公开(公告)号：US20020037591A1

公开(公告)日：2002-03-28

申请号：US09967975

申请日：2001-10-02

申请人： KYOTO DAIICHI KAGAKU CO., LTD.

发明人： Hideko Kosaka

IPC分类号： G01N021/75 ,  G01N033/00

CPC分类号： G01N33/683 ,  Y10S436/815

摘要： A composition capable of showing a color change sufficient for indicating the presence and/or concentration of a protein in a protein-containing liquid sample by contacting with the sample, comprising: indium or an indium compound, and a dye or pigment capable of forming a complex with indium.

摘要翻译： 能够显示足够的颜色变化的组合物，该颜色变化足以通过与样品接触来指示含蛋白质的液体样品中的蛋白质的存在和/或浓度，包括：铟或铟化合物，以及能够形成 与铟复合。

公开(公告)号：US6130055A

公开(公告)日：2000-10-10

申请号：US135915

申请日：1998-08-18

申请人： Atsuko Nanbu ,  Satoshi Fukunaga

发明人： Atsuko Nanbu ,  Satoshi Fukunaga

IPC分类号： G01N33/15 ,  C12Q1/37 ,  C12Q1/34

CPC分类号： C12Q1/37 ,  C12Q2337/12 ,  G01N2333/811 ,  G01N2333/8114 ,  G01N2333/976 ,  Y10S435/962

摘要： A method for measuring the concentration or the activity of UTI quickly and easily at high sensitivity. A urine sample, a buffer solution, a trypsin solution and a substrate solution are mixed and the trypsin activity is then measured. Thus, the UTI concentration in the urine sample is determined. In this case, a substrate solution having only L-BAPNA is used as the substrate, and the surfactant is mixed in at least one selected from the buffer solution and the enzyme solution. The mixing ratio of the surfactant is about 1 wt. % in the entire enzyme reaction solution. Examples of the surfactant include polyoxyethylene (40) octylphenylether, polyoxyethylene (10) octylphenylether, 3-[(3-cholamido propyl)dimethylammonio]-propanesulfonic acid, 3-[(3-cholamido propyl)dimethylammonio]-2-hydroxypropanesulfonic acid, and polyoxyethylene sorbitan monolaurate. As shown in FIG. 1, the sensitivity improves when using L-BAPNA.

摘要翻译： 用于以高灵敏度快速，容易地测量UTI的浓度或活性的方法。 将尿样，缓冲溶液，胰蛋白酶溶液和底物溶液混合，然后测定胰蛋白酶活性。 因此，测定尿样中的UTI浓度。 在这种情况下，使用仅具有L-BAPNA的底物溶液作为底物，并且将表面活性剂混合在选自缓冲溶液和酶溶液中的至少一种。 表面活性剂的混合比为约1wt。 ％在整个酶反应溶液中。 表面活性剂的实例包括聚氧乙烯（40）辛基苯基醚，聚氧乙烯（10）辛基苯基醚，3 - [（3-胆酰胺基丙基）二甲基氨基] - 丙磺酸，3 - [（3-胆酰胺基丙基）二甲基氨基] -2-羟基丙磺酸和 聚氧乙烯脱水山梨醇单月桂酸酯。 如图所示。 1，使用L-BAPNA时灵敏度提高。

公开(公告)号：US6126636A

公开(公告)日：2000-10-03

申请号：US145336

申请日：1998-09-01

申请人： Michio Naka

发明人： Michio Naka

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/107 ,  A61B5/1455 ,  A61M5/00

CPC分类号： A61B5/6842 ,  A61B5/0059 ,  A61B5/1078 ,  A61B5/6833

摘要： A method of and a device for accurately positioning a measuring means such as a measurement probe relative to that target area of a living body which has a unique marking peculiar to the living body. A transparent sheet member is first applied to the target part, and an image of the unique marking is then transferred onto the transparent sheet member. The transparent sheet member bearing the image of the unique marking is associated with the measuring device so that a subsequent measurement can be performed by the measuring device after the image transferred onto the transparent sheet member has been aligned with the unique marking in the target area.

摘要翻译： 一种用于相对于具有生物特有的独特标记的生物体的目标区域精确地定位诸如测量探针的测量装置的方法和装置。 首先将透明片材部件施加到目标部件，然后将唯一标记的图像转印到透明片材部件上。 承载独特标记的图像的透明片材与测量装置相关联，使得在转印到透明片材上的图像已经与目标区域中的唯一标记对准后，可以通过测量装置执行随后的测量。

公开(公告)号：US5973822A

公开(公告)日：1999-10-26

申请号：US998042

申请日：1997-12-23

申请人： Kexin Xu ,  Hiroshi Yamamoto ,  Bin Xue

发明人： Kexin Xu ,  Hiroshi Yamamoto ,  Bin Xue

IPC分类号： G02F1/33 ,  G02F1/11

CPC分类号： G02F1/116

摘要： In a non-collinear type acousto-optic tunable filter, the incident angle of a source light beam L.sub.1 radiated from a light source 6 onto an acoustic medium 1 is set at an equivalence incident angle for which the wavelength .lambda..sub.i of the diffracted ordinary ray L.sub.3 and the wavelength .lambda..sub.i ' of the diffracted extraordinary ray L.sub.4 become approximately identical. Further, the diffracted ordinary ray L.sub.3 and the diffracted extraordinary ray L.sub.4 of the approximately identical wavelength are superposed, and the intensity of the superposed ray is detected. Consequently, spectrometry is performed based on the superposed diffracted ray having twice the intensity and a very sharp waveform, so that accurate spectroscopy can be made possible even if the intensity of the source light beam is low.

摘要翻译： 在非共线型声光可调滤波器中，从光源6辐射到声学介质1上的源光束L1的入射角被设定为等于入射角，对于该入射角，衍射普通光线的波长λi L3和衍射异常射线L4的波长λi'变得大致相同。 此外，将衍射的普通光线L3和大致相同波长的衍射非凡光线L4重叠，并且检测叠加的光线的强度。 因此，基于具有两倍强度和非常尖锐的波形的叠加衍射光线进行光谱测定，使得即使源光束的强度低，也可以使精确的光谱学成为可能。

公开(公告)号：US5972671A

公开(公告)日：1999-10-26

申请号：US30442

申请日：1998-02-25

申请人： Nobuo Kato ,  Yasuyoshi Sakai ,  Yoshiki Tani ,  Masayuki Yagi ,  Fumiyo Funatsu

发明人： Nobuo Kato ,  Yasuyoshi Sakai ,  Yoshiki Tani ,  Masayuki Yagi ,  Fumiyo Funatsu

IPC分类号： C12N1/26 ,  C12N9/06 ,  C12Q1/26 ,  C12N1/14 ,  C12N9/02 ,  C12N9/04

CPC分类号： C12N9/0022 ,  C12N1/26 ,  C12Q1/26 ,  C12R1/77 ,  Y10S435/929

摘要： A novel fructosyl amino acid oxidase derived from genus Fusarium or Gibberella, a process for producing the enzyme, an assay of an amadori compound using the enzyme, a reagent or a kit containing the enzyme, a process for producing fructosyl lysine and/or fructosyl N.sup..alpha. -Z-lysine as a substrate of a fructosyl amino acid oxidase, which is useful for screening and/or culturing a microorganism capable of producing the enzyme, and a medium containing fructosyl lysine and/or fructosyl N.sup..alpha. -Z-lysine for screening and/or culturing a microorganism capable of producing a fructosyl amino acid oxidase is provided.

摘要翻译： 来自镰刀菌属或赤霉属的新型果糖基氨基酸氧化酶，生产酶的方法，使用该酶的阿马多利化合物的试验，含有酶的试剂或试剂盒，生产果糖基赖氨酸和/或果糖基N的方法 作为果糖基氨基酸氧化酶底物的α-Z-赖氨酸，其可用于筛选和/或培养能够产生该酶的微生物，以及含有果糖基赖氨酸和/或果糖基Nα-Z-赖氨酸的培养基用于筛选 和/或培养能产生果糖基氨基酸氧化酶的微生物。

公开(公告)号：US5776779A

公开(公告)日：1998-07-07

申请号：US809108

申请日：1997-03-13

申请人： Hiroshi Tamura ,  Satoshi Chosa ,  Satoshi Yonehara

发明人： Hiroshi Tamura ,  Satoshi Chosa ,  Satoshi Yonehara

IPC分类号： C12Q1/00 ,  C12Q1/32 ,  C12Q1/34 ,  C12Q1/44 ,  G01N33/52 ,  G01N33/72

CPC分类号： G01N33/526 ,  C12Q1/32 ,  C12Q1/44 ,  G01N2333/904 ,  Y10T436/13 ,  Y10T436/146666

摘要： An integral multi-layer analytical element for analyzing bile acid sulfate comprising a support member, a reagent layer on said support member and a porous developing layer on said reagent layer, at least one of the reagent layer and developing layer containing bile acid sulfate sulfatase, 3.beta.-hydroxysteroid dehydrogenase and a combination of thio-NAD.sup.+ and reduced NAD or reduced NADP, in which the reagent layer contains a water-soluble polymer, a buffer and at least one component selected from the group consisting of sugar alcohols and Mn.sup.2+, which element suppresses the increase of blank values and prevents agglomeration of the enzyme during the preparation of a solution for forming the reagent layer.

摘要翻译： PCT No.PCT / JP95 / 01808 Sec。 371日期1997年3月13日 102（e）1997年3月13日PCT PCT 1995年9月12日PCT公布。 公开号WO96 / 08581 日期1996年3月21日一种用于分析胆汁酸硫酸盐的整体多层分析元件，包括支撑构件，所述支撑构件上的试剂层和所述试剂层上的多孔显影层，所述试剂层和显影层中的至少一个含有 胆汁酸硫酸硫酸酯酶，3β-羟基类固醇脱氢酶和硫代NAD +和还原的NAD或还原的NADP的组合，其中试剂层含有水溶性聚合物，缓冲剂和至少一种选自糖 醇和Mn 2+，该元素在制备用于形成试剂层的溶液中抑制空白值的增加并防止酶的结块。

公开(公告)号：US5589045A

公开(公告)日：1996-12-31

申请号：US331813

申请日：1994-10-31

申请人： Hiroshi Hyodo

发明人： Hiroshi Hyodo

IPC分类号： G01N33/50 ,  G01N27/416 ,  G01N33/487 ,  G01N33/66 ,  G01N27/26

CPC分类号： G01N33/48792 ,  Y10S435/817

摘要： A managing method includes steps of selecting a function according to the type of an electrode mounted on the portable blood sugar value-measuring apparatus; executing a process of clocking a predetermined period of time; deciding whether or not the clocking process has been switched over to a different process while the predetermined period of time is being clocked; and reading out data of measured blood sugar values stored in a storing device from a termination point of the first predetermined period of time when the first predetermined period of time has terminated without the switch-over from the first clocking process to the blood sugar value-measuring process being decided in the deciding process.

摘要翻译： 管理方法包括根据安装在便携式血糖值测量装置上的电极的类型选择功能的步骤; 执行计时预定时间段的处理; 在所述预定时间段被计时的情况下，判断所述计时过程是否切换到不同的进程; 并且从第一预定时间段终止的第一预定时间段的终止点读出存储在存储装置中的测量血糖值的数据，而不从第一计时过程切换到血糖值 - 测量过程在决定过程中决定。

公开(公告)号：US5439827A

公开(公告)日：1995-08-08

申请号：US148321

申请日：1993-11-08

申请人： Yuji Yagi ,  Tamaki Kagawa ,  Hiroshi Tamura ,  Tetsuya Ota

发明人： Yuji Yagi ,  Tamaki Kagawa ,  Hiroshi Tamura ,  Tetsuya Ota

IPC分类号： C12Q1/26 ,  C12Q1/28 ,  G01N31/00 ,  G01N31/22 ,  G01N33/72 ,  G01N33/82 ,  G01N21/75

CPC分类号： G01N33/82 ,  C12Q1/26 ,  C12Q1/28 ,  G01N33/725 ,  C12Q2326/12 ,  Y10T436/144444 ,  Y10T436/25125

摘要： A composition for detecting or quantitatively measuring a peroxide active material in a sample, containing an organic hydroperoxide, a chromogen, and an iron (111) complex of the formula: [(OOC-X-COO).sub.3 Fe]M.sub.3 in which X is an alkylene group:-(CH.sub.2).sub.n - (n=0-5) or an allyl group, and M is a monovalent cation, which can eliminate the influence of reducing compounds such as ascorbic acid contained in the sample.

摘要翻译： 一种用于检测或定量测量样品中过氧化物活性物质的组合物，其含有下式的有机氢过氧化物，色原和铁（111）络合物：其中X为 亚烷基： - （CH 2）n - （n = 0-5）或烯丙基，M是一价阳离子，其可以消除样品中所含的还原化合物如抗坏血酸的影响。

公开(公告)号：US5366868A

公开(公告)日：1994-11-22

申请号：US753371

申请日：1991-08-30

申请人： Hisashi Sakamoto

发明人： Hisashi Sakamoto

IPC分类号： G01N33/52 ,  C12Q1/00 ,  C12Q1/26 ,  G01N33/66 ,  C12Q1/62 ,  G01N31/22

CPC分类号： G01N33/66 ,  Y10S435/805

摘要： A multilayer analytical element for assaying fructosamine, having a liquid-impermeable support, a buffer-containing layer which contains a buffer having pH of 8 to 12 formed on the support, a tetrazolium salt containing layer which is formed on the buffer-containing layer and, optionally, an intermediate layer interposed between the buffer-containing layer and the tetrazolium salt-containing layer to prevent contact of these two layers, which element assays fructosamine in a short time with good accuracy.

摘要翻译： 一种用于测定具有液体不可渗透载体的果糖胺的多层分析元件，含有形成在载体上的pH为8-12的缓冲液的含缓冲液层，形成在含缓冲液层上的含四氮鎓盐的层和 可选地，介于含缓冲剂层和含四唑鎓盐的层之间的中间层，以防止这两个层的接触，该元素在短时间内以高精度测定果糖胺。

公开(公告)号：US5332479A

公开(公告)日：1994-07-26

申请号：US883367

申请日：1992-05-15

申请人： Harumi Uenoyama ,  Hisashi Okuda

发明人： Harumi Uenoyama ,  Hisashi Okuda

IPC分类号： G01N27/327 ,  C12Q1/00 ,  G01N27/416 ,  G01N27/26

CPC分类号： C12Q1/004 ,  Y10S435/817

摘要： A biosensor which electrochemically detects a material which relates to a reaction of a specific compound in a liquid sample with a biologically active substance or its related substance, in which the biologically active material or an optionally used mediator is placed at a part which is remote from a position of an electrode which acts as electrochemical detector means, and optionally the biological active material or the mediator is covered with a polymer layer.

摘要翻译： 电化学检测与液体样品中的特定化合物与生物活性物质或其相关物质的反应相关的材料的生物传感器，其中生物活性物质或任选使用的介体放置在远离 充当电化学检测器装置的电极的位置，以及任选的生物活性材料或介体的聚合物层被覆盖。