公开(公告)号：US11690935B2

公开(公告)日：2023-07-04

申请号：US16953224

申请日：2020-11-19

申请人： NATIONAL CHIAO TUNG UNIVERSITY

发明人： Hsin-Chieh Lin ,  Imam Sahroni

IPC分类号： A61L27/52 ,  A61L27/18 ,  A61L27/22 ,  A61L27/50 ,  C12N5/00

CPC分类号： A61L27/52 ,  A61L27/18 ,  A61L27/22 ,  A61L27/50 ,  C12N5/0068 ,  A61L2400/06 ,  C12N2533/20 ,  C12N2533/30

摘要： The invention provides a thermosensitive peptide hydrogel, which comprises water, a polyether/polyol polymer and a peptide molecule. The peptide molecule has a structure represented by the following chemical formula (1).
Chemical Structure (1):

公开(公告)号：US11684700B2

公开(公告)日：2023-06-27

申请号：US17847832

申请日：2022-06-23

申请人： The Johns Hopkins University

发明人： Xuesong Jiang ,  Sashank Reddy ,  Gerald Brandacher ,  Hai-Quan Mao ,  Justin Sacks ,  Xiaowei Li ,  Kevin Feng ,  Russell Martin ,  Georgia C. Yalanis ,  Ji Suk Choi

IPC分类号： A61L27/52 ,  A61L27/16 ,  A61L27/24 ,  A61L27/36 ,  A61L27/56 ,  A61L27/58 ,  A61L27/18 ,  A61L27/48

CPC分类号： A61L27/52 ,  A61L27/16 ,  A61L27/18 ,  A61L27/24 ,  A61L27/3633 ,  A61L27/56 ,  A61L27/58 ,  A61L27/48 ,  A61L2400/06 ,  A61L2430/06 ,  A61L2430/34 ,  A61L27/16 ,  C08L5/08 ,  A61L27/18 ,  C08L67/04

摘要： A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. A method for manufacturing a composite material for use in healing soft tissue defects can include providing a gel and disposing nanofibers within the gel.

公开(公告)号：US20230183253A1

公开(公告)日：2023-06-15

申请号：US18156306

申请日：2023-01-18

申请人： RHODE ISLAND HOSPITAL

发明人： Qian CHEN ,  Hongchuan YU ,  Yupeng CHEN

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61L27/54 ,  A61K45/06 ,  A61L27/50 ,  A61L27/22 ,  A61K47/54 ,  A61K47/69 ,  A61L27/20 ,  A61L27/52 ,  C07D471/04

CPC分类号： C07D487/04 ,  C07D519/00 ,  A61L27/54 ,  A61K45/06 ,  A61L27/50 ,  A61L27/227 ,  A61K47/542 ,  A61K47/6925 ,  A61K47/545 ,  A61L27/20 ,  A61L27/52 ,  C07D471/04 ,  A61L2400/12 ,  A61F2/30756

摘要： Compositions or an assembly of a series of biomimetic compounds include chemical structures that mimic or structurally resemble a nucleic acid base pair. Complexes of nanotubes and agents are useful to deliver agents into the cells or bodily tissues of individuals for therapeutic and diagnostic purposes. Exemplary compounds include those of Formula (I), (III), (V) or (VII), or of Formula (II), (IV), (VI) or (VIII).

公开(公告)号：US20230181308A1

公开(公告)日：2023-06-15

申请号：US18079345

申请日：2022-12-12

申请人： CONMED Corporation

发明人： Kevin A. Rocco ,  Bhavana Mohanraj ,  Jeffrey Ott ,  Justin Bendigo ,  Jacob Edward Komenda ,  Mark Theodore Aronson ,  Andrew James Carter

IPC分类号： A61F2/08 ,  A61L27/24 ,  A61L27/52 ,  A61L27/18 ,  A61L27/56 ,  A61F2/00 ,  A61L27/48 ,  D06N3/00 ,  A61L27/14 ,  A61L27/26 ,  A61L27/58

CPC分类号： A61F2/08 ,  A61L27/24 ,  A61L27/52 ,  A61L27/18 ,  A61L27/56 ,  A61F2/0063 ,  A61L27/48 ,  D06N3/0043 ,  A61L27/14 ,  A61L27/26 ,  A61L27/58 ,  A61L2430/10 ,  A61F2240/001 ,  A61F2002/0068 ,  A61F2002/0081 ,  A61F2210/0004 ,  A61F2210/0057 ,  A61F2210/0061 ,  A61F2210/0076 ,  Y10T428/249978 ,  Y10T428/249921 ,  Y10T442/2484 ,  Y10T442/419 ,  A61L27/34

摘要： A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

公开(公告)号：US20230174725A1

公开(公告)日：2023-06-08

申请号：US18076369

申请日：2022-12-06

申请人： University of Washington

发明人： Alshakim Nelson ,  Patrick Thomas Smith ,  Siyami Cem Millik ,  Gokce Altin Yavuzarslan

IPC分类号： C08J3/075 ,  C08J3/24 ,  A61L27/34 ,  A61L27/22 ,  A61L27/16 ,  A61L27/58 ,  A61L27/52 ,  A61L31/14 ,  A61L31/10 ,  A61L31/04

CPC分类号： C08J3/075 ,  C08J3/245 ,  A61L27/34 ,  A61L27/227 ,  A61L27/16 ,  A61L27/58 ,  A61L27/52 ,  A61L31/148 ,  A61L31/145 ,  A61L31/10 ,  A61L31/048 ,  A61L31/047 ,  C08J2389/00 ,  C08J2351/08 ,  A61L2420/00 ,  C08J2335/02

摘要： Hydrogels, bioplastics, and techniques for generating the same are described herein. An example method includes generating a resin including a globular protein, a co-monomer, water, and a photoinitiator. A hydrogel is generated by exposing the resin to light, thereby polymerizing the globular protein and the co-monomer. Further, the example method includes dehydrating the hydrogel by removing at least a portion of the water; and rehydrating the hydrogel in the presence of a hydrogen bonding agent.

公开(公告)号：US20230173141A1

公开(公告)日：2023-06-08

申请号：US17916215

申请日：2021-04-02

申请人： CORNELL UNIVERSITY

发明人： Wanjun LIU ,  Minglin MA ,  James A. FLANDERS ,  Longhai WANG ,  Daniel T. BOWERS ,  Qingsheng LIU

IPC分类号： A61L27/54 ,  B82Y5/00 ,  A61L27/52 ,  A61L27/56 ,  A61L27/34

CPC分类号： A61L27/54 ,  B82Y5/00 ,  A61L27/52 ,  A61L27/56 ,  A61L27/34 ,  A61L2400/12

摘要： The present application relates to implantable therapeutic delivery system, its method of making and use. The therapeutic delivery system includes a nanofiber core substrate having proximal and distal ends, and an interior nanofiber wall defining an internal space extending longitudinally along the core substrate, with one or more therapeutic agents positioned within the internal space. A hydrogel surrounds the nanofiber core substrate, where the hydrogel includes 0.1% to 20% of an alginate mixture. The alginate mixture includes zwitterionically modified alginate and pure alginate in a ratio of 1:1000 to 1000:1 (v/v). Also disclosed is a thermo sealing device useful for the formation of the implantable therapeutic delivery system.

公开(公告)号：US11667756B2

公开(公告)日：2023-06-06

申请号：US17514183

申请日：2021-10-29

申请人： Ethicon, Inc.

发明人： Duan Li Ou ,  Leo B. Kriksunov ,  Lamar Kirchhevel ,  Clifford Dwyer

IPC分类号： C08G77/20 ,  C08L83/04 ,  A61L27/18 ,  A61L27/52 ,  A61M5/00 ,  A61M5/19 ,  A61M5/24 ,  A61M5/32 ,  C08G77/38 ,  C08G77/12 ,  A61F2/12 ,  A61M5/31

CPC分类号： C08G77/20 ,  A61L27/18 ,  A61L27/52 ,  A61M5/002 ,  A61M5/19 ,  A61M5/2448 ,  A61M5/3294 ,  C08G77/38 ,  C08L83/04 ,  A61F2/12 ,  A61F2240/001 ,  A61L2400/06 ,  A61M2005/3114 ,  A61M2210/1007 ,  C08G77/12 ,  C08L83/04 ,  C08L83/00 ,  C08L83/00 ,  C08L83/00 ,  C08K5/56

摘要： Provided are rapidly cross-linkable silicone compositions, systems, kits, and methods for filling implanted medical devices in situ, the implanted medical devices, including for example, body implants and tissue expanders, the compositions including a platinum divinyl disiloxane complex; a low viscosity vinyl terminated polydimethylsiloxane; a low viscosity hydride terminated polydimethylsiloxane; and a silicone cross-linker, where the rapidly cross-linkable silicone composition has a viscosity of ≤150 cPs for ≥1 min. post-preparation and ≤300 cPs≤5 min. post-preparation, at ambient temperature.

公开(公告)号：US20230165605A1

公开(公告)日：2023-06-01

申请号：US18101600

申请日：2023-01-26

申请人： UMC UTRECHT HOLDING B.V. ,  BO-IP B.V.

发明人： Joannes Jacobus VERLAAN ,  Bas Jeroen OOSTERMAN

IPC分类号： A61B17/70 ,  A61L27/20 ,  A61L27/22 ,  A61L27/52 ,  A61M31/00

CPC分类号： A61B17/7044 ,  A61B17/7061 ,  A61L27/20 ,  A61L27/222 ,  A61L27/227 ,  A61L27/52 ,  A61M31/002 ,  A61B2017/00004

摘要： The present invention provides a deformable body (2), wherein the deformable body comprises a force application surface (12) opposite a bone contact surface (52) to be pressed against periosteum of a bone surface (52) of a bone such that the bone contact surface adapts its shape to the shape of the bone surface, wherein the deformable body comprises one or more through-going openings (3) and/or one or more fixation locations (34) arranged to receive a fixation element such as as screw (20), and wherein the deformable body comprises an anaesthetic that is released from or through the bone contact surface. The anaesthetic can be bupivicaine, liposome bupivacaine, lidocaine or levobupivacaine. The anaestethic can be arranged in one or more compartments (6, 7) which have ifferent release rates. The screw can comprise a detent or rim to mate with the deformable body. A sleeve (80) can be arranged in the opening (3) to receive the screw. A pusher element (81) can push the deformable body from the sleeve into position on the screw.

公开(公告)号：US11660372B2

公开(公告)日：2023-05-30

申请号：US17592312

申请日：2022-02-03

申请人： EVOLVED BY NATURE, INC.

发明人： Gregory H. Altman ,  Peng Xu ,  Erlei Jin

IPC分类号： A61L27/26 ,  A61L27/52

CPC分类号： A61L27/26 ,  A61L27/52 ,  A61L2300/402 ,  A61L2400/06 ,  A61L2430/34

摘要： Hyaluronic acid and silk protein fragments based tissue fillers and methods of using the same are provided herein.

公开(公告)号：US20190240379A1

公开(公告)日：2019-08-08

申请号：US16343473

申请日：2017-10-24

申请人： BIOXIS PHARMACEUTICALS

发明人： Frédéric BERTAINA ,  Alexandre GUERRY

IPC分类号： A61L27/60 ,  A61L27/20 ,  A61L27/54 ,  A61K45/06 ,  A61P17/00 ,  A61K9/00

CPC分类号： A61L27/60 ,  A61K8/736 ,  A61K9/0021 ,  A61K9/2068 ,  A61K9/4875 ,  A61K31/167 ,  A61K31/445 ,  A61K31/722 ,  A61K38/39 ,  A61K45/06 ,  A61K2800/91 ,  A61L27/20 ,  A61L27/3633 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/63 ,  A61L2400/06 ,  A61P17/00 ,  A61P25/04 ,  A61Q19/08 ,  C08L5/08 ,  A61K2300/00

摘要： An aqueous composition of chitosan including between 0.1 and 5 wt.-% chitosan relative to the total weight of the composition, for use in increasing the volume and/or number of adipocytes. The increase in the volume and/or number of adipocytes allows for use in the treatment of or combating against ageing of the skin, for filling in skin defeats, or the repair or reconstruction of continuous or subcutaneous tissues.