公开(公告)号：US06210591B1

公开(公告)日：2001-04-03

申请号：US09348130

申请日：1999-07-02

Applicant: Nikolai M. Krivitski

Inventor： Nikolai M. Krivitski

IPC: A61B5026

CPC classification number: A61M1/367 ,  A61M1/16 ,  A61M1/3653 ,  A61M1/3655 ,  A61M1/3656 ,  A61M1/3658 ,  A61M1/3663 ,  A61M1/3669

Abstract: The invention provides a method of determining a shunt flow and particularly for hemodialysis shunts. The method includes determining a shunt flow in a shunt connected between a first point and a second point in a circulating system, wherein a first flow rate is established in the circulating system; a first flow time, or flow velocity is determined between spaced locations in the shunt during the first flow rate in the circulating system; a second flow rate is established in the circulating system; a second flow time, or flow velocity is determined between spaced locations in the shunt during the second flow rate in the circulating system; and a shunt flow is calculated from the first flow time or velocity, the second flow time or velocity, the first flow rate and the second flow rate.

Abstract translation: 本发明提供了一种确定分流流量的方法，特别是用于血液透析分流器。 该方法包括确定连接在循环系统中的第一点和第二点之间的分流器中的分流流，其中在循环系统中建立第一流量; 在循环系统中的第一流量期间在分流器中的间隔位置之间确定第一流动时间或流速; 在循环系统中建立第二流量; 在循环系统中的第二流量期间在分流器中的间隔位置之间确定第二流动时间或流速; 并且从第一流动时间或速度，第二流动时间或速度，第一流量和第二流量计算分流。

公开(公告)号：US5900726A

公开(公告)日：1999-05-04

申请号：US876445

申请日：1997-06-16

Applicant: James M. Brugger ,  George W. Buffaloe, IV ,  Francis T. Ogawa

Inventor： James M. Brugger ,  George W. Buffaloe, IV ,  Francis T. Ogawa

IPC: A61M1/16 ,  A61M1/36 ,  G01F1/704 ,  G01F1/708 ,  G01N27/02 ,  G01N33/487 ,  G01N27/08

CPC classification number: A61M1/16 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3653 ,  A61M1/3658 ,  A61M1/3669 ,  G01F1/7046 ,  G01F1/708 ,  G01F1/7088

Abstract: A flow rate of a fluid flowing in a tube is quantitatively determined by altering the electrical conductivity of the fluid by injection of a bolus of saline. The electrical conductivity of the altered conductivity is measured over the time it takes the altered conductivity fluid to pass a conductivity measuring location. The measured conductivity is integrated over the time it takes to pass the conductivity measuring location. The integral is interpreted to determine the flow rate.

公开(公告)号：US5595182A

公开(公告)日：1997-01-21

申请号：US485790

申请日：1995-06-07

Applicant: Nikolai M. Krivitski

Inventor： Nikolai M. Krivitski

IPC: A61B5/0275 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1495 ,  A61B8/12 ,  A61M1/16 ,  A61M1/36 ,  A61B8/00

CPC classification number: A61B5/0275 ,  A61M1/3653 ,  A61M1/3658 ,  A61M1/16 ,  A61M1/3669

Abstract: An apparatus and method for measuring hemodynamic parameters includes a sound velocity sensor coupled to at least one of an arterial or venous portion of a blood system. An indicator medium is injected into the blood system upstream of the sensor to dilute the bloodstream, and the sensor detects the dilution through changes in measured sound velocity. The changes are recorded and used to determine hemodynamic parameters.

Abstract translation: 用于测量血液动力学参数的装置和方法包括耦合到血液系统的动脉或静脉部分中的至少一个的声速传感器。 将指示剂介质注入到传感器上游的血液系统中以稀释血流，并且传感器通过测量的声速的变化来检测稀释度。 记录变化并用于确定血液动力学参数。

公开(公告)号：US5453576A

公开(公告)日：1995-09-26

申请号：US327984

申请日：1994-10-24

Applicant: Nikolai M. Krivitski

Inventor： Nikolai M. Krivitski

IPC: A61B5/0275 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1495 ,  A61B8/12 ,  A61M1/16 ,  A61M1/36 ,  A61B5/00

CPC classification number: A61B5/0275 ,  A61M1/3653 ,  A61M1/3658 ,  A61M1/16 ,  A61M1/3669

Abstract: An apparatus and method for measuring hemodynamic parameters includes a sound velocity sensor coupled to at least one of an arterial or venous portion of a blood system. An indicator medium is injected into the blood system upstream of the sensor to dilute the bloodstream, and the sensor detects the dilution through changes in measured sound velocity. The changes are recorded and used to determine hemodynamic parameters.

Abstract translation: 用于测量血液动力学参数的装置和方法包括耦合到血液系统的动脉或静脉部分中的至少一个的声速传感器。 将指示剂介质注入到传感器上游的血液系统中以稀释血流，并且传感器通过测量的声速的变化来检测稀释度。 记录变化并用于确定血液动力学参数。

公开(公告)号：US5055198A

公开(公告)日：1991-10-08

申请号：US525536

申请日：1990-05-18

Applicant: U. Ramakrishna Shettigar

Inventor： U. Ramakrishna Shettigar

IPC: B01D61/18 ,  A61M1/00 ,  A61M1/02 ,  A61M1/34 ,  A61M1/36

CPC classification number: A61M1/3627 ,  A61M1/0007 ,  A61M1/02 ,  A61M1/3603 ,  A61M1/3604 ,  A61M1/3612 ,  A61M1/3692 ,  A61M1/34 ,  A61M1/3626 ,  A61M1/3669 ,  A61M2205/3382 ,  A61M2205/3386 ,  A61M2205/3389

Abstract: An apparatus for recycling autologous blood from a patient for reinfusion back to the patient comprising suction means, admixing means for admixing aspirated blood with a washing fluid, filtering means for filtering the admixture through an emboli filter and a membrane filter, monitoring means for measuring the amount of cellular component volume in the filtered blood, filtration means for removing excess fluid and particulates from the blood, and reinfusion means is disclosed. Embodiments for use during surgery for on-line purification and reinfusion on a real time basis are disclosed along with embodiments for use post-surgically when the wound site is closed and drainage tubing has been implanted at the wound site to draw off blood post-surgically. Methods for performing the autotransfusion process are also disclosed.

Abstract translation: 一种用于将患者的自体血液再循环回患者的装置，包括抽吸装置，用于将吸入的血液与洗涤液混合的混合装置，用于通过栓塞过滤器和膜过滤器过滤混合物的过滤装置，用于测量 过滤血液中的细胞组分体积的量，用于从血液中除去过量的液体和颗粒的过滤装置以及再灌注装置。 在实时的在线净化和再灌注期间使用的实施例与实施例一起公开，当手术时使用伤口部位闭合并且将引流管植入伤口部位以在手术后抽出血液时使用 。 还公开了进行自体输注过程的方法。

公开(公告)号：US4976682A

公开(公告)日：1990-12-11

申请号：US272241

申请日：1988-11-16

Applicant: Perry L. Lane ,  Udipi R. Shettigar

Inventor： Perry L. Lane ,  Udipi R. Shettigar

IPC: A61M1/00 ,  A61M1/02 ,  A61M1/34 ,  A61M1/36

CPC classification number: A61M1/02 ,  A61M1/0031 ,  A61M1/0084 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3621 ,  A61M1/3626 ,  A61M1/3627 ,  A61M1/3669 ,  A61M1/3675 ,  A61M2205/331 ,  A61M2205/3375 ,  A61M2205/3386

Abstract: Improved methods and apparatus for the collection, purification and reinfusion of blood from a wound site. The present invention provides a source of anticoagulated washing fluid in proportion to the bleeding rate which can be directed to the suction tip in such a way that the wound or surgical site is washed.The present invention minimizes blood damage and maximizes blood recovery by (i) automatically regulating the suction in proportion to the bleeding rate, (ii) minimizing the air suction or blood frothing, (iii) washing the wound site with the anticoagulated washing fluid, and (iv) reducing the number of blood pumps, preferably to one.The present invention also provides a system to operate automatically by including automatic venting of entrapped air, continuous determination of irrigation fluid added into the wound site and its removal, continuous monitoring of hematocrit, continuous neutralization of anticoagulant, and reinfusion of purified blood to patient on realtime basis irrespective of bleeding rate.

Abstract translation: 改善了从伤口部位收集，纯化和回输血液的方法和装置。 本发明提供与出血率成比例的抗凝血清洗液源，其可以以伤口或手术部位被洗涤的方式引导至吸引尖端。 本发明通过以下方式使血液损伤最小化并使血液回收最大化：（i）与出血率成比例地自动调节吸力，（ii）使吸气或血液起泡最小化，（iii）用抗凝血清洗液洗涤伤口部位，以及 （iv）减少血泵的数量，最好减少一个。 本发明还提供了一种通过包括自动排出夹带空气，连续确定添加到伤口部位中的灌洗液及其去除，血细胞比容连续监测，抗凝血剂连续中和以及将纯化血液输送给患者的方法自动操作的系统。 不考虑出血率的实时基准。

公开(公告)号：US4711715A

公开(公告)日：1987-12-08

申请号：US823887

申请日：1986-01-29

Applicant: Hans-Dietrich Polaschegg

Inventor： Hans-Dietrich Polaschegg

IPC: A61M1/14 ,  A61M1/16 ,  A61M1/30 ,  A61M1/34 ,  A61M1/36 ,  B01D61/14 ,  B01D61/20 ,  B01D61/22 ,  B01D61/26 ,  B01D61/30 ,  B01D61/32 ,  B01D61/34

CPC classification number: A61M1/3413 ,  A61M1/16 ,  A61M1/30 ,  A61M1/302 ,  A61M1/306 ,  A61M1/309 ,  A61M1/3437 ,  A61M1/3465 ,  A61M1/3609 ,  A61M1/361 ,  A61M1/3612 ,  B01D61/22 ,  A61M1/3669

Abstract: An apparatus for controlling the ultrafiltration rate in machines for the extracorporeal purification of blood in which the difference obtained in the blood circuit by an electromagnetic flow meter is used for controlling the ultrafiltration rate.The ultrafiltration rate is controlled by controlling the transmembrane pressure across the membrane separating the blood chamber from the dialysis fluid chamber in a dialyzer. In one embodiment, the pressure in the blood circuit is varied to change the transmembrane pressure. In a second embodiment, the pressure in the dialysis solution circuit is varied.

Abstract translation: 一种用于控制血液体外净化的机器中的超滤速率的装置，其中使用电磁流量计在血液回路中获得的差异来控制超滤率。 超滤速率通过控制跨膜的跨膜压力来控制，所述跨膜将透析器中的血液室与透析液室隔离开。 在一个实施例中，改变血液回路中的压力以改变跨膜压力。 在第二实施例中，透析溶液回路中的压力是变化的。

公开(公告)号：US4209392A

公开(公告)日：1980-06-24

申请号：US905956

申请日：1978-05-15

Applicant: Richard A. Wallace

Inventor： Richard A. Wallace

IPC: A61M1/16 ,  A61M1/34 ,  A61M1/36 ,  B01D15/00 ,  B01D13/00 ,  B01D31/00

CPC classification number: A61M1/1696 ,  A61M1/3427 ,  A61M1/3486 ,  B01D15/00 ,  A61M1/3669 ,  A61M2205/331 ,  Y10S128/03 ,  Y10S210/929

Abstract: Portable hepatic-assist closed loop method and apparatus utilizing hemofiltration membrane and sterilizable disposable sorbents cartridge for adsorption of hepatic toxins.

Abstract translation: 便携式肝辅助闭环法和利用血液滤膜和可消毒的一次性吸着剂药筒吸附肝毒素的装置。

公开(公告)号：US12029555B2

公开(公告)日：2024-07-09

申请号：US16982317

申请日：2019-03-20

Applicant: GAMBRO LUNDIA AB

Inventor： Paolo Rovatti ,  Enrico Ravagli ,  Stefano Severi

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/02 ,  A61B5/026 ,  A61B5/1455 ,  A61B8/00 ,  A61M1/16 ,  A61M1/36

CPC classification number: A61B5/14535 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0261 ,  A61B5/1455 ,  A61B5/6866 ,  A61B8/00 ,  A61M1/1603 ,  A61M1/1619 ,  A61M1/3601 ,  A61M1/3609 ,  A61M1/3612 ,  A61M1/3669 ,  A61B2562/00 ,  A61B2562/04 ,  A61B2562/146 ,  A61B2562/16 ,  A61B2562/164 ,  A61B2562/166 ,  A61B2562/228 ,  A61M1/1605 ,  A61M1/1613 ,  A61M2205/3306 ,  A61M2205/3334

Abstract: An apparatus for extracorporeal treatment of blood (1) comprising a treatment unit (2), a blood withdrawal line (6), a blood return line (7), a preparation line (19) and a spent dialysate line (13); a non-invasive blood volume sensor (50) for determining an additional property of blood is active on a tube segment (61) of the blood withdrawal line or of the blood return line; the sensor includes one source (53) for directing a signal towards the blood, a plurality of detectors (57) for receiving the signal, and a controller (65) receiving the output signals from the detectors (57) and determining a blood volume variation and a value of sodium concentration in the blood (Napl) both based on the output signals. A process of determining at least one parameter and on property of blood circulating an extracorporeal blood circuit is also disclosed.

公开(公告)号：US09415146B2

公开(公告)日：2016-08-16

申请号：US13421275

申请日：2012-03-15

Applicant: Alan Robert Brunsman

Inventor： Alan Robert Brunsman

IPC: A61M1/16 ,  B01D61/34 ,  A61M1/02 ,  B01D61/32 ,  A61M1/36

CPC classification number: A61M1/0281 ,  A61M1/1682 ,  A61M1/3669 ,  B01D61/32

Abstract: A system for removing cryoprotectant from a cryoprotectant-containing liquid stored a container comprises a cryoprotectant removal device that receives the cryoprotectant-containing liquid and a cryoprotectant-free dialysate liquid and that is operable to transfer cryoprotectant to the dialysate liquid. A differential conductivity device is arranged to continuously measure the difference in conductivity between dialysate liquid entering the device and dialysate liquid that has received cryoprotectant transferred by the dialyzer discharged from the device. A controller is operable to control the flow of the liquids through the device in response to the measured difference in conductivity, and particularly to stop the flow of the cryoprotectant-containing liquid when the measured differential conductivity indicates that the cryoprotectant has been substantially removed from the liquid.

Abstract translation: 从含有冷冻保护剂的液体中除去冷冻保护剂的系统存储容器包括冷冻保护剂去除装置，其接收含冷冻保护剂的液体和无冷冻保护剂的透析液，并且可操作以将冷冻保护剂转移到透析液中。 差分电导率装置被设置为连续地测量进入装置的透析液和已经接收了从装置排出的透析器转移的冷冻保护剂的透析液之间的电导率差。 控制器可操作以响应于测量的导电性差异来控制液体通过装置的流动，特别是当测量的差分电导率表明冷冻保护剂已经从 液体。