High-strength degradable materials and molded articles for implantation
into human and animal organisms
    81.
    发明授权
    High-strength degradable materials and molded articles for implantation into human and animal organisms 失效
    用于植入人和动物生物体的高强度可降解材料和模塑制品

    公开(公告)号:US6166159A

    公开(公告)日:2000-12-26

    申请号:US66087

    申请日:1993-05-26

    申请人: Wolfgang Ritter

    发明人: Wolfgang Ritter

    摘要: Described are high-strength materials which are degradable and resorbable in the human and animal organisms and shaped articles manufactured therefrom, such as implants, based on cured (meth)acrylic acid esters of polyfunctionally hydroxyl-terminated oligomers of lower hydroxycarboxylic acids {polyfunctional (meth)acrylic acid esters}. The invention is characterized in that said materials and/or shaped articles have been three-dimensionally cross-linked by radiation-curing and/or any other, however boron-free, free radical-initiated polymerization of the polyfunctional (meth)acrylic acid esters and exhibit a tensile strength under standard conditions of at least 10 N/mm.sup.2.

    摘要翻译: PCT No.PCT / EP91 / 02169 Sec。 371日期:1993年5月26日 102(e)日期1993年5月26日PCT 1991年11月18日PCT PCT。 出版物WO92 / 09313 日期1992年6月11日描述了在人和动物生物体中可降解和可再吸收的高强度材料以及由其制造的成型制品,例如植入物,其基于羟基封端的低级羟基羧酸低聚物的固化的(甲基)丙烯酸酯 酸(多官能(甲基)丙烯酸酯})。 本发明的特征在于,所述材料和/或成形制品已经通过辐射固化和/或任何其它多官能(甲基)丙烯酸酯的无硼自由基引发聚合而被三维交联 并且在标准条件下呈现至少10N / mm 2的拉伸强度。

    Thermoplastically processable starch-based materials, shaped articles
manufactured therefrom and process for producing said materials
    84.
    发明授权
    Thermoplastically processable starch-based materials, shaped articles manufactured therefrom and process for producing said materials 失效
    可热塑加工的淀粉基材料,由其制造的成型制品和用于生产所述材料的方法

    公开(公告)号:US5512617A

    公开(公告)日:1996-04-30

    申请号:US307597

    申请日:1994-09-16

    CPC分类号: C08L3/02 C08L67/08

    摘要: Described are materials based on a starch which has been thermomechanically digested at elevated temperatures and pressures and upon the addition of water and/or lower molecular weight plasticizers and which contains oxidatively cross-linkable alkyd resins having been incorporated in an intimate admixture. Preferably, these alkyd resins have been at least predominantly composed of key substances based on re-growable raw materials.The starch blends thus modified are suitable for the manufacture of shaped articles which in the presence of air will be reactively cured and thereupon are imparted with an increased strength, and especially an increased resistance to water.

    摘要翻译: PCT No.PCT / EP93 / 00673 Sec。 371日期1994年9月16日 102(e)1994年9月16日PCT 1993年3月19日PCT公布。 公开号WO93 / 19124 日期为1993年9月30日。描述了基于淀粉的材料,其在升高的温度和压力下热机械消化,并且在加入水和/或较低分子量的增塑剂并且其中含有可掺入的氧化可交联的醇酸树脂 一种贴心的外加剂。 优选地,这些醇酸树脂至少主要由基于可再生原料的关键物质组成。 如此改性的淀粉共混物适用于制造成型制品,其在空气存在下将被反应固化,从而赋予增强的强度,特别是增加的耐水性。

    Resorbable bone wax
    85.
    发明授权
    Resorbable bone wax 失效
    可再吸收骨蜡

    公开(公告)号:US5482717A

    公开(公告)日:1996-01-09

    申请号:US209322

    申请日:1994-03-10

    摘要: The invention is a resorbable, viscous to solid wax for the mechanical staunching of blood on hard body tissue, particularly bones, based on oligomers of glycolic acid and/or lactic acid and derivatives thereof with monofunctional and/or polyfunctional alcohols and/or corresponding carboxylic acids. The new waxes are characterized by containing body-compatible salts of organic and/or inorganic acids which are formed by corresponding reaction of any free carboxyl groups present in the oligomer wax and/or are incorporated in the wax in homogeneous distribution as added salts.

    摘要翻译: 本发明是一种可再吸收的粘稠固体蜡,用于在基于乙醇酸和/或乳酸及其衍生物的低聚物与单官能和/或多官能醇和/或相应的羧酸的硬体组织,特别是骨骼上机械地起搏血液 酸。 新的蜡的特征在于含有通过与低聚物蜡中存在的任何游离羧基的相应反应形成的有机和/或无机酸的体相容的盐和/或以均匀分布的形式加入到蜡中作为加成盐。

    Reactive systems and/or polymer composition for tissue contact with the
living body
    86.
    发明授权
    Reactive systems and/or polymer composition for tissue contact with the living body 失效
    组织与活体接触的活性体系和/或聚合物组合物

    公开(公告)号:US5461124A

    公开(公告)日:1995-10-24

    申请号:US220409

    申请日:1994-03-30

    摘要: Described is the use of physiologically compatible tocopherols and especially of vitamin E as an inhibitor against premature polymerization initiation in reactive systems capable of undergoing a free radical-initiated polymerization, which systems before and/or after the polymerization thereof are placed in tissue contact with the living human or animal body and, more specifically, are implanted into the living organism thereby. The reactive systems and the polymers formed therefrom may be degradation resistant. However, a special embodiment relates to compositions or molded bodies which are decomposed by the living organism, and especially so under time-controlled conditions. The invention further relates to surgical binder systems which are suitable for adhesion bonding endogenous body tissue and which have been based on an adhesive component capable of being activated by free radicals, said adhesive component being present in admixture with a free radical inhibitor and being characterized in that the inhibitor or at least the predominant portion of the inhibitor is vitamin E. It is preferred that the described compositions are free from physiologically unacceptable solvents or residual amounts of solvents left from the preparation process.

    摘要翻译: 描述了生理上相容的生育酚,特别是维生素E作为抑制抗过敏引发反应体系的能够进行自由基引发聚合的抑制剂的用途,该反应体系在其聚合之前和/或之后与其组合接触 活的人或动物体,更具体地,植入生物体中。 反应体系和由其形成的聚合物可以是耐劣化的。 然而,一个特殊的实施方案涉及由活体分解的组合物或模塑体,特别是在时间控制的条件下。 本发明还涉及适于粘附内源性身体组织并且基于能够被自由基活化的粘合剂组分的外科粘合剂体系,所述粘合剂组分与自由基抑制剂混合存在,其特征在于 抑制剂或至少主要部分的抑制剂是维生素E。优选所述组合物不含生理上不可接受的溶剂或从制备过程中残留的溶剂残留量。

    Method for blood coagulation on hard tissues
    88.
    发明授权
    Method for blood coagulation on hard tissues 失效
    硬组织上凝血的方法

    公开(公告)号:US5277900A

    公开(公告)日:1994-01-11

    申请号:US700351

    申请日:1985-02-11

    申请人: Wolfgang Ritter

    发明人: Wolfgang Ritter

    CPC分类号: A61L24/046 A61L27/18

    摘要: A method of using resorbable waxes for coagulation of blood on endogenous hard tissue, especially bone, which waxes consist of waxy polyester-oligomers of hydroxybarboxylic acids which are viscous to solid at body temperature. On the basis of their structure, these waxes are degradable by endogenous metabolic mechanism, wherein the rate of degradation can be adjusted.

    摘要翻译: 一种使用可再吸收的蜡来凝固内源性硬组织,特别是骨的方法,该蜡由在体温下粘稠至固体的羟基羧酸的蜡状聚酯低聚物组成。 基于它们的结构,这些蜡可通过内源代谢机制降解,其中可以调节降解速率。

    Simplified process for sterilizing semi-solid to solid preparations
based on oligomers of lower hydroxycarboxylic acids or their salts
    89.
    发明授权
    Simplified process for sterilizing semi-solid to solid preparations based on oligomers of lower hydroxycarboxylic acids or their salts 失效
    基于低级羟基羧酸或其盐的低聚物将半固体灭菌至固体制剂的简化方法

    公开(公告)号:US5244628A

    公开(公告)日:1993-09-14

    申请号:US768715

    申请日:1991-10-28

    IPC分类号: A61L2/12 A61L24/04

    CPC分类号: A61L2/12 A61L24/046

    摘要: Described is a process for the simplified sterilization, by heating to high temperatures, of semisolid to solid preparations based on oligomers of lower carboxylic acids or their salts, as well as their transformation products with molecular weight regulating components, the preparations also optionally including biocompatible minerals. According to the invention, the materials to be sterilized are subjected to the action of high frequency oscillations in the microwave range (microwaves).

    摘要翻译: PCT No.PCT / EP90 / 00627 Sec。 371日期1991年10月28日 102(e)日期1991年10月28日PCT 1990年4月19日PCT PCT。 第WO90 / 13319号公报 日期1990年11月15日。描述了一种通过将低温羧基或其盐的低聚物的半固体加热至固体制剂以及其具有分子量调节组分的转化产物来简化灭菌的方法, 制剂还可任选地包括生物相容的矿物质。 根据本发明,要消毒的材料在微波范围(微波)中受到高频振荡的作用。

    Table having a connection device
    90.
    发明授权
    Table having a connection device 失效
    表具有连接装置

    公开(公告)号:US5035186A

    公开(公告)日:1991-07-30

    申请号:US319149

    申请日:1989-03-03

    IPC分类号: A47B13/00 A47B87/00

    摘要: On a table (10), a support element (14, 15) is provided on the table leg (13) and below the tabletop (11). This support element is pivotable about the vertical axis of the table leg (13). When the support element (14, 15) is pivoted outward, it can serve as a support for a tabletop (21) and is formed accordingly. The tabletop (21) has an elongated engagement element (24) on its underside, which element upon connection positively engages the inside of a corresponding elongated recess (23) of the support element (14, 15). A table connection formed in this way is very stable, and makes it possible for the thus-formed table arrangement to be moved about practically like a rigid unit. Also, it is possible for a single person without additional help, using this connection device, to couple one table (10) to an adjacent tabletop (21).

    摘要翻译: 在桌子(10)上,在桌腿(13)上和桌面(11)下面设置支撑元件(14,15)。 该支撑元件围绕桌腿(13)的竖直轴线可枢转。 当支撑元件(14,15)向外枢转时,其可以用作桌面(21)的支撑件并且相应地形成。 桌面(21)在其下侧具有细长的接合元件(24),该连接元件在连接时主动地与支撑元件(14,15)的相应的细长凹槽(23)的内部啮合。 以这种方式形成的工作台连接是非常稳定的,并且使得如此形成的工作台布置可以实际上像刚性单元一样移动。 而且,使用该连接装置,单个人无需额外的帮助即可将一个桌子(10)连接到相邻的桌面(21)。