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91 条记录 (耗时 0.074 秒)

    Targeted enzyme prodrug therapy
    85.
    发明申请
    Targeted enzyme prodrug therapy 审中-公开
    靶向酶前药治疗

    公开(公告)号：US20080044400A1

    公开(公告)日：2008-02-21

    申请号：US11824865

    申请日：2007-07-02

    申请人： Volker Schellenberger

    发明人： Volker Schellenberger

    IPC分类号： A61K38/43 ,  A61K38/46 ,  A61K38/48 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  C12N9/00

    CPC分类号： C12N9/86 ,  A61K38/00 ,  C12Y305/02006

    摘要： The present invention provides targeted enzymes that bind to targets better than the corresponding pre-targeted enzymes bind the target under like conditions, methods of making targeted enzymes, methods of using targeted enzymes to treat diseases, and pharmaceutical compositions comprising targeted enzymes.

    摘要翻译： 本发明提供了靶向酶，其比相同的预靶向酶更好地结合靶，在相似条件下与目标酶结合，制备靶向酶的方法，使用靶向酶治疗疾病的方法，以及包含靶向酶的药物组合物。

    Information rich libraries
    86.
    发明申请
    Information rich libraries 审中-公开
    信息丰富的图书馆

    公开(公告)号：US20070264698A1

    公开(公告)日：2007-11-15

    申请号：US11599672

    申请日：2006-11-14

    申请人： Volker Schellenberger ,  Donald Naki ,  Thomas Morrison

    发明人： Volker Schellenberger ,  Donald Naki ,  Thomas Morrison

    IPC分类号： C12P1/04 ,  G06G7/48

    CPC分类号： G16C20/60 ,  G16B15/00 ,  G16B30/00 ,  G16B35/00

    摘要： Methods of creating libraries of biological polymers are provided. The construction of a library employs a probability matrix for a reference sequence, and a constraint vector for which is applied to the probability matrix to produce a substitution scheme. The substitution scheme is then used to generate a library comprising substitutions recommended by the substitution scheme. The library members, or host cells comprising and/or expressing them, can be screened for desired changes in a property of interest in the biological polymers in the library.

    摘要翻译： 提供了生成生物聚合物库的方法。 图书馆的构建使用参考序列的概率矩阵，并将其约束向量应用于概率矩阵以产生替代方案。 然后将替代方案用于生成包含取代方案推荐的取代的文库。 文库成员或包含和/或表达它们的宿主细胞可以筛选出在文库中的生物聚合物中感兴趣的性质的期望变化。

    Proteinaceous pharmaceuticals and uses thereof
    87.
    发明申请
    Proteinaceous pharmaceuticals and uses thereof 审中-公开
    蛋白质药物及其用途

    公开(公告)号：US20070191272A1

    公开(公告)日：2007-08-16

    申请号：US11528927

    申请日：2006-09-27

    申请人： Willem Stemmer ,  Volker Schellenberger ,  Martin Bader ,  Michael Scholle

    发明人： Willem Stemmer ,  Volker Schellenberger ,  Martin Bader ,  Michael Scholle

    IPC分类号： A61K38/16 ,  C40B40/08 ,  C40B40/10 ,  C07K14/47

    CPC分类号： G01N33/6845 ,  C07K14/001 ,  C07K14/415 ,  C12N15/1044

    摘要： The present invention provides cysteine-containing scaffolds and/or proteins, expression vectors, host cell and display systems harboring and/or expressing such cysteine-containing products. The present invention also provides methods of designing libraries of such products, methods of screening such libraries to yield entities exhibiting binding specificities towards a target molecule. Further provided by the invention are pharmaceutical compositions comprising the cysteine-containing products of the present invention.

    摘要翻译： 本发明提供含半胱氨酸的支架和/或蛋白质，表达载体，宿主细胞和含有和/或表达这种含半胱氨酸的产品的显示系统。 本发明还提供了设计这样的产物的文库的方法，筛选这些文库以产生显示针对目标分子的结合特异性的实体的方法。 本发明进一步提供的是包含本发明的含半胱氨酸的产品的药物组合物。

    Multi-through hole testing plate for high throughput screening
    89.
    发明授权
    Multi-through hole testing plate for high throughput screening 有权
    多通孔测试板，用于高通量筛选

    公开(公告)号：US06306578B1

    公开(公告)日：2001-10-23

    申请号：US09528085

    申请日：2000-03-17

    申请人： Volker Schellenberger ,  Amy Deming Liu

    发明人： Volker Schellenberger ,  Amy Deming Liu

    IPC分类号： C12Q100

    CPC分类号： B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00317 ,  B01J2219/00319 ,  B01J2219/0052 ,  B01J2219/00524 ,  B01J2219/00533 ,  B01J2219/00596 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00662 ,  B01J2219/00707 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50857 ,  B01L2300/0654 ,  B01L2300/0809 ,  B01L2300/161 ,  C40B60/14 ,  G01N35/1065 ,  G01N2035/00237

    摘要： A method for holding samples for analysis and an apparatus thereof includes a testing plate with a pair of opposing surfaces and a plurality of holes. Each of the holes extends from one of the opposing surfaces to the other one of the opposing surfaces. The holes are arranged in groups, where each group has at least two rows and two columns of holes. The groups are arranged in sets, where each set has at least two rows and two columns of groups. To analyze samples, at least one of the opposing surfaces of the testing plate is immersed in a solution to be analyzed. A portion of the solution enters openings for each of the holes in the immersed opposing surface. Once the holes are filled with solution, the testing plate is removed and is held above a supporting surface. Surface tension holds the solution in each of the holes. The solution in one or more of the holes is then analyzed and the solution in one of these holes is identified for further study. The location of the identified solution is marked based upon its location within a particular set and group of holes.

    摘要翻译： 用于保持用于分析的样品的方法及其装置包括具有一对相对表面和多个孔的测试板。 每个孔从相对表面中的一个延伸到相对表面中的另一个。 孔分组排列，每组具有至少两排和两列孔。 这些组以组合的形式排列，其中每组具有至少两行和两列组。 为了分析样品，将测试板的相对表面中的至少一个浸入待分析的溶液中。 溶液的一部分进入浸入的相对表面中的每个孔的开口。 一旦孔充满了溶液，测试板被移除并被保持在支撑表面上方。 表面张力将溶液保持在每个孔中。 然后分析一个或多个孔中的溶液，并鉴定其中一个孔中的溶液用于进一步研究。 所识别的解决方案的位置基于其在特定组和一组孔内的位置被标记。

    Compartmentalization method for screening microorganisms
    90.
    发明授权
    Compartmentalization method for screening microorganisms 失效
    微生物筛选方法

    公开(公告)号：US6001586A

    公开(公告)日：1999-12-14

    申请号：US625488

    申请日：1996-03-29

    申请人： Volker Schellenberger

    发明人： Volker Schellenberger

    IPC分类号： C12M1/18 ,  C12M1/22 ,  C12M1/32 ,  C12Q1/08 ,  C12Q1/20 ,  C12Q1/04 ,  C12Q1/02 ,  C12Q1/54

    CPC分类号： C12Q1/08 ,  C12Q1/20

    摘要： A method is provided for screening microorganisms having a selectable characteristic comprising: (a) providing a growth chamber capable of forming a plurality of discrete compartments, said compartments comprising a barrier which inhibits the diffusion of metabolites or nutrients between said compartments within said growth chamber; (b) preparing a growth medium which, by its lack of or addition of one or more metabolites or nutrients, preferentially facilitates growth of microorganisms exhibiting said selectable characteristic from microorganisms which do not exhibit said selectable characteristic; (c) inoculating said growth medium with a plurality of microorganisms, a portion of which comprise said selectable characteristic; (d) placing said inoculated growth medium into said growth chamber so as to randomly disperse said microorganisms among discrete compartments in said growth chamber; and (e) incubating said growth chamber for a suitable time and under suitable conditions to obtain a detectable disparity of growth between microorganisms having said selectable characteristic and microorganisms lacking said selectable characteristic.

    摘要翻译： 提供了一种用于筛选具有可选择特征的微生物的方法，包括：（a）提供能够形成多个离散隔室的生长室，所述隔室包含阻挡代谢物或营养物在所述生长室内的所述隔室之间扩散的屏障; （b）制备生长培养基，其通过缺乏或添加一种或多种代谢物或营养物质，优先促进显示出不具有所述可选择特性的微生物表现出所述可选特征的微生物的生长; （c）用多种微生物接种所述生长培养基，其中一部分包含所述可选择的特征; （d）将所述接种的生长培养基置于所述生长室中，以使所述微生物在所述生长室中的离散隔室中随机分散; 和（e）在合适的条件下孵育所述生长室适当的时间以获得具有所述可选择特性的微生物与缺乏所述可选择特征的微生物之间生长的可检测差异。