利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

548 条记录 (耗时 0.016 秒)

    Oxime derivatives for protecting plant crops
    77.
    发明授权
    Oxime derivatives for protecting plant crops 失效

    公开(公告)号：US4439228A

    公开(公告)日：1984-03-27

    申请号：US398453

    申请日：1982-07-14

    申请人： Werner Fory ,  Henry Martin ,  Georg Pissiotas

    发明人： Werner Fory ,  Henry Martin ,  Georg Pissiotas

    IPC分类号： A01N25/32 ,  A01N37/32 ,  A01N37/34 ,  C07C67/00 ,  C07C251/32 ,  C07C251/54 ,  C07C313/00 ,  C07C315/04 ,  C07C317/28 ,  C07C317/44 ,  C07C323/47 ,  C07C325/00 ,  C07C327/28 ,  C07D207/26 ,  C07D207/273 ,  C07D207/325 ,  C07D207/404 ,  C07D207/408 ,  C07D207/44 ,  C07D207/452 ,  C07D207/456 ,  C07D209/48 ,  A01N43/36 ,  C07D207/24

    CPC分类号： C07D207/273 ,  A01N25/32 ,  C07D207/452 ,  C07D207/456 ,  C07D209/48

    摘要： Oxime derivatives of the formula (I) ##STR1## wherein n is 0, 1 or 2 and m is 0 or 1, and Ar is a phenyl radical ##STR2## a naphthyl radical substituted by R.sub.2 and R.sub.3, a 5- to 10-membered heterocyclic radical which contains not more than 3 identical or different heteroatoms N, O and/or S and which is substituted by R.sub.2, R.sub.3 and R.sub.4 and can be substituted by oxo or thiono, or if m is O, Ar is a radical R--CO, wherein R is a radical --OR.sub.5, in which R.sub.5 is an aliphatic group containing not more than 8 carbon atoms or is an araliphatic group containing not more than 15 carbon atoms or is a cycloaliphatic or aromatic group, each containing not more than 10 carbon atoms, while the possible substituents of the aromatic radicals or of the cycloaliphatic radical are halogen, --CN, --NO.sub.2, lower alkyl, lower alkoxy, haloalkyl; or R is a radical --NH--CO--NH--R.sub.7 or a radical --N(R.sub.6)(R.sub.7), wherein R.sub.6 is hydrogen or lower alkyl and R.sub.7 is hydrogen or an aliphatic group containing not more than 8 carbon atoms or an araliphatic group containing not more than 15 carbon atoms, or a cycloaliphatic ##STR3## wherein R.sub.9 is hydrogen, a cycloaliphatic, araliphatic or aromatic group which is unsubstituted or mono- or polysubstituted at the ring by CN, NO.sub.2, halogen, lower alkyl, lower alkoxy or haloalkyl, or is lower alkenyl, lower haloalkenyl or lower alkynyl, R.sub.10 is an aliphatic group or a cycloaliphatic, araliphatic or aromatic group which is unsubstituted or mono- or polysubstituted at the ring by CN, NO.sub.2, halogen, lower alkyl, lower alkoxy or haloalkyl, R.sub.11 is hydrogen, lower alkyl or cycloalkyl, R.sub.12 is lower alkyl or an aromatic group, while Y is O, S SO, SO.sub.2 or ##STR4## and A is C.sub.2 -C.sub.3 alkylene or C.sub.2 -C.sub.3 alkenylene which is unsubstituted or substituted by halogen, CN or lower alkyl and which together with a carbon chain which is unsubstituted or substituted by halogen, CN or lower alkyl can form a fused ring, and Hal is halogen. These compounds are used for protecting plant crops from the action of aggressive agricultural chemicals.

    N-Aryl-N-phenoxy-alkyl-piperazine compounds useful in decreasing intracranial pressure
    78.
    发明授权
    N-Aryl-N-phenoxy-alkyl-piperazine compounds useful in decreasing intracranial pressure 失效
    可用于降低颅内压的N-芳基-N-苯氧基 - 烷基 - 哌嗪化合物

    公开(公告)号：US4413006A

    公开(公告)日：1983-11-01

    申请号：US374106

    申请日：1982-05-03

    申请人： Takeshi Kanno ,  Mitsunori Gaino ,  Michio Yamamura ,  Ryuichi Ishida ,  Keiichi Shintomi

    发明人： Takeshi Kanno ,  Mitsunori Gaino ,  Michio Yamamura ,  Ryuichi Ishida ,  Keiichi Shintomi

    IPC分类号： C07D295/08 ,  A61K31/495 ,  A61P43/00 ,  C07D207/40 ,  C07D207/404 ,  C07D295/092 ,  C07D309/12 ,  C07D295/00 ,  A01N43/48 ,  C07D241/04 ,  C07D403/00

    CPC分类号： C07D207/404 ,  C07D295/088 ,  C07D309/12

    摘要： A piperazine derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen, alkyl (C.sub.1-8), alkyl (C.sub.1-4)-sulfonyl or an acyl group of the formula: R.sup.3 CO--(wherein R.sup.3 is hydrogen, alkyl (C.sub.1-7), halogenoalkyl (C.sub.1-4), alkoxy (C.sub.1-4)-carbonyl-alkyl (C.sub.1-4), cycloalkyl (C.sub.3-6), alkenyl (C.sub.2-5), alkoxy (C.sub.1-4), amino, alkyl (C.sub.1-4)-amino or anilino), R.sup.2 is hydrogen, alkyl (C.sub.1-4), alkoxy (C.sub.1-4)-carbonyl-alkyl (C.sub.1-4), carboxy-alkyl (C.sub.1-4), alkenyl (C.sub.2-5) or alkyl (C.sub.1-4)-sulfonyl, or R.sup.1 and R.sup.2 are combined together to form succinyl group, Ring A is phenyl, alkyl (C.sub.1-4)-phenyl or halogenophenyl, and n is an integer of 2 to 6, or a pharmaceutically acceptable acid addition salt thereof. The piperazine derivative (I) has an intracranial pressure-lowering activity. Said derivative also has a depressing effect on central nervous system.

    摘要翻译： 下式的哌嗪衍生物：其中R 1是氢，烷基（C 1-8），烷基（C 1-4） - 磺酰基或下式的酰基：R 3 CO-（其中R 3是氢，烷基 （C1-7），卤代烷基（C1-4），烷氧基（C1-4） - 羰基 - 烷基（C1-4），环烷基（C3-6），烯基（C2-5） 氨基，烷基（C1-4） - 氨基或苯胺基），R2是氢，烷基（C1-4），烷氧基（C1-4） - 羰基 - 烷基（C1-4），羧基 - 烷基（C1-4） 烯基（C 2-5）或烷基（C 1-4） - 磺酰基，或R 1和R 2结合在一起形成琥珀酰基，环A是苯基，（C 1-4） - 苯基或卤代苯基，n是 2至6，或其药学上可接受的酸加成盐。 哌嗪衍生物（I）具有颅内降压活性。 所述衍生物对中枢神经系统也具有抑郁作用。