公开(公告)号：US07235640B2

公开(公告)日：2007-06-26

申请号：US10802332

申请日：2004-03-16

申请人： Naoki Kimura ,  Tomoko Toyoshima

发明人： Naoki Kimura ,  Tomoko Toyoshima

IPC分类号： C07K16/00 ,  C12P21/08

CPC分类号： G01F11/18 ,  C07K14/705 ,  C07K14/70575 ,  G01F11/40

摘要： Three genes encoding secretory membrane proteins have been successfully isolated from an osteoblast-like cell line by a method for specifically cloning secretory membrane proteins. One of these genes encodes a novel receptor protein. The protein has only the extracellular region, binds to the cell membrane via a GPI anchor, and carries therein a cysteine-rich, repetitive region commonly conserved in the TNF receptor super family. Overexpression of this protein in osteoblast-like cell line cells suppresses cell proliferation, changes cell morphology, and increases alkaline phosphatase activity, which is one of markers for differentiation of osteoblasts.

摘要翻译： 已经通过特异性克隆分泌膜蛋白的方法从成骨细胞样细胞系成功地分离了编码分泌膜蛋白的三个基因。 这些基因之一编码新的受体蛋白。 蛋白质仅具有细胞外区域，通过GPI锚定体与细胞膜结合，并携带其中通常在TNF受体超家族中保守的富含半胱氨酸的重复区域。 这种蛋白质在成骨细胞样细胞系细胞中的过表达抑制细胞增殖，改变细胞形态，并增加碱性磷酸酶活性，这是成骨细胞分化的标志物之一。

公开(公告)号：US20060208262A1

公开(公告)日：2006-09-21

申请号：US11344126

申请日：2006-02-01

申请人： Ken Sakuma ,  Naoki Kimura ,  Koichiro Masuko ,  Naoto Hirosaki

发明人： Ken Sakuma ,  Naoki Kimura ,  Koichiro Masuko ,  Naoto Hirosaki

IPC分类号： H01L33/00

CPC分类号： C04B35/597 ,  C04B2235/3224 ,  C04B2235/3865 ,  C04B2235/3873 ,  C04B2235/766 ,  C04B2235/767 ,  C09K11/0883 ,  C09K11/7734 ,  H01L33/504 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2224/48247 ,  H01L2224/8592 ,  H01L2924/181 ,  H01L2924/00014 ,  H01L2924/00 ,  H01L2924/00012

摘要： A light-emitting device and illumination apparatus using the same are provided. The light-emitting device includes a semiconductor light-emitting element that emits blue-violet or blue light and a fluorescent material that absorbs the light emitted by the semiconductor light-emitting element and emits fluorescence of wavelengths different from the light, wherein the fluorescent material includes a mixture of a first fluorescent material, a second fluorescent material that has a longer emission wavelength than that of the first fluorescent material, and a third fluorescent material that has a longer emission wavelength than the second fluorescent material, and the first fluorescent material is a europium-activated β-SiAlON fluorescent material, the second fluorescent material is a europium-activated α-SiAlON fluorescent material, and the third fluorescent material is a nitride crystalline red fluorescent material of a general formula of (Ca,Eu)AlSiN3. The illumination apparatus includes a light source including a light emitting device as described above.

摘要翻译： 提供了一种使用其的发光装置和照明装置。 发光装置包括发射蓝紫色或蓝色光的半导体发光元件和吸收由半导体发光元件发射的光并发射与光不同的波长的荧光的荧光材料，其中荧光材料 包括第一荧光材料，具有比第一荧光材料的发光波长长的发光波长的第二荧光材料和具有比第二荧光材料更长的发射波长的第三荧光材料的混合物，并且第一荧光材料是 铕活化的β-SiAlON荧光材料，第二荧光材料是铕活化的α-SiAlON荧光材料，第三荧光材料是通式为（Ca，Eu）AlSiN 3的氮化物结晶红色荧光材料。 照明装置包括如上所述的包括发光装置的光源。

公开(公告)号：US20060096737A1

公开(公告)日：2006-05-11

申请号：US11315191

申请日：2005-12-23

申请人： Naoki Kimura

发明人： Naoki Kimura

IPC分类号： H05K7/20

CPC分类号： H01L23/473 ,  F28F3/02 ,  F28F13/06 ,  F28F2250/02 ,  H01L23/367 ,  H01L2924/0002 ,  H01L2924/00

摘要： A heat exchanger having a plurality of fin plates (2) provided in parallel on a face (1a) of a base (1), wherein the fin plate (2) is provided with a rectifier portion (2b) having a tapered cross sectional shape at, at least, one tip (2a) thereof.

摘要翻译： 一种热交换器，具有在基座（1）的表面（1a）上平行设置的多个翅片（2），其中所述翅片（2）设置有具有锥形十字的整流部分（2b） 截面形状，其至少一个尖端（2a）。

公开(公告)号：US07037649B2

公开(公告)日：2006-05-02

申请号：US09771043

申请日：2001-01-26

申请人： Naoki Kimura ,  Tatsuo Ichihara ,  Shogo Moriya

发明人： Naoki Kimura ,  Tatsuo Ichihara ,  Shogo Moriya

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/00 ,  C07H21/02 ,  C12M1/34

CPC分类号： C12Q1/6837 ,  C12Q1/6834 ,  C12Q2525/197 ,  C12Q2523/101 ,  C12Q2523/313 ,  C12Q2525/161

摘要： A nucleic acid to be immobilized and used for hybridization of nucleic acids using an immobilized nucleic acid, which has a polymer comprising a compound having an unsaturated bond, said polymer being bonded to the 3′ end or 5′ end or both ends of the nucleic acid; a nucleic acid-immobilized substrate comprising a substrate for immobilizing a nucleic acid and the polymer-having nucleic acid immobilized on the substrate; and a method for detecting a nucleic acid by hybridization using an immobilized nucleic acid, which comprises using the nucleic acid-immobilized substrate.

公开(公告)号：US20050100275A1

公开(公告)日：2005-05-12

申请号：US11011446

申请日：2004-12-15

申请人： Naoki Kimura

发明人： Naoki Kimura

IPC分类号： G02B6/122 ,  G02B6/13 ,  G02B6/34 ,  G02B6/42 ,  H01L31/0232 ,  H01L33/60 ,  H01S5/022 ,  H01S5/026 ,  G02B6/26

CPC分类号： G02B6/29361 ,  G02B6/12007 ,  G02B6/29368 ,  G02B6/4214 ,  G02B6/423 ,  G02B6/4246 ,  G02B2006/12109

摘要： An optical communication module for communicating a light signal including a groove portion whose section is V-shaped and provided on the surface of an optical waveguide substrate, on one of two surfaces of which groove portion a mirror is formed by the coating with a metal film and in the vicinity of the other surface of which groove portion, a tip of an optical waveguide on the optical waveguide substrate is provided, whereby a signal light guided by the optical waveguide is reflected by the mirror of the metal film so as to be incident on a light-receiving element disposed on the surface of the optical waveguide substrate.

摘要翻译： 一种光通信模块，用于将包括具有V形并且设置在光波导基板的表面上的槽部的光信号传送到其两个表面中的一个表面上，该两个表面的沟槽部分通过涂覆金属膜形成反射镜 并且在其另一个表面附近设置光波导基板上的光波导的尖端，由此由光波导引导的信号光被金属膜的反射镜反射以入射 在设置在光波导基板的表面上的光接收元件上。

公开(公告)号：US06853776B2

公开(公告)日：2005-02-08

申请号：US09983105

申请日：2001-10-23

申请人： Naoki Kimura

发明人： Naoki Kimura

IPC分类号： G02B6/122 ,  G02B6/13 ,  G02B6/34 ,  G02B6/42 ,  H01L31/0232 ,  H01L33/60 ,  H01S5/022 ,  H01S5/026 ,  G02B6/26

CPC分类号： G02B6/29361 ,  G02B6/12007 ,  G02B6/29368 ,  G02B6/4214 ,  G02B6/423 ,  G02B6/4246 ,  G02B2006/12109

摘要： An optical communication module for communicating a light signal including a groove portion whose section is V-shaped and provided on the surface of an optical waveguide substrate, on one of two surfaces of which groove portion a mirror is formed by the coating with a metal film and in the vicinity of the other surface of which groove portion, a tip of an optical waveguide on the optical waveguide substrate is provided, whereby a signal light guided by the optical waveguide is reflected by the mirror of the metal film so as to be incident on a light-receiving element disposed on the surface of the optical waveguide substrate.

公开(公告)号：US06826916B2

公开(公告)日：2004-12-07

申请号：US10125299

申请日：2002-04-16

申请人： Mamoru Shimada ,  Naoki Kimura ,  Hajime Noda ,  Yoshio Nakamura

发明人： Mamoru Shimada ,  Naoki Kimura ,  Hajime Noda ,  Yoshio Nakamura

IPC分类号： F25B2102

CPC分类号： H01S5/02415 ,  F25B21/02 ,  H01L23/38 ,  H01L23/552 ,  H01L35/00 ,  H01L35/32 ,  H01L2924/16152

摘要： A Peltier module comprising: thermoelectric elements in which plural p-type and n-type thermoelectric elements are alternately arranged, metal electrodes placed in both ends of the thermoelectric elements in order to connect the thermoelectric elements in series, and metal substrates on at least a part of which surfaces an insulating thin film is formed, the metal substrates being oppositely placed so as to be connected to the metal electrodes and sandwich the metal electrodes and the thermoelectric elements.

摘要翻译： 一种珀耳帖模块，包括：多个p型和n型热电元件交替布置的热电元件，将热电元件串联连接在热电元件的两端的金属电极和至少一个 其一部分表面形成绝缘薄膜，金属基板相对地放置成与金属电极连接并夹着金属电极和热电元件。

公开(公告)号：US09023993B2

公开(公告)日：2015-05-05

申请号：US12311950

申请日：2007-10-19

申请人： Naoki Kimura

发明人： Naoki Kimura

IPC分类号： C07K16/00 ,  C07K16/22 ,  C07K16/30 ,  A61K39/00

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/30

摘要： A monoclonal antibody having a neutralizing activity on HB-EGF is disclosed. The monoclonal antibody of the present invention is preferably an antibody that does not bind to the HB-EGF protein on the cell surface of HB-EGF-expressing cells. Also provided are an anti-cancer agent and a cell proliferation inhibitor, which comprise the monoclonal antibody of the present invention as an active ingredient, and a method of treating cancer, the method comprising administering the monoclonal antibody of the present invention. Cancers that can be treated by the anti-cancer agent of the present invention include pancreatic cancer, liver cancer, esophageal cancer, melanoma, colorectal cancer, gastric cancer, ovarian cancer, bladder cancer, and brain tumors.

摘要翻译： 公开了具有HB-EGF中和活性的单克隆抗体。 本发明的单克隆抗体优选为在HB-EGF表达细胞的细胞表面不结合HB-EGF蛋白的抗体。 还提供了包含本发明的单克隆抗体作为活性成分的抗癌剂和细胞增殖抑制剂以及治疗癌症的方法，所述方法包括施用本发明的单克隆抗体。 可以通过本发明的抗癌剂治疗的癌症包括胰腺癌，肝癌，食管癌，黑素瘤，结肠直肠癌，胃癌，卵巢癌，膀胱癌和脑肿瘤。

公开(公告)号：US08975374B2

公开(公告)日：2015-03-10

申请号：US12584360

申请日：2009-09-03

申请人： Naoki Kimura

发明人： Naoki Kimura

IPC分类号： C07K16/00

CPC分类号： C07K16/22 ,  A61K47/48546 ,  A61K47/6845 ,  A61K51/1018 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2319/30 ,  G01N33/57484

摘要： An anti-HB-EGF antibody having an internalizing activity is disclosed. A cytotoxic substance is preferably bound to the anti-HB-EGF antibody of the present invention. Also provided are an anti-cancer agent and a cell proliferation inhibitor, which comprise the antibody of the present invention as an active ingredient, a method of treating cancer and a method of diagnosing cancer, which comprise the administration of the antibody of the present invention. Cancers that can be treated by the anti-cancer agent of the present invention include pancreatic cancer, liver cancer, esophageal cancer, melanoma, colorectal cancer, gastric cancer, ovarian cancer, uterine cervical cancer, breast cancer, bladder cancer, brain tumors, and hematological cancers.

摘要翻译： 公开了具有内在活性的抗HB-EGF抗体。 细胞毒性物质优选与本发明的抗HB-EGF抗体结合。 还提供了包含本发明的抗体作为活性成分的抗癌剂和细胞增殖抑制剂，治疗癌症的方法和诊断癌症的方法，其包括施用本发明的抗体 。 可以用本发明的抗癌剂治疗的癌症包括胰腺癌，肝癌，食管癌，黑素瘤，结肠直肠癌，胃癌，卵巢癌，子宫颈癌，乳腺癌，膀胱癌，脑肿瘤和 血液癌。

公开(公告)号：US08909010B2

公开(公告)日：2014-12-09

申请号：US13542241

申请日：2012-07-05

申请人： Naoki Kimura ,  Masato Takigahira

发明人： Naoki Kimura ,  Masato Takigahira

IPC分类号： G02B6/30 ,  H01S5/022 ,  G02B6/42 ,  H01S5/40

CPC分类号： H01S5/02284 ,  G02B6/4214 ,  G02B6/422 ,  G02B6/4239 ,  H01L2224/45124 ,  H01L2224/45144 ,  H01L2224/45147 ,  H01L2224/48091 ,  H01S5/0226 ,  H01S5/02276 ,  H01S5/02292 ,  H01S5/4025 ,  H01L2924/00014

摘要： Provided is an optical coupling structure including an optical semiconductor element including a light receiving/emitting portion, an optical transmission path having an optical axis that intersects the optical axis of the optical semiconductor element at a predetermined angle, and an optical coupling portion configured to convert the optical path between the optical semiconductor element and the optical transmission path and optically couple them. The optical coupling portion is made of a resin that is transparent with respect to a transmitted light, the resin adhering to both at least a portion of the light receiving/emitting portion and at least a portion of the end portion of the optical transmission path, and the optical semiconductor element and the optical transmission path are bonded to each other with the resin itself that constitutes the optical coupling portion.

摘要翻译： 提供一种光耦合结构，其包括光学半导体元件，该光学半导体元件包括光接收/发射部分，具有与光学半导体元件的光轴以预定角度相交的光轴的光传输路径和被配置为转换 光学半导体元件和光学传输路径之间的光路并且光学耦合它们。 光耦合部分由相对于透射光透明的树脂制成，树脂粘附在光接收/发射部分的至少一部分和光传输路径的端部的至少一部分上， 并且光学半导体元件和光传输路径通过构成光耦合部分的树脂本身彼此接合。