专利检索 ipc:"C07C211/40" 第 8 页

71.

发明授权
Process for controlling the catalytic co-oligomerization of 1,3-dienes with Schiff's bases 失效
标题翻译：用Schiff（3s碱基）控制1,3-二烯的催化共低聚的方法

公开(公告)号：US4163024A

公开(公告)日：1979-07-31

申请号：US820962

申请日：1977-08-01

申请人： Paul Heimbach , Achim Roloff , Erich F. Nabbefeld-Arnold

发明人： Paul Heimbach , Achim Roloff , Erich F. Nabbefeld-Arnold

IPC分类号： C08F2/00 , B01J20060101 , B01J31/00 , B01J31/02 , B01J31/04 , B01J31/16 , C07C20060101 , C07C67/00 , C07C209/00 , C07C209/60 , C07C211/21 , C07C211/25 , C07C211/28 , C07C211/40 , C07C241/00 , C07C251/02 , C07C251/78 , C08F20060101 , C08F2/38 , C08F236/04 , C07C119/00

CPC分类号： C07C215/40

摘要： A process has been developed for controlling the catalytic co-oligmoerization of 1,3-dienes with Schiff's bases which comprises condensing a 1,3-diene of the formula ##STR1## wherein R.sup.4 and R.sup.5, independently of one another, represent hydrogen or an alkyl group having 1 to 4 carbon atoms with a Schiff base of the formula ##STR2## wherein each of R.sup.1, R.sup.2 and R.sup.3 represents hydrogen alkyl, cycloalkyl, aralkyl, aryl or dimethylamino groups which, in addition, optionally contain functional groups of the group consisting of ethers esters, C.dbd.N double bonds and which can be closed to form a ring, in the presence of a nickel (O)-containing catalyst, and optionally in the presence of an X--H compound with a molar ratio of Ni: X H of from 1:0 to 1:10.

摘要翻译： 已经开发了一种用于控制具有席夫碱的1,3-二烯的催化共 - 低聚缩合的方法，该方法包括将式（I）的1,3-二烯缩合，其中R 4和R 5彼此独立地表示氢或具有1至4个碳原子的烷基，具有式“IMAGE”的希夫碱，其中R 1，R 2和R 3各自表示烷基，环烷基，芳烷基，芳基或二甲基氨基，其另外任选地含有该基团的官能团由醚酯，C = N双键组成，并且可以在含镍（O）的催化剂的存在下，并且任选地在摩尔比为Ni:XH的XH化合物存在下封闭形成环为1:0至1:10。

72.

发明授权
Substituted cyclohexyl compounds as NOP inhibitors 有权

公开(公告)号：US11945808B2

公开(公告)日：2024-04-02

申请号：US17841570

申请日：2022-06-15

申请人： Dart NeuroScience, LLC

发明人： Jillian Basinger Thompson , Brett C. Bookser , Scott Burley , Pablo Garcia-Reynaga , Andrew Hudson , Marco Peters , Benjamin Pratt , Aaron Thompson , Joe Tran , Lino Valdez

IPC分类号： C07D309/14 , A61P25/28 , C07C211/40 , C07C237/24 , C07C255/46 , C07D207/14 , C07D207/273 , C07D211/58 , C07D211/76 , C07D211/96 , C07D213/38 , C07D401/12 , C07D405/12

CPC分类号： C07D405/12 , A61P25/28 , C07C211/40 , C07C237/24 , C07C255/46 , C07D207/14 , C07D207/273 , C07D211/58 , C07D211/76 , C07D211/96 , C07D213/38 , C07D309/14 , C07D401/12 , C07C2601/08 , C07C2601/14 , C07C2601/16

摘要： Substituted cyclohexyl chemical entities of Formula (I):

wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

73.

发明授权
LSD1 inhibitor and preparation method and application thereof 有权

公开(公告)号：US11433053B2

公开(公告)日：2022-09-06

申请号：US16479602

申请日：2018-01-24

申请人： CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD.

发明人： Lingyun Wu , Li Zhang , Lele Zhao , Jianjun Sun , Zhaoguo Chen , Jian Li , Shuhui Chen

IPC分类号： C07D207/09 , C07D207/335 , C07D209/44 , C07D211/18 , C07D211/34 , C07D213/38 , C07D217/26 , C07D223/16 , C07D231/12 , C07D233/64 , C07D249/06 , A61K31/4245 , A61P35/00 , A61K33/243 , A61K31/135 , A61K31/165 , A61K31/277 , A61K31/40 , A61K31/4035 , A61K31/41 , A61K31/415 , A61K31/417 , A61K31/4188 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4439 , A61K31/451 , A61K31/4545 , A61K31/472 , A61K31/519 , A61K31/55 , C07C211/40 , C07C233/58 , C07C255/46 , C07D249/08 , C07D257/04 , C07D261/20 , C07D263/56 , C07D271/06 , C07D277/28 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04

摘要： A cyclopropylamine compound as a lysine-specific demethylase 1 (LSD1) inhibitor. Particularly, the present invention relates to a compound represented by formula (I) and a pharmaceutically acceptable salt thereof. The present invention also provides an application of the same in preparing a drug for treating an LSD1-related disease.

74.

发明申请
METHODS OF SYNTHESIS OF (1R,2R,5R)-5-AMINO-2-METHYL-CYCLOHEXANOL HYDROCHLORIDE AND INTERMEDIATES USEFUL THEREIN 有权

公开(公告)号：US20220234990A1

公开(公告)日：2022-07-28

申请号：US17518552

申请日：2021-11-03

申请人： Celgene Corporation

发明人： Terrence Joseph CONNOLLY , Hon-Wah MAN , Periyandi NAGARAJAN , Chinnapillai RAJENDIRAN , Jasti VENKATESWARLU

IPC分类号： C07C213/02 , C07C209/88 , C07C67/347 , C07C51/09 , C07C269/04 , C07C269/06 , C07C209/58 , C07C231/02 , C07C211/40

摘要： Provided herein are methods and intermediates for making (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.

75.

发明授权
Analgesic compounds 有权

公开(公告)号：US11242327B2

公开(公告)日：2022-02-08

申请号：US16613397

申请日：2018-05-11

申请人： RECURIUM IP HOLDINGS, LLC

发明人： Chad Daniel Hopkins , Joseph Robert Pinchman , Kevin Duane Bunker , Deborah Helen Slee , Brant Clayton Boren , Mehmet Kahraman

IPC分类号： C07D277/28 , C07D213/38 , C07D235/14 , C07D239/26 , C07D263/56 , C07D277/64 , A61P29/00 , A61P25/04 , C07C211/38 , C07C211/40 , C07C215/08 , C07C217/52 , C07C229/14 , C07C235/14 , C07C237/04 , C07C271/24

摘要： Disclosed herein are compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), methods of synthesizing compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), and methods of using compounds of Formulae (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It) as an analgesic.

76.

发明授权
Methods of synthesis of (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein 有权

公开(公告)号：US11192847B2

公开(公告)日：2021-12-07

申请号：US16992219

申请日：2020-08-13

申请人： Celgene Corporation

发明人： Terrence Joseph Connolly , Hon-Wah Man

IPC分类号： C07C213/02 , C07C209/88 , C07C67/347 , C07C51/09 , C07C269/04 , C07C269/06 , C07C209/58 , C07C231/02 , C07C211/40

摘要： Provided herein are methods and intermediates for making (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.

77.

发明授权
Process for the preparation of enantiomerically and diastereomerically enriched cyclobutane amines and amides 有权

公开(公告)号：US11053188B2

公开(公告)日：2021-07-06

申请号：US16764666

申请日：2018-11-14

申请人： SYNGENTA PARTICIPATIONS AG

发明人： Raphael Dumeunier , Tomas Smejkal , Brijnandan Premnath Mishra , Vijayagopal Raman Gopalsamuthiram , Edouard Godineau , Anthony Cornelius O'Sullivan

IPC分类号： C07C231/06 , C07C45/44 , C07C49/593 , C07C49/467 , C07C49/647 , C07C49/697 , C07C49/39 , C07C231/02 , C07C211/40 , C07C45/54 , C07C209/26 , C07D213/803 , C07C47/457 , C07C233/58 , B01J21/02

摘要： The present invention relates to a process for the preparation of enantiomerically and diastereomerically enriched cyclobutane amines and amides by reacting (a) cyclopropylcarbonitrile to a cyclopropylcarbaldehyde, (b) further reacting to a cyclobutanone, or (d′) further reacting to an enamide, (c) further reacting to enantiomerically and diastereomerically enriched cyclobutane amines, or (d) further reacting to an enamide and (e) to an enantiomerically and diastereomerically enriched cyclobutylamide to obtain (f) an enantiomerically and diastereomerically enriched cyclobutane amine, and (g) further reacting to an enantiomerically and diastereomerically enriched cyclobutane amide.

78.

发明申请
METHODS OF SYNTHESIS OF (1R,2R,5R)-5-AMINO-2-METHYLCYCLOHEXANOL HYDROCHLORIDE AND INTERMEDIATES USEFUL THEREIN 审中-公开

公开(公告)号：US20200369600A1

公开(公告)日：2020-11-26

申请号：US16992219

申请日：2020-08-13

申请人： Celgene Corporation

发明人： Terrence Joseph CONNOLLY , Hon-Wah MAN

IPC分类号： C07C213/02 , C07C209/88 , C07C67/347 , C07C51/09 , C07C269/04 , C07C269/06 , C07C209/58 , C07C231/02 , C07C211/40

摘要： Provided herein are methods and intermediates for making (1R,2R,5R)-5-amino-2-methylcyclohexanol hydrochloride, which are useful for the preparation of compounds useful for the treatment of a disease, disorder, or condition associated with the JNK pathway.