公开(公告)号：US20200060586A1

公开(公告)日：2020-02-27

申请号：US16552780

申请日：2019-08-27

Applicant: Medtronic MiniMed, Inc.

Inventor： Ting Huang ,  Ashwin K. Rao ,  Rajiv Shah ,  Qingling Yang

IPC: A61B5/145 ,  C12Q1/00 ,  A61B5/1486 ,  C25D5/18 ,  A61B5/1477

Abstract: The invention disclosed herein includes amperometric glucose sensors having electrodes formed from processes that electrodeposit platinum black in a manner that produces relatively smooth three dimensional metal architectures, ones that contribute to sensor reliability and stability. Embodiments of the invention provide analyte sensors having such uniform electrode architectures as well as methods for making and using these sensor electrodes. A number of working embodiments of the invention are shown to be useful in amperometric glucose sensors worn by diabetic individuals.

公开(公告)号：US10478102B2

公开(公告)日：2019-11-19

申请号：US15996304

申请日：2018-06-01

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rebecca K. Gottlieb ,  Rajiv Shah ,  Katherine T. Wolfe ,  Eric Allan Larson

IPC: A61B5/05 ,  A61B5/145 ,  A61B5/00 ,  A61M5/158 ,  A61M5/32 ,  A61M25/06 ,  A61M37/00 ,  A61B5/1473 ,  A61B17/34

Abstract: An introducer is provided for introducing a sensor into the body of a patient. The introducer connects to a sensor hub. When the sensor hub and introducer are connected, the introducer needle is exposed. When the sensor hub and introducer are disconnected, a needle cover and the needle move with respect to each other so that the needle cover substantially covers the needle, protecting a user from being injured by the needle.

公开(公告)号：US20190338339A1

公开(公告)日：2019-11-07

申请号：US16508127

申请日：2019-07-10

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Yiwen Li ,  Jenn-Hann Larry Wang ,  Rajiv Shah

IPC: C12Q1/54 ,  C12Q1/00

Abstract: Embodiments of the invention provide methods and materials for making analyte sensors having a plurality of layered elements such as amperometric glucose sensors that are used by diabetic individuals to monitor blood sugar concentrations. Embodiments of the invention utilize plasma deposition technologies to form thin films of adhesion promoting compositions useful in such sensors. Sensors that incorporate the thin film compositions formed by these processes exhibit a number of desirable characteristics.

公开(公告)号：US10420496B2

公开(公告)日：2019-09-24

申请号：US15366247

申请日：2016-12-01

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Bahar Reghabi ,  James L. Henke ,  Wayne A. Morgan ,  Gopikrishnan Soundararajan ,  David Y. Choy ,  Peter Schultz ,  Udo Hoss

IPC: A61B5/00 ,  A61B5/1495 ,  G01N27/327 ,  A61B5/145 ,  A61B5/1486 ,  A61M5/172

Abstract: A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.

公开(公告)号：US20190246961A1

公开(公告)日：2019-08-15

申请号：US16397156

申请日：2019-04-29

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Jaeho Kim ,  Mike C. Liu ,  Andy Y. Tsai

IPC: A61B5/1495 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/00 ,  A61B5/053

CPC classification number: A61B5/1495 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/6848 ,  A61B5/6868 ,  A61B5/7221 ,  A61B5/7225 ,  A61B5/742 ,  A61B2560/0204

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

公开(公告)号：US10342468B2

公开(公告)日：2019-07-09

申请号：US15818341

申请日：2017-11-20

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Jenn-Hann Larry Wang ,  Michael E. Miller ,  Raghavendhar Gautham ,  Yiwen Li ,  Rajiv Shah

IPC: G01N27/02 ,  A61B5/1495 ,  G01N27/416 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/00 ,  A61B5/053 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  A61M5/142 ,  A61M5/172 ,  G01N33/96 ,  G01N33/49

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US10335076B2

公开(公告)日：2019-07-02

申请号：US15818111

申请日：2017-11-20

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Jenn-Hann Larry Wang ,  Michael E. Miller ,  Raghavendhar Gautham ,  Yiwen Li ,  Rajiv Shah

IPC: G01N27/02 ,  A61B5/1495 ,  G01N27/416 ,  G01R35/00 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/00 ,  A61B5/053 ,  G01N33/66 ,  A61B5/1459 ,  A61M5/158 ,  A61B5/1486 ,  A61M5/142 ,  A61M5/172 ,  G01N33/96 ,  G01N33/49

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

公开(公告)号：US10251588B2

公开(公告)日：2019-04-09

申请号：US14686653

申请日：2015-04-14

Applicant: Medtronic Minimed, Inc.

Inventor： Bradley Liang ,  Kenneth W. Cooper ,  Raghavendhar Gautham ,  Rajiv Shah

IPC: A61B5/00 ,  A61B5/145 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1486 ,  A61B5/1495

Abstract: Disclosed are methods, apparatuses, etc. for glucose sensor signal reliability analysis.

公开(公告)号：US20180271422A1

公开(公告)日：2018-09-27

申请号：US15996304

申请日：2018-06-01

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rebecca K. Gottlieb ,  Rajiv Shah ,  Katherine T. Wolfe ,  Eric Allan Larson

IPC: A61B5/145 ,  A61B17/34 ,  A61B5/1473

CPC classification number: A61B5/14532 ,  A61B5/1473 ,  A61B5/6849 ,  A61B17/3496 ,  A61M5/158 ,  A61M5/3243 ,  A61M25/0612 ,  A61M37/0069 ,  A61M2005/1585 ,  A61M2005/3247

Abstract: An introducer is provided for introducing a sensor into the body of a patient. The introducer connects to a sensor hub. When the sensor hub and introducer are connected, the introducer needle is exposed. When the sensor hub and introducer are disconnected, a needle cover and the needle move with respect to each other so that the needle cover substantially covers the needle, protecting a user from being injured by the needle.

公开(公告)号：US10001450B2

公开(公告)日：2018-06-19

申请号：US14256229

申请日：2014-04-18

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Benyamin Grosman ,  Desmond Barry Keenan ,  John J. Mastrototaro ,  Rajiv Shah ,  Andrea Varsavsky ,  Ning Yang

IPC: C25D3/38 ,  G01N27/02

CPC classification number: G01N27/026

Abstract: A method of measuring blood glucose of a patient is presented here. In accordance with certain embodiments, the method applies a constant voltage potential to a glucose sensor and obtains a constant potential sensor current from the glucose sensor, wherein the constant potential sensor current is generated in response to applying the constant voltage potential to the glucose sensor. The method continues by performing an electrochemical impedance spectroscopy (EIS) procedure for the glucose sensor to obtain EIS output measurements. The method also performs a nonlinear mapping operation on the constant potential sensor current and the EIS output measurements to generate a blood glucose value.