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公开(公告)号:US6040157A
公开(公告)日:2000-03-21
申请号:US42105
申请日:1998-03-13
申请人: Jing-Shan Hu , Craig A. Rosen , Liang Cao
发明人: Jing-Shan Hu , Craig A. Rosen , Liang Cao
CPC分类号: C07K14/52 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/026
摘要: Disclosed are human VEGF2 polypeptides, biologically active, diagnostically or therapeuticall sefl fragments, analogs, or derivatives thereof, and DNA (RNA) enco such VEGF2 polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Such polypeptides may be used therapeutically for stimulating wound healing and for vascular tissue repair. Also provided are methods of using the antibodies and antagonists to inhibit tumor angiogenesis and thus tumor growth, inflammation, diabetic retinopathy, rheumatoid arthritis, and psoriasis.
摘要翻译: 公开了人类VEGF2多肽,生物学活性,诊断学或治疗学的sefl片段,类似物或其衍生物,和遇到这种VEGF2多肽的DNA(RNA)。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 这样的多肽可以治疗性地用于刺激伤口愈合和维持血管组织修复。 还提供了使用抗体和拮抗剂抑制肿瘤血管发生,从而抑制肿瘤生长,炎症,糖尿病性视网膜病,类风湿性关节炎和牛皮癣的方法。
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公开(公告)号:US5958729A
公开(公告)日:1999-09-28
申请号:US982412
申请日:1997-12-02
申请人: Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
发明人: Daniel R. Soppet , Yi Li , Craig A. Rosen , Steven M. Ruben
IPC分类号: A61K38/00 , C07K14/705 , C07K14/72 , C12N5/10 , C12N15/12
CPC分类号: C07K14/72 , C07K14/705 , A61K38/00
摘要: A human G-protein receptor HCEGH45 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for identifying antagonists and agonists to such polypeptide. Antagonists against such polypeptides may be used therapeutically to treat PACAP hypersecretory conditions and to create pharmacological amnesia models while the agonists may be employed to treat amnesia and Alzheimer's disease. Also disclosed are diagnostic methods for detecting a mutation in the receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.
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公开(公告)号:US5800986A
公开(公告)日:1998-09-01
申请号:US456346
申请日:1995-06-01
CPC分类号: C07K14/005 , C12N15/85 , C12N2740/14022 , C12N2740/16322 , C12N2800/108 , C12N2830/00 , C12N2830/55 , C12N2840/44
摘要: Assays screened for compounds that inhibit tat transactivation of the HIV (HTLV-III) LTR are taught. The assay involves tranfecting a cell line containing the tat gene by a vector containing a gene under the control of an HIV-1 LTR, adding the compound to be screened and determining the effect of the compound by looking at the effect of tat as measured by the expression of the gene under the control of the HIV LTR.
摘要翻译: 针对抑制HIV转录激活(HTLV-III)LTR的化合物进行了筛选。 该测定包括通过含有在HIV-1LTR控制下的基因的载体来染色含有tat基因的细胞系,加入待筛选的化合物,并通过观察tat的作用来确定化合物的作用,通过 该基因在HIV LTR控制下的表达。
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公开(公告)号:US5789223A
公开(公告)日:1998-08-04
申请号:US451777
申请日:1995-05-26
CPC分类号: C12N9/1205 , C12Y207/01006 , A01K2217/05 , A61K38/00 , A61K48/00
摘要: This invention relates to human galactokinase and the identification of galactokinase mutations, a missense and nonsense, as well as isolated nucleic acids encoding same, recombinant host cell transformed with DNA encoding such proteins and to uses of the expressed proteins and nucleic acid sequences in therapeutic and diagnostic applications.
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公开(公告)号:US5652117A
公开(公告)日:1997-07-29
申请号:US411635
申请日:1995-04-11
申请人: Paul A. Moore , Craig A. Rosen
发明人: Paul A. Moore , Craig A. Rosen
CPC分类号: C07K14/4705 , C07K16/18 , A61K38/00
摘要: The small (.gamma.) subunit of human Transcription Factor IIA and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for regulating gene-specific and global transcription. Antagonists against such polypeptide and their use to inhibit transcription are also disclosed.
摘要翻译: PCT No.PCT / US94 / 10644 Sec。 371日期1995年04月11日 102(e)日期1995年4月11日PCT 1994年9月20日PCT PCT。 公开号WO96 / 09311 日期1996年3月28日编码这种多肽的人转录因子IIA和DNA(RNA)的小(γ)亚基和通过重组技术产生这种多肽的方法。 还公开了利用这种多肽调节基因特异性和全局转录的方法。 还公开了抗这种多肽的拮抗剂及其抑制转录的用途。
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公开(公告)号:US09505823B2
公开(公告)日:2016-11-29
申请号:US11835114
申请日:2007-08-07
申请人: Adam C. Bell , Craig A. Rosen , Indrajit Sanyal , Qinghai Zhao
发明人: Adam C. Bell , Craig A. Rosen , Indrajit Sanyal , Qinghai Zhao
CPC分类号: C07K14/62 , A61K38/28 , C07K14/765 , C07K2319/35 , C12N15/62
摘要: Disclosed are fusion proteins that include albumin fused to a polypeptide that has insulin activity. The fusion proteins may include albumin fused to insulin or an insulin analog. In particular, the fusions proteins may include albumin fused to a single chain insulin analog. The fusion proteins may exhibit extended insulin activity in vivo or in vitro relative to insulin that is not fused to albumin. The fusion proteins may be formulated as aerosol compositions.
摘要翻译: 公开了融合蛋白,其包括与具有胰岛素活性的多肽融合的白蛋白。 融合蛋白可包括与胰岛素或胰岛素类似物融合的白蛋白。 特别地,融合蛋白可以包括与单链胰岛素类似物融合的白蛋白。 融合蛋白可以在体内或体外相对于不与白蛋白融合的胰岛素表现出延长的胰岛素活性。 融合蛋白可以配制成气溶胶组合物。
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公开(公告)号:US08211439B2
公开(公告)日:2012-07-03
申请号:US11929939
申请日:2007-10-30
申请人: Craig A. Rosen , Steven M. Ruben , Olivier Blondel
发明人: Craig A. Rosen , Steven M. Ruben , Olivier Blondel
CPC分类号: C07K14/765 , A61K31/155 , A61K31/426 , A61K31/4439 , A61K31/4965 , A61K38/00 , A61K38/04 , A61K38/17 , A61K38/28 , A61K39/21 , C07K7/06 , C07K14/005 , C07K14/435 , C07K14/4713 , C07K14/4723 , C07K14/475 , C07K14/50 , C07K14/505 , C07K14/51 , C07K14/521 , C07K14/525 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/55 , C07K14/555 , C07K14/56 , C07K14/565 , C07K14/575 , C07K14/57563 , C07K14/5759 , C07K14/585 , C07K14/59 , C07K14/60 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/705 , C07K14/7151 , C07K14/82 , C07K16/00 , C07K16/241 , C07K16/26 , C07K2317/622 , C07K2317/76 , C07K2319/00 , C07K2319/20 , C07K2319/30 , C07K2319/31 , C12N7/00 , C12N9/0006 , C12N9/0008 , C12N15/62 , C12N2501/335 , C12N2740/16111 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12Y101/01105 , C12Y102/01 , C12Y207/01095
摘要: The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译: 本发明包括白蛋白融合蛋白。 编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中,载体含有这些核酸,用这些核酸载体转化的宿主细胞,以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法 酸,载体和/或宿主细胞。 另外,本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗,预防或改善疾病,病症或病症的方法。
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公开(公告)号:US08106165B2
公开(公告)日:2012-01-31
申请号:US11745580
申请日:2007-05-08
申请人: Steven M. Ruben , Craig A. Rosen , Guo-Liang Yu , Jian Ni , Ping Feng
发明人: Steven M. Ruben , Craig A. Rosen , Guo-Liang Yu , Jian Ni , Ping Feng
CPC分类号: C07K14/4748 , A61K38/00 , C07K14/47 , G01N33/566 , G01N2800/00
摘要: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体,宿主细胞,抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病,病症和/或病症的诊断和治疗方法。
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公开(公告)号:US07973139B2
公开(公告)日:2011-07-05
申请号:US11090847
申请日:2005-03-25
申请人: Adam Bell , Craig A. Rosen
发明人: Adam Bell , Craig A. Rosen
IPC分类号: C07K16/00 , C07K14/00 , C12N15/85 , C12N5/12 , A61K39/395
CPC分类号: C07K16/28 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to antibodies and related molecules that specifically bind to the Nogo receptor (NogoR). Such antibodies have uses, for example, in the treatment of spinal cord injury, brain trauma, paralysis, degenerative nervous system diseases, and stroke. The invention also relates to nucleic acid molecules encoding anti-NogoR antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same.
摘要翻译: 本发明涉及特异性结合Nogo受体(NogoR)的抗体和相关分子。 这样的抗体具有例如用于治疗脊髓损伤,脑损伤,麻痹,退行性神经系统疾病和中风的用途。 本发明还涉及编码抗NogoR抗体的核酸分子,含有这些核酸的载体和宿主细胞及其制备方法。
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公开(公告)号:US20110151473A1
公开(公告)日:2011-06-23
申请号:US12952967
申请日:2010-11-23
申请人: Jian Ni , Craig A. Rosen , Reiner L. Gentz
发明人: Jian Ni , Craig A. Rosen , Reiner L. Gentz
IPC分类号: C12Q1/68 , C07H21/00 , C07K14/705
CPC分类号: C07K14/70535 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C12N9/6421 , C12N9/6475 , C12N9/6489 , C12N9/6491 , C12N2799/026
摘要: Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing receptor polypeptides and polynucleotides in the design of protocols for the treatment of diseases and diagnostic assays for such conditions.
摘要翻译: 公开了受体多肽和多核苷酸以及通过重组技术产生这种多肽的方法。 还公开了在设计用于治疗疾病的方案和用于这些病症的诊断测定中使用受体多肽和多核苷酸的方法。
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