公开(公告)号：US06439032B1

公开(公告)日：2002-08-27

申请号：US09669669

申请日：2000-09-26

申请人： Martin Lehmann

发明人： Martin Lehmann

IPC分类号： G01M336

CPC分类号： G01M3/36 ,  G01M3/363

摘要： Method and apparatus for leak testing a closed container with at least one flexible wall area, whether or not the container undergoing leakage testing is is filled with a product or not. A biasing member is moved towards and onto the flexible wall area in order to apply a predetermined force and the accompanying reaction forces are monitored over time. The instant invention of this leakage or integrity testing system constitutes an improvement over conventional prior art pressure monitoring sytems by instead monitoring a biasing force applied by such biasing member to such flexible wall area at different times over a testing cycle, whereby storage of two biasing force values at different times allows the later processing of a difference signal that is generated by using two measured force signals over time to thus result in both a leak indicative signal and an updated compensating zero offset signal. Furthermore, the moving of the biasing member may be done at a constant rate or predetermined rate, or the moving accomplished by establishing a pressure difference between the inside of the container and its ambient surroundings, such as may be done by evacuating such surroundings by application of vacuum.

摘要翻译： 用于对具有至少一个柔性壁面积的密封容器进行泄漏测试的方法和装置，不管进行泄漏测试的容器是否被填充产品。 偏压构件朝着柔性壁区域移动到柔性壁区域上，以便施加预定的力，随着时间的推移监测伴随的反作用力。 该泄漏或完整性测试系统的本发明通过在测试周期上不同时间监视由这种偏压构件施加的这种柔性壁面积的偏压力而构成对传统现有技术压力监测系统的改进，由此存储两个偏压力 在不同时间的值允许稍后处理通过使用两个测量的力信号随时间产生的差分信号，从而导致泄漏指示信号和更新的补偿零偏移信号。 此外，偏置构件的移动可以以恒定速率或预定速率进行，或者通过在容器的内部和周围环境之间建立压力差而实现的移动，例如可以通过应用来排空这种环境 的真空。

公开(公告)号：US6153418A

公开(公告)日：2000-11-28

申请号：US121425

申请日：1998-07-23

申请人： Martin Lehmann

发明人： Martin Lehmann

IPC分类号： A23K1/165 ,  A23J3/20 ,  A23L1/03 ,  A61K38/00 ,  A61K38/46 ,  C12N1/15 ,  C12N1/19 ,  C12N9/00 ,  C12N9/16 ,  C12N15/09 ,  C12N15/55 ,  C12R1/685 ,  C12R1/78 ,  C12R1/865 ,  A61K38/43 ,  A61K38/53 ,  C12N9/14

CPC分类号： C07K14/38 ,  C12N9/16 ,  A61K38/00

摘要： A process for obtaining a consensus protein from a group of amino acid sequences of a defined protein family, proteins and polynucleotides so obtained, and compositions containing such proteins.

公开(公告)号：US5962776A

公开(公告)日：1999-10-05

申请号：US944183

申请日：1997-10-06

申请人： Martin Lehmann

发明人： Martin Lehmann

IPC分类号： G01M3/16 ,  G01M3/18 ,  G01M3/32

CPC分类号： G01M3/186 ,  G01M3/187 ,  G01M3/329

摘要： In order to obtain a reliable idea of the state of tightness for tightness testing of containers filled with liquids in which a pressure differential .DELTA.p is created between the interior of the container and its exterior, and also relative to the container wall in contact with the filling, an impedance measurement (7) is performed using measuring electrodes (3a, 3b) on the exterior of container (1).

摘要翻译： 为了获得对容器充满液体紧密度测试的可靠状态的可靠性，其中容器内部与外部之间产生压差ΔTA，并且相对于与容器壁相接触的容器壁 填充时，使用容器（1）外部的测量电极（3a，3b）进行阻抗测量（7）。

公开(公告)号：US5915270A

公开(公告)日：1999-06-22

申请号：US591731

申请日：1996-01-25

申请人： Martin Lehmann

发明人： Martin Lehmann

IPC分类号： G01M3/32

CPC分类号： G01M3/329 ,  G01M3/3281

摘要： A method and device for testing containers, the method calling for a difference in pressure to be generated between the pressure inside the container and the pressure immediately surrounding the container, the behavior of one of these pressures permitting the gas tightness of the container to be assessed. A pressure value is stored and subsequently compared with one of the pressures, the stored pressure value being stored electronically and compared with at least one value of the output signal from a pressure sensor. The container is housed in an enclosure which is connected to a pressure or suction line, and a pressure-value storage unit, a comparator unit and a pressure sensor are associated with the pressure or suction line.

公开(公告)号：US5287729A

公开(公告)日：1994-02-22

申请号：US708226

申请日：1991-05-31

申请人： Martin Lehmann

发明人： Martin Lehmann

IPC分类号： G01M3/36

CPC分类号： G01M3/363

摘要： To test a closed container having at least one flexible wall area in order to determine a leakage by an increasing of the inner volume of the container and a measuring of a correspondingly caused changed measured value, at least one outer wall area of the container is exposed to a medium having a pressure which is greater than a pressure produced by the increase of the volume of the container if such has no leakage. The increase of the volume can be made by a pneumatic or mechanical application of a force at a flexible wall area. The arrangement is specifically suitable when the wall of the container or its contents strive to self-seal a leakage spot in a wall area.

摘要翻译： 为了测试具有至少一个柔性壁面积的密闭容器，以便通过增加容器的内部体积并测量相应地引起的改变的测量值来确定泄漏，容器的至少一个外壁区域暴露 如果没有泄漏，则压力大于由容器的体积增加产生的压力的介质。 体积的增加可以通过在柔性壁区域上的力的气动或机械施加来进行。 当容器的壁或其内容物的壁试图自我密封壁区域中的泄漏点时，这种布置特别合适。

公开(公告)号：US09624521B2

公开(公告)日：2017-04-18

申请号：US13510636

申请日：2010-11-24

申请人： Hans-Peter Hohmann ,  Martin Lehmann ,  Muriel Merkamm ,  Denis Pompon

发明人： Hans-Peter Hohmann ,  Martin Lehmann ,  Muriel Merkamm ,  Denis Pompon

IPC分类号： C12N9/02 ,  C12N9/10 ,  C12N1/19 ,  C12P33/06 ,  C12P33/00

CPC分类号： C12P33/00 ,  C12N9/001 ,  C12N9/0067 ,  C12N9/0071 ,  C12N9/0083 ,  C12N9/1007 ,  C12P33/06

摘要： This invention relates to the production of 7-dehydrocholesterol, 25-hydroxy-7-dehydrocholesterol, and 25-hydroxy ergosterol in yeast such as Saccharomyces cerevisiae. It also relates to various enzymes catalyzing the reduction of the double bond at position 24 of lanosterol, dimethyl zymosterol, methyl zymosterol, zymosterol, cholesta-7, 24-dienol, or cholesta-5,7,24-trienol; or the hydroxylation at position 25 of ergosterol, 7-dehydrocholesterol, cholesta-8-enol, and cholesta-7-enol. It also relates to various nucleic acids encoding cholesterol C25-hydroxylases and sterol Δ24-reductases and their use to produce and hydroxylate 7-dehydrocholesterol or ergosterol. It also relates to the yeast strains so produced, and methods of making these sterols that include the steps of cultivaton a transformed yeast cell, and harvesting the resulting sterol(s).

公开(公告)号：US08975576B2

公开(公告)日：2015-03-10

申请号：US14207876

申请日：2014-03-13

申请人： Martin Lehmann

发明人： Martin Lehmann

IPC分类号： G01M3/02 ,  H01J47/00 ,  G01M3/20 ,  G01M3/22 ,  G01M3/32 ,  B65B3/04 ,  H01J49/04 ,  H01J49/00 ,  B65B57/00

CPC分类号： G01M3/02 ,  B65B3/04 ,  B65B57/00 ,  G01M3/202 ,  G01M3/227 ,  G01M3/329 ,  H01J49/00 ,  H01J49/04

摘要： Close containers which are filled with a consumer product are tested on leakiness by means of mass spectrometry (10) in that an impact (AN(P)) by the consumer product (P) upon the surrounding atmosphere (A(P)) of the container to be leak tested is monitored by the mass spectrometry (10).

摘要翻译： 填充消费品的封闭容器通过质谱法（10）进行泄漏测试，消费品（P）对周围大气（A（P））的影响（AN（P））为 通过质谱法（10）监测要进行泄漏测试的容器。

公开(公告)号：US20140312217A1

公开(公告)日：2014-10-23

申请号：US14207876

申请日：2014-03-13

申请人： Martin Lehmann

发明人： Martin Lehmann

IPC分类号： G01M3/02 ,  H01J49/04 ,  B65B3/04

CPC分类号： G01M3/02 ,  B65B3/04 ,  B65B57/00 ,  G01M3/202 ,  G01M3/227 ,  G01M3/329 ,  H01J49/00 ,  H01J49/04

摘要： Close containers which are filled with a consumer product are tested on leakiness by means of mass spectrometry (10) in that an impact (AN(P)) by the consumer product (P) upon the surrounding atmosphere (A(P)) of the container to be leak tested is monitored by the mass spectrometry (10).

摘要翻译： 填充消费品的封闭容器通过质谱法（10）进行泄漏测试，消费品（P）对周围大气（A（P））的影响（AN（P））为 通过质谱法（10）监测要进行泄漏测试的容器。

公开(公告)号：US08551732B2

公开(公告)日：2013-10-08

申请号：US12601614

申请日：2008-06-09

申请人： Martin Lehmann ,  Zoltan Pragai ,  Michéle Schaber

发明人： Martin Lehmann ,  Zoltan Pragai ,  Michéle Schaber

IPC分类号： C12P25/00 ,  C12P17/16 ,  C12P13/04 ,  C12P17/12 ,  C12P17/18 ,  C12N15/74 ,  C12N15/75

CPC分类号： C12N15/75 ,  C12P1/04 ,  C12P13/02 ,  C12P17/12 ,  C12P17/167 ,  C12P17/182 ,  C12P17/186 ,  C12P21/02 ,  C12P25/00

摘要： The present invention relates to newly identified mRNA stabilizing elements useful for the production of a target fermentation product, such as e.g. vitamins or enzymes, in particular riboflavin (vitamin B2), biotin, pantothenic acid (vitamin B5), folic acid, thiamin, pyridoxine (vitamin B6), vitamin B12, xylanase, amylase, protease, glucanase, amylomaltase or maltogenic amylase.

摘要翻译： 本发明涉及用于生产靶发酵产物的新鉴定的mRNA稳定化元件，例如， 维生素或酶，特别是核黄素（维生素B2），生物素，泛酸（维生素B5），叶酸，硫胺素，吡哆醇（维生素B6），维生素B12，木聚糖酶，淀粉酶，蛋白酶，葡聚糖酶，淀粉芽孢杆菌或麦芽糖淀粉酶。

公开(公告)号：US08262487B2

公开(公告)日：2012-09-11

申请号：US13346199

申请日：2012-01-09

申请人： Martin Lehmann

发明人： Martin Lehmann

IPC分类号： F16D3/223

CPC分类号： F16D3/227 ,  F16D2003/22303

摘要： A ball joint having an inner hub which has an inner hub axis and an outer surface, in which inner races and cage guide surfaces are arranged in the inner hub; an outer hub which has an outer hub axis and an inner surface, in which outer races and cage guide surfaces are arranged in the outer hub, and a cage which is ring-shaped and has a cage axis. The inner surface of the cage extends in the direction of the cage axis, the outer surface of the cage extends away from the direction of the cage axis, an inner race is constructed to extend straight and/or parallel to the inner hub axis, and an outer race is constructed to extend straight and/or parallel to the outer hub axis.

摘要翻译： 一种球形接头，其具有内轮毂轴线和外表面，内轮毂和轿厢导向面布置在内轮毂中; 具有外轮毂轴线和内表面的外轮毂，其中外座圈和保持架引导表面布置在外轮毂中，以及保持架，其为环形且具有保持架轴线。 保持架的内表面沿着保持架轴线的方向延伸，保持架的外表面远离保持架轴线的方向延伸，内座圈构造成直线和/或平行于内轮毂轴线延伸，并且 外圈构造成直线和/或平行于外轮毂轴线延伸。