公开(公告)号：US07860645B2

公开(公告)日：2010-12-28

申请号：US11571383

申请日：2005-06-30

申请人： Do-Sung Kim ,  Won-Hee Cho ,  Jin-Kyung Park ,  In-Joon Choi ,  Min-Hui Park

发明人： Do-Sung Kim ,  Won-Hee Cho ,  Jin-Kyung Park ,  In-Joon Choi ,  Min-Hui Park

IPC分类号： G08G1/0968 ,  G08G7/78 ,  G01C21/00

CPC分类号： G01C21/36 ,  G01C21/3492

摘要： The telematics service providing system generates a path from the departure point to the destination based on traffic information, generates guidance information for each guidance point where a turn to a direction that is different from the current progress direction of the client is needed on the generated path, clips a vicinity map covering a predetermined area with reference to the guidance point from the total map to generate a guidance point vicinity map, converts the generated guidance point vicinity map into a format displayable by the client, and provides the converted map to the client terminal. Accordingly, confusion caused by complex crossroads or paths that need consecutive and same direction turns may be prevented, the client terminal may not need a memory for storing large-volume geographic information data, and the client may not additionally need to upgrade the geographic information data.

摘要翻译： 远程信息处理服务提供系统基于交通信息生成从出发点到目的地的路径，生成对于在所生成的路径上需要转向与客户端的当前进度方向不同的方向的每个引导点的引导信息 参照来自总图的引导点剪辑覆盖预定区域的附近地图以产生引导点附近地图，将生成的引导点附近地图转换为客户可显示的格式，并将转换后的地图提供给客户端 终奌站。 因此，可以防止由复杂的十字路口或需要连续和相同方向转弯的路径引起的混乱，客户终端可能不需要用于存储大量地理信息数据的存储器，并且客户端可能不需要另外需要升级地理信息数据 。

公开(公告)号：US20090234140A1

公开(公告)日：2009-09-17

申请号：US11721366

申请日：2004-12-20

申请人： Jae Suk Koh ,  Chun Young Kim ,  Byoung In Lee ,  Sang Soo Lee ,  Seong Jun Lee ,  Jong Ho Lim ,  Seon Yeong Jeon ,  Jun Bae Hong

发明人： Jae Suk Koh ,  Chun Young Kim ,  Byoung In Lee ,  Sang Soo Lee ,  Seong Jun Lee ,  Jong Ho Lim ,  Seon Yeong Jeon ,  Jun Bae Hong

IPC分类号： C07D495/04

CPC分类号： C07D495/04 ,  C07B57/00

摘要： Disclosed herein is a method of producing an optically active thiophene-based compound using a simulated moving bed adsorption separation process, and more specifically, a method of continuously separating a racemic thiophene-based compound into its optically active thiophene-based compounds having high purity, through optical resolution using the simulated moving bed process. According to the method of the current invention, a racemic mixture of a thiophene-based compound can be continuously separated into its optically active thiophene-based compounds having high purity, which is an intermediate of optically active dorzolamide acting as a topical therapeutic agent for glaucoma, using a simulated moving bed adsorption separation technique, thereby increasing industrial usability.

摘要翻译： 本文公开了使用模拟移动床吸附分离方法制造光学活性噻吩类化合物的方法，更具体地说，是将外消旋噻吩类化合物连续分离成其高纯度的光学活性噻吩类化合物的方法， 通过使用模拟移动床过程的光学分辨率。 根据本发明的方法，可以将噻吩类化合物的外消旋混合物连续分离成其高纯度的光学活性噻吩类化合物，其是用作青光眼的局部治疗剂的光学活性多吡咯酰胺的中间体 ，使用模拟移动床吸附分离技术，从而提高工业可用性。

公开(公告)号：US20070142220A1

公开(公告)日：2007-06-21

申请号：US10598147

申请日：2005-03-07

申请人： Myung Ahn Ok ,  Dae Ho Shin ,  Jong Hahn ,  Mal woo Lee ,  Seoung Ryu

发明人： Myung Ahn Ok ,  Dae Ho Shin ,  Jong Hahn ,  Mal woo Lee ,  Seoung Ryu

IPC分类号： B01J37/00

CPC分类号： C08F10/00 ,  C08F110/02 ,  C08F210/16 ,  C08F4/6543 ,  C08F4/6565 ,  C08F4/6546 ,  C08F4/651 ,  C08F2500/18 ,  C08F2500/12 ,  C08F210/08

摘要： The present invention relates to a method of preparing an ethylene polymerization catalyst, which comprises reacting a solid reaction product of magnesium halide (such as magnesium chloride), alcohol, an organic magnesium compound, and a halogen compound with a transition metal compound and an electron donor. When ethylene and a-olefin are co-polymerized by slurry polymerization in the presence of the above catalyst, the amount of wax component extracted by the polymerization solvent is very low, and the polymer particles do not agglomerate. The catalyst is prepared in the form of so uniform particles that the resultant polymer has uniform particle morphology, thus increasing bulk density.

摘要翻译： 本发明涉及一种制备乙烯聚合催化剂的方法，该方法包括使卤化镁（如氯化镁），醇，有机镁化合物和卤素化合物的固体反应产物与过渡金属化合物和电子 捐赠者。 当在上述催化剂存在下，通过淤浆聚合将乙烯和α-烯烃共聚时，由聚合溶剂提取的蜡组分的量非常低，并且聚合物颗粒不聚集。 催化剂以均匀的颗粒的形式制备，所得聚合物具有均匀的颗粒形态，从而增加堆积密度。

公开(公告)号：US20070077632A1

公开(公告)日：2007-04-05

申请号：US10596068

申请日：2004-11-03

申请人： Nahm Cho ,  Jong Lim ,  Jong Kim

发明人： Nahm Cho ,  Jong Lim ,  Jong Kim

IPC分类号： C12P17/10

CPC分类号： C12P17/10 ,  C07D209/42 ,  C12P41/005

摘要： Disclosed is a method for preparing (S)-indoline-2-carboxylic acid and (S)-indoline-2-carboxylic acid methyl ester using an inexpensive industrially available enzyme capable of assuring superior optical purity and yield. At this time, the hydrolytic enzyme is selected from the group consisting of Savinase, Alcalase, Novozym 243, Everlase, Esperase, Protease 7 and Acylase, whereby (S)-indoline-2-carboxylic acid and methyl ester thereof having an optical purity of at least 99% e.e. can be obtained through a simplified preparation process, thus generating economic benefits.

摘要翻译： 公开了一种使用廉价的工业可得的酶制备（S） - 二氢吲哚-2-羧酸和（S） - 二氢吲哚-2-羧酸甲酯的方法，其能够确保优异的光学纯度和产率。 此时，水解酶选自Savinase，Alcalase，Novozym 243，Everlase，Esperase，Protease 7和Acylase，由此得到具有光学纯度的（S） - 二氢吲哚-2-羧酸及其甲酯 至少99％ee 可以通过简化的制备过程获得，从而产生经济效益。

公开(公告)号：US07189289B2

公开(公告)日：2007-03-13

申请号：US10503302

申请日：2003-02-06

申请人： Jeon-Keun Oh ,  Wha-Sik Min ,  Sam-Ryong Park ,  Gi-Won Park

发明人： Jeon-Keun Oh ,  Wha-Sik Min ,  Sam-Ryong Park ,  Gi-Won Park

IPC分类号： B08B7/02

CPC分类号： C11D7/105 ,  C11D11/0041 ,  C11D17/06

摘要： Disclosed is a cleaning agent for heater tubes, which is capable of eliminating deposits such as soot particulates in tubes installed in industrial heaters that typically use oil, coal or gas. The cleaning agent of the present invention is prepared by formulating a chemical composition comprising ammonium nitrate into pellets. Also, the present invention discloses a method of cleaning heater tubes using the cleaning agent. When being utilized for cleaning the heater tubes, the cleaning agent can improve mechanical and chemical cleaning effects, thus shortening of working time and reducing a required amount of the chemical composition, as well as preventing rapid evaporation of the chemical composition, thus increasing cleaning effect. In addition, the cleaning agent can eliminate the cementing effect of sulfur oxides or vanadic oxides in the heater tubes and thus control stably emission of NOx, by selectively containing other additives including magnesium and urea.

公开(公告)号：US07132112B2

公开(公告)日：2006-11-07

申请号：US10634689

申请日：2003-08-05

申请人： Yong Moon Choi ,  Lianli Li ,  Kwon H. Kim

发明人： Yong Moon Choi ,  Lianli Li ,  Kwon H. Kim

IPC分类号： A61F13/00 ,  A61L9/04

CPC分类号： A61K9/0043 ,  A61K47/10 ,  A61K47/24 ,  A61K47/28 ,  Y10S514/975

摘要： A novel method of vehicle modulated administration of an anticonvulsive agent to the mucous membranes of humans and animals is disclosed. The vehicle system is an aqueous pharmaceutical carrier comprising an aliphatic alcohol (10–80%) or a glycol (10–80%), and their combinations with a biological surfactant such as a bile salt or a lecithin. The pharmaceutical composition provides a means to control and promote the rate and extent of transmucosal permeation and absorption of the medicaments via a single and multiple administration. Nasal administration of the pharmaceutical preparation produces a high plasma concentration of the anticonvulsant nearly as fast as intravenous administration. Such compositions are particularly suitable for a prompt and timely medication of patients in the acute and/or emergency treatment of status epilepticus and other fever-induced seizures.

摘要翻译： 公开了一种抗人惊厥剂对人和动物粘膜的车辆调节施用的新方法。 载体系统是包含脂族醇（10-80％）或二醇（10-80％））及其与生物表面活性剂如胆汁盐或卵磷脂的组合的水性药物载体。 药物组合物通过单次和多次施用提供控制和促进药物经粘膜渗透和吸收的速率和程度的手段。 药物制剂的鼻内给药几乎与静脉内施用一样快地产生抗惊厥药的高血浆浓度。 这种组合物特别适用于急性和/或紧急治疗癫痫持续状态和其他发热引起的发作的患者的及时和及时的药物。

公开(公告)号：US20060128981A1

公开(公告)日：2006-06-15

申请号：US11285836

申请日：2005-11-22

申请人： Byong Kwak ,  Ki Chung ,  Jun Choi ,  Jong Lim

发明人： Byong Kwak ,  Ki Chung ,  Jun Choi ,  Jong Lim

IPC分类号： C07C253/30

CPC分类号： C07C253/30 ,  C07C2601/14 ,  C07C255/37

摘要： The present invention is directed to a method of preparing 1-[cyano(p-methoxyphenyl)methyl]cyclohexanol. Particularly, the method of this invention includes reacting p-methoxyphenylacetonitrile with cyclohexanone in the presence of a solvent mixture including an aqueous solution of basic material and a water-soluble alcohol, to prepare 1-[cyano(p-methoxyphenyl)methyl]cyclohexanol represented by Formula 1 below. According to this method, 1-[cyano(p-methoxyphenyl)methyl]cyclohexanol, which is an important intermediate for use in the preparation of venlafaxine, exhibiting excellent efficacy as an antidepressant, may be very purely and economically prepared, and as well, may be industrially mass produced.

摘要翻译： 本发明涉及1- [氰基（对甲氧基苯基）甲基]环己醇的制备方法。 特别地，本发明的方法包括在包含碱性物质的水溶液和水溶性醇的溶剂混合物的存在下，使对甲氧基苯基乙腈与环己酮反应，从而制备1- [氰基（对甲氧基苯基）甲基]环己醇 通过下面的公式1。 根据该方法，作为用于制备文拉法辛的重要中间体的1- [氰基（对甲氧基苯基）甲基]环己醇，作为抗抑郁药具有优异的疗效，可以是非常纯粹和经济地制备的， 可能在工业上大规模生产。

公开(公告)号：US20060052617A1

公开(公告)日：2006-03-09

申请号：US10528246

申请日：2002-09-18

申请人： Byong-Sung Kwak ,  Ki-Nam Chung ,  Tae-Yun Kim ,  Ki-Ho Koh ,  Jin-Woong Kim ,  Sang-Il Lee

发明人： Byong-Sung Kwak ,  Ki-Nam Chung ,  Tae-Yun Kim ,  Ki-Ho Koh ,  Jin-Woong Kim ,  Sang-Il Lee

IPC分类号： C07D305/12

CPC分类号： C07D307/33 ,  C07D307/32

摘要： Disclosed is a continuous process for the production of optically pure (S)-β-hydroxy-γ-butyrolactone having constantly maintained optical activity, consisting of hydrogenating 2-50 wt % of a substituted carboxylic acid derivative in a solvent using a fixed bed reactor filled with a precious metal catalyst-impregnated inorganic oxide carrier at 50-500° C. under pressure of 15-5,500 psig at weight-space-velocity of 0.1-10 h−1, in which a molar ratio of hydrogen to carboxylic acid derivative ranges from 2 to 10. The desired material can be produced in higher optical purity and at higher yield by the current process which is relatively simpler and environmentally safer than conventional processes. Additionally, increased production efficiency leads to production of the desired material on a large scale.

摘要翻译： 公开了一种用于生产具有持续保持光学活性的光学纯（S）-β-羟基-γ-丁内酯的连续方法，其包括使用固定床反应器在溶剂中2-50重量％的取代的羧酸衍生物 在50-500℃下在15-5,500psig的压力下填充贵重金属催化剂浸渍的无机氧化物载体，重量 - 空间速度为0.1-10小时-1，其中摩尔 氢与羧酸衍生物的比例范围为2至10.所需材料可以通过现有方法以更高的光学纯度和更高的产率生产，其比常规方法相对简单且环境更安全。 此外，提高的生产效率导致所需材料的大规模生产。

公开(公告)号：US06946020B2

公开(公告)日：2005-09-20

申请号：US10492983

申请日：2002-10-21

申请人： Jae-Sung Han ,  Il-Su Kim ,  Keun-Seob Choi

发明人： Jae-Sung Han ,  Il-Su Kim ,  Keun-Seob Choi

IPC分类号： C01B3/56 ,  B01D53/22 ,  C01B3/50 ,  H01M8/06 ,  B01D71/02

CPC分类号： B01D53/22 ,  B01D53/227 ,  B01D63/08 ,  B01D2317/02 ,  B01D2317/04 ,  C01B3/501 ,  C01B2203/0405 ,  C01B2203/047 ,  Y02P20/149

摘要： A compact hydrogen purification module capable of affording high-grade purified hydrogen, easy assembly and easy control of size is disclosed. The module includes a plurality of unit cells. Each of the unit cells includes two metal membranes permeable only by hydrogen, a metal support ring attached between the metal membranes by diffusion bonding to support the metal membranes, and having a radial hole to allow hydrogen to flow therethrough, a porous plate disposed between the metal membranes to allow the hydrogen to flow therethrough, and a fitting coupled to the metal support ring and having a hole communicating with the hole of the metal support ring to allow the hydrogen to flow therethrough. The individual fittings are connected to each other so that hydrogen collected in the individual fittings is discharged through a hydrogen product line.

摘要翻译： 公开了一种能够提供高品位净化氢，易于组装和容易控制尺寸的紧凑型氢气净化组件。 该模块包括多个单元电池。 每个单电池包括两个仅可由氢气渗透的金属膜，金属支撑环通过扩散接合而附着在金属膜之间，以支撑金属膜，并具有径向孔以允许氢流过其中;多孔板设置在 金属膜以允许氢流过其中，以及联接到金属支撑环并具有与金属支撑环的孔连通以允许氢流过其中的孔的配件。 各个配件彼此连接，使得收集在各个配件中的氢气通过氢气产品线排出。

公开(公告)号：US06867340B2

公开(公告)日：2005-03-15

申请号：US10268649

申请日：2002-10-10

申请人： Seung-Hoon Oh ,  Sang-Il Lee ,  Kyoung-Hak Seong ,  Sang-Hoon Park

发明人： Seung-Hoon Oh ,  Sang-Il Lee ,  Kyoung-Hak Seong ,  Sang-Hoon Park

IPC分类号： B01J29/18 ,  B01J29/22 ,  B01J29/40 ,  B01J29/44 ,  B01J29/70 ,  B01J29/80 ,  B01J37/00 ,  C07C6/12 ,  C07C15/02 ,  C07C15/08

CPC分类号： C07C6/126 ,  B01J29/18 ,  B01J29/22 ,  B01J29/40 ,  B01J29/44 ,  B01J29/7007 ,  B01J29/80 ,  B01J37/0009 ,  B01J2229/26 ,  B01J2229/42 ,  C07C6/123 ,  C07C2521/04 ,  C07C2521/12 ,  C07C2529/18 ,  C07C2529/22 ,  C07C2529/40 ,  C07C2529/44 ,  C07C2529/70 ,  C07C2529/74 ,  Y02P20/52

摘要： A catalyst for the disproportionation/transalkylation of various hydrocarbons consists of a carrier and a metal component supported on the carrier. The carrier comprises 10 to 80 wt % of mordenite and/or beta type zeolite with a mole ratio of silica/alumina ranging from 10 to 200; 0 to 70 wt % of ZSM-5 type zeolite with a mole ratio of silica/alumina ranging from 30 to 500; and 5 to 90 wt % of at least one inorganic binder selected from the group consisting of gamma-alumina, silica, silica alumina, bentonite, kaolin, clinoptilolite, and montmorillonite. The metal component comprises platinum and either tin or lead. The catalyst enables mixed xylenes to be produced at remarkably high yields from benzene, toluene and C9 or higher aromatic compounds through disproportionation/transalkylation with a great reduction in aromatic loss. In addition, the catalyst can maintain its catalytic activity for a long period of time without deactivation.

摘要翻译： 用于各种烃的歧化/烷基转移的催化剂由负载在载体上的载体和金属组分组成。 载体包含10至80重量％的二氧化硅/氧化铝的摩尔比为10至200的丝光沸石和/或β型沸石; 0〜70重量％的二氧化硅/氧化铝摩尔比为30〜500的ZSM-5型沸石; 和5至90重量％的至少一种选自γ-氧化铝，二氧化硅，二氧化硅氧化铝，膨润土，高岭土，斜发沸石和蒙脱石的无机粘合剂。 金属组分包括铂和锡或铅。 该催化剂能够通过歧化/烷基转移从苯，甲苯和C9或更高级芳族化合物以非常高的收率产生混合二甲苯，并大大降低芳族损失。 此外，催化剂可以长时间保持其催化活性而不失活。