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    Stabilization and hydrogenation methods for microbial-derived olefins
    82.
    发明授权
    Stabilization and hydrogenation methods for microbial-derived olefins 有权

    公开(公告)号：US10183901B2

    公开(公告)日：2019-01-22

    申请号：US15458907

    申请日：2017-03-14

    Applicant: AMYRIS, INC.

    Inventor： Nicholas L. Ohler ,  Roberto Vazquez

    IPC: C07C1/00 ,  C07C5/03 ,  C07C7/20 ,  C07C11/21 ,  C10G45/00 ,  C10G53/04 ,  C10G53/08 ,  C10G67/04 ,  C10G67/06 ,  C10L1/04 ,  C10L1/16 ,  C10L1/183

    Abstract: Methods and compositions for stabilization and subsequent hydrogenation of a microbial-derived immiscible olefin are described. The methods comprise separating immiscible olefin from a mixture comprising an aqueous solution, microbial cells and immiscible olefin thereby forming a crude olefin composition; purifying the crude olefin composition thereby forming a purified olefin composition; and adding a phenolic antioxidant to the purified olefin composition wherein the phenolic antioxidant is a phenol derivative containing an unfused phenyl ring with one or more hydroxyl substituents. The methods further comprise reacting the purified olefin composition with hydrogen in the presence of a hydrogen catalyst such that hydrogen saturates at least one double bond in the olefin. Hydrogenated compositions produced by the methods are further provided.

    Microbial derived isoprene and methods for making the same
    83.
    发明授权
    Microbial derived isoprene and methods for making the same 有权

    公开(公告)号：US10125376B2

    公开(公告)日：2018-11-13

    申请号：US15851715

    申请日：2017-12-21

    Applicant: AMYRIS, INC.

    Inventor： Derek McPhee

    IPC: C12P5/00 ,  C07C7/09 ,  C07C11/16 ,  C12M1/00

    Abstract: Provided herein is a gaseous isoprene composition comprising isoprene, carbon dioxide and water, wherein the isoprene is in an amount between about 0.1% and about 15% by volume; wherein the carbon dioxide is in an amount between about 0.04% and about 35% by volume; wherein the water is in an amount greater than about 70% of its saturation amount. Also provided herein is a liquid isoprene composition comprising isoprene in an amount of at least 65% by weight and carbon dioxide in an amount between about 0.01% and about 1% by weight.

    Methods for genomic integration
    84.
    发明授权
    Methods for genomic integration 有权

    公开(公告)号：US10041092B2

    公开(公告)日：2018-08-07

    申请号：US15261727

    申请日：2016-09-09

    Applicant: Amyris, Inc.

    Inventor： Andrew Horwitz ,  Kristy Michelle Hawkins ,  Max Schubert ,  Wayne Szeto

    IPC: C12N9/22 ,  C12N15/90 ,  C12Q1/6897 ,  C12N15/11

    Abstract: Provided herein are methods of integrating one or more exogenous nucleic acids into one or more selected target sites of a host cell genome. In certain embodiments, the methods comprise contacting the host cell genome with one or more integration polynucleotides comprising an exogenous nucleic acid to be integrated into a genomic target site, a nuclease capable of causing a break at the genomic target site, and a linear nucleic acid capable of homologous recombination with itself or with one or more additional linear nucleic acids contacted with the population of cells, whereupon said homologous recombination results in formation of a circular extrachromosomal nucleic acid comprising a coding sequence for a selectable marker. In some embodiments, the methods further comprise selecting a host cell that expresses the selectable marker.

    MALTOSE DEPENDENT DEGRONS, MALTOSE-RESPONSIVE PROMOTERS, STABILIZATION CONSTRUCTS, AND THEIR USE IN PRODUCTION OF NON-CATABOLIC COMPOUNDS
    85.
    发明申请
    MALTOSE DEPENDENT DEGRONS, MALTOSE-RESPONSIVE PROMOTERS, STABILIZATION CONSTRUCTS, AND THEIR USE IN PRODUCTION OF NON-CATABOLIC COMPOUNDS 审中-公开

    公开(公告)号：US20180186841A1

    公开(公告)日：2018-07-05

    申请号：US15738555

    申请日：2016-06-24

    Applicant: AMYRIS, INC. ,  TOTAL MARKETING SERVICES

    Inventor： Penelope R. CHUA ,  Hanxiao JIANG ,  Adam Leon MEADOWS

    IPC: C07K14/395 ,  C12P5/02

    Abstract: The present disclosure relates to the use of a maltose dependent degron to control stability of a protein of interest fused thereto at the post-translational level. The present disclosure also relates to the use of a maltose dependent degron in combination with a maltose-responsive promoter to control gene expression at the transcriptional level and to control protein stability at the post-translational level. The present disclosure also relates to the use of a stabilization construct that couples expression of a cell-growth-affecting protein with the production of non-catabolic compounds. The present disclosure further relates to the use of a synthetic maltose-responsive promoter. The present disclosure further provides compositions and methods for using a maltose dependent degron, a maltose-responsive promoter, and a stabilization construct, either alone or in various combinations, for the production of non-catabolic compounds in genetically modified host cells.

    Methods for genomic modification
    89.
    发明授权
    Methods for genomic modification 有权

    公开(公告)号：US09701971B2

    公开(公告)日：2017-07-11

    申请号：US14178203

    申请日：2014-02-11

    Applicant: Amyris, Inc.

    Inventor： Zach Serber ,  Andrew Horwitz

    IPC: C12N15/90 ,  C12N15/81

    CPC classification number: C12N15/905 ,  C12N15/1082 ,  C12N15/1093 ,  C12N15/81

    Abstract: Provided herein are methods of integrating one or more exogenous nucleic acids into one or more selected target sites of a host cell genome. In certain embodiments, the methods comprise contacting the host cell genome with one or more integration polynucleotides comprising an exogenous nucleic acid to be integrated into a genomic target site, and a nuclease capable of causing a double-strand break near or within the genomic target site.

    THERMOPLASTIC ELASTOMER COMPOSITION, MOLDED ARTICLE, AND ADHESIVE AGENT
    90.
    发明申请
    THERMOPLASTIC ELASTOMER COMPOSITION, MOLDED ARTICLE, AND ADHESIVE AGENT 有权
    热塑性弹性体组合物，成型品和胶粘剂

    公开(公告)号：US20160312023A1

    公开(公告)日：2016-10-27

    申请号：US15103218

    申请日：2014-12-11

    Applicant: KURARAY CO., LTD. ,  AMYRIS, INC.

    Inventor： Yusuke TANAKA ,  Hiromitsu SASAKI ,  Shota SUZUKI ,  Yosuke UEHARA

    IPC: C08L53/02 ,  C09J153/02

    CPC classification number: C08L53/025 ,  C08F8/46 ,  C08F255/02 ,  C08F297/04 ,  C08L23/26 ,  C08L29/14 ,  C08L51/06 ,  C08L53/02 ,  C08L2205/03 ,  C08L2207/04 ,  C09J123/26 ,  C09J153/02 ,  C09J153/025 ,  C08F110/06 ,  C08F222/06

    Abstract: A thermoplastic elastomer composition comprising 100 parts by mass of a hydrogenated block copolymer (A) comprising a polymer block (a) consisting of a structural unit derived from an aromatic vinyl compound and a polymer block (b) comprising 1 to 100% by mass of a structural unit (b1) derived from farnesene and comprising 99 to 0% by mass of a structural unit (b2) derived from a conjugated diene other than farnesene, a mass ratio[(a)/(b)] of the polymer block (a) to the polymer block (b) being 1/99 to 70/30; and 5 to 300 parts by mass of a polar group-containing olefinic polymer (B), is excellent in flexibility and molding processability and capable of adhering to a ceramic, a metal, a synthetic resin, or the like even through a heat treatment at low temperatures (for example, 190° C. or lower) without requiring a primer treatment or the like.

    Abstract translation: 一种热塑性弹性体组合物，其包含100质量份包含由衍生自芳族乙烯基化合物的结构单元组成的聚合物嵌段（a）的氢化嵌段共聚物（A）和包含1〜100质量％ 来自法呢烯的结构单元（b1），其含有99质量％以上的由法呢烯以外的共轭二烯衍生的结构单元（b2），聚合物嵌段的质量比[（a）/（b）] a）聚合物嵌段（b）为1/99至70/30; 和含有极性基团的烯烃类聚合物（B）为5〜300质量份时，通过热处理，柔软性和成型加工性优异，能够附着在陶瓷，金属，合成树脂等上 低温（例如190℃以下），不需要底漆处理等。

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