摘要:
A method for preparing compounds having the formula(I) by using P(3HB), wherein R is R1, R2, R3 are lower linear or branched C1-C4 alkyl, comprising the steps of: a: obtaining (3R)-3-RO—CH(CH3)CH2COOCH3 by pyrolysis of P(3HB) and protection; b: obtaining (3R)-3-RO—CH(CH3)CH2CHO by reduction of (3R)-3-RO—CH(CH3)CH2COOCH3 ; c: enolizing (3R)-3-RO—CH(CH3)CH2CHO and then reacting with chlorosulfonyl isocyanate, at last getting the final product by reduction; wherein (3R)-3-RO—CH(CH3)CH2CHO is enolized by reacting (3R)-3-RO—CH(CH3)CH2CHO with isopropenyl acetate and p-toluenesulfonic acid by heating under reflux.
摘要:
The invention provides methods of inhibiting epigenetic gene silencing in a cell expressing NPM/ALK or decreasing NPM/ALK content in a cell, by contacting a cell with an agent capable of increasing the concentration of Stat5a protein or its functional analog. Further, the invention provides a method of treating malignancies expressing oncogenic kinase by administering to a patient affected with a malignancy an agent capable of increasing the concentration of Stat5a protein or its epigenetically silenced functional tumor suppressor analog in a malignant cell. Finally, it provides a method to diagnose malignancy and monitor patient's response to therapy by analysis of the degree of DNA methylation of the gene encoding for Stat5a or its analog, their mRNA, or protein.
摘要:
A method and device for detaching a user equipment (UE) are disclosed in the present invention. The UE is registered with a mobility management entity (MME) in a packet switched (PS) network and a mobile switching center (MSC) in a circuit switched (CS) network. When the UE needs to detach from the PS network, the MSC receives a Detach Request with a Detach Type indicating the detaching from the PS network only; after receiving the Detach Request, the MSC deletes the context of the PS core network entity and clears the connection between the MSC and the MME. An MME for performing UE detachment is also disclosed in the present invention. The present invention helps reduce the time delay during the subsequent handover and quickly provide users with communications services, so as to improve user's experience and meet the carriers' requirements.
摘要:
Systems and methods for use in communication between a client and a server, via a networking device, are provided. The method may include sending a request to establish a data connection from the client to the server via the networking device, setting a data connection keep-alive interval for the data connection to a predetermined safe value, and sending a request to establish a test connection between the client and the server. The method may further include determining an efficient keep-alive interval for communication between the client and server via the networking device, using the test connection, setting the data connection keep-alive interval to the efficient keep-alive interval determined using the test connection, and uploading the efficient keep-alive interval from the client to the server in an efficient keep-alive interval notification message, for communication to other clients connected to the server.
摘要:
Described herein is a context-free protocol (i.e., the COFFEE protocol) for stimulating cooperation among selfish nodes. Various embodiments have the ability to transmit a packet over the path successfully without the dependency on the information of other packets' transmissions. It is assumed that every node in the network is rational, and therefore during the packet forwarding stage, if the intermediate nodes can not clearly tell whether the packet is destined to them or not, they do not simply drop the packet. Thus, in the COFFEE protocol, by introducing several techniques, for a packet received by a node, the node thinks the packet could potentially be destined to itself and forwards the packet to find out the answer. Detailed analysis and performance evaluations have been conducted to demonstrate the effectiveness of the COFFEE protocol.
摘要:
Therapeutic methods and microorganisms therefor are provided. The microorganisms are designed to accumulate in immunoprivileged tissues and cells, such as in tumors and other proliferating tissue and in inflamed tissues, compared to other tissues, cells and organs, so that they exhibit relatively low toxicity to host organisms. The microorganisms also are designed or modified to result in leaky cell membranes of cells in which they accumulate, resulting in production of antibodies reactive against proteins and other cellular products and also permitting exploitation of proferating proliferating tissues, particularly tumors, to produce selected proteins and other products. Vaccines containing the microorganisms are provided. Combinations of the microorganisms and anti-cancer agents and uses thereof for treating cancer also are provided.
摘要:
Systems and methods for compressing markup language data, such as XML data, are provided that utilize a finite state machine (FSM), which is representative of an XML schema, and a rule file. Information defined in an XML schema is abstracted into a finite state machine (FSM). The rule file ensures that a compressor and de-compressor have consistent FSMs when the compressor and de-compressor for XML data are not in the same location, such as is generally the case for Web Services scenarios or other client/server scenarios. With the rule file, FSMs can thus be be easily stored, transmitted and updated.
摘要:
Modified viruses and methods for preparing the modified viruses are provided. Vaccines that contain the viruses are provided. The viruses can be used in methods of treatment of diseases, such as proliferative and inflammatory disorders, including cancer, and as anti-tumor and/or antiangiogenic agents. The viruses also can be used in diagnostic methods.
摘要:
A fuel-fired water heater has a three-pass condensing type heat exchanger disposed within its tank and having a central vertical first pass flue pipe separated into upper and lower portions by an internal dividing structure. Respectively coupled to the upper and lower first pass flue pipe portions are circumferentially spaced series of vertical second and third pass flue pipes which circumscribe the central flue pipe within the tank. During firing of the water heater, combustion gases from a power burner are sequentially forced downwardly through the upper portion of the first pass flue pipe, upwardly through the second pass flue pipes to an upper plenum external to the tank, and then downwardly through the third pass flue pipes and the lower central pipe portion into a bottom plenum external to the tank for discharge from the water heater.
摘要:
A fuel-fired commercial water heater has a three-pass condensing type heat exchanger disposed within its tank and having a vertical flue connected at its lower end to a central collector plenum horizontally circumscribed by an outer plenum to which an exhaust pipe is coupled. A series of vertical tube structures are disposed above and intercommunicate the central and outer collector plenums. The outlet of a fuel burner is coupled to the upper end of the flue and is operative to sequentially flow combustion gases downwardly through the flue into the central collector plenum, upwardly and then downwardly through the tube structures into the outer collector plenum and then outwardly through the exhaust pipe.