Process for the preparation of flavone derivatives
    82.
    发明授权
    Process for the preparation of flavone derivatives 有权
    黄酮衍生物的制备方法

    公开(公告)号:US07009062B2

    公开(公告)日:2006-03-07

    申请号:US10470773

    申请日:2002-01-12

    IPC分类号: C07D311/30

    CPC分类号: C07D493/04 C07D311/30

    摘要: The invention relates to a process for the preparation of flavone derivatives in which a 2-hydroxyacetophenone compound is metallated using a lithium compound at low temperatures and subsequently reacted with a keto compound, and where the ratio of the molar equivalents of lithium compound to the 2-hydroxyacetophenone compound functional groups to be metallated is from 1 to 1.2. The resultant β-diketone compound is subsequently cyclized with warming in an acidic medium.

    摘要翻译: 本发明涉及一种制备黄酮衍生物的方法,其中2-羟基苯乙酮化合物在低温下使用锂化合物进行金属化,随后与酮化合物反应,其中锂化合物的摩尔当量与2 - 羟基苯乙酮化合物官能团的金属化为1〜1.2。 随后在酸性介质中加温使所得的β-二酮化合物环化。