公开(公告)号：US20080132426A1

公开(公告)日：2008-06-05

申请号：US12028767

申请日：2008-02-08

申请人： Mark Whitney Hart ,  Ho-Cheol Kim ,  Robert Dennis Miller ,  Gregory Michael Wallraff

发明人： Mark Whitney Hart ,  Ho-Cheol Kim ,  Robert Dennis Miller ,  Gregory Michael Wallraff

IPC分类号： C40B40/00

CPC分类号： B01L3/5085 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00644 ,  B01L2200/12 ,  B01L2300/0609 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/165 ,  B01L2300/168 ,  C40B60/08

摘要： A biomolecular array includes a substrate across which is distributed an array of discrete regions of a porous substance formed from a porogen-containing organosilicate material. The porous substance is designed to bind chemical targets useful in biotechnology applications, such as gene expression, protein, antibody, and antigen experiments. The regions are preferably optically isolated from each other and may be shaped to enhance detection of optical radiation emanating from the porous substance, e.g., as a result of irradiation of the regions with ultraviolet light. The discrete regions may be configured as microscopic wells within the substrate, or they may reside on top of the substrate in the form of microscopic mesas.

摘要翻译： 生物分子阵列包括基底，其上分布有由含致孔剂的有机硅酸盐材料形成的多孔物质的离散区域的阵列。 多孔物质被设计用于结合可用于生物技术应用的化学靶，例如基因表达，蛋白质，抗体和抗原实验。 这些区域优选地彼此光学隔离，并且可以被成形为增强从多孔物质发出的光辐射的检测，例如，作为由紫外线照射该区域的结果。 离散区域可以被配置为衬底内的微观阱，或者它们可以以微观台面的形式驻留在衬底的顶部上。

公开(公告)号：US07341788B2

公开(公告)日：2008-03-11

申请号：US11077804

申请日：2005-03-11

申请人： Jennifer Nam Cha ,  James Lupton Hedrick ,  Ho-Cheol Kim ,  Robert Dennis Miller ,  Willi Volksen

发明人： Jennifer Nam Cha ,  James Lupton Hedrick ,  Ho-Cheol Kim ,  Robert Dennis Miller ,  Willi Volksen

IPC分类号： B32B27/30

CPC分类号： C08L101/12 ,  C08L53/00 ,  G03F7/0002 ,  Y10T428/24 ,  Y10T428/2495 ,  Y10T428/24975 ,  Y10T428/249921 ,  Y10T428/249953 ,  Y10T428/249958 ,  Y10T428/249975 ,  Y10T428/249978 ,  Y10T428/249979 ,  Y10T428/24998 ,  Y10T428/25 ,  Y10T428/26 ,  Y10T428/31504 ,  Y10T428/31511 ,  Y10T428/31612 ,  Y10T428/31663 ,  Y10T428/31931 ,  Y10T428/31935 ,  Y10T428/31938

摘要： A material and an associated method of formation. A self-assembling block copolymer that includes a first block species and a second block species respectively characterized by a volume fraction of F1 and F2 with respect to the self-assembling block copolymer is provided. At least one crosslinkable polymer that is miscible with the second block species is provided. The self-assembling block copolymer and the at least one crosslinkable polymer are combined to form a mixture. The mixture having a volume fraction, F3, of the crosslinkable polymer, a volume fraction, F1A, of the first block species, and a volume fraction, F2A, of the second block species is formed. A material having a predefined morphology where the sum of F2A and F3 were preselected is formed.

摘要翻译： 一种材料和相关的形成方法。 一种自组装嵌段共聚物，其包括分别以相对于自组装的F 1和F 2的体积分数表征的第一嵌段物质和第二嵌段物质 嵌段共聚物。 提供了与第二嵌段物质混溶的至少一种可交联聚合物。 自组装嵌段共聚物和至少一种可交联聚合物组合形成混合物。 具有第一嵌段物质的可交联聚合物的体积分数F 3 N 3，体积分数F 1 A 1，以及体积分数F _{2A 。 预先选择具有预定形态的材料，其中预先选择F 2 A 2和F 3 3之和。}

公开(公告)号：US07282241B2

公开(公告)日：2007-10-16

申请号：US10421161

申请日：2003-04-22

申请人： Ho-Cheol Kim ,  Robert Dennis Miller

发明人： Ho-Cheol Kim ,  Robert Dennis Miller

IPC分类号： B05D3/00 ,  B05D3/04 ,  B05D3/06

CPC分类号： B82Y5/00 ,  G01N33/54393 ,  Y10T428/249953 ,  Y10T428/249961 ,  Y10T428/249979

摘要： Nanoporous structures are constructed that have hydrophilic regions separated by hydrophobic regions. The porous, hydrophilic regions have reaction sites suitable for use in a bioassay application and have a higher density of reaction sites than that of a non-porous (2-D) surface. The structure may be made by depositing a layer of a matrix material (e.g., an organosilicate) and a porogen, and then crosslinking the matrix material to form a nanohybrid composite structure. The porogen is decomposed to form pores within the matrix material, and a reactive gas phase species (e.g., ozone) is patternwise directed onto a surface of the matrix material. Ultraviolet light (directed through a mask) activates the gas phase species to form a reactive species that then reacts with the matrix material to make it hydrophilic. The porogen may be decomposed thermally or by exposing it to an oxidizing atmosphere in the presence of ultraviolet light.

摘要翻译： 构建了具有疏水区域分离的亲水区域的纳米孔结构。 多孔亲水区域具有适用于生物测定应用的反应位点，并具有比无孔（2-D）表面更高的反应位点密度。 该结构可以通过沉积基质材料（例如有机硅酸盐）和致孔剂层，然后交联基质材料以形成纳米杂化复合结构来制备。 造孔剂在基质材料内分解形成孔隙，反应性气相物质（如臭氧）以图形方式导向基质材料的表面。 紫外线（通过掩模引导）激活气相物质以形成反应物质，然后与基质材料反应以使其亲水。 造孔剂可能会被热分解，或者在紫外光的存在下暴露于氧化气氛。

公开(公告)号：US20070023870A1

公开(公告)日：2007-02-01

申请号：US11190644

申请日：2005-07-27

申请人： Geraud Dubois ,  James Hedrick ,  Ho-Cheol Kim ,  Victor Lee ,  Teddie Magbitang ,  Robert Miller ,  Muthumanickam Sankarapandian ,  Linda Sundberg ,  Willi Volksen

发明人： Geraud Dubois ,  James Hedrick ,  Ho-Cheol Kim ,  Victor Lee ,  Teddie Magbitang ,  Robert Miller ,  Muthumanickam Sankarapandian ,  Linda Sundberg ,  Willi Volksen

IPC分类号： H01L23/58 ,  H01L21/4763

CPC分类号： C08L101/12 ,  H01L21/02118 ,  H01L21/02126 ,  H01L21/02203 ,  H01L21/02216 ,  H01L21/02282 ,  H01L21/31695 ,  H01L21/76807 ,  H01L21/7682 ,  H01L2221/1047

摘要： A composition of matter and a structure fabricated using the composition. The composition comprising: a resin; polymeric nano-particles dispersed in the resin, each of the polymeric nano-particle comprising a multi-arm core polymer and pendent polymers attached to the multi-arm core polymer, the multi-arm core polymer immiscible with the resin and the pendent polymers miscible with the resin; and a solvent, the solvent volatile at a first temperature, the resin cross-linkable at a second temperature, the polymeric nano-particle decomposable at a third temperature, the third temperature higher than the second temperature, the second temperature higher than the first temperature, wherein a thickness of a layer of the composition shrinks by less than about 3.5% between heating the layer from the second temperature to the third temperature.

摘要翻译： 使用该组合物制造的物质组成和结构。 所述组合物包含：树脂; 分散在树脂中的聚合物纳米颗粒，每个聚合纳米颗粒包含多臂芯聚合物和连接到多臂芯聚合物的悬置聚合物，与树脂不混溶的多臂芯聚合物和可混溶的侧链聚合物 与树脂; 和溶剂，所述溶剂在第一温度下挥发，所述树脂在第二温度下可交联，所述聚合物纳米颗粒在第三温度下可分解，所述第三温度高于所述第二温度，所述第二温度高于所述第一温度 ，其中在从第二温度到第三温度的层之间加热组合物的层的厚度收缩小于约3.5％。

公开(公告)号：US20060240240A1

公开(公告)日：2006-10-26

申请号：US11111055

申请日：2005-04-20

申请人： Jennifer Cha ,  Geraud Dubois ,  James Hedrick ,  Ho-Cheol Kim ,  Victor Lee ,  Teddie Magbitang ,  Robert Miller ,  Willi Volksen

发明人： Jennifer Cha ,  Geraud Dubois ,  James Hedrick ,  Ho-Cheol Kim ,  Victor Lee ,  Teddie Magbitang ,  Robert Miller ,  Willi Volksen

IPC分类号： B32B3/26

CPC分类号： H01L21/3121 ,  G03F7/0002 ,  H01L21/02118 ,  H01L21/02126 ,  H01L21/02203 ,  H01L21/02216 ,  H01L21/02282 ,  H01L21/312 ,  H01L21/31695 ,  Y10T428/249953 ,  Y10T428/31663

摘要： A nanoporous material exhibiting a lamellar structure is disclosed. The material comprises three or more substantially parallel sheets of an organosilicate material, separated by highly porous spacer regions. The distance between the centers of the sheets lies between 1 nm and 50 nm. The highly porous spacer regions may be substantially free of condensed material. For the manufacture of such materials, a process is disclosed in which matrix non-amphiphilic polymeric material and templating polymeric material are dispersed in a solvent, where the templating polymeric material includes a polymeric amphiphilic material. The solvent with the polymeric materials is distributed onto a substrate. Organization is induced in the templating polymeric material. The solvent is removed, leaving the polymeric materials in place. The matrix polymeric material is cured, forming a lamellar structure.

公开(公告)号：US07056840B2

公开(公告)日：2006-06-06

申请号：US10676422

申请日：2003-09-30

申请人： Robert Dennis Miller ,  Ho-Cheol Kim ,  Eric Connor ,  Victor Yee-Way Lee ,  Gregory Michael Wallraff ,  Willi Volksen

发明人： Robert Dennis Miller ,  Ho-Cheol Kim ,  Eric Connor ,  Victor Yee-Way Lee ,  Gregory Michael Wallraff ,  Willi Volksen

IPC分类号： H01L21/31 ,  H01L21/469

CPC分类号： H01L21/02126 ,  G03F7/0757 ,  G03F7/40 ,  H01L21/02203 ,  H01L21/02216 ,  H01L21/02282 ,  H01L21/02348 ,  H01L21/3122 ,  H01L21/31695

摘要： A low dielectric constant, patterned, nanoporous material and a method of forming the material. The material is formed by depositing a layer onto a substrate, said layer comprising a reactive organosilicate material, a porogen, an initiator, and a solvent; exposing portions of the layer to energy (e.g., thermal energy or electromagnetic radiation) to change the solubility of portions of the organosilicate material with respect to the solvent; selectively removing more soluble portions of the layer to generate a relief pattern; and decomposing the porogen to thereby generate a nanoporous organosilicate layer.

摘要翻译： 低介电常数，图案化，纳米多孔材料和形成材料的方法。 该材料通过在基底上沉积一层而形成，所述层包含反应性有机硅酸盐材料，致孔剂，引发剂和溶剂; 将层的部分暴露于能量（例如，热能或电磁辐射）以改变部分有机硅酸盐材料相对于溶剂的溶解度; 选择性地去除层的更多可溶部分以产生浮雕图案; 并分解致孔剂从而产生纳米多孔有机硅酸盐层。

公开(公告)号：US06962822B2

公开(公告)日：2005-11-08

申请号：US10214951

申请日：2002-08-07

申请人： Mark Whitney Hart ,  Ho-Cheol Kim ,  Robert Dennis Miller ,  Gregory Michael Wallraff

发明人： Mark Whitney Hart ,  Ho-Cheol Kim ,  Robert Dennis Miller ,  Gregory Michael Wallraff

IPC分类号： B01L3/00 ,  H01L21/00

CPC分类号： B01L3/5085 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00644 ,  B01L2200/12 ,  B01L2300/0609 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/165 ,  B01L2300/168 ,  C40B60/08

摘要： A biomolecular array includes a substrate across which is distributed an array of discrete regions of a porous substance. The porous substance is designed to bind chemical targets useful in biotechnology applications, such as gene expression, protein, antibody, and antigen experiments. The regions are preferably optically isolated from each other and may be shaped to enhance detection of optical radiation emanating from the porous substance, e.g., as a result of irradiation of the regions with ultraviolet light. The discrete regions may be configured as microscopic wells within the substrate, or they may reside on top of the substrate in the form of microscopic mesas.

摘要翻译： 生物分子阵列包括分布有多孔物质的离散区域的阵列的基底。 多孔物质被设计用于结合可用于生物技术应用的化学靶，例如基因表达，蛋白质，抗体和抗原实验。 这些区域优选地彼此光学隔离，并且可以被成形为增强从多孔物质发出的光辐射的检测，例如，作为由紫外线照射该区域的结果。 离散区域可以被配置为衬底内的微观阱，或者它们可以以微观台面的形式驻留在衬底的顶部上。