Lipopolysaccharide-producing bacteria, lipopolysaccharides, and
lipopolysaccharide-containing, medicines and veterinary medicines
    74.
    发明授权
    Lipopolysaccharide-producing bacteria, lipopolysaccharides, and lipopolysaccharide-containing, medicines and veterinary medicines 失效
    脂多糖生产细菌,脂多糖和含脂多糖,药物和兽药

    公开(公告)号:US5346891A

    公开(公告)日:1994-09-13

    申请号:US747633

    申请日:1991-08-20

    摘要: Novel LPS having the following physical properties, novel bacilli providing those LPS, and novel immunity stimulators, anagesics, and antiwithdrawal agents, and novel veterinary immunity stimulators, analgesics, and antiwithdrawal agents containing LPS selected from the group consisting of those LPSs and mixtures thereof.LPS1 Dominant molecular weight: 5,000.+-.1,000 as determined by______________________________________ SDS-PAGE method ______________________________________ Phosphorus number: 2 .+-. 1/5,000 (m.w.) Hexosamine number: 9 .+-. 1/5,000 (m.w.) KDO number: 2 .+-. 1/5,000 (m.w.) ______________________________________ LPS2 Dominant molecular weight: 6,500.+-.2,500 as determined by______________________________________ SDS-PAGE method ______________________________________ Phosphorus number: 1 to 2/5,000 (m.w.) Hexosamine number: 7 .+-. 1/5,000 (m.w.) KDO number: 1 to 2/5,000 (m.w.) ______________________________________ LPS3 Dominant molecular weight: 6,500.+-.2,500 as determined by______________________________________ SDS-PAGE method ______________________________________ Phosphorus number: 2 .+-. 1/5,000 (m.w.) Hexosamine number: 5 .+-. 1/5,000 (m.w.) KDO number: 2 .+-. 1/5,000 (m.w.) ______________________________________

    摘要翻译: 具有以下物理性质的新型LPS,提供这些LPS的新型杆菌,以及新型免疫刺激剂,分泌物和抗引发剂,以及含有选自LPS和其混合物的LPS的新型兽用免疫刺激剂,止痛剂和抗提取剂。 LPS1主要分子量:通过-SDS-PAGE法测定的5,000 +/- 1,000磷数:2 +/- 1 / 5,000(mw) - 脱氨基胺数:9 +/- 1 / 5,000(mw)-KDO数: 2 +/- 1 / 5,000(mw) - LPS2主要分子量:6,500 +/- 2,500,通过-SDS-PAGE方法测定 - 磷数:1至2 / 5,000(mw) - 脱氨基胺数:7 +/- 1 / 5,000(mw)-KDO数量:1〜2 / 5,000(mw) - LPS3通过-SDS-PAGE法测定的主要分子量:6,500 +/- 2,500 - 磷数:2 +/- 1 / 5,000(mw) -Hexosamine数量:5 +/- 1 / 5,000(mw)-KDO数量:2 +/- 1 / 5,000(mw) -

    Immunopotentiating protocol for chemotherapy-responsive tumors
    75.
    发明授权
    Immunopotentiating protocol for chemotherapy-responsive tumors 失效
    化疗反应性肿瘤的免疫增强方案

    公开(公告)号:US5149527A

    公开(公告)日:1992-09-22

    申请号:US584272

    申请日:1990-09-18

    IPC分类号: A61K35/74 A61K38/19 A61K45/00

    CPC分类号: A61K45/05 A61K35/74 A61K38/19

    摘要: Immunopotentiating compositions which are useful in causing tumor necrosis and/or regression in subjects who have previously received successful therapy which destroys tumors and stimulates cytotoxic macrophages are described. The immunopotentiators are administered at a time when formation of macrophages specifically cytotoxic for the tumor have been generated by previous therapy.

    摘要翻译: 描述了可以在以前接受破坏肿瘤和刺激细胞毒性巨噬细胞的成功治疗的受试者中引起肿瘤坏死和/或消退的免疫增强组合物。 在通过先前的治疗已经产生对肿瘤特异性细胞毒性的巨噬细胞的形成的时候施用免疫增强剂。