Abstract:
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
Abstract:
A computer-implemented method of automatically configuring a platform of storage devices includes querying components of the platform to gather information about the capability of the platform, locating one or more storage devices within the platform, automatically determining one or more RAID levels that are supported by the platform, and automatically configuring one or more storage devices within the platform as a RAID system having a particular RAID level, where the particular RAID level is selected based on the capability of the platform.
Abstract:
Provided are compounds of Formula V and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
Abstract:
Immunological assays for several biological markers for thyroid disorders in a biological sample are performed in a single test with a combination of sandwich-type, sequential competitive, and serological assays by the use of particles classified into groups that are distinguishable by flow cytometry, one group for the assay of each marker. Each group of particles is coated with a different immunological binding member, and coating densities, co-coating materials, and special buffer solutions are used to adjust for differences in the sensitivities and dynamic ranges of each of the markers in the typical sample.
Abstract:
Immunological assays for several biological markers for thyroid disorders in a biological sample are performed in a single test with a combination of sandwich-type, sequential competitive, and serological assays by the use of particles classified into groups that are distinguishable by flow cytometry, one group for the assay of each marker. Each group of particles is coated with a different immunological binding member, and coating densities, co-coating materials, and special buffer solutions are used to adjust for differences in the sensitivities and dynamic ranges of each of the markers in the typical sample.
Abstract:
An ultrasonic welding assembly comprising a horn, an anvil and an anvil cover. The horn comprises a generally T-shaped flattening surface and a rail projecting forward of the flattening surface. The rail is shaped to serve as a dam for flowing thermoplastic zipper material during stomping of slider end stops. The horn further comprises a plurality of vertical energy directors designed to direct ultrasonic energy into the mass of zipper material and deflect flowing zipper material toward the dam. The horn further comprises first and second recesses located on opposite sides of a stem of the T-shaped flattening surface. The anvil cover overlies opposing portions of the anvil and comprises a T-shaped cutout. The T-shaped flattening surface of the horn fits in the T-shaped cutout of the anvil cover. The resulting zipper has slider end stops located at opposing ends. Each end stop comprises flattened zipper material having a plurality of spaced indentations, the indentations being formed by the energy directors during stomping. The zipper can be pre-heated prior to ultrasonic stomping. A flange of the zipper can be cooled by fluid during ultrasonic stomping of the zipper parts.
Abstract:
The present invention is a combination of in-situ etching with a grating mask pattern comprised only of semiconductor material, together with the fabrication of a protective layer beneath the semiconductor grating mask that protects the semiconductor material that readily oxidises. As such the present invention is based on a two-stage process. First the grating pattern is defined in a semiconductor material, wherein this pattern is called the semiconductor grating mask. The semiconductor grating mask sits on top of a layer of protective material, which in turn is on top of the semiconductor material that readily oxidises, wherein the protective layer prevents oxidation of the material below. The semiconductor structure is then moved to a reactor, where, in the second stage, the mask pattern is transferred into the underlying protective layer and the semiconductor material that readily oxidises, by in-situ etching. The grating is then overgrown in the same reactor without exposing the etched grating to the atmosphere. The overgrown material protects the underlying semiconductor material from oxidation when the structure is removed from the reactor.
Abstract:
An apparatus for closing a slider-operated zipper on a moving filled package, comprising means for performing the following steps: conveying a package forward in a straight line; guiding a slider on a zippered portion of the package through a channel as the package moves forward; blocking forward movement of the slider at a predetermined position inside the channel as the package continues to move forward; and releasing the slider when the force being exerted by the slider in the forward direction reaches a level substantially equal to a predetermined threshold. This apparatus can be employed in association with a continuous band sealing apparatus. The means for blocking forward movement of the slider at a predetermined position inside the channel are a pair of spring-loaded plungers, e.g., ball plungers. If the slider end stop is weak, the slider will be pulled off the advancing package and will fall onto an ejection ramp.
Abstract:
An apparatus for closing a slider-operated zipper on a moving filled package, comprising means for performing the following steps: conveying a package forward in a straight line; guiding a slider on a zippered portion of the package through a channel as the package moves forward; blocking forward movement of the slider at a predetermined position inside the channel as the package continues to move forward; and releasing the slider when the force being exerted by the slider in the forward direction reaches a level substantially equal to a predetermined threshold. This apparatus can be employed in association with a continuous band sealing apparatus. The means for blocking forward movement of the slider at a predetermined position inside the channel are a pair of spring-loaded plungers, e.g., ball plungers. If the slider end stop is weak, the slider will be pulled off the advancing package and will fall onto an ejection ramp.
Abstract:
A method of supplying a ruminant with its nutritional requirements for methionine is provided wherein a hydroxy analogue of methionine that is available for absorption by a ruminant is administered to the ruminant. Preferably, the, ruminant is administered an isopropyl ester of a hydroxy analogue of methionine, wherein at least 40% of the isopropyl ester of the hydroxy analogue of methionine is available for absorption by the cow.