method ______________________________________ Phosphorus number: 2 .+-. 1/5,000 (m.w.) Hexosamine number: 9 .+-. 1/5,000 (m.w.) KDO number: 2 .+-. 1/5,000 (m.w.) ______________________________________ LPS2 Dominant molecular weight: 6,500.+-.2,500 as determined by______________________________________ SDS-PAGE method ______________________________________ Phosphorus number: 1 to 2/5,000 (m.w.) Hexosamine number: 7 .+-. 1/5,000 (m.w.) KDO number: 1 to 2/5,000 (m.w.) ______________________________________ LPS3 Dominant molecular weight: 6,500.+-.2,500 as determined by______________________________________ SDS-PAGE method ______________________________________ Phosphorus number: 2 .+-. 1/5,000 (m.w.) Hexosamine number: 5 .+-. 1/5,000 (m.w.) KDO number: 2 .+-. 1/5,000 (m.w.) ______________________________________
摘要翻译: 具有以下物理性质的新型LPS,提供这些LPS的新型杆菌,以及新型免疫刺激剂,分泌物和抗引发剂,以及含有选自LPS和其混合物的LPS的新型兽用免疫刺激剂,止痛剂和抗提取剂。 LPS1主要分子量:通过-SDS-PAGE法测定的5,000 +/- 1,000磷数:2 +/- 1 / 5,000(mw) - 脱氨基胺数:9 +/- 1 / 5,000(mw)-KDO数: 2 +/- 1 / 5,000(mw) - LPS2主要分子量:6,500 +/- 2,500,通过-SDS-PAGE方法测定 - 磷数:1至2 / 5,000(mw) - 脱氨基胺数:7 +/- 1 / 5,000(mw)-KDO数量:1〜2 / 5,000(mw) - LPS3通过-SDS-PAGE法测定的主要分子量:6,500 +/- 2,500 - 磷数:2 +/- 1 / 5,000(mw) -Hexosamine数量:5 +/- 1 / 5,000(mw)-KDO数量:2 +/- 1 / 5,000(mw) -
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公开(公告)号:US5149527A
公开(公告)日:1992-09-22
申请号:US584272
申请日:1990-09-18
申请人: Larry M. Weisenthal
发明人: Larry M. Weisenthal
摘要: Immunopotentiating compositions which are useful in causing tumor necrosis and/or regression in subjects who have previously received successful therapy which destroys tumors and stimulates cytotoxic macrophages are described. The immunopotentiators are administered at a time when formation of macrophages specifically cytotoxic for the tumor have been generated by previous therapy.
摘要翻译: 描述了可以在以前接受破坏肿瘤和刺激细胞毒性巨噬细胞的成功治疗的受试者中引起肿瘤坏死和/或消退的免疫增强组合物。 在通过先前的治疗已经产生对肿瘤特异性细胞毒性的巨噬细胞的形成的时候施用免疫增强剂。
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76.Immunostimulating preparations based on ribosomal RNA's and a process for the preparation of the RNA's 失效
标题翻译: 基于核糖体RNA的免疫刺激制剂和RNA的制备方法公开(公告)号:US4389396A
公开(公告)日:1983-06-21
申请号:US293639
申请日:1981-08-18
IPC分类号: C07H21/02 , A61K31/70 , A61K35/74 , A61K45/00 , A61P31/04 , A61P35/00 , A61P37/00 , C12P19/34 , A61K39/108 , A61K39/02
CPC分类号: A61K31/70 , A61K31/7105 , A61K45/05 , C12P19/34
摘要: This invention relates to a non-specific immunostimulating preparation for the treatment of immunodeficits, such as those encountered in leprosy and cancer, characterized in that it contains as sole active principle one or more bacterial ribosomal RNA's extracted from the following strains:Klebsiella pneumoniaeSerratia marcescens
摘要翻译: PCT No.PCT / FR80 / 00186 Sec。 371日期1981年8月18日 102(e)1981年8月18日PCT日期1980年12月19日PCT。本发明涉及用于治疗免疫缺陷的非特异性免疫刺激制剂,例如麻风病和癌症中遇到的那些,其特征在于其含有唯一的 活性成分从以下菌株中提取一种或多种细菌核糖体RNA:肺炎克雷伯杆菌
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公开(公告)号:US3119741A
公开(公告)日:1964-01-28
申请号:US18630762
申请日:1962-04-10
申请人: PRINCETON LAB INC
发明人: FREEDMAN HENRY H , SULTZER BARNET M
IPC分类号: A61K45/00
CPC分类号: A61K45/05
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公开(公告)号:US11905318B2
公开(公告)日:2024-02-20
申请号:US17011059
申请日:2020-09-03
发明人: Neil R. Cashman , Steven S. Plotkin
IPC分类号: C07K7/00 , C07K14/00 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/12 , A61K38/17 , C07K14/47 , C07K16/18 , C07K5/103 , C07K5/117 , A61K47/64 , C07K7/06 , C12N5/10 , C07K7/64 , A61P25/28 , A61K39/00 , A61K39/39 , A61K51/10 , G01N33/68 , A61K49/18 , A61K39/395 , A61K38/07 , A61K47/68 , A61K45/00 , A61K51/08 , A61K47/69 , A61K38/05 , A61K45/06 , C07K7/08 , C07K16/00 , C07K14/435 , G01N33/50 , A61L27/22 , A61L27/34 , A61L31/10 , A61L31/16 , A61L29/08 , A61L29/16
CPC分类号: C07K14/4711 , A61K38/1716 , A61K39/0007 , A61K39/39 , A61K47/643 , A61K47/646 , A61K51/1018 , A61P25/28 , C07K5/101 , C07K5/1024 , C07K7/06 , C07K7/64 , C07K16/18 , C12N5/10 , G01N33/6896 , A61K38/00 , A61K38/05 , A61K38/07 , A61K38/08 , A61K38/12 , A61K39/00 , A61K39/395 , A61K39/3955 , A61K39/39533 , A61K45/05 , A61K45/06 , A61K47/6803 , A61K47/6921 , A61K49/1818 , A61K49/1866 , A61K51/088 , A61K51/10 , A61K2039/505 , A61K2039/55505 , A61K2039/6081 , A61K2300/00 , A61L27/227 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , C07K7/08 , C07K14/435 , C07K16/00 , C07K2317/20 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/524 , C07K2317/526 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/624 , C07K2317/626 , C07K2317/70 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , G01N33/5058 , G01N2333/4709 , G01N2800/28 , G01N2800/2821 , G01N2800/387
摘要: The disclosure pertains to conformational epitopes in A-beta, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.
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公开(公告)号:US11801264B2
公开(公告)日:2023-10-31
申请号:US17155933
申请日:2021-01-22
发明人: Heiko Schuster , Franziska Hoffgaard , Jens Fritsche , Oliver Schoor , Toni Weinschenk , Daniel Johannes Kowalewski , Chih-Chiang Tsou
IPC分类号: A61K39/00 , A61K35/17 , A61P35/00 , A61K39/39 , C07K16/28 , C07K7/06 , C07K14/54 , A61P35/02 , A61K45/06 , C12N5/0783 , A61K39/12 , C07K16/24 , A61K39/395 , A61K38/08 , C07K14/47 , A61K45/00
CPC分类号: A61K35/17 , A61K38/08 , A61K39/001102 , A61K39/001114 , A61K39/001118 , A61K39/12 , A61K39/39 , A61K39/39558 , A61K45/06 , A61P35/00 , A61P35/02 , C07K7/06 , C07K14/4748 , C07K14/5434 , C07K16/244 , C07K16/2818 , C07K16/2821 , C12N5/0636 , A61K45/05 , A61K2039/5154 , A61K2039/5156 , A61K2039/5158 , A61K2039/55516 , A61K2039/55533 , A61K2039/55538 , A61K2039/55561 , A61K2039/572 , A61K2039/585
摘要: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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公开(公告)号:US11779629B2
公开(公告)日:2023-10-10
申请号:US16999849
申请日:2020-08-21
发明人: Neil R. Cashman
IPC分类号: A61K38/00 , A61K38/17 , C07K7/00 , C07K5/12 , A61K38/07 , A61K38/12 , A61K39/385 , A61K47/64 , C07K14/47 , C07K5/117 , C07K7/06 , C07K7/64 , C12N5/16 , G01N33/68 , A61P25/28 , C07K16/18 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/097 , C07K5/113 , A61K39/00 , A61K51/08 , A61K49/18 , A61K45/00 , A61K39/395 , A61K38/05 , A61K51/10 , A61K47/68 , A61K38/08 , A61K39/39 , A61K45/06 , A61K47/69 , A61L31/10 , A61L27/34 , A61L29/16 , A61L31/16 , A61L29/08 , A61L27/22 , G01N33/50 , C07K5/103 , C07K14/435 , C12N5/10 , C07K7/08
CPC分类号: A61K38/07 , A61K38/12 , A61K39/385 , A61K47/643 , A61K47/646 , A61P25/28 , C07K5/081 , C07K5/0808 , C07K5/0812 , C07K5/0815 , C07K5/0819 , C07K5/0821 , C07K5/1021 , C07K5/1024 , C07K7/06 , C07K7/64 , C07K14/4711 , C07K16/18 , C12N5/16 , G01N33/6896 , A61K38/00 , A61K38/05 , A61K38/08 , A61K39/00 , A61K39/39 , A61K39/395 , A61K39/3955 , A61K39/39533 , A61K45/05 , A61K45/06 , A61K47/6803 , A61K47/6921 , A61K49/1818 , A61K49/1866 , A61K51/088 , A61K51/10 , A61K51/1018 , A61K2039/505 , A61K2039/55505 , A61K2039/6081 , A61K2300/00 , A61L27/227 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , C07K5/101 , C07K7/08 , C07K14/435 , C07K2317/20 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/524 , C07K2317/526 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/624 , C07K2317/626 , C07K2317/70 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C12N5/10 , G01N33/5058 , G01N2333/4709 , G01N2800/28 , G01N2800/2821 , G01N2800/387
摘要: The disclosure pertains to methods of treating or preventing a disease or condition associated with and/or induced by soluble A-beta oligomer such as Alzheimer's disease by administering to a subject in need thereof conformation specific and/or selective antibodies or binding fragments thereof and related products.
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